CN102008697B - Medicinal liquor for curing nephropathy and preparation method thereof - Google Patents

Abstract

The invention discloses medicinal liquor for curing nephropathy and a preparation method thereof. The medicinal liquor is prepared from the following Chinese medicinal plants in parts by weight: 20-30 parts of cordyceps sinensis, 30-40 parts of radix astragali, 30-40 parts of tuckahoe, 30-40 parts of motherwort, 20-30 parts of rhizoma zingiberis, 30-40 parts of houttuynia cordata, 10-20 parts of ephedra, 20-30 parts of pericarpium arecae, 30-40 parts of golden cypress, 30-40 parts of Chinese pyrola herb, 20-30 parts of cassia twig and 30-40 parts of mongolian dandelion herb. The preparation method is as follows: 1) preprocessing the raw materials: sorting, cleaning, cutting, drying, grinding, sterilizing, drying and sieving the raw materials; 2) weighting the raw materials processed in step 1), and soaking in yellow wine for 1 hour, wherein the ratio of the total raw material weight to the wine yellow weight is (1-3):(7-9); and 3) steaming the raw materials alongwith the yellow wine for 2-3 hours in a pot, cooling, and filtering out the yellow wine to obtain the medicinal liquor. Clinical applications prove that the medicinal liquor needed by the invention is safe, and has no toxicor side effect, high total effective rate, and high recovery rate (up to about 90%) for nephropathy.

Description

Medicated wine of treatment nephropathy and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of nephropathy, specifically is medicated wine of feedstock production and preparation method thereof with Chinese medicine.

Background technology

Nephropathy is a kind of immune disease relevant with infection, is frequently-occurring disease, commonly encountered diseases, difficult treatment, its symptom complexity, and hazardness is big, often is referred to as chronic cancer by people, has a strong impact on people's orthobiosis.From global range, the annual nephrotic in the world increases progressively just with surprising rapidity.Nephropathy is sick plant many, the chronic nephritis and the nephrotic syndrome clinically difficult persistent ailment especially wherein, easily outbreak repeatedly is difficult to control.

In recent years, studies show that, nephropathy is relevant with cellular immune function, doctor trained in Western medicine from five, the sixties bring into use hormone and immunosuppressant, adopt the seventies heavy dose of hormone to carry out flooding again, though the case fatality rate of primary disease is reduced greatly, and thing followed toxic and side effects also can not be ignored.

The traditional Chinese medical science thinks that the nephrotic syndrome belongs to " edema ", " asthenia " category.Because kidney yin fire mutually is not enough, kidney qi loss, " the spleen then absurd row of water of suffering from a deficiency of the kidney, brim over skin and make the health generalized edema with distention of the chest and abdomen " have been set forth the etiology and pathogenesis of primary disease to a certain extent.Can not move water, and then cause not legendary venomous insect of lung qi, cause nutritional disorder, cause kidney to be subjected to the chloride deposition pressure, be difficult to get rid of,, cause glomerule or renal pelvis to be inflamed, even kidney lose function once with the passing of time.

Summary of the invention

The technical problem to be solved in the present invention be low at acute and chronic nephritis and nephrotic syndrome cure rate, easily repeatedly, change the high characteristics of uremia's probability, medicated wine of a kind of treatment rate height, the difficult treatment nephropathy that recurs and preparation method thereof is provided, reaches about 90% with taking 1～6 month effective percentage continuously.

For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of medicated wine for the treatment of nephropathy, and it is steamed through yellow wine by following materials based on weight and forms: Cordyceps 20～30, the Radix Astragali 30～40, Poria 30～40, Herba Leonuri 30～40, Rhizoma Zingiberis 20～30, Herba Houttuyniae 30～40, Herba Ephedrae 10～20, Pericarpium Arecae 20～30, Cortex Phellodendri 30～40, Herba Pyrolae 30～40, Ramulus Cinnamomi 20～30 and Herba Taraxaci 30～40.

Preferably, described Chinese medicine is made by the following weight proportion raw material: Cordyceps 25, the Radix Astragali 35, Poria 35, Herba Leonuri 35, Rhizoma Zingiberis 25, Herba Houttuyniae 35, Herba Ephedrae 15, Pericarpium Arecae 25, Cortex Phellodendri 35, Herba Pyrolae 30, Ramulus Cinnamomi 25, Herba Taraxaci 35.

