CN101966307A - Medicinal composition for treating damp-heat icterohepatitis - Google Patents
Medicinal composition for treating damp-heat icterohepatitis Download PDFInfo
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- CN101966307A CN101966307A CN 201010525758 CN201010525758A CN101966307A CN 101966307 A CN101966307 A CN 101966307A CN 201010525758 CN201010525758 CN 201010525758 CN 201010525758 A CN201010525758 A CN 201010525758A CN 101966307 A CN101966307 A CN 101966307A
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Abstract
The invention relates to a medicinal composition for treating damp-heat icterohepatitis. A preparation method of the medicinal composition comprises the following steps of: decocting red paeony root, kudzuvine root, Chinese angelica, peach seed, coix seed, pinellia tuber, fortune eupatorium herb, plantain seed and raw malt in water twice, concentrating decoction to form extractum with the relative density of between 1.04 and 1.05 at the temperature of 50 DEG C, drying under reduced pressure, pulverizing to form fine powder, and loading the fine powder into capsules to prepare capsules. The medicinal composition has the effects of clearing heat, detoxicating, normalizing gallbladder to cure jaundice, promoting blood circulation, removing blood stasis, warming yang, invigorating the spleen and dehumidifying, has the obvious curative effect on the treatment of the damp-heat icterohepatitis and is small in toxic and side effect; and through the observation of the clinical curative effect, the effective rate of treating the damp-heat icterohepatitis is 91.2 percent.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of hepatitis, particularly relating to a kind of is the Chinese medicine composition of the treatment damp-heat type icterohepatitis of crude drug preparation with Chinese medicine.
Background technology
Hepatitis is the diffuse inflammation of liver parenchyma, show as the congested swelling of liver, hepatocellular degeneration necrosis, inflammatory infiltration, blood sinus inner cell propagation, these change compressing and inaccessible branch of portal vein, and hepatic sinusoid and hepatocyte blood flow are reduced, and Peripheral resistance increases, slow blood flow, blood stagnation causes bile secretion excretory function obstacle, and bilirubin stays and sends out in blood is jaundice; Or calculus of intrahepatic duct causes the narrow companion's distal dilation of stones in intrahepatic bile duct limitation, the intrinsic pressure rising of bile duct, and then involve biliary ductuli and blood capillary, bile component enters blood via blood gallbladder barrier, is the major reason that intrahepatic cholestasis takes place.
Hepatitis belongs to the traditional Chinese medical science " hypochondriac pain, jaundice " category according to its clinical characters, makes a general survey of the pathogenic factor of primary disease, how, damage in liver the liver failing to maintain the normal flow of QI by invading in unhygienic diet, the evil poison, depression of liver-QI, blood-stasis internal-depression, functional activity of QI being not smooth, horizontal gram spleen soil, dysfunction of the spleen in transportation, retention of water-damp in the body, with the passing of time heat-transformation, retention of damp-heat in the interior, general then is jaundice in the flesh table.Clinically mainly show as skin, the face xanthochromia is obvious, and is yellow dark and gloomy, with weak, poor appetite, the abdominal part distension, pale tongue is dark, corpulent tongue is big etc.
The medicine of treatment damp-heat type icterohepatitis is a lot of at present, though the Western medicine instant effect, many side effect, and also very poor to the therapeutic effect of complication.According to the traditional Chinese medical science dialectical to this type of disease, use Chinese medicine can reach the effect for the treatment of both the principal and secondary aspects of a disease fully, but because a variety of causes such as Chinese medicine preparation reasonable recipe shortcoming, the preparation technology of this type of disease of treatment be unreasonable at present, can't obtain the curative effect of picture Western medicine.So, providing a kind of and can bring into play the Chinese medicine speciality, the Chinese medicine composition of reasonable recipe, preparation technology's science is necessary.
Motherland's medical science early has understanding to the etiology and pathogenesis of damp-heat type icterohepatitis, points out in " interior warp ": " damp and hot intersecting, the people are when sick illness." continue it " Medical Treasures of the Golden Chamber " add: " yellow tame gained, caused by pathogenic dampness." illustrate that the cause of disease of jaundice due to damp-heat is damp and hot for suffering from.After " interior warp ", eating and drinking without temperance, overstrain are further elucidated by back physicians from a family for generations family all can cause the jaundice generation." Shengji Zonglu " cloud: " big rate is how excessive because of food and drink, and water paddy phase is also amassed in taste, is invasion of the body by blended pathogenic wind and dampness again, so steam steams the jaundice subcutaneous ulcer." " red platform five cases " point out: " card of jaundice all damp and hotly becomes, and dampness can not give vent to, and is then strongly fragrant and give birth to heat, and steam can not be declared freely, then fixed and give birth to wetly, wet hot and beneficial deeply, and heat is more vehement because of wetting, and the two help and coordinating is healed for a long time more the person also." illustrate damp and hot in human body generation development and change and influence each other.In a word, no matter ancient Chinese medicine doctor is respectively elucidated the jaundice due to damp-heat etiology and pathogenesis, and also has doctor family to mention the problem of " stasis of blood ", but always emphasizes with damp and hot to be guiding principle, has but ignored the important function of the stasis of blood in jaundice caused by damp-heat.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition for the treatment of damp-heat type icterohepatitis, this Drug therapy damp-heat type icterohepatitis is evident in efficacy, and toxic and side effects is little.
