CN101984840B - Multielement organism antioxidant for animals and preparation method thereof - Google Patents
Multielement organism antioxidant for animals and preparation method thereof Download PDFInfo
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- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 33
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 241001465754 Metazoa Species 0.000 title description 11
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 30
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 108010024636 Glutathione Proteins 0.000 claims abstract description 15
- 229960003180 glutathione Drugs 0.000 claims abstract description 15
- 229920002472 Starch Polymers 0.000 claims abstract description 13
- 235000019698 starch Nutrition 0.000 claims abstract description 13
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- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 12
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229910021536 Zeolite Inorganic materials 0.000 claims abstract description 11
- 239000006229 carbon black Substances 0.000 claims abstract description 11
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 11
- 239000010457 zeolite Substances 0.000 claims abstract description 11
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims abstract description 6
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims abstract description 6
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims abstract description 6
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims abstract description 6
- 229940074393 chlorogenic acid Drugs 0.000 claims abstract description 6
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims abstract description 6
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims abstract description 6
- 235000006708 antioxidants Nutrition 0.000 claims description 25
- 235000019241 carbon black Nutrition 0.000 claims description 10
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims description 10
- -1 chromium picolinates Chemical class 0.000 claims description 6
- 229940046374 chromium picolinate Drugs 0.000 claims description 5
- GJYSUGXFENSLOO-UHFFFAOYSA-N chromium;pyridine-2-carboxylic acid Chemical compound [Cr].OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1 GJYSUGXFENSLOO-UHFFFAOYSA-N 0.000 claims description 5
- 238000007664 blowing Methods 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims 1
- 241000282887 Suidae Species 0.000 abstract description 5
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 4
- 230000010534 mechanism of action Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 2
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 abstract 1
- 229920001991 Proanthocyanidin Polymers 0.000 abstract 1
- OZKRURPNXOGYGD-UHFFFAOYSA-N chromium;pyridine-2-carboxylic acid Chemical compound [Cr].OC(=O)C1=CC=CC=N1 OZKRURPNXOGYGD-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 230000004792 oxidative damage Effects 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000013372 meat Nutrition 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 4
- 230000003064 anti-oxidating effect Effects 0.000 description 4
- 229910052711 selenium Inorganic materials 0.000 description 4
- 239000011669 selenium Substances 0.000 description 4
- 229940091258 selenium supplement Drugs 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
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- RJFAYQIBOAGBLC-UHFFFAOYSA-N 2-amino-4-methylselanyl-butanoic acid Chemical compound C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 description 1
- KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical compound C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 description 1
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- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
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Abstract
The invention discloses a multielement organism antioxidant for pigs and a preparation method thereof. The multielement organism antioxidant for pigs comprises the following raw materials in parts by weight: 57-100 parts of 8% glutathione, 205-300 parts of dihydropyridine, 200-280 parts of proanthocyanidin with the total polyphenol content of 75%, 40-100 parts of 30% chlorogenic acid, 200-300 parts of 9.90% pyridine carboxylic acid chromium, 10-80 parts of white carbon black, 30-100 parts of starch and 60-160 parts of zeolite powder. The preparation method comprises the following steps: premixing the raw materials to obtain the multielement organism antioxidant for pigs through three-step mixing. The multielement organism antioxidant for pigs in the invention has the advantages that the technology control is simple and the mechanism of action is comprehensive.
Description
Technical field
The present invention relates to anti-oxidant and preparation method thereof, be specially and a kind ofly improve antioxidant ability of organism, be used to combined feed additive that solves the caused oxidative damage problem of excessive free radicals in the letting animals feed body and preparation method thereof through polynary approach.
Background technology
Improve constantly in living standards of the people, under the conditions such as WTO adding, Animal Husbandry in China just progressively develops to mass type from scalar type.Yet in the industry of China's herding in recent years; Some perplexing problems appear often, like: yellow fat meat, PSE meat, the yellowish pink of pig be that waterpower is bad, and the caused gastrointestinal mucosal damage of weaning syndrome of piglets, immunosupress; The sudden death of fowl, ascites; Unusual, the liver and gall syndrome of the body colour of fish, somatic number exceeds standard etc. in the milk, has had a strong impact on meat, egg, the quality of dairy products and the sustainable development of animal husbandry.
