CN101954104A - Paeonol solid dispersion air freshener - Google Patents
Paeonol solid dispersion air freshener Download PDFInfo
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- CN101954104A CN101954104A CN2010102577922A CN201010257792A CN101954104A CN 101954104 A CN101954104 A CN 101954104A CN 2010102577922 A CN2010102577922 A CN 2010102577922A CN 201010257792 A CN201010257792 A CN 201010257792A CN 101954104 A CN101954104 A CN 101954104A
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- paeonol
- air freshener
- solid dispersion
- beta
- essence
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Abstract
The invention relates to a paeonol solid dispersion air freshener. The air freshener is prepared by a solvent volatilization method or melting method and comprises the following components in part by mass: 1 to 40 parts of paeonol, 0 to 5 parts of L-menthol, 1 to 90 parts of inorganic carrier material, and 0 to 1 part of beta-cyclodextrin included essence and spice, wherein the inorganic carrier material is talcpowder, diatomite, bentonite or attapulgite and the like with high specific surface area. The air freshener is used for freshening and sterilizing air in families and automobiles and can also be used for the mold prevention of textiles, paper and the like.
Description
One, technical field
The present invention relates to a kind of household chemicals compositions, specifically a kind of paeonol solid dispersion air freshener.
Two, background technology
Common air freshener all is made up of preparations such as essence and ethanol organic solvents basically, neither possesses health care, does not also have the effect of sterilizing, only plays the effect that abnormal smells from the patient improves.Paeonol is a kind of spice, is a kind of Chinese medicine again, and is safe, and oral administration LD50 is 3430mg/Kg.Paeonol claims paeonol again, and chemical name is 2-hydroxyl-4-methoxyacetophenone, and pure product are colourless acicular crystal.
The clinical diseases such as cardiovascular and cerebrovascular vessel, tumor, inflammation, allergy and immune system [Chinese medicine information, 2009,26 (1): 20-22, Chinese invention patent 200510042537.5,200610096653.X] etc. that are used for more; Also can be used as cosmetics [Chinese invention patent 200810157199.3], spot dispelling whitening, delaying decrepitude of skin, skin moistening are preserved moisture, anti-inflammation etc. all have better action.Medicinal paeonol dosage form mainly contains injection, Emulsion, gel, ointment, liniment, pelliculae pro cavo oris, soft capsule [200410035585.7] and nano-emulsion [Chinese invention patent 200610104592.7] etc.Except being used for medicine, also be used as anti-mould and moth-proof agent.
Because paeonol is the crystalline particle of 51 ± 1 ℃ of fusing points, highly regular crystallization makes that its rate of release in environment is slow excessively, in order to make paeonol enough concentration be arranged in air to reach the effect of anti-mould and anti-moth, Yang Shunqi and Yao Risheng etc. [Chinese invention patent 200310112844] promote the volatilization of paeonol by adding Borneolum Syntheticum, and utilize free Borneolum Syntheticum or/and speed releaser that natural camphor and beta-cyclodextrin inclusion compound Borneolum Syntheticum or natural camphor constitute and paeonol etc. have been mixed with control release type paeonol anti-mould and anti-moth solid tablet.But the adding of Borneolum Syntheticum makes the abnormal smells from the patient of goods have stronger zest, is inappropriate to the air disinfection and refreshing of environment such as family and automobile.
Three, summary of the invention
The object of the invention is to provide a kind of and has health care, as family and the pure and fresh disinfectant paeonol of automobile indoor air solid dispersion.
Thinking of the present invention is to realize the high degree of dispersion of paeonol and promote the release of paeonol by the high-ratio surface of inorganic carrier material.
