CN102016039B - 异常线粒体dna、相关的融合转录物及其杂交探针 - Google Patents

异常线粒体dna、相关的融合转录物及其杂交探针 Download PDF

Info

Publication number
CN102016039B
CN102016039B CN200980114773.XA CN200980114773A CN102016039B CN 102016039 B CN102016039 B CN 102016039B CN 200980114773 A CN200980114773 A CN 200980114773A CN 102016039 B CN102016039 B CN 102016039B
Authority
CN
China
Prior art keywords
cancer
transcript
seq
mtdna
transcripts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980114773.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN102016039A (zh
Inventor
瑞安·帕尔
布赖恩·赖古伊
加布里埃尔·达库波
珍妮弗·克里德
凯丽·鲁滨逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dodik Landau Ltd
MDNA LIFE SCIENCES Inc
Original Assignee
Mitomics Inc
MDNA LIFE SCIENCES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitomics Inc, MDNA LIFE SCIENCES Inc filed Critical Mitomics Inc
Priority to CN201710183734.1A priority Critical patent/CN107011428B/zh
Publication of CN102016039A publication Critical patent/CN102016039A/zh
Application granted granted Critical
Publication of CN102016039B publication Critical patent/CN102016039B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
CN200980114773.XA 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针 Expired - Fee Related CN102016039B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710183734.1A CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4061608P 2008-03-28 2008-03-28
US61/040,616 2008-03-28
PCT/CA2009/000351 WO2009117811A1 (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710183734.1A Division CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针

Publications (2)

Publication Number Publication Date
CN102016039A CN102016039A (zh) 2011-04-13
CN102016039B true CN102016039B (zh) 2017-06-09

Family

ID=41112880

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201710183734.1A Active CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针
CN200980114773.XA Expired - Fee Related CN102016039B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针
CN201080014122.6A Expired - Fee Related CN102388140B (zh) 2008-03-28 2010-03-29 异常线粒体dna、相关的融合转录本和翻译产物及其杂交探针

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201710183734.1A Active CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201080014122.6A Expired - Fee Related CN102388140B (zh) 2008-03-28 2010-03-29 异常线粒体dna、相关的融合转录本和翻译产物及其杂交探针

Country Status (10)

Country Link
US (4) US20110172113A1 (OSRAM)
EP (1) EP2274426B1 (OSRAM)
JP (1) JP5938690B2 (OSRAM)
KR (2) KR101693387B1 (OSRAM)
CN (3) CN107011428B (OSRAM)
AU (1) AU2009227935B2 (OSRAM)
CA (2) CA2719718C (OSRAM)
NZ (2) NZ588658A (OSRAM)
SG (3) SG192453A1 (OSRAM)
WO (1) WO2009117811A1 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101693387B1 (ko) * 2008-03-28 2017-01-05 엠디엔에이 라이프 사이언시즈 인코퍼레이티드 비정상적인 미토콘드리아 ｄｎａ, 그것에 연관된 융합 트랜스크립트 및 혼성화 프로브
JP5734947B2 (ja) * 2009-03-27 2015-06-17 ミトミクス インコーポレイテッドＧｅｎｅｓｉｓ Ｇｅｎｏｍｉｃｓ Ｉｎｃ． 異常型ミトコンドリアｄｎａ、関連融合転写物および翻訳産物、並びにそのハイブリダイゼーションプローブ
RU2012141575A (ru) * 2010-03-01 2014-04-10 Майтомикс Инк. ТРАНСКРИПТЫ СЛИТОЙ мтДНК, АССОЦИИРОВАННЫЕ С ВОЗДЕЙСТВИЕМ УФ ИЗЛУЧЕНИЯ, СПОСОБЫ И ИХ ПРИМЕНЕНИЕ
CN108129554A (zh) 2010-08-10 2018-06-08 洛桑聚合联合学院 红细胞结合性治疗剂
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
SG10202010936RA (en) 2014-02-21 2020-12-30 Ecole Polytecnique Fed De Lausanne Epfl Epfl Tto Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
CA3029211A1 (en) * 2016-06-22 2017-12-28 Degen Zhuo Method and kit for detecting fusion transcripts
WO2018144782A1 (en) * 2017-02-01 2018-08-09 The Translational Genomics Research Institute Methods of detecting somatic and germline variants in impure tumors
EP3638296A1 (en) 2017-06-16 2020-04-22 The University Of Chicago Compositions and methods for inducing immune tolerance
EP3774890A4 (en) * 2018-03-26 2022-05-04 The University of Chicago METHODS AND COMPOSITIONS FOR THE TARGETING OF C-TYPE LECTIN FROM SINUSOIDAL ENDOTHELIAL CELLS OF THE LIVER AND LYMPH NODES (LSECTIN)
CN112384239A (zh) 2018-05-09 2021-02-19 芝加哥大学 影响免疫耐受的组合物和方法
US20220251655A1 (en) * 2018-12-22 2022-08-11 Mdna Life Sciences Inc. Mitochondrial dna deletions associated with endometriosis
CN117384269B (zh) * 2023-09-21 2024-06-18 南方医科大学南方医院 短肽mfrlp及其在制备动脉重塑相关疾病药物中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6605433B1 (en) * 1998-08-20 2003-08-12 The Johns Hopkins University Mitochondrial dosimeter
US6203990B1 (en) * 1998-11-06 2001-03-20 Mitokor Method and system for pattern analysis, such as for analyzing oligonucleotide primer extension assay products
US6933120B2 (en) * 2000-06-20 2005-08-23 Michael D. Seidman Method of determining biological/molecular age
US20030162174A1 (en) * 2001-06-11 2003-08-28 Sutherland John W. Detecting nucleic acid deletion sequences
EP1397508A2 (en) * 2001-06-11 2004-03-17 1304854 Ontario Ltd Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
US20050026167A1 (en) * 2001-06-11 2005-02-03 Mark Birch-Machin Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
GB2380194B (en) * 2001-10-01 2005-06-22 Roger Michael Marchbanks A mitochondrial mutation associated with schizophrenia and increased oxidative stress
US20060051796A1 (en) * 2004-09-09 2006-03-09 Inga Boell Real time PCR with the addition of pyrophosphatase
CA2792443A1 (en) * 2005-04-18 2006-10-26 Ryan Parr Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
US20070134678A1 (en) * 2005-12-12 2007-06-14 Rees Dianne M Comparative genome hybridization of organelle genomes
EP2203570B1 (en) 2007-09-26 2014-04-23 Mitomics Inc. 3.4 kb mitochondrial dna deletion for use in the detection of cancer
KR101693387B1 (ko) * 2008-03-28 2017-01-05 엠디엔에이 라이프 사이언시즈 인코퍼레이티드 비정상적인 미토콘드리아 ｄｎａ, 그것에 연관된 융합 트랜스크립트 및 혼성화 프로브
JP5734947B2 (ja) 2009-03-27 2015-06-17 ミトミクス インコーポレイテッドＧｅｎｅｓｉｓ Ｇｅｎｏｍｉｃｓ Ｉｎｃ． 異常型ミトコンドリアｄｎａ、関連融合転写物および翻訳産物、並びにそのハイブリダイゼーションプローブ
RU2012141575A (ru) * 2010-03-01 2014-04-10 Майтомикс Инк. ТРАНСКРИПТЫ СЛИТОЙ мтДНК, АССОЦИИРОВАННЫЕ С ВОЗДЕЙСТВИЕМ УФ ИЗЛУЧЕНИЯ, СПОСОБЫ И ИХ ПРИМЕНЕНИЕ

