CN101978944B - Water-soluble preparation of anesthetic eugenol for fish and preparation method thereof - Google Patents
Water-soluble preparation of anesthetic eugenol for fish and preparation method thereof Download PDFInfo
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- CN101978944B CN101978944B CN201010530112A CN201010530112A CN101978944B CN 101978944 B CN101978944 B CN 101978944B CN 201010530112 A CN201010530112 A CN 201010530112A CN 201010530112 A CN201010530112 A CN 201010530112A CN 101978944 B CN101978944 B CN 101978944B
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Abstract
The invention provides a water-soluble preparation of anesthetic eugenol serving as an effective ingredient for fish. The preparation is prepared from the following raw materials in part by weight: 10 to 30 parts of eugenol, 10 to 30 parts of solvent, 1 to 10 parts of thickening agent and 100 parts of deionized distilled water. The preparation has good effect, short anesthesia time and low toxicity, and is favorable for scale application. The invention also provides a preparation method for the preparation. The preparation method is simple.
Description
Technical field:
The present invention and fish are relevant with water soluble preparation of anesthetis eugenol and preparation method thereof.
Background technology:
Eugenol is the adopted name of 4-pi-allyl-2-methoxyphenol, and its structural formula is following.Mainly being present in the oil of Ocimum Basilicum (Oci-mum gratissimum L) and in the oil of Cinnamomum basyleaves, is multiple aromatic oil
1972, the rattan far away of Japan found that this spice has intensive anaesthetic effect to fish, begins it has been carried out series of studies as fish with anesthetis.In recent years, along with deep research, this natural perfume material of eugenol does not have the advantage of influence because have cheap and easy to getly to health, and beginning is applied to parent fish as fish with anesthetis and adopts in ovum, live fish transportation and the operation process anesthesia to aquatic animal.Wherein Japan with its classify as be used for fish production fish with one of anesthetis.
Because the eugenol self character is insoluble in water, be unfavorable for producing scale and use, therefore limited it and applied.
Summary of the invention:
The objective of the invention is for a kind of good drug efficacy is provided; The fish that anesthesia duration is short, toxicity is little, be beneficial to the scale application is with anesthetis eugenol water soluble preparation, and another object of the present invention is for the method for preparing of the simple fish of a kind of production technology with the water soluble preparation of anesthetis eugenol is provided.
Fish of the present invention is processed by following raw materials according with the water soluble preparation of anesthetis eugenol by weight:
Eugenol 10～30,
Solvent 10～30,
Thickening agent 1～10,
No ion distilled water 100.
Above-mentioned solvent adopts at least a in ethanol, ether, chloroform, caustic solution, the glacial acetic acid.
Above-mentioned thickening agent adopts at least a in gelatin, pectin, agar, Sargassum fat, the plain derivant of polysaccharide.
Above-mentioned eugenol adopts medical grade tooth section operation type other eugenol raw material of level.
Fish of the present invention comprises the steps: with the method for preparing of the water soluble preparation of anesthetis eugenol
(1), prepares burden in proportion;
(2), respectively eugenol and solvent, no ion distilled water are mixed the formation mixing material with thickening agent; The mixing material that in the mixing material of eugenol and solvent, adds no ion distilled water and thickening agent; Stirring reaction is 10～30 minutes under 35～55 ℃ of conditions of constant temperature, becomes transparent water soluble preparation.
Fish provided by the invention has the advantage of the following aspects with the water soluble preparation of anesthetis eugenol: 1, because said preparation is a water soluble preparation, therefore is convenient to clinical scale and uses; 2, production technology is simple, is convenient to preparation; 3, good drug efficacy; As preparation of the present invention being used for the artificial propagation of Ctenopharyngodon idellus, Misgurni anguillicaudati, acipenser schrencki; Compare with anesthetis MS-222 with the first-selected fish that FDA (food and drug administration) recommends, anesthesia duration shortens 10%～50%, and oxygenation can be revived after 5～20 minutes again.4, toxicity is little, compares with MS-222, and eugenol toxicity is littler, is 10mg/L to the 30min median lethal concentration (TLm) of Carnis Pseudosciaenae, is 112mg/L (rattan far away, 1972) to 30 minutes TLm of Cyprinus carpio dipping.And MS-222 is 8.2mg/L to 15 minutes the median lethal concentration of juvenile fish dipping of the long 6.5-9.0cm of body, to the toxicity of fish apparently higher than eugenol.
The specific embodiment
Embodiment 1:
The embodiment of the invention 1 preparation is processed by following raw materials according by weight:
Eugenol 20,
Ethanol 30,
Gelatin 4,
No ion distilled water 100.
