CN102008289A - Aberration compensation fundus microscope based on automatic optimization algorithm - Google Patents
Aberration compensation fundus microscope based on automatic optimization algorithm Download PDFInfo
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Abstract
The invention discloses an aberration compensation fundus microscope based on an automatic optimization algorithm. The aberration compensation fundus microscope comprises a light source module, an aberration compensation module, a two-dimensional imaging and scanning module, a wide-field-of-view scanning module and an optical fiber receiving module, wherein, the two-dimensional imaging and scanning module is connected with the wide-field-of-view scanning module through a spherical reflecting telescope system; the optical fiber receiving module is placed at a terminal of a returning optical path of the microscope system and is behind a spectroscope; the illuminating light emitted from the light source module successively passes through the two-dimensional imaging and scanning module and the wide-field-of-view scanning module and then enters eyes; and the diffuse signal light from fundus retina of eyes returns along the original optical path, aberration correction is carried out on the light through an aberration correction module by the automatic optimization algorithm, and then the light enters the optical fiber receiving module through the spectroscope for signal detection. The aberration compensation fundus microscope greatly reduces the cost and the control difficulty of the traditional aberration compensation system, solves the synchronous imaging difficulty in the case of high resolution and wide view field, and greatly improves the imaging view field and the imaging quality of the traditional fundus imaging instrument.
Description
Technical field
The present invention relates to a kind of optical fundus microscope, specifically, what relate to is a kind of aberration compensation optical fundus microscope based on the automatic optimal algorithm, by the automatic optimal algorithm, human eye retina's image is carried out in real time, optimizes automatically, to the high-resolution video imaging on human eye (or animal eye) the retina realization cell yardstick.
Background technology
Retina micro-imaging field, cofocus scanning imaging technique are one of very important retina image-forming technology.The cofocus scanning technology is applied to biological tissue's imaging (Webb RH the earliest, Hughes GW.Scanning Laser Ophthalmoscope.Biomedical Engineering, IEEE Transactions on.1981, BME-28 (7): 488-92.), formed laser cofocus scanning imaging device (Webb R in 1987, Hughes G, Delori F.Confocal scanning laser ophthalmoscope.Applied optics.1987; 26 (8): 1492-9).
The patent No. is the notion that the patent of invention of US4863226 (1989) has proposed the laser cofocus scanning imaging, this patent realizes transversal scanning to sample by acousto-optic modulator, realize that by scan mirror the longitudinal scanning to sample is frame scan, use pin hole to realize confocal imaging.But this patent has only provided the principle arrangement of cofocus scanning imaging, its acousto-optic modulator can bring bigger effect of dispersion, significantly reduces the imaging resolution of system, the existence of human eye and system aberration, the capital reduces systemic resolution, can't realize the high-resolution imaging on the cell yardstick.The patent No. be US5825533 (1998) patent of invention by two independently scanning galvanometer carry out horizontal and vertical synchronous scanning, to realize the cofocus scanning imaging.But this patent only by simple two-dimensional scanning, is subject to system aberration and human eye aberration equally, can't realize the function of high-resolution imaging.
The patent No. is that the patent of invention of ZL200810117071.4 has also proposed the basic device of confocal imaging, but does not have scanning means, but passes through the principle of point source single frames imaging, realizes the confocal imaging to sample.Resolution is lower and can't realize video imaging.The patent No. is the patent of invention of ZL99115053.8 (1999) etc., proposed the retinal imaging device based on adaptive optical technique, but this device is not realized the cofocus scanning imaging, does not more propose the notion of big visual field.
The patent No. is that the patent of US20020231491, US2003053026A1, US20050125331 and US2006087617A1 has proposed the application self-adapting optical technology and human eye aberration surveyed and gauged notion, but be subject to dizzy angle restrictions such as human eye, its imaging viewing field is generally 1～3 °, and the visual field is too little.The present invention proposes big visual field scanning notion, can be to human eye retina's scanning imagery in 15 ° of field ranges.
The patent No. is that the patent of US20020231491, US2003053026A1, US20050125331 and US2006087617A1 all realizes confocal imaging by pin hole is set with the mode that rearmounted detector combines.Very difficult on optics is adjusted, system design is huge, integrated level is low.The present invention proposes to use optical fiber to come received signal light, the coupling of Optical Fiber Numerical Aperture and collecting lens numerical aperture, and optical fiber replaces pin hole, and then detector can be positioned over outside the system optics parts, makes level of integrated system significantly improve, and adjusts difficulty and significantly reduces.