See from essence; These problems all belong to excessive in the body " free radical " caused letting animals feed " oxidative damage " problem; And the method for this type of feed industry reply oxidative damage problem is limited, and commonly used has heavy dose of utilization VitE acetate or volume for adding organic selenium (yeast selenium, selenium methionine) etc.No matter be VitE or organic selenium, because the single mechanism of action that its single component constitutes, the comprehensive antioxidant effect of body is limited, shows the phenomenon that solves letting animals feed oxidative damage problem poor effect often; In addition, in recent years cost of material rise steadily that (the VitE acetate raw material as 50% has turned over 5～6 times from 50 yuan/kg, and the peak period increases to 260 yuan/kg; Though and its utilization rate of organic selenium improves 1.3～1.5 times than inorganic sodium selenite etc., it is high 50～80 times that unit price is wanted), the feed industry of low value lacks corresponding cost ability to bear.
The tri-layer that the present invention is based on the animal body antioxidant system is theoretical; Development can improve body activities of antioxidant enzymes (glutathione, OPC etc.), increase in the animal body fat-soluble (dihydropyridine) and water-soluble (OPC, chlorogenic acid) reducing power with direct elimination free radical, simultaneously take into account anti-stress and polynary, the efficient body anti-oxidant of minimizing free-radical generating (chromium picolinate); Offer feed industry; Both can solve the oxidative damage problem of letting animals feed, use cost can be industry again and accepts.
Summary of the invention
The technical problem that the present invention solved is to provide a boar with polynary body anti-oxidant and preparation method thereof, to solve the problem in the background technology:
The technical problem that the present invention solved adopts following technical scheme to realize:
One, pig is with polynary body anti-oxidant, and is composed of the following components, and counts by weight; Raw material is formed as follows: 57～100 parts of the glutathione of content 8%, 205～300 parts of dihydropyridines, 200～280 parts of the OPCs of total polyphenols content 75%; 40～100 parts of the chlorogenic acids of content 30%, 200～300 parts of the chromium picolinates of content 9.90%, 10～80 parts of white carbon blacks; 30～100 parts of starch, 60～160 parts of zeolite powders.
Optimum formula of the present invention: 70 parts of the glutathione of content 8%, 280 parts of dihydropyridines, 220 parts of the OPCs of total polyphenols content 75%; 60 parts of the chlorogenic acids of content 30%, 210 parts of the chromium picolinates of content 9.90%, 15 parts of white carbon blacks; 50 parts of starch, 95 parts of zeolite powders.
Two, and by following processing step and technological parameter prepare:
(1), premixed: with the chlorogenic acid of 40～100 parts of content 30%, 10～80 parts of white carbon blacks, 2 kinds of raw materials drop in the little mixing apparatus successively, and start is mixed to evenly, and shutdown, blowing get 50～180 parts premix;
(2), the big mixing of the first step: open big mixing apparatus; With 60～160 parts of zeolite powders; The premix of the glutathione of 30～100 parts of starch or 57～100 parts of content 8%, above-mentioned (1) step preparation, 3 kinds of raw materials and premix have high input in the mixing apparatus successively, are mixed to evenly;
(3), the big mixing in second step: with glutathione or 30～100 parts of starch of 57～100 parts of content 8%, input still is in the described big mixing apparatus of above-mentioned (2) step of open state, continues to be mixed to evenly;
(4), the big mixing in the 3rd step: with the OPC of the chromium picolinate of 200～300 parts of content 9.90%, 200～280 parts of total polyphenols content 75%, 205～300 parts of dihydropyridines; 3 kinds of raw materials drop in the described big mixing apparatus of above-mentioned (3) step that still is in open state successively; Continue to be mixed to evenly, promptly get pig with polynary body anti-oxidant.
Above-mentioned each blend step, strictness have been controlled each expansion of every kind of material all below 5 times and 5 times, can guarantee that the mixovariation coefficient of whole mixture is up to standard.
Main quality standard of the present invention and assay method are following:
(1), total polyphenols content >=150,000mg/kg presses the Folin-Ciocalteu method or claims GAE method
(2), dihydropyridine content >=200,000mg/kg measures by the correlation technique of " dihydropyridine " in Ministry of Agriculture's version veterinary drug in 2003 quality standard.
(3), glutathione content >=4,500mg/kg measures by the DTNB method.
(4), mixovariation coefficient≤7%, measure by GB-T 5918.