The embodiment of the invention 1 formulation preparation method following steps:
(1), prepares burden in proportion;
(2), respectively with eugenol mix with ethanol, no ion distilled water mixes with gelatin and forms mixing material; The mixing material that in eugenol and alcoholic acid mixing material, adds no ion distilled water and gelatin; Stirring reaction is 20 minutes under 35 ℃ of conditions of constant temperature, becomes transparent water soluble preparation.
Embodiment 2:
The embodiment of the invention 2 preparations are processed by following raw materials according by weight:
Eugenol 10,
Ether 10,
Agar 1,
No ion distilled water 100.
The embodiment of the invention 2 formulation preparation method following steps:
(1), prepares burden in proportion;
(2), respectively with eugenol mix with ether, no ion distilled water mixes with agar and forms mixing material; The mixing material that in the mixing material of eugenol and ether, adds no ion distilled water and agar; Stirring reaction is 30 minutes under 50 ℃ of conditions of constant temperature, becomes transparent water soluble preparation.
Embodiment 3:
The embodiment of the invention 3 preparations are processed by following raw materials according by weight:
Eugenol 30,
Chloroform 15,
Sargassum fat 10,
No ion distilled water 100.
The embodiment of the invention 3 formulation preparation method following steps:
(1), prepares burden in proportion;
(2), respectively with eugenol mix with chloroform, no ion distilled water mixes with Sargassum fat and forms mixing material; The mixing material that in the mixing material of eugenol and chloroform, adds no ion distilled water and Sargassum fat; Stirring reaction is 10 minutes under 55 ℃ of conditions of constant temperature, becomes transparent water soluble preparation.
Above-mentioned each embodiment is further described foregoing of the present invention, but should this scope that is interpreted as the above-mentioned theme of the present invention only not limited to the foregoing description.All technology that realizes based on foregoing all belong to scope of the present invention.
Claims (1)
1. fish is processed by following raw materials according with the water soluble preparation of anesthetis eugenol by weight:
Above-mentioned solvent adopts ethanol or ether or chloroform, and thickening agent adopts gelatin or agar or Sargassum fat, and eugenol adopts medical grade tooth section operation type other eugenol raw material of level;
Above-mentioned fish comprises the steps: with the method for preparing of the water soluble preparation of anesthetis eugenol
(1), prepares burden in proportion;
(2), respectively eugenol and solvent, no ion distilled water are mixed the formation mixing material with thickening agent; The mixing material that in the mixing material of eugenol and solvent, adds no ion distilled water and thickening agent; Stirring reaction is 10～30 minutes under 35～55 ℃ of conditions of constant temperature, becomes transparent water soluble preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010530112A CN101978944B (en) | 2010-11-03 | 2010-11-03 | Water-soluble preparation of anesthetic eugenol for fish and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010530112A CN101978944B (en) | 2010-11-03 | 2010-11-03 | Water-soluble preparation of anesthetic eugenol for fish and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101978944A CN101978944A (en) | 2011-02-23 |
| CN101978944B true CN101978944B (en) | 2012-10-03 |
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| CN201010530112A Expired - Fee Related CN101978944B (en) | 2010-11-03 | 2010-11-03 | Water-soluble preparation of anesthetic eugenol for fish and preparation method thereof |
Country Status (1)
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103283651A (en) * | 2013-05-23 | 2013-09-11 | 山东省海水养殖研究所 | Transportation method of narcotized fish by atomized anesthetic |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259167A (en) * | 2008-04-14 | 2008-09-10 | 中国水产科学研究院淡水渔业研究中心 | Carp anaesthesia method |
| CN101720702A (en) * | 2009-12-13 | 2010-06-09 | 山东省海水养殖研究所 | Method for reducing stress response in manual operations of juvenile fish of black rockfish |
-
2010
- 2010-11-03 CN CN201010530112A patent/CN101978944B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259167A (en) * | 2008-04-14 | 2008-09-10 | 中国水产科学研究院淡水渔业研究中心 | Carp anaesthesia method |
| CN101720702A (en) * | 2009-12-13 | 2010-06-09 | 山东省海水养殖研究所 | Method for reducing stress response in manual operations of juvenile fish of black rockfish |
Non-Patent Citations (2)
| Title |
|---|
| 吕世明等.丁香酚乳液和醇溶液对鲤鱼麻醉作用的对比研究.《天津农业科学》.2009,第15卷(第03期), * |
| 张富林等.丁香酚对鲤麻醉作用的研究.《江西水产科技》.2007,(第04期), * |
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