To be the paeonol solid dispersion that adopts solvent evaporation method or fusion method processing be made of each component of following mass parts technical scheme of the present invention:
Paeonol 1～40
L-menthol 0～5
Inorganic carrier material 1～90
The essence and flavoring agent 0～1 of beta-cyclodextrin inclusion compound
Described solvent evaporation method is: utilize organic solvent that paeonol or paeonol/lysigenous solution of L-menthol are mixed with the inorganic material of high-ratio surface, evaporation under agitation removes the solvent about 90%, then, slowly dry, obtain the paeonol solid dispersion.Described slow drying can be to be lower than 10 ℃ of following vacuum dryings, perhaps at room temperature volatilizes naturally.
Described fusion method is: earlier paeonol or paeonol/L-menthol are mixed with the inorganic material of high-ratio surface, then, disperse in 45～55 ℃ of ball millings or extruding, be cooled to the room temperature pulverizing and obtain the paeonol solid dispersion.
Resultant paeonol solid dispersion mixes to strengthen fragranced with the essence and flavoring agent powder body of an amount of beta-cyclodextrin inclusion compound.
Described inorganic carrier material is selected from the inert substance of the safety non-toxics such as Pulvis Talci, kieselguhr, bentonite or attapulgite of high-ratio surface.
Described solvent is selected from low boiling point solvents such as methanol, ethanol, ether and acetone, preferably ethanol or acetone.
Utilize the essence and flavoring agent of beta-cyclodextrin inclusion compound to adjust fragrance, used essence and flavoring agent is selected from natural or synthetic Flos Rosae Rugosae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil or vanillin etc.
This product is not limited to as family and the pure and fresh sterilization of automobile indoor air, can be used for equally weaving and the mildew-resistant of paper etc.
Four, description of drawings
Fig. 1 is transmission electron microscope (TEM) figure of paeonol solid dispersion.Paeonol/Pulvis Talci mass ratio 4: 1, it is deposited on the spherical particle that the inorganic carrier surface is 100～200nm.
Fig. 2 is the release rate profile of paeonol and paeonol solid dispersion.A is a paeonol among the figure, B be paeonol/kieselguhr quality than 4: 1, C is paeonol/Pulvis Talci mass ratio 4: 1, D is that paeonol/L-menthol/Pulvis Talci mass ratio is 4: 1: 1.Wherein, the rate of release of paeonol solid dispersion all is higher than paeonol, and the rate of release of non-porous Pulvis Talci load is higher than the porous materials load, the adding of menthol makes overall release further accelerate, and rate of release is under 35 ℃, and open environment records under the normal pressure.
Five, the specific embodiment
Non-limiting examples is described below:
1, get the 10g paeonol, stirring and dissolving is in the dehydrated alcohol of 50ml, then, add 2g kieselguhr, distill out about ethanol of about 90% after, at 5 ℃ of following vacuum dryings, then, the rose essence that adds the 12mg beta-cyclodextrin inclusion compound stir dried be mixed even, the paeonol solid dispersion; It is enclosed venting bags.
2, get the 6g paeonol and 4g L-menthol is dissolved in the dehydrated alcohol of 50ml, stirring makes dissolving, then, add the 2g Pulvis Talci, after distilling out about ethanol of about 95%, at 10 ℃ of following vacuum dryings, then, the rose essence that adds the 5mg beta-cyclodextrin inclusion compound stir dried be mixed even, the paeonol solid dispersion; It is enclosed venting bags.
3, get the 8g paeonol and 2g L-menthol is dissolved in the anhydrous propanone of 50ml, stir and make dissolving, then, add the 2g Pulvis Talci, distill out about 85% acetone after, volatilize naturally, then, the Herba Lysimachiae foenum-graeci quintessence oil that adds the 8mg beta-cyclodextrin inclusion compound stir dried be mixed even, the paeonol solid dispersion; It is enclosed venting bags.
4, get the 0.1ml Flos Rosae Rugosae quintessence oil and 3 gram beta-schardinger dextrin-s mix with the dehydrated alcohol of 20ml, in 40 ℃ of stirring in water bath 4 hours; The dehydrated alcohol and 50g paeonol and the 20g kieselguhr that add 300ml then, distill out about 90% ethanol after, at 5 ℃ of following vacuum dryings, the paeonol solid dispersion; It is enclosed venting bags.