In sum as can be known, there are many deficiencies in existing optical fundus scanning imagery equipment, demands urgently improving.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of aberration compensation optical fundus microscope based on the automatic optimal algorithm is provided, by optical fiber input, output modular design, solve the problem that the design of conventional laser scanning ophthalmoscope system instrument is huge, be difficult to adjust; By changing the relative position of optical fiber receiving port and collecting lens, solve problem to the multilamellar observation imaging of human eye retina biological tissue; By automatic optimal algorithm controls aberration compensation device, solve the problem that the conventional aberration compensating device need be equipped with special aberration measurement device, reduction system control difficulty is simplified apparatus structure; By the aberration on aberration compensation device bucking-out system full gloss road, solved the problem that the conventional aberration compensating device can't correction system be demarcated aberration, increased the precision of system to aberration correction.
For achieving the above object, technical scheme of the present invention is:
The invention provides a kind of aberration compensation optical fundus microscope based on the automatic optimal algorithm, it is characterized in that, described microscope comprises light source module, aberration compensation module, two-dimensional imaging scan module, wide visual field scanning module and optic fiber transceiver module.Wherein: the two-dimensional imaging scan module is connected by spheric reflection formula telescopic system with wide visual field scanning module.Optical fiber receiving terminal module places system to return the terminal of light path, after the spectroscope; By the illumination light of light source module emission successively by entering human eye after the two-dimensional imaging scan module of system, the wide visual field scanning module, the flashlight of returning from the retina diffuse-reflectance of human eye optical fundus returns along original optical path, carry out aberration correction through the aberration correction module, go into the optical fiber receiver module and carry out signal detection by spectroscope is laggard.
Further, described two-dimensional imaging scan module comprises a transversal scanning galvanometer and a longitudinal scanning galvanometer, synchronous scanning by this two sides galvanometer, finish face scanning to the human eye retina, according to the intensity of the optic fiber transceiver module recorder of institute eyes retina inverse signal and the positional information of two scanning galvanometers, implement human eye retina's image reconstruction.
Further, described wide visual field scanning module by one at horizontal X with vertically produce the quick titling mirror at certain angle of inclination on the Y both direction synchronously and one group of big visual field transmission-type bundle telescope that contracts is formed.Described tilting mirror angle of inclination is 0～5 °.Described big visual field transmission-type telescope comprises incident lens and exit lens, exit lens can be changed according to actual persons eye pupil hole pore size, to change the telescopical beam ratio that contracts of big visual field transmission-type, change imaging viewing field or the imaging area of system simultaneously to human eye.
Further, described optic fiber transceiver module is made up of collecting lens, reception optical fiber and photodetector.Receive optical fiber and collect the flashlight that returns from the human eye retina, transfer to photodetector.Described photodetector is charge-coupled device (CCD) or avalanche photomultipiler (PMT).
Further, the numerical aperture of described reception optical fiber will be complementary with the numerical aperture of collecting lens focused beam, and receiving optical fiber core diameter size will be complementary with the diffraction pattern size of collecting lens at the focus place.
Further, described aberration compensation module is the transmutability reflecting mirror, and deformable mirror is the deformation reflection mirror based on the piezoelectric ceramics deformation technology, perhaps is the deformation reflection mirror based on the micromechanics deformation technology.
Further, described aberration correction module is carried out aberration correction by the automatic optimal algorithm, the automatic optimal algorithm is the random paralleling gradient descent algorithm, or the simulated annealing optimization algorithm etc., its typical control method is by sending voltage signal to the aberration compensation device, is reference with the performance indications of system, passes through interative computation, seek the Optimal Control voltage of aberration compensation device, to reach the purpose of corrective system complete light path aberration.
Further, in the described reception optic module, the port that receives optical fiber is coaxial with the collecting lens center, and fiber port is adjustable continuously to the distance of collecting lens.By the centre distance of increase/minimizing fiber port to collecting lens, then can in human eye retina's illumination path, just introduce/minus defocusing amount, realize human eye retina biological tissue is carried out the purpose of layering observation.
The present invention can obtain the high-definition picture of a certain imaging subregion by quick titling mirror and the scanning of two-dimensional scan galvanometer conjugation.Realize active scan to human eye optical fundus zones of different significantly increasing imaging viewing field by the control quick titling mirror.Take the aberration compensation device to proofread and correct human eye and system's complete light path aberration, realize the high-resolution video imaging on the cell yardstick.Control the aberration compensation device by the automatic optimal algorithm, significantly reduce system cost and control difficulty.Total system adopts optical fiber input laser illuminator, and optical fiber output human eye retina picture signal has significantly improved compactedness, the portability of product design.Receive relatively moving of collecting lens by receiving fiber port and optical signal, realize observation, significantly increased the microscopical imaging function imaging in this optical fundus scope human eye retina's multiple structure.Convenient, realization high-resolution video imaging on human eye (or animal eye) retina cell yardstick efficiently.