Pharmaceutical composition of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Radix Paeoniae Rubra 30～60 Radix Puerariaes 30～60
Radix Angelicae Sinensis 10～30 Semen Persicaes 30～60
Semen Coicis 30～60 Rhizoma Pinelliaes 10～30
Herba Eupatorii 15～30 Semen Plantaginiss 15～30
Fructus Hordei Germinatus 30～60.
Said medicine can be made any conventional peroral dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each crude drug being made medicine of the present invention is:
Get Radix Paeoniae Rubra, Radix Puerariae, Radix Angelicae Sinensis, Semen Persicae, Semen Coicis, the Rhizoma Pinelliae, Herba Eupatorii, Semen Plantaginis and Fructus Hordei Germinatus, according to described parts by weight mix homogeneously, decoct with water 2 times, each amount of water was not advisable collecting decoction to have powder, filter, decocting liquid is concentrated into 50 ℃ of extractum of surveying relative density 1.04～1.05, and drying under reduced pressure is broken into fine powder with dry extract, in incapsulating, make capsule of the present invention.
Usage: the adult takes 2, every day 2 times, oral meal at every turn.
It is considered herein that the formation of jaundice is not only with damp and hot relevant, and stagnate relevantly, and play crucial effects with the stasis of blood.Damp being a kind of YIN pathogen, the deep viscous of its property, the human feeling easily blocks mechanism of qi, causes functional activity of QI being not smooth.Heat is YANG pathogen, on its property inflammation, easily goes into blood system, the absurd row of forcing blood.If wet be harmonious with heat, as face, glue is difficult to resolve admittedly as oil, and is wet that hot benefit is dark, and hotly must wet more vehemently, and damp and hot folder is malicious, and suffocating of liver and gall, intrusion blood system cause blood-vessel obstructive, and blood operation loses in Chang Dao, and the bile criminal of overflowing is in skin and the subcutaneous ulcer of turning to be yellow.Secondly, the many disharmony between the liver and spleen of primary disease are this, blood stored in the liver, main catharsis, spleen master blood, main fortuneization, under the normal condition, the two function is coordinated mutually, and the catharsis function of liver is normal, the pivotal role that taste are brought into normal play, ascending or descending movement of vital Qi is orderly, the strong fortune of taste, fail on the essence of water and grain in cardiopulmonary, QI and blood biochemistry continually, thereby liver get support, liver is transferred blood volume, and system blood is had the right.If liver-spleen disharmony, catharsis is not normal, the strongly fragrant numbness of mechanism of qi, and transformation failure of spleen, retention of damp-heat in the interior causes the hepatocholic depression hot smoking and burns, and then body fluid is consumed, and body fluid deficiency is not enough to carry blood and causes hematogenous blockage, and blockage of the vessel, bile lose catharsis, excessive skin generation jaundice.So, damp and hot glued numbness air resister, damp and hot intrusion blood system hyperamization liquid operation is not smooth, is the pathogenesis of jaundice due to damp-heat.Therefore, the treatment jaundice should adopt the method for heat-clearing and toxic substances removing, dampness removing jaundice eliminating, blood circulation promoting and blood stasis dispelling.In the prescription of the present invention, Radix Paeoniae Rubra, Radix Puerariae heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice; Radix Angelicae Sinensis, Semen Persicae blood circulation promoting and blood stasis dispelling; Semen Coicis, Fructus Hordei Germinatus spleen invigorating dehumidifying jaundice eliminating; Rhizoma Pinelliae regulating the stomach and sending down the adverse rising QI to arrest nausea; Herba Eupatorii, the Semen Plantaginis dampness of regulating the flow of vital energy.All medicine compatibilities have the effect of heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, blood circulation promoting and blood stasis dispelling, warming YANG and strengthening the spleen dehumidifying.
Drug administration safety of the present invention can reduce complication and take place, and the patient is easy to take, and easy to use, and price is suitable.
For further investigating the clinical efficacy and the safety of medicine of the present invention, we select 500 routine damp-heat type icterohepatitis, and the curative effect of Drug therapy damp-heat type icterohepatitis of the present invention is carried out clinical observation.
MethodsThe cases enrolled is divided into two groups at random with 500 routine cases, matched group 250 examples, and 250 examples are organized in treatment.Male 123 examples in the matched group, women 127 examples; 17～54 years old age, average 48.3 years old; The course of disease 1 month～10 months, average 4.9 months.Male 128 examples in the treatment group, women 122 examples; 18～43 years old age, average 47.3 years old; Course of disease 20d～12 month, average 3.8 months.Two groups of cases at aspects such as sex, age, the courses of disease by statistics credit analyse the difference not statistically significant.The diagnosis of all cases is diagnosed with reference to the diagnostic criteria of hepatitis in " new Chinese medicine clinical guidance Therapeutic Principle ".And meet diagnostic criteria.