Described medicated wine prepares according to following steps:

1. the pretreatment of raw material: with raw material selection, clean, cutting, drying, pulverizing, sterilization, dry, sieve;

2. take by weighing the raw material after 1. step is handled, and be soaked in the yellow wine, described yellow wine total amount is 3～6 times of raw material total amount, and soak time is 0.5～3h;

3. yellow wine is steamed 2～3h together with the raw material that is soaked in the yellow wine down at 90～100 ℃, after the cooling, raw material is leached, get medicated wine.

The side that the present invention treats nephropathy separates as follows:

Cordyceps: sweet, flat; Return kidney, lung meridian.Effect: kidney-replenishing, kidney tonifying essence, tonifying the lung gas, expelling phlegm for arresting cough are relievingd asthma.Body void after being ill had to help the weak recover the merit of immunity.

The Radix Astragali: sweet, tepor; Return spleen, lung meridian.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, stain is not held back chronic nephritis proteinuria for a long time.Among the present invention, the Radix Astragali mainly contains and helps eliminate nephritis and effects such as albuminuria, rising hypoglycemia, reduction hyperglycemia, blood fat reducing, enhancing myocardial contraction, protection cardiovascular system, arrhythmia, coronary artery dilator and peripheral blood vessel.

Poria: sweet, light, flat; Return lung, kidney channel; Effect is the hydroderma that disappears, tonneau urine.

Herba Leonuri: bitter, hot, be slightly cold; Return liver, urinary bladder channel; Be used for blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, heat-clearing and toxic substances removing.

Rhizoma Zingiberis: hot, hot; Return spleen, stomach, kidney channel; The row lung qi is good at the logical epidermis water that looses and is stagnated, and has the hydroderma of disappearing, and disperses damp.

Herba Houttuyniae: hot, be slightly cold; Return lung meridian; Heat-clearing and toxic substances removing, the pain that disappears evacuation of pus, antiinflammatory diuresis, antitussive, hemostasis, expansion blood capillary, increase renal artery blood flow amount etc.

Herba Ephedrae: hot, little hardship, temperature; Return lung, urinary bladder channel; Diaphoresis cold expelling, inducing diuresis to remove edema are used for the disease of edema dysuria.

Pericarpium Arecae: hot, tepor; Return spleen, stomach, intestine and small intestine warp; Be the critical medication of treatment nephritis, bias toward diarrhea Jiao clearly, the kidney invigorating void, system be fire mutually, is used for symptoms such as retention of damp leading to blockage of QI, gastral cavity abdominal distention are vexed, stool is not well, edema distension, dysuria.

Herba Pyrolae: sweet, bitter, warm; Return liver, kidney channel; Be used for rheumatic arthralgia, weakness of the waist and knees, chronic cough labor is gargled.

Ramulus Cinnamomi: hot, sweet, warm; GUIXIN, lung, urinary bladder channel; The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, edema, cardiopalmus.

Herba Taraxaci: bitter, sweet, cold, return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.

Toxicity test: give 150 mice lavages with medicated wine of the present invention, administration 10mL/kg, 40 times of quite clinical human body consumption, the viewing duration animal diet followed is normal, do not see that the animal generation is dead, animal activity reduces to some extent behind the filling stomach, but animal survival is in good condition, recover normal behind the 8h, illustrate that it is safe that said preparation is taken.

The present invention is with pure Chinese medicine system side, and at heat-clearing and toxic substances removing, on the basis of blood circulation promoting and blood stasis dispelling, tonifying the lung gas, enhancing myocardial contraction improve immunity, strengthen the anti-stress ability of human body.The elite of trace element in the yellow wine and aminoacid and Chinese medicine produces good synergism, makes medicated wine of the present invention have better curative effect.

For showing the therapeutic effect of medicine of the present invention, illustrated with the clinical observation of following system to nephropathy.

One, case is selected

Selecting 203 of Zhang Ying (woman), Cai (man) etc. is the patient of the nephrotic syndrome or acute and chronic nephritis through hospital diagnosis above county level, male's 120 examples wherein, women's 83 examples, age 18-55 year.

Two, efficacy assessment standard

Alleviate fully: transference cure, repeatedly survey the urine protein feminine gender, blood fat is normal, and renal function is normal.

Part is alleviated: urine protein is (0.3～0.2) g/24h, and is continuous more than three times, transference cure, and renal function takes a turn for the better.

Invalid: urine protein does not have minimizing, and symptom does not disappear, and renal function does not have improvement.

Recurrence: recur after the clinical remission.