The present invention is imaged as the basis with point-to-point conjugation optics, under the prerequisite that guarantees the optical conjugate relation, realizes the face in human eye retina zone is scanned by the synchronous scanning on the both direction; Take adaptive optical technique to proofread and correct human eye aberration, reach the purpose of high-resolution imaging.Promptly in system and device of the present invention, the optically accurate conjugation of light source, two-dimensional scan galvanometer group, quick titling mirror, aberration compensation device and human eye pupil, and, realize the expansion imaging viewing field by placing the quick titling mirror of optical conjugate face to human eye retina's active scan.
The present invention compared with prior art has following advantage:
Advantage 1) the present invention takes the design of optical fiber input illumination light, optical fiber output human eye inverse signal light, has solved that traditional non-optical fiber type confocal laser surface sweeping system design is huge, the problem of system complex.
Advantage 2) the present invention solves the problem to human eye retina biological tissue multilamellar continuous imaging by changing the relative position of optical fiber receiving port and collecting lens.
Advantage 3) traditional confocal scan microscope is subject to the influence of human eye aberration system aberration, can't reach the purpose of optical diffraction limit imaging.The present invention introduces the aberration compensation module, especially by the automatic optimal algorithm, solves the problem that the conventional aberration compensating device need be equipped with special aberration measurement device, and reduction system control difficulty is simplified apparatus structure.And can proofread and correct the aberration on human eye and system full gloss road, and significantly improve image quality, can realize other vivo observation of cell grade.
Advantage 4) the present invention significantly increases traditional confocal scan microscope imaging viewing field.The tradition confocal scan microscope is subject to dizzy angles such as human eye, and imaging viewing field is less, generally at 1～3 °.The present invention is by the quick titling mirror active scan, expansion imaging viewing field to 15 °.The size of its visual field, expansion back only is subject to the angle of inclination of quick titling mirror, has the very big rising space.
Advantage 5) the imaging initiative significantly strengthens, and the patient comfort sense increases.The tradition confocal scan microscope needs patient to watch the zones of different sighting target attentively because imaging viewing field is little, reaches the purpose of the different retina zoness of different of imaging.The present invention promptly can realize the active scan to zones of different at the bottom of the patient's eyes by the active scan of quick titling mirror, and the imaging initiative significantly strengthens, and the patient comfort sense significantly increases.
Advantage 6) level of integrated system significantly improves, easily miniaturization.Tradition confocal scan microscope detector directly docks with system by the mode of optical glass, so the instrument adjustment is relatively more difficult, and the instrument volume is bigger.The present invention uses optical fiber recipient eyes retina inverse signal, by optical fiber and detector coupling, has then significantly reduced the size of system design, easily miniaturization, commercialization.
In sum, the present invention uses automatic optimal algorithm controls aberration compensation device aberration correction is carried out on system full gloss road, work asynchronously with the two-dimensional imaging scan module by quick titling mirror, on the basis that obtains the small field of view single-frame images, in conjunction with automatic splicing, obtain human eye retina's high-definition picture in the big field range.This invention has significantly reduced the cost and the control difficulty of conventional aberration corrective system, solved the difficulty of high-resolution with big visual field synchronous imaging, realized a kind of compact to design, imaging resolution is high, imaging viewing field is big, control simple optical fundus microscope, has significantly improved the imaging viewing field and the image quality of traditional fundus imaging instrument.Mat the present invention can be to the high-resolution video imaging on the realization cell yardstick in big field range of human eye (or animal eye) retina.
Description of drawings
The optical fundus microscope principle schematic that Fig. 1 proposes for the present invention.
Fig. 2 for the present invention before the automatic optimal algorithmic statement, the human eye retina's image before the aberration correction.
Fig. 3 uses the resulting normalized image performance parameter of automatic optimal algorithm convergence curve for the present invention.
Fig. 4 for the present invention in the automatic optimal algorithmic statement, the human eye retina's image after system's complete light path aberration is corrected.
The specific embodiment
The technical solution of the present invention is further explained below in conjunction with accompanying drawing, but following content is not intended to limit the scope of the invention, and protection scope of the present invention is as the criterion with claims.