The Therapeutic Method matched group is taken and is protected proheparinum tablet treatment, each 2, every day 3 times.The treatment group gives drug oral of the present invention, and each 2, every day 2 times, oral meal.2 months is a course of treatment.
The curative effect determinate standard produce effects: symptom, sign disappear in 1 course of treatment, and liver function recovery is normal; Effectively: symptom, sign disappear in 2 courses of treatment, and liver function recovery is normal; Invalid: symptom, sign do not have improvement after 3 courses of treatment, though or improvement arranged, it is little to take a turn for the better, the basic no change of liver function.
Curative effect comparative result after two groups of cases are treated sees Table 1.
Table 1 liang group case treatment back curative effect relatively
The specific embodiment
Embodiment 1
Get and choose most impurity, screening dry in the sun, the Radix Paeoniae Rubra 40Kg after the oven dry, Radix Puerariae 40Kg, Radix Angelicae Sinensis 25Kg, Semen Persicae 40Kg, Semen Coicis 60Kg, Rhizoma Pinelliae 15Kg, Herba Eupatorii 30Kg, Semen Plantaginis 30Kg, Fructus Hordei Germinatus 30Kg decocts with water 2 times, each water consumption was not advisable there not to be powder, decocted 4h, collecting decoction, filter, decocting liquid is concentrated into 50 ℃ of extractum of surveying relative density 1.04～1.05, drying under reduced pressure, dry extract is broken into fine powder, and mixing is made capsule in incapsulating.Usage: the adult takes 2, every day 2 times, oral meal at every turn.
Embodiment 2
Get and choose most impurity, screening dry in the sun, the Radix Paeoniae Rubra 60Kg after the oven dry, Radix Puerariae 60Kg, Radix Angelicae Sinensis 15Kg, Semen Persicae 60Kg, Semen Coicis 30Kg, Rhizoma Pinelliae 25Kg, Herba Eupatorii 20Kg, Semen Plantaginis 15Kg, Fructus Hordei Germinatus 60Kg decocts with water 2 times, each water consumption was not advisable there not to be powder, decocted 4h, collecting decoction, filter, decocting liquid is concentrated into 50 ℃ of extractum of surveying relative density 1.04～1.05, drying under reduced pressure, dry extract is broken into fine powder, and mixing is made capsule in incapsulating.
Claims (3)
1. pharmaceutical composition for the treatment of damp-heat type icterohepatitis is to be that crude drug prepares by following parts by weight of traditional Chinese medicines:
Radix Paeoniae Rubra 30～60 Radix Puerariaes 30～60
Radix Angelicae Sinensis 10～30 Semen Persicaes 30～60
Semen Coicis 30～60 Rhizoma Pinelliaes 10～30
Herba Eupatorii 15～30 Semen Plantaginiss 15～30
Fructus Hordei Germinatus 30～60.
2. the pharmaceutical composition of treatment damp-heat type icterohepatitis according to claim 1 is characterized in that described medicine is made capsule.
3. the preparation of drug combination method of the described treatment damp-heat type icterohepatitis of claim 2, it is characterized in that getting Radix Paeoniae Rubra, Radix Puerariae, Radix Angelicae Sinensis, Semen Persicae, Semen Coicis, the Rhizoma Pinelliae, Herba Eupatorii, Semen Plantaginis and the Fructus Hordei Germinatus mix homogeneously of described parts by weight, decoct with water 2 times, each amount of water was not advisable to have powder, and collecting decoction filters, decocting liquid is concentrated into 50 ℃ of extractum of surveying relative density 1.04～1.05, drying under reduced pressure is broken into fine powder with dry extract, makes capsule in incapsulating.
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| CN 201010525758 CN101966307A (en) | 2010-10-26 | 2010-10-26 | Medicinal composition for treating damp-heat icterohepatitis |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1504210A (en) * | 2002-11-28 | 2004-06-16 | 勇 韩 | Prepared Chinese traditional medicine for alopecia |
| CN1891284A (en) * | 2005-07-08 | 2007-01-10 | 仁和（集团）发展有限公司 | Chinese medicine composition, and its preparing method and quality control method |
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- 2010-10-26 CN CN 201010525758 patent/CN101966307A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1504210A (en) * | 2002-11-28 | 2004-06-16 | 勇 韩 | Prepared Chinese traditional medicine for alopecia |
| CN1891284A (en) * | 2005-07-08 | 2007-01-10 | 仁和（集团）发展有限公司 | Chinese medicine composition, and its preparing method and quality control method |
Non-Patent Citations (1)
| Title |
|---|
| 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 20091115 林清 清利活血汤治疗慢性淤胆型肝炎（湿热瘀阻型）的临床研究 第3页－第10页 1－3 , 第11期 2 * |
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