CN102007213B - 用于预防和/或逆转新发作的自身免疫性糖尿病的基于微球的组合物 - Google Patents

用于预防和/或逆转新发作的自身免疫性糖尿病的基于微球的组合物 Download PDF

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CN102007213B
CN102007213B CN200980113547.XA CN200980113547A CN102007213B CN 102007213 B CN102007213 B CN 102007213B CN 200980113547 A CN200980113547 A CN 200980113547A CN 102007213 B CN102007213 B CN 102007213B
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seq
microspheres
antisense
oligonucleotides
cells
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CN102007213A (zh
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拉里·R·布朗
尼克·吉安努卡基斯
马西莫·特鲁克
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Baxter Healthcare SA
Baxter International Inc
University of Pittsburgh
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University of Pittsburgh
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Physics & Mathematics (AREA)
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  • Diabetes (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
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  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN200980113547.XA 2008-04-18 2009-04-20 用于预防和/或逆转新发作的自身免疫性糖尿病的基于微球的组合物 Active CN102007213B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4603408P 2008-04-18 2008-04-18
US61/046,034 2008-04-18
US4824608P 2008-04-28 2008-04-28
US61/048,246 2008-04-28
PCT/US2009/041167 WO2009129544A1 (en) 2008-04-18 2009-04-20 Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes

Publications (2)

Publication Number Publication Date
CN102007213A CN102007213A (zh) 2011-04-06
CN102007213B true CN102007213B (zh) 2014-08-06

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US (1) US8022046B2 (https=)
EP (2) EP2281042B1 (https=)
JP (4) JP5685182B2 (https=)
CN (1) CN102007213B (https=)
AU (1) AU2009237577B2 (https=)
CA (1) CA2720675C (https=)
DK (2) DK2281042T3 (https=)
ES (2) ES2686708T3 (https=)
MX (1) MX2010011508A (https=)
PL (2) PL2281042T3 (https=)
WO (1) WO2009129544A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009237577B2 (en) * 2008-04-18 2014-06-05 Baxter Healthcare Sa Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
WO2012068463A2 (en) * 2010-11-18 2012-05-24 Beth Israel Deaconess Medicall Center, Inc. Methods of treating obesity by inhibiting nicotinamide n-methyl transferase (nnmt)
US10081809B2 (en) * 2012-04-18 2018-09-25 University Of Miami Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation
CA3239291A1 (en) * 2013-11-18 2015-05-21 Nick Giannoukakis Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies
CN107849537A (zh) 2015-06-30 2018-03-27 西北生物治疗药物公司 诱发改善的或增加的抗肿瘤免疫应答的经最佳活化的树突细胞
US20230277510A1 (en) * 2022-03-07 2023-09-07 M.A. Med Alliance SA Sirolimus microspheres and method of making sirolimus microspheres

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000074786A1 (en) * 1999-06-07 2000-12-14 Firefly Ab A detector arrangement for detection of fire risk in a process plant
CN1980641A (zh) * 2004-05-12 2007-06-13 巴克斯特国际公司 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用
WO2008019346A2 (en) * 2006-08-04 2008-02-14 Baxter International Inc. Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes

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