Among the present invention, the two-dimensional imaging scan module is connected by spheric reflection formula telescopic system (13-14) with wide visual field scanning module.Optical fiber receiving terminal module places system to return the terminal of light path, and spectroscope (5) afterwards.Enter human eye after two-dimensional imaging scan module (9-12) by system, the wide visual field scanning module (15-17) successively by the illumination light of light source module (1-4) emission, the flashlight of returning from the retina diffuse-reflectance of human eye optical fundus returns along original optical path, carry out aberration correction through aberration correction module (6), go into optical fiber receiver module (19-21) and carry out signal detection by spectroscope (5) is laggard.
As shown in Figure 1, the present invention is based on the aberration compensation optical fundus microscope of automatic optimal algorithm, job step is as follows:
The first, the LASER Light Source 1 of light source module is by optical fiber output illumination light, and the end of output optical fibre places coupled lens 2 focus places.Through coupled lens 3 coupling back outputs, the parallel laser after the coupling enters spectroscope 5 through reflecting mirror 4.Spectroscope 5 of the present invention is the low spectroscope of absorbance high reflectance, and absorbance reflectance ratio is between 4: 1～5: 1.Absorbance is high for guaranteeing that returning the signal luminous energy of returning from human eye enters detector by spectroscope 5 largely.Laser illuminator is entering reflective sphere telescope 5 and 6 through behind the spectroscope 5.Through deformation reflection mirror 6 reflections, by entering two-dimensional imaging scan module 9～12 behind reflective sphere telescope 7 and 8.
The second, the two-dimensional imaging scan module comprises two independently optical scan vibration lens, connects by reflective sphere telescope 10,11 between the galvanometer.Become line sweep light after the scanning of illumination light through transversal scanning galvanometer 9, line sweep light expands the bundle back by 12 scannings of longitudinal scanning galvanometer through telescope 10 and 11, forms the face illumination light.
The 3rd, enter wide visual field scanning module through the face illumination light behind the longitudinal scanning galvanometer 12 by spheric reflection formula telescope 13 and 14.Because quick titling mirror 15 places the optical system conjugate planes in the wide visual field scanning module, with the accurate conjugation of transversal scanning galvanometer, longitudinal scanning galvanometer and human eye pupil.Therefore the banking motion of quick titling mirror on X (laterally) and Y (vertically) both direction will make illuminating bundle form bigger angle of incidence in incident place of human eye pupil, and its incident angle of visual field reaches 15 ° by active scan.Illuminating bundle by big visual field contract the bundle telescope 16 and 17 after, direct irradiation is at the human eye pupil.
The 4th, illuminating bundle is incident on human eye pupil surface, and crystalline lens focuses on behind pupil, enters the human eye retina.The flashlight of returning from the retina diffuse-reflectance returns (turning back to 6 from 17) by original optical path, through behind the spectroscope 5, enters the optic fiber transceiver module part.Optic fiber transceiver module is made up of collecting lens 19, reception optical fiber 20 and detector 21.Incided reception fiber port place by the flashlight after the collecting lens convergence, the reception core diameter size of fiber port is 1～2 times of Ai Li diffraction spot size of collecting lens 19, the numerical aperture coupling of the numerical aperture of optical fiber and collecting lens 19 receives fiber port as for collecting lens 19 focus places.Fiber port and human eye retina are confocal, the flashlight that detector 21 received signals return for human eye retina's diffuse-reflectance.The noise signal that non-retina returns can't enter reception optical fiber, thereby be prevented from entering detector, so the signal to noise ratio of detector received signal light is very high.The mode that the present invention takes optical fiber to receive has realized the effect of confocal imaging, has avoided the complexity of system design simultaneously, makes product more miniaturization, simplification.
The 5th, when quick titling mirror is in off working state, by two independently scanning galvanometer 9 and 12 two-dimensional scan finish single frames small field of view image reconstruction, obtain the confocal images video image, this moment, the system imaging visual field was smaller, and the typical scan visual field is 1 °-3 °.
The 6th, when quick titling mirror was in running order, the control quick titling mirror carried out active scan at X and Y both direction to the human eye optical fundus, can carry out optical scanning to any subregion of human eye retina.Suppose that the angle of inclination that quick titling mirror can produce at human eye pupil place is 12 °, then the total imaging viewing field of system is 12 °+3 °=15 °, has significantly improved the imaging viewing field of system.In the imaging successively of human eye optical fundus all subregion, the automatic splicing of application image obtains human eye retina's big view field image by the control quick titling mirror.And sweep limits only depends on the mechanical rotation angle of quick titling mirror, and very big room for promotion is still arranged.