Clinical test results of the present invention is following:
(1), clinical testing method
Select 48 of healthy, that body weight (about 8kg) is consistent Rongchang County pig weanling pigs, be divided into 4 processed group at random by body weight, every group of 2 repetitions, 6 piglets of every repetition.The according to the form below design that makes an experiment:
Test pig is every to repeat to raise in a hurdle, and every pig on average occupies 1m
2About, free choice feeding and drinking-water carry out feeding and management by routine raising and immune programme for children, to body weight 20kg, finish.
Testing index: mensuration of anti-oxidant index etc. in the mensuration of piglet production performance, piglet small intestine morphological analysis, piglet immunological performance, the serum.
(2), clinical test results
The body anti-oxidant sees the following form to the influence of weanling pig production performance:
The body anti-oxidant sees the following form to the influence of weanling pig intestinal villi:
The body anti-oxidant sees the following form to the influence of weanling pig immunity:
The body anti-oxidant sees the following form to the influence of weanling pig oxidation resistance:
(3), conclusion
1), refuel when improving production performance, also can cause the raising of body degree of oxidation, and then reduce immunity and animal health level etc.; The body anti-oxidant just in time can be retrieved this negative effect; Make the resultant effect of oiling even more ideal.
2), body anti-oxidant (VitE and product of the present invention etc.) can be brought into play in newborn baby pig feedstuff: reduce body oxidation level, raising immunity, protection intestinal villus, minimizing wean-commentaries on classics crowd etc. and stress, improve biological effectiveness such as piglet production performance.
3), with regard to the antioxidation biology of same dose learn tire with regard to, this research shows: because the mechanism of action of product of the present invention is comprehensive comprehensively, so it is 50% more than 2 times of VitE acetate that its antioxidation biology is tired.
Beneficial effect:
The pig that the present invention makes is with polynary body anti-oxidant, and its technology controlling and process is simple, and the mechanism of action is comprehensive, and the body antioxidation biology is learned and tired is more than 2 times of 50%VitE acetate and comprehensive, and the use cost feed industry can be accepted.
The specific embodiment
Best embodiment of the present invention divides other scheme according to integral body, implements respectively, through embodiment the present invention is specifically described below:
Embodiment 1:
1, pig is with the preparation method of polynary body anti-oxidant, and its characteristics are that this method initiation material is composed of the following components, and count by weight; Raw material is formed as follows: 60 parts of the glutathione of content 8%, 220 parts of dihydropyridines, 210 parts of the OPCs of total polyphenols content 75%; 45 parts of the chlorogenic acids of content 30%, 260 parts of the chromium picolinates of content 9.90%, 12 parts of white carbon blacks; 70 parts of starch, 123 parts of zeolite powders.
2, and by following processing step and technological parameter prepare:
(1), premixed: with the chlorogenic acid of 45 parts of content 30%, 12 parts of white carbon blacks, 2 kinds of raw materials drop in the little mixing apparatus successively, and start is mixed to evenly, and shutdown, blowing get 57 parts premix;
(2), the big mixing of the first step: open big mixing apparatus, with the premix of the glutathione of 123 parts of zeolite powders, 60 parts of content 8%, above-mentioned (1) step preparation, 3 kinds of raw materials and premix have high input in the mixing apparatus successively, are mixed to evenly;
(3), the big mixing in second step: with 70 parts of starch, input still is in the described big mixing apparatus of above-mentioned (2) step of open state, continues to be mixed to evenly;
(4), the big mixing in the 3rd step: with the OPC of the chromium picolinate of 260 parts of content 9.90%, 210 parts of total polyphenols content 75%, 220 parts of dihydropyridines; 3 kinds of raw materials drop in the described big mixing apparatus of above-mentioned (3) step that still is in open state successively; Continue to be mixed to evenly, promptly get pig with polynary body anti-oxidant.
The pig of producing is added in the big pig material of the later outer ternary of 60kg (claiming foreign ternary again) with the dosage of polynary body anti-oxidant by 200g/T, deliver the PSE meat phenomenon complete obiteration after pig kills for sale, yellowish pink ruddy, be that waterpower is good.
Embodiment 2:
1, pig is with the preparation method of polynary body anti-oxidant, and its characteristics are that this method initiation material is composed of the following components, and count by weight; Raw material is formed as follows: 70 parts of the glutathione of content 8%, 280 parts of dihydropyridines, 220 parts of the OPCs of total polyphenols content 75%; 60 parts of the chlorogenic acids of content 30%, 210 parts of the chromium picolinates of content 9.90%, 15 parts of white carbon blacks; 50 parts of starch, 95 parts of zeolite powders.