Three, treatment statistical data

By the treatment clinical observation to Zhang Ying (woman), 203 people such as (men) Cai, clinical test results is: alleviating number fully is 147 people in the period of 2006 to 2010 four, and remission rate is 72.4%; Total significant figure is 182 people, and total effective rate is 89.7%; Invalid number 21 people, inefficiency 10.3%; Relapse rate is 5.7%.

Four, model case:

Cai, the man, 53 years old, Gaocheng City increased Huang Jia people from village, village township, the mute, acute glomerulonephritis, examination in hospital albumen (+++) hematuria, and swollen with the edema over the face abdomen, symptoms such as waist soreness were taken medicated wine of the present invention after 50 days, and above-mentioned symptom is all eliminated, and does not have recurrence again.

Zhang Ying, the woman, 48 years old, west, suburb million logical township Dong Zhuan people from village in the practice, the nephrotic syndrome, albumen (++) hematuria, took medicated wine of the present invention 2 months in July, 2008, transference cure, not recurrence so far.

The Wang, the man, 40 years old, Zhengding County Xi Guan people from village was diagnosed as chronic nephritis existing 3 years in County Hospital, simultaneous phenomenon limbs edema, afternoon lower limb is swollen heavier, and oliguria, the gastral cavity lack of appetite that expands was taken medicated wine of the present invention after 3 months in 2008, recovered normal, recurred so far.

Zhang, the man, 18 years old, Zhengding County triangle people from village, in by the end of May, 2009 county hospital be diagnosed as acute glomerulonephritis, change by heavy cold, urine protein (+++), take medicated wine two weeks of the present invention at the beginning of 6 months the same years after, transference cure, recurrence so far.

Lee, the woman, 32 years old, Zhengding County east Room Li Jie people from village, pyelonephritis, urine protein (++) has hematuria, takes medicated wine of the present invention and recovers normal after 2 months.

The specific embodiment

Embodiment one

1. the pretreatment of raw material: with raw material selection, clean, cutting, drying, pulverizing, sterilization, dry, sieve.

2. take by weighing raw material after 1. step is handled according to following weight parts, and be soaked in the yellow wine, described yellow wine total amount is 4 times of raw material total amount, and soak time is 0.5～3h:

Cordyceps 25, the Radix Astragali 35, Poria 35, Herba Leonuri 35, Rhizoma Zingiberis 25, Herba Houttuyniae 35, Herba Ephedrae 15, Pericarpium Arecae 25, Cortex Phellodendri 35, Herba Pyrolae 30, Ramulus Cinnamomi 25, Herba Taraxaci 35.

3. yellow wine is steamed 2～3h together with the raw material that is soaked in the yellow wine down at 90～100 ℃, after the cooling, raw material is leached, get medicated wine.

Instructions of taking: one after each meal, every day twice, each 10～15mL.

Embodiment two～embodiment four

Adopt the feedstock production of following weight parts, preparation method and take method with embodiment one.

Claims (3)

1. medicated wine for the treatment of nephropathy, it is characterized in that it is steamed through yellow wine by following materials based on weight forms: Cordyceps 20～30, the Radix Astragali 30～40, Poria 30～40, Herba Leonuri 30～40, Rhizoma Zingiberis 20～30, Herba Houttuyniae 30～40, Herba Ephedrae 10～20, Pericarpium Arecae 20～30, Cortex Phellodendri 30～40, Herba Pyrolae 30～40, Ramulus Cinnamomi 20～30 and Herba Taraxaci 30～40.

2. the medicated wine of treatment nephropathy according to claim 1 is characterized in that it is steamed through yellow wine by following materials based on weight: Cordyceps 25, the Radix Astragali 35, Poria 35, Herba Leonuri 35, Rhizoma Zingiberis 25, Herba Houttuyniae 35, Herba Ephedrae 15, Pericarpium Arecae 25, Cortex Phellodendri 35, Herba Pyrolae 30, Ramulus Cinnamomi 25, Herba Taraxaci 35.

3. the preparation method of the medicated wine of treatment nephropathy according to claim 1 is characterized in that preparing according to following steps:

1. the pretreatment of raw material: with raw material selection, clean, cutting, drying, pulverizing, sterilization, dry, sieve;

2. take by weighing the raw material after 1. step is handled, and be soaked in the yellow wine, described yellow wine total amount is 3～6 times of raw material total amount, and soak time is 0.5～3h;

3. yellow wine is steamed 2～3h together with the raw material that is soaked in the yellow wine down at 90～100 ℃, after the cooling, raw material is leached, get medicated wine.