5, get 8g paeonol, 2g L-menthol and 2g attapulgite, mix in 50 ℃ of melt extruded 30min～1h, natural cooling, room temperature are pulverized; Then, with the Herba Lysimachiae foenum-graeci quintessence oil that adds the 8mg beta-cyclodextrin inclusion compound stir dried be mixed even, the paeonol solid dispersion; It is enclosed venting bags.
Claims (3)
1. paeonol solid dispersion air freshener is characterized in that: the paeonol solid dispersion that adopts the processing of solvent evaporation method or fusion method is made of each component of following mass fraction:
Paeonol 1～40
L-menthol 0～5
Inorganic carrier material 1～90
The essence and flavoring agent 0～1 of beta-cyclodextrin inclusion compound.
2. air freshener according to claim 1 is characterized in that: described inorganic carrier material is selected from Pulvis Talci, kieselguhr, bentonite or the attapulgite of high-ratio surface.
3. air freshener according to claim 1 is characterized in that: the essence and flavoring agent of described beta-cyclodextrin inclusion compound is selected from natural or synthetic Flos Rosae Rugosae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil or vanillin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102577922A CN101954104A (en) | 2010-08-12 | 2010-08-12 | Paeonol solid dispersion air freshener |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102577922A CN101954104A (en) | 2010-08-12 | 2010-08-12 | Paeonol solid dispersion air freshener |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101954104A true CN101954104A (en) | 2011-01-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102577922A Pending CN101954104A (en) | 2010-08-12 | 2010-08-12 | Paeonol solid dispersion air freshener |
Country Status (1)
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| CN (1) | CN101954104A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908648A (en) * | 2012-10-24 | 2013-02-06 | 合肥工业大学 | Gel type paeonol air freshener |
| CN104586795A (en) * | 2014-12-30 | 2015-05-06 | 山东博迈康药物研究有限公司 | Invokana tablet and preparation method thereof |
| CN111704749A (en) * | 2020-06-30 | 2020-09-25 | 吉利汽车研究院（宁波）有限公司 | Slow-release essence, preparation method, sealing strip and vehicle |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1633849A (en) * | 2003-12-31 | 2005-07-06 | 合肥工业大学 | Control released type paeonol mildew-resistant and moth-proofing agent |
| CN1850285A (en) * | 2006-05-10 | 2006-10-25 | 薛二娜 | Formula of peony fragrant fumigation-oil and method for preparing and using it |
| CN101743963A (en) * | 2009-12-25 | 2010-06-23 | 孟正木 | Mosquito repellent and preparation method thereof |
-
2010
- 2010-08-12 CN CN2010102577922A patent/CN101954104A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1633849A (en) * | 2003-12-31 | 2005-07-06 | 合肥工业大学 | Control released type paeonol mildew-resistant and moth-proofing agent |
| CN1850285A (en) * | 2006-05-10 | 2006-10-25 | 薛二娜 | Formula of peony fragrant fumigation-oil and method for preparing and using it |
| CN101743963A (en) * | 2009-12-25 | 2010-06-23 | 孟正木 | Mosquito repellent and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908648A (en) * | 2012-10-24 | 2013-02-06 | 合肥工业大学 | Gel type paeonol air freshener |
| CN102908648B (en) * | 2012-10-24 | 2014-01-15 | 合肥工业大学 | Gel type paeonol air freshener |
| CN104586795A (en) * | 2014-12-30 | 2015-05-06 | 山东博迈康药物研究有限公司 | Invokana tablet and preparation method thereof |
| CN104586795B (en) * | 2014-12-30 | 2017-08-08 | 山东博迈康药物研究有限公司 | A kind of canagliflozin piece and preparation method thereof |
| CN111704749A (en) * | 2020-06-30 | 2020-09-25 | 吉利汽车研究院（宁波）有限公司 | Slow-release essence, preparation method, sealing strip and vehicle |
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Application publication date: 20110126 |