CN101970017B - 中枢神经系统的显像 - Google Patents

中枢神经系统的显像 Download PDF

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Publication number
CN101970017B
CN101970017B CN2009801067913A CN200980106791A CN101970017B CN 101970017 B CN101970017 B CN 101970017B CN 2009801067913 A CN2009801067913 A CN 2009801067913A CN 200980106791 A CN200980106791 A CN 200980106791A CN 101970017 B CN101970017 B CN 101970017B
Authority
CN
China
Prior art keywords
developer
formula
group
precursor
vivo imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2009801067913A
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English (en)
Chinese (zh)
Other versions
CN101970017A (zh
Inventor
P·A·琼斯
I·威尔逊
V·莫里森-艾夫森
C·琼斯
J·伍德克拉夫特
A·杰克逊
D·怀恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN101970017A publication Critical patent/CN101970017A/zh
Application granted granted Critical
Publication of CN101970017B publication Critical patent/CN101970017B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2009801067913A 2008-02-29 2009-02-26 中枢神经系统的显像 Expired - Fee Related CN101970017B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3244208P 2008-02-29 2008-02-29
US61/032442 2008-02-29
GBGB0803729.3A GB0803729D0 (en) 2008-02-29 2008-02-29 Imaging the central nervous system
GB0803729.3 2008-02-29
PCT/EP2009/052280 WO2009106564A2 (en) 2008-02-29 2009-02-26 Imaging the central nervous system

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2012100777571A Division CN102600488B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777139A Division CN102600487B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Publications (2)

Publication Number Publication Date
CN101970017A CN101970017A (zh) 2011-02-09
CN101970017B true CN101970017B (zh) 2012-05-23

Family

ID=39315680

Family Applications (3)

Application Number Title Priority Date Filing Date
CN2009801067913A Expired - Fee Related CN101970017B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777139A Expired - Fee Related CN102600487B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777571A Expired - Fee Related CN102600488B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2012100777139A Expired - Fee Related CN102600487B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777571A Expired - Fee Related CN102600488B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Country Status (6)

Country Link
US (1) US20110027178A1 (https=)
EP (1) EP2247316B1 (https=)
JP (1) JP2011513277A (https=)
CN (3) CN101970017B (https=)
GB (1) GB0803729D0 (https=)
WO (1) WO2009106564A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0906274D0 (en) * 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
GB0917611D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd Automated radiosynthesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704546D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
EP1495031A1 (en) * 2002-04-16 2005-01-12 Pharmacia & Upjohn Company LLC Labeled oxazinocarbazoles as diagnostic agents
JP2006513996A (ja) * 2002-10-24 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
AU2004294989B2 (en) * 2003-12-01 2009-03-19 Ignasi Carrio Novel differential imaging method
CA2654369C (en) * 2006-06-21 2014-10-14 Ge Healthcare Limited Radiopharmaceutical products
MX2009000117A (es) * 2006-07-06 2009-01-23 Glaxo Group Ltd N-fenilmetil-5-oxo-prolin-2-amidas sustituidas como antagonistas de receptores p2x7 y sus metodos de uso.
WO2008064432A1 (en) * 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Michel AD, Chambers LJ, Walter DS..《Negative and positive allosteric modulators of the P2X(7) receptor》.《Br J Pharmacol.》.2008,第153卷(第4期),737-750. *
Nelson DW, et. al..《Structure-activity relationship studies on a series of novel,substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists 》.《J Med Chem.》.2006,第49卷(第12期),3659-66. *
Stokes L, et. al..《Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373》.《Br J Pharmacol.》.2006,第149卷(第7期),880-7. *

Also Published As

Publication number Publication date
JP2011513277A (ja) 2011-04-28
CN101970017A (zh) 2011-02-09
EP2247316A2 (en) 2010-11-10
CN102600487B (zh) 2013-11-20
GB0803729D0 (en) 2008-04-09
EP2247316B1 (en) 2013-11-06
WO2009106564A2 (en) 2009-09-03
WO2009106564A3 (en) 2010-03-25
CN102600488B (zh) 2013-11-20
US20110027178A1 (en) 2011-02-03
CN102600487A (zh) 2012-07-25
CN102600488A (zh) 2012-07-25

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120523

Termination date: 20140226