CN101953859A

CN101953859A - Medicament for treating burns, scalds, furuncles and skin trauma infections and preparation method thereof

Info

Publication number: CN101953859A
Application number: CN2010101069148A
Authority: CN
Inventors: 陶庆朝
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-02-08
Filing date: 2010-02-08
Publication date: 2011-01-26

Abstract

The invention discloses a medicament for treating burns, scalds, furuncles and skin trauma infections, which is prepared mainly from penicillin and gentamicin in percentage by weight. The medicament of the invention has the effects of heat clearing, detoxification, inflammation diminishment and analgesia, good curative effect and high curative ratio, and is used for treating the burns, various scalds, furuncles, chilblains and skin trauma infections.

Description

A kind of medicine for the treatment of burn, scald, furuncle, skin injury infection and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of skin injury, especially a kind of solution for the treatment of burn, scald, furuncle and traumatic infection.

Background technology:

Burn, scald, furuncle and traumatic infection are a kind of common wound illness, and be clinical how impaired with the local skin of head, neck, trunk, upper limb and hands face, and severe patient involves the whole body large tracts of land to be infected, and patient's high fever is with threat to life.The medicine of this disease of treatment comprises the antibiotic medicine and the analgesic for oral administration of external at present, and these medicines can only carry out partial alleviation and treatment to the patient, can't reach curative effect fast.

Summary of the invention:

Therefore people better treat the medicine that burn, burn due to hot liquid or fire, furuncle and skin injury infect to curative effect and have great demand, also do not find the relevant report about medicine of the present invention up to now.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, worked out finally the treatment of better curative effect burn is arranged, active drug that scald, furuncle and skin injury infect, thereby finished the present invention.

Purpose of the present invention just provides the solution that a kind of more efficiently treatment burn, scald, furuncle and skin injury infect.

Another object of the present invention has just provided the preparation method of solution.

Medicine of the present invention selects penicillin, gentamycin, refined sesame oil to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat burn, scald, furuncle and skin injury infects, wherein select for use penicillin to be because penicillin, molecular formula: C13H20N202, the another name benzylpenicillin; Peillin G penicillin, penicillin, penicillin sodium, sodium benzylpenicillin, benzylpenicillin potassium, potassium phenylacetamidopenicillanate.Penicillin sodium (potassium) has stronger antibacterial action for beta-lactam antibiotic to gram positive bacteria and some gram-negative bacteria, and staphylococcus aureus (golden Portugal bacterium), streptococcus pneumoniae, gonococcus and streptococcus etc. are extremely sensitive to penicillin; Meningococcus, diphtheria corynebacterium, clostridium tetani and treponema pallidum are also very sensitive.Be mainly used in responsive microbial various actute infection, as pneumonia, bronchitis, meningitis, endocarditis, peritonitis, abscess, septicemia, cellulitis, mastitis, gonorrhea, coupler body disease, relapsing fever, syphilis, diphtheria and otitis media etc.Gentamycin is a kind of aminoglycoside antibiotics, is mainly used in the treatment bacterial infection, the especially infection that causes of gram negative bacteria.Gentamycin can combine with bacterial ribosome 30s subunit, and the blocking-up bacterioprotein is synthetic.Gentamycin is the antibiotic of heat stability few in number, thereby is widely used in the culture medium configuration.The independent broad ectrum antibiotic of succeeding in developing of China, main component: produced by micromonospora, be a kind of multicomponent antibiotic.Character: its sulfate commonly used is white or off-white color crystalline powder; Odorless; Have draw moist.Easily molten in water, insoluble in ethanol, ether, acetone or chloroform.Function cures mainly: gram-negative bacterias such as escherichia coli, aerobacteria, klebsiella bacillus, proteus mirabilis, some indole Bacillus proteus, bacillus pyocyaneus, some Neisseria, some non-pigment serratia marcecens and shigella dysenteriae are had antibacterial action.In the gram positive bacteria, staphylococcus aureus is to this product sensitivity; Streptococcus is to this product drug resistance.Anaerobe, tubercule bacillus, rickettsia, virus and fungus are also to this product drug resistance.In recent years, because the extensive use of this product, Resistant strain increases gradually, and bacillus pyocyaneus, klebsiella bacillus and serratia marcecens, the positive Bacillus proteus of indole are very high to the resistant rate of this product.To golden Portugal bacterium and escherichia coli, aerobacteria, proteus mirabilis, the effect of G-bacterium such as bacillus pyocyaneus is stronger.Be applicable to neonate sepsis, septicemia, central nervous system infection due to the sensitive bacterial, comprise meningitis, urinary tract genital system infection, respiratory tract infection, gastrointestinal infection, comprise peritonitis, biliary tract infection, skin, skeleton, otitis media, sinusitis, soft tissue infection, comprise burn, listeriosis.Refined sesame oil is an Oleum sesami; have another name called Oleum sesami; have heat clearing away, detoxifcation, analgesia and Physical temperature-lowering effect; mix the blending agents that formation has sticking viscosity with penicillin and gentamycin; be used in and form the medicament protection film on the wound surface immediately, can prevent that antibacterial from going into to soak prevention infection; the electrolyte disturbance that can prevent tissue fluid from exosmosing again and cause, and can promote histiocytic growth and reparation fast.