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JUN-ICHI HAYASHI et al..Introduction of disease-related mitochondrial DNA deletion into Hela cells lacking mitochondrial DNA results in mitochondrial dysfunction.《Cell Biology》.1991,第88卷10614-10618. *
M Brandon et al..Mitochondrial mutations in cancer.《Oncogene》.2006,第25卷4647-4662. *
立彦.线粒体DNA的研究现状.《国际检验医学杂志》.2006,第27卷(第7期),第636-638页. *
陈刚等.线粒体DNA突变与相关人类疾病.《遗传》.2007,第29卷(第11期),第1299-1308页. *

Also Published As

Publication number Publication date
KR20170004033A (ko) 2017-01-10
CA3044262A1 (en) 2009-10-01
NZ602175A (en) 2014-03-28
US20170152567A1 (en) 2017-06-01
SG10201400985RA (en) 2014-05-29
SG174514A1 (en) 2011-10-28
KR101819852B1 (ko) 2018-02-28
CA2719718C (en) 2019-07-02
JP5938690B2 (ja) 2016-06-22
JP2011515091A (ja) 2011-05-19
AU2009227935A1 (en) 2009-10-01
EP2274426B1 (en) 2016-11-16
WO2009117811A1 (en) 2009-10-01
AU2009227935B2 (en) 2015-07-09
US20110172113A1 (en) 2011-07-14
EP2274426A4 (en) 2011-11-16
US10266899B2 (en) 2019-04-23
US8715960B2 (en) 2014-05-06
US20190382846A1 (en) 2019-12-19
CN107011428A (zh) 2017-08-04
SG192453A1 (en) 2013-08-30
CN102388140A (zh) 2012-03-21
CN107011428B (zh) 2022-02-25
CA3044262C (en) 2023-02-28
CA2719718A1 (en) 2009-10-01
KR101693387B1 (ko) 2017-01-05
NZ588658A (en) 2012-10-26
CN102388140B (zh) 2015-07-08
CN102016039A (zh) 2011-04-13
EP2274426A1 (en) 2011-01-19
US20130059299A1 (en) 2013-03-07
KR20110004860A (ko) 2011-01-14

Similar Documents

Publication Publication Date Title
CN102016039B (zh) 异常线粒体dna、相关的融合转录物及其杂交探针
CN102439174B (zh) 基于检测slc45a3-elk4融合转录子的用于诊断前列腺癌的组合物和方法
US20090298052A1 (en) Diagnosing or Predicting the Course of Breast Cancer
AU2010234238B2 (en) Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor
JP4756288B2 (ja) ガンのリンパ節転移またはそのリスクを判定する方法及びそのための迅速判定キット
JP2006166789A (ja) 癌の新規診断方法
HK1153224A (en) Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
HK1153224B (en) Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
HK1244815A1 (en) Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
HK1244815B (en) Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
CN110616264A (zh) Dlx1和hoxc6在制备前列腺癌标志物中的应用及其试剂盒
HK1166818B (en) Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor
HK1166818A (en) Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20170329

Address after: Delaware

Applicant after: MDNA Life Sciences Inc.

Address before: Ontario, Canada

Applicant before: Dodik Landau Ltd.

Effective date of registration: 20170329

Address after: Ontario, Canada

Applicant after: Dodik Landau Ltd.

Address before: Ontario

Applicant before: Mitomics Inc.

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170609

Termination date: 20210327

CF01 Termination of patent right due to non-payment of annual fee