CN101970472B - Rtef-1变体及其用于抑制血管发生的用途 - Google Patents

Rtef-1变体及其用于抑制血管发生的用途 Download PDF

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CN101970472B
CN101970472B CN2008801004835A CN200880100483A CN101970472B CN 101970472 B CN101970472 B CN 101970472B CN 2008801004835 A CN2008801004835 A CN 2008801004835A CN 200880100483 A CN200880100483 A CN 200880100483A CN 101970472 B CN101970472 B CN 101970472B
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rtef
cancer
polypeptide
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cells
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CN101970472A (zh
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J·蒂莫西·斯托特
特雷弗·麦可法兰德
本诺伊·阿普库坦
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CN2008801004835A 2007-06-06 2008-06-06 Rtef-1变体及其用于抑制血管发生的用途 Expired - Fee Related CN101970472B (zh)

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US94224907P 2007-06-06 2007-06-06
US60/942,249 2007-06-06
PCT/US2008/066058 WO2008154351A1 (en) 2007-06-06 2008-06-06 Rtef-1 variants and the use thereof for inhibition of angiogenesis

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CN101970472B true CN101970472B (zh) 2013-10-30

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US (3) US8748379B2 (enExample)
EP (1) EP2170938B1 (enExample)
JP (2) JP5410416B2 (enExample)
CN (1) CN101970472B (enExample)
AT (1) ATE553771T1 (enExample)
AU (1) AU2008261969B2 (enExample)
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DK (1) DK2170938T3 (enExample)
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Families Citing this family (11)

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US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
KR101553740B1 (ko) * 2009-08-17 2015-09-17 트라콘 파마수티칼즈, 인코포레이티드 항엔도글린 항체 및 항ｖｅｇｆ 제제를 사용한 암 치료를 위한 병용 요법
US8785385B2 (en) 2010-04-19 2014-07-22 Research Development Foundation RTEF-1 variants and uses thereof
IT1405683B1 (it) * 2010-10-18 2014-01-24 Istituto Giannina Gaslini Vettori lipidici veicolanti silenziatori genici
EP2825191B1 (en) 2012-03-16 2019-08-28 University Health Network Soluble toso protein and its use in treating autoimmune disorders
UA115789C2 (uk) 2012-09-05 2017-12-26 Трейкон Фармасутікалз, Інк. Композиція антитіла до cd105 та її застосування
CA2917077A1 (en) 2013-07-03 2015-01-08 University Health Network Antibodies to toso
WO2015130783A1 (en) * 2014-02-25 2015-09-03 Research Development Foundation Sty peptides for inhibition of angiogenesis
CA2966905A1 (en) 2014-11-12 2016-05-19 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
TWI843989B (zh) 2021-02-19 2024-06-01 美商美威高能離子醫療系統公司 用於粒子治療系統之支架

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2005034881A2 (en) * 2003-10-10 2005-04-21 Beth Israel Deaconess Medical Center Methods and compositions for treating conditions involving abnormal angiogenesis

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Publication number Priority date Publication date Assignee Title
WO1995020975A1 (en) 1994-02-04 1995-08-10 The Regents Of The University Of California Tef-1 isoforms and uses thereof
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
US7122181B2 (en) 2000-12-19 2006-10-17 Research Development Foundation Lentiviral vector-mediated gene transfer and uses thereof
US7183388B2 (en) 2001-03-30 2007-02-27 The Regents Of The University Of California Anti-MUC-1 single chain antibodies for tumor targeting
US20060223114A1 (en) 2001-04-26 2006-10-05 Avidia Research Institute Protein scaffolds and uses thereof
DK1412493T3 (da) 2001-08-02 2012-01-09 Inst Clayton De La Rech Fremgangsmåder og sammensætninger der angår forbedrede lentiviral-vektor.-produktionsystemer
WO2005073384A2 (en) 2004-01-28 2005-08-11 Research Development Foundation Human soluble neuropilin-1 primary polyadenylation signal and uses thereof
WO2006055689A2 (en) 2004-11-16 2006-05-26 Avidia Research Institute Protein scaffolds and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005034881A2 (en) * 2003-10-10 2005-04-21 Beth Israel Deaconess Medical Center Methods and compositions for treating conditions involving abnormal angiogenesis

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ATE553771T1 (de) 2012-05-15
CA2689913A1 (en) 2008-12-18
CN101970472A (zh) 2011-02-09
EP2170938B1 (en) 2012-04-18
WO2008154351A9 (en) 2010-01-14
AU2008261969B2 (en) 2013-06-06
EP2170938A1 (en) 2010-04-07
US20090117119A1 (en) 2009-05-07
US20170081377A1 (en) 2017-03-23
US8748379B2 (en) 2014-06-10
JP2013215210A (ja) 2013-10-24
US20140322205A1 (en) 2014-10-30
JP2010528663A (ja) 2010-08-26
WO2008154351A1 (en) 2008-12-18
CA2689913C (en) 2014-10-07
IL202338A0 (en) 2011-08-01
US9937269B2 (en) 2018-04-10
IL202338A (en) 2014-03-31
DK2170938T3 (da) 2012-07-16
US9512423B2 (en) 2016-12-06
JP5410416B2 (ja) 2014-02-05
AU2008261969A1 (en) 2008-12-18

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