2, and by following processing step and technological parameter prepare:
(1), premixed: with the chlorogenic acid of 60 parts of content 30%, 15 parts of white carbon blacks, 2 kinds of raw materials drop in the little mixing apparatus successively, and start is mixed to evenly, and shutdown, blowing get 75 parts premix;
(2), the big mixing of the first step: open big mixing apparatus, with the premixs of 95 parts of zeolite powders, 50 parts of starch, the preparation of above-mentioned (1) step, 3 kinds of raw materials and premix have high input in the mixing apparatus successively, are mixed to evenly;
(3), the big mixing in second step: with the glutathione of 70 parts of content 8%, input still is in the described big mixing apparatus of above-mentioned (2) step of open state, continues to be mixed to evenly;
(4), the big mixing in the 3rd step: with the OPC of the chromium picolinate of 210 parts of content 9.90%, 220 parts of total polyphenols content 75%, 280 parts of dihydropyridines; 3 kinds of raw materials drop in the described big mixing apparatus of above-mentioned (3) step that still is in open state successively; Continue to be mixed to evenly, promptly get pig with polynary body anti-oxidant.
The pig of producing is offered pig feed manufacturing enterprise with polynary body anti-oxidant, and the amount that keeps VitE in the feed formula does, sucking pig material, child care material: 16ppm, little, in, big pig material: 11ppm, each phase sow material: 40ppm, boar material: 45ppm; And the VitE dosage in the original formulation and the difference of above-mentioned retained dose multiply by 2, are the using dosage of product of the present invention; This scheme of pressing is on the basis that keeps the VitE nutritional need; Implement body anti-oxidation function substituting with the present invention's article; Then this enterprise needs only had the 50%VitE of 200kg acetate to be replaced in every month; 1 year with regard to escapable cost more than 120,000 yuan, and the oxidative damage property problem of the fresh meat article that the body antioxidant effect of animal is better, breeding process is extremely produced still less.
More than show and described basic principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the specification just explains principle of the present invention; Under the prerequisite that does not break away from spirit and scope of the invention, the present invention also has various changes and modifications, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by appending claims and equivalent thereof.
Claims (3)
1. pig is with polynary body anti-oxidant, it is characterized in that composed of the following componentsly, and raw material is formed as follows: 57～100 parts of the glutathione of content 8%; 205～300 parts of dihydropyridines, 200～280 parts of the OPCs of total polyphenols content 75%, 40～100 parts of the chlorogenic acids of content 30%; 200～300 parts of the chromium picolinates of content 9.90%; 10～80 parts of white carbon blacks, 30～100 parts of starch, 60～160 parts of zeolite powders.
2. pig according to claim 1 is characterized in that with polynary body anti-oxidant, described optimum formula: 70 parts of the glutathione of content 8%; 280 parts of dihydropyridines, 220 parts of the OPCs of total polyphenols content 75%, 60 parts of the chlorogenic acids of content 30%; 210 parts of the chromium picolinates of content 9.90%; 15 parts of white carbon blacks, 50 parts of starch, 95 parts of zeolite powders.
3. a pig as claimed in claim 1 is characterized in that with the preparation method of polynary body anti-oxidant, may further comprise the steps:
(1), premixed: with the chlorogenic acid of 40～100 parts of content 30%, 10～80 parts of white carbon blacks, 2 kinds of raw materials drop in the little mixing apparatus successively, and start is mixed to evenly, and shutdown, blowing get 50～180 parts premix;
(2), open big mixing apparatus, with the glutathione of 60～160 parts of zeolite powders, 30～100 parts of starch or 57～100 parts of content 8%, the premix of above-mentioned steps (1) preparation, in the mixing apparatus that has high input, be mixed to evenly;
(3), with glutathione or 30～100 parts of starch of 57～100 parts of content 8%, drop into and still be in the described big mixing apparatus of above-mentioned steps (2) of open state, continue to be mixed to evenly;
(4), with the OPC of the chromium picolinate of 200～300 parts of content 9.90%, 200～280 parts of total polyphenols content 75%, 205～300 parts of dihydropyridines; Input still is in the described big mixing apparatus of above-mentioned steps (3) of open state successively, continues to be mixed to evenly to get final product.
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| EP2163252A1 (en) * | 2007-05-17 | 2010-03-17 | Kaneka Corporation | Composition containing licorice-derived polyphenol |
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| EP2163252A1 (en) * | 2007-05-17 | 2010-03-17 | Kaneka Corporation | Composition containing licorice-derived polyphenol |
Non-Patent Citations (2)
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