The 7th, the signal beams of returning from human eye retina's 18 diffuse-reflectance returns along system's original optical path, after 6 reflections of aberration compensation device, enter spectroscope 5, enter optic fiber transceiver module 19-21 again and carry out the measurement of signal gray value, in conjunction with two- dimensional scan galvanometer 9,12 corresponding position information, finish the reconstruct of human eye retina's image.
The 8th, Fig. 2 is for before the automatic optimal algorithm starts, human eye retina's image that system obtains, owing to proofread and correct through system's complete light path aberration, image resolution ratio is lower.
The 9th, the human eye retina's image that obtains according to Fig. 2 is according to formula P=∫ ∫ I
2(wherein (x is that (x, y) the gray value size of place respective pixel are calculated all grey scale pixel value sums of this image to coordinate on the retinal images y) to I for x, y) dxdy.In the present invention, select to calculate human eye retina's gradation of image value sum, be used as the standard of picture quality quality.According to automatic optimal algorithm as described below, calculate the control voltage of aberration compensation device 6:
(a) according to certain statistical law, be generally Bernoulli Jacob and distribute, produce one group of disturbance voltage vector at random
Add the initial voltage vector of aberration compensation device
Send to aberration compensation device 6.Wherein
Be the voltage of delivering to i driver behind the k time interative computation,
(b) obtain retinal images according to claim 2, by formula P=∫ ∫ I
2(x, y) dxdy, the image property parameter P of calculating retinal images
+This image property parametric description retinal images overall gray level value size.
(c) according to the statistical law in a), produce at random one group with a) opposite voltage vector
Send to aberration compensation device 6.
(d) by b) in formula calculate image property parameter P once more
-And computed image performance parameter increment Delta J
k=P
+-P
-
(e) according to a)-d), by formula
Calculate the voltage vector of aberration compensator after the k+1 time iteration, wherein Г is the control parameter.
(f) repeat a)-e), till the performance parameter of image is stablized and satisfied the observation requirements of instrument.
The tenth, Fig. 3 is according to the resulting image property parameter of automatic optimal algorithm of the present invention astringent curve.From test data as seen, through after about 200 iteration, gradation of image value sum reaches extreme value.Human eye retina's image when Fig. 4 is extreme value for gradation of image value sum.
At the automatic optimal algorithm that the present invention proposes, the speed of its convergence rate generally depends on the single iteration time.In pilot system of the present invention, the system imaging frame frequency was 30 frame/seconds, if each two field picture according to the 32 grades split image of assigning to, and with this calculate each split image part gradation of image and.Then the time of image parameter test each time is 1 millisecond, and the calculating of iteration and testing time then are about 2 milliseconds each time, can finish about 500 interative computations in such one minute time, whole convergence process that fully can the automatic optimal computing.For the static aberration of human eye, in 1 minute, finish aberration and calculate and proofread and correct, can satisfy optical fundus microscope imaging demand proposed by the invention fully.
Through said process, can finish proposed by the invention, by using the automatic optimal algorithm, control aberration compensation device, the aberration on compensation human eye and system full gloss road on the cell yardstick, is realized the amphiblestroid high-resolution video imaging of human eye (or animal eye).
Contrast international and domestic technological achievement in human eye retina's micro-imaging field, the present invention is on the ultimate principle basis of laser cofocus scanning imaging, propose a kind of optical fundus microscopie unit, control the aberration compensation device, significantly reduce system cost and control difficulty by the automatic optimal algorithm.Total system adopts optical fiber input laser illuminator, and optical fiber output human eye retina inverse signal has significantly improved compactedness, the portability of product design.Receive relatively moving of collecting lens 19 by optical fiber receiving port and optical signal, realize observation, significantly increased the microscopical imaging function imaging in this optical fundus scope human eye retina's multiple structure.Convenient, realization high-resolution video imaging on human eye (or animal eye) retina cell yardstick efficiently.
Need to prove, although preferable embodiment of the present invention is open as above, but it is not restricted to listed utilization in description and the embodiment, it can be applied to various suitable the field of the invention fully, for those skilled in the art, can easily realize other modification, therefore under the general concept that does not deviate from claim and equivalency range and limited, the legend that the present invention is not limited to specific details and illustrates here and describe.