Also to be the inventor through a large amount of groping sum up amount of drug of the present invention draws, and the consumption of each component has curative effect preferably in following weight range.

800,000 penicillin sodium 10-15 restrain the 1 milliliter of 40,000 gentamycin 45-55 of unit milliliter

Refined sesame oil 80-120 milliliter

Preferable amount is:

800,000 penicillin sodiums, 12 gram 1 milliliter of 40,000 50 milliliters of unit gentamycin (200 unit)

100 milliliters of refined sesame oils

Preparation method:

Said medicine is put into the container mixing and stirring by measuring foot, bottle after fully dissolving is creamy white, become the true qualities of pure Oleum Sesami after half an hour, also can smell the giving off a strong fragrance flavor of Oleum sesami.

Medicine of the present invention has the effect of heat clearing away, detoxifcation, anti-inflammatory analgesic, is used for the treatment of burn, various scald, furuncle, chilblain and skin injury, traumatic infection, good effect, cure rate height.

The specific embodiment:

Below further set forth the beneficial effect of medicine of the present invention by testing example, these tests have comprised that the pharmacodynamics animal experiment of medicine of the present invention and clinical observation on the therapeutic effect test.

The animal experiment data of [test row 1] medicine of the present invention

Get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups, and 10 every group, wherein one group is the treatment group, and another group is matched group.

With rabbit abdominal part depilation diameter is 3cm-5cm, there is not hair place's modeling with electric soldering iron at the rabbit abdomen, make its skin scald diameter 3cm, the blister that differing in size appears in wound surface, after cutting off blister and cleaning, the treatment group adopts solution treatment of the present invention, smeared once in per 2 hours, red granulation appears in wound surface after three days, scabs after seven days, takes off the scar recovery from illness after ten days.

Matched group adopts gentian voiet to smear, and smears once in per 2 hours, after ten days, in 10 rabbits of matched group, wherein has two to scab, and one red granulation occurs, and seven have formed ulcer.

The clinical trial data of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 286 examples for medical treatment, wherein male 173 examples, women 113 examples, age 1-10 year 56 examples, 11-20 year 67 examples, 21-30 year 15 examples, 31-40 year 51 examples, 41-50 year 40 examples, 57 examples more than 50 years old.

2, diagnostic criteria

Burn: for naked light is burnt, the patient has more present head, face, upper limb and shoulder back, and burn surface area differs in size, skin burn position redness, foaming, and the wound surface with carbonization is burnt in serious having.

Scald: be burn due to hot liquid or fire or electric burn, red and swollen blister appears in the burn position, mostly occurs at patient's chest, cervical region and upper limb.

Furuncle: the name skin ulcer skin ulcer of furuncle swelling toxin and infection suppurates, because of patient's innominate toxic swelling causes Skin ulcer or long-term bed do not rise, and by the decubital ulcer that spinal nerves damage pressurized causes, severe patient buttocks tail festers the big small size of the rim of a bowl, is deep to undisguised.

3, Therapeutic Method

Empyrosis: clean wound surface, smear in the affected part, and per 2 hours once, and 10 is a course of treatment.

Decubital ulcer, electric burn: remove mashed meat, rinse well, apply this medicine, the wrapping of medicine yarn was changed dressings once in per two days, and 10 is a course of treatment, three courses of treatment of logotype.

4, efficacy assessment standard

Produce effects: after burn, scald, furuncle and 1-3 course of therapy of decubital ulcer process, it is normal that affected part recovers, and skin surface does not have cicatrix.

Take a turn for the better: patient's sx, pain disappears, and it is normal that limbs progressively recover.

Invalid: as not reach improvement standard person.