Claims (10)
1. aberration compensation optical fundus microscope based on the automatic optimal algorithm, it is characterized in that: described microscope comprises light source module, aberration compensation module, two-dimensional imaging scan module, wide visual field scanning module and optic fiber transceiver module; Wherein: the two-dimensional imaging scan module is connected by spheric reflection formula telescopic system with wide visual field scanning module; Optical fiber receiving terminal module places this telescopic system to return the terminal of light path, after the spectroscope; By the illumination light of light source module emission successively by entering human eye after two-dimensional imaging scan module, the wide visual field scanning module, the flashlight of returning from the retina diffuse-reflectance of human eye optical fundus returns along original optical path, adopt the automatic optimal algorithm to carry out aberration correction through the aberration correction module, go into the optical fiber receiver module and carry out signal detection by spectroscope is laggard.
2. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 1, it is characterized in that: described two-dimensional imaging scan module comprises a transversal scanning galvanometer and a longitudinal scanning galvanometer, synchronous scanning by this two sides galvanometer, finish face scanning to the human eye retina, according to the intensity of the optic fiber transceiver module recorder of institute eyes retina inverse signal and the positional information of two scanning galvanometers, implement human eye retina's image reconstruction.
3. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 1, it is characterized in that: described wide visual field scanning module by one at horizontal X with vertically produce the quick titling mirror at an angle of inclination on the Y both direction synchronously and one group of big visual field transmission-type bundle telescope that contracts is formed, described big visual field transmission-type telescope comprises incident lens and exit lens, exit lens is changed according to actual persons eye pupil hole pore size, to change the telescopical beam ratio that contracts of big visual field transmission-type, change imaging viewing field or the imaging area of system simultaneously to human eye.
4. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 3, it is characterized in that: described tilting mirror angle of inclination is 0～5 °.
5. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 1 and 2, it is characterized in that: described optic fiber transceiver module is made up of collecting lens, reception optical fiber and photodetector, receive optical fiber and collect the flashlight that returns from the human eye retina, transfer to photodetector.
6. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 5, it is characterized in that: in the described reception optic module, the port that receives optical fiber is coaxial with the collecting lens center, and fiber port is adjustable continuously to the distance of collecting lens, by the centre distance of increase/minimizing fiber port to collecting lens, in human eye retina's illumination path, just introducing/minus defocusing amount, realizing human eye retina biological tissue is carried out layering observation.
7. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 5 is characterized in that: described photodetector is charge coupled device ccd or avalanche photomultipiler PMT.
8. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 5, it is characterized in that: the numerical aperture of described reception optical fiber will be complementary with the numerical aperture of collecting lens focused beam, receives optical fiber core diameter size and is complementary with the diffraction pattern size of collecting lens at the focus place.
9. the aberration compensation optical fundus microscope based on the automatic optimal algorithm according to claim 1, it is characterized in that: described aberration correction module is carried out aberration correction by the automatic optimal algorithm, specifically be by sending voltage signal to the aberration compensation device, performance indications with system are reference, pass through interative computation, seek the Optimal Control voltage of aberration compensation device, realize the corrective system complete light path aberration, described automatic optimal algorithm is implemented successively by following several steps:
(a), produce one group of disturbance voltage vector at random according to Bernoulli Jacob's distribution statistics rule
Add the initial voltage vector of aberration compensation device
Send to the aberration compensation device; Wherein
Be the voltage of delivering to i driver behind the k time interative computation;
(b) according to the retinal images that obtains, by formula P=∫ ∫ I
2(x, y) dxdy, the image property parameter P of calculating retinal images
+, this image property parametric description retinal images overall gray level value size; Wherein (x y) is (x, y) the gray value size of place respective pixel of coordinate on the retinal images to I;
(c) according to the statistical law in a), produce at random one group with a) opposite voltage vector
Send to the aberration compensation device;
A) by b) in formula calculate image property parameter P once more
-, and computed image performance parameter increment Delta J
k=P
+-P
-
(d) according to a)-d), by formula
Calculate the voltage vector of aberration compensator after the k+1 time iteration, wherein Г is the control parameter;
(e) repeat a)-e), till the performance parameter of image is stablized and satisfied the observation requirements of instrument.
10. according to claim 1 or 9 described aberration compensation optical fundus microscopes based on the automatic optimal algorithm, it is characterized in that: described aberration compensation module is the transmutability reflecting mirror, deformable mirror is the deformation reflection mirror based on the piezoelectric ceramics deformation technology, perhaps is the deformation reflection mirror based on the micromechanics deformation technology.
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