5, therapeutic outcome:

In the treatment of three courses of treatment, with Drug therapy fire victim's 86 examples of the present invention, produce effects 78 examples, 7 examples take a turn for the better, invalid 1 example, obvious effective rate are 90.7%, and improvement rate is 8.1%, and total effective rate is 98.8%, patient's 131 examples are scalded in treatment, produce effects 126 examples, and 5 examples that take a turn for the better, obvious effective rate is 96.2%, improvement rate is 3.8%, and total effective rate is 100%, treatment furuncle, patients with bedsore 69 examples, produce effects 63 examples, 4 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 91.3%, and improvement rate is 5.8%, and total effective rate is 97.1%.

Below in conjunction with the accompanying drawing photo, be further elaborated therapeutic effect of the present invention.

The explanation of attaching pictures:

The photo that Fig. 1, Fig. 3 take during for keeping of poplar burn;

Fig. 2 is the burn photo of patient Yang Xiumei;

Fig. 4 is the photo of Wang Siyuan;

The photo that Fig. 5, Fig. 6 take when scalding for patient A Xiu;

Fig. 7, Fig. 8 scald the photo that takes for the Zhu Huailan degree of depth.

Among Fig. 1, Fig. 3, patient Yang Shouhua, the man, 73 years old now, Wang Ji township, Mengcheng County, Anhui Province Yang Gou people from village, in on June 5th, 2009 at wheat field steamed dumplings stubble, sweep strong wind, many people that burn, dead two people suddenly, wherein poplar Songization burn face, head, both hands, upper limbs and whole body burn surface area reach 48%, burn, the surface of a wound of charing has 40%. Adopt medicine of the present invention to smear the affected part, per 2 hours are once, decrustation in 23 days, and healing in 1 month is left hospital.

Among Fig. 2, patient Yang Xiumei, the woman, 58 years old, the Gong Qiaoyang village, village, north, whirlpool, Mengcheng County, Anhui Province, afternoon on June 5th, 2009 is in the big fire wound of wheat field steamed dumplings stubble quilt, be sent at that time Mengcheng County hospital burn department treatment, burn surface area reaches 75%, and second day forwards Bengbu burn special outpatient clinic treatment to, after 19 days, the patient is in peril of one's life, and forwards again the treatment of Huaibei City miner hospital to, after several days, hypoglycemia appears in patient, the skin infection of planting worsens, and smears with medicine of the present invention afterwards, after 10 days, sb.'s illness took a favorable turn, recovery from illness in 20 days.

Young infant Wang Si circle among Fig. 4,4 months, Mengcheng County slab bridge town First Officer people from village, on January 22nd, 2009, at that time within doors unmanned, fired quilt by the charcoal fire in the basin of warming oneself, burn till severe injury, 10 fingers are burned, successively send Mengcheng County hospital, Bangbu Department of B urn outpatient service, because of no money treatment, in the village, report death after getting home, rear being accompanied by neighbours sent into my institute's treatment, cures in 50 days.

A Xiu among Fig. 5, Fig. 6, woman, 7 years old, the Mengcheng County king collects the village people, the pelvic surface of sacrum soup that on July 8th, 1994 was just taken the dish out of the pot is scalded, both hands, trunk, predecessor whole, rear bodies part, the big section of two lower limb, and scalding area reaches 60%, smear with medicine of the present invention, per 2 hours once, steeps subcutaneous after 4 days and red granulation occurs, the hardening of epidermis blackout, fried skin after 8 days, decrustation after 10 days is left hospital.

Zhu Huailan among Fig. 7, Fig. 8, the woman, 29 years old, Su County, Anhui Chen Ji village people, on September 5th, 2006 because of traffic accident by car inner water tank scald, patient's neck, chest, the upper limbs 30% area degree of depth are scalded, and smear medicine of the present invention 20 days, healing is left hospital.

Claims

1. treat the medicine that burn, scald, furuncle and skin injury infect for one kind, it is characterized in that: be to make by the crude drug in the following weight range:

Refined sesame oil 80-120 milliliter.

2. a kind of medicine that burn, scald, furuncle and skin injury infect for the treatment of according to claim 1, wherein the consumption of each crude drug is:

100 milliliters of refined sesame oils.

3. according to the preparation method of claim 1 or 2 described medicines, the steps include: to get 800,000 penicillin sodiums, 12 grams, 50 milliliters of 1 milliliter of 40,000 gentamycins, 100 milliliters of refined sesame oils are put into the container mixing and stirring, and fully bottle in the dissolving back that is creamy white.