CN101951927A - 诱饵流感疗法 - Google Patents

诱饵流感疗法 Download PDF

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Publication number
CN101951927A
CN101951927A CN2009801016606A CN200980101660A CN101951927A CN 101951927 A CN101951927 A CN 101951927A CN 2009801016606 A CN2009801016606 A CN 2009801016606A CN 200980101660 A CN200980101660 A CN 200980101660A CN 101951927 A CN101951927 A CN 101951927A
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CN
China
Prior art keywords
glycan
umbrella topology
amino acids
topology glycan
decoy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801016606A
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English (en)
Chinese (zh)
Inventor
拉姆·萨西谢卡尔安
卡西克·维斯瓦那坦
阿尔特希·钱德拉赛卡安
拉胡尔·拉曼
阿拉温德·斯里尼瓦桑
S·拉古拉姆
维斯瓦那坦·萨西谢卡尔安
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of CN101951927A publication Critical patent/CN101951927A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Walking Sticks, Umbrellas, And Fans (AREA)
CN2009801016606A 2008-01-03 2009-01-02 诱饵流感疗法 Pending CN101951927A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1878308P 2008-01-03 2008-01-03
US61/018,783 2008-01-03
PCT/US2009/030056 WO2009089119A2 (en) 2008-01-03 2009-01-02 Decoy influenza therapies

Publications (1)

Publication Number Publication Date
CN101951927A true CN101951927A (zh) 2011-01-19

Family

ID=40853715

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801016606A Pending CN101951927A (zh) 2008-01-03 2009-01-02 诱饵流感疗法

Country Status (8)

Country Link
US (1) US8815522B2 (https=)
EP (1) EP2237787A4 (https=)
JP (1) JP2011508785A (https=)
KR (1) KR20100111275A (https=)
CN (1) CN101951927A (https=)
AU (1) AU2009204345A1 (https=)
CA (1) CA2711330A1 (https=)
WO (1) WO2009089119A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011003100A2 (en) 2009-07-02 2011-01-06 Massachusetts Institute Of Technology Compositions and methods for diagnosing and/or treating influenza infection
AU2011210840B2 (en) * 2010-01-27 2014-12-11 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
WO2011130575A1 (en) * 2010-04-16 2011-10-20 Massachusetts Institute Of Technology Modular glycan arrays
JP2013541528A (ja) * 2010-09-21 2013-11-14 マサチューセッツ インスティテュート オブ テクノロジー ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置
JP6029586B2 (ja) 2010-10-04 2016-11-24 マサチューセッツ インスティテュート オブ テクノロジー 血球凝集素ポリペプチド、ならびにそれに関連する試薬および方法
WO2014116723A1 (en) * 2013-01-22 2014-07-31 The Charles Stark Draper Laboratory, Inc. Multivalent liposome formulations
US10526375B2 (en) 2013-06-05 2020-01-07 Massachusetts Institute Of Technology Human Adaptation of H7 HA
KR101529654B1 (ko) 2013-11-15 2015-06-19 한국지질자원연구원 시추부 경사를 감안한 시추시스템 및 이를 이용한 심도 보정 방법
US20160256388A1 (en) * 2015-03-05 2016-09-08 Uri Galili Compositions and methods for treatment of respiratory tract infections
AU2016281477A1 (en) 2015-06-25 2018-01-04 Nanyang Technological University Broad-spectrum anti-infective peptides
ES2991988T3 (es) 2017-10-30 2024-12-05 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070184065A1 (en) * 2006-01-26 2007-08-09 Jan Holgersson Compositions and Methods for Inhibiting Viral Adhesion
US20070243629A1 (en) * 2003-10-20 2007-10-18 Glykos Finland Oy High Affinity Ligands for Influenza Virus and Methods for Their Production
CN101553502A (zh) * 2006-08-14 2009-10-07 麻省理工学院 血球凝集素多肽和其相关试剂和方法

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CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
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GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
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JP4651213B2 (ja) * 2001-03-27 2011-03-16 株式会社グライコメディクス インフルエンザウイルス・ヘマグルチニン結合性ペプチド
BE1017134A5 (nl) 2006-05-11 2008-03-04 Delaere Marc Borstel voor een schrob-,veeg- en/of boenmachine en sproei-inrichting voor het reinigen van meerdere door middel van groeven en/of voegen van elkaar gescheiden oppervlakten.
WO2008073161A2 (en) 2006-08-14 2008-06-19 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243629A1 (en) * 2003-10-20 2007-10-18 Glykos Finland Oy High Affinity Ligands for Influenza Virus and Methods for Their Production
US20070184065A1 (en) * 2006-01-26 2007-08-09 Jan Holgersson Compositions and Methods for Inhibiting Viral Adhesion
CN101553502A (zh) * 2006-08-14 2009-10-07 麻省理工学院 血球凝集素多肽和其相关试剂和方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMES STEVENS等: "Glycan Microarray Analysis of the Hemagglutinins from Modern and Pandemic Influenza Viruses Reveals Different Receptor Specificities", 《JOURNAL OF MOLECULAR BIOLOGY》 *

Also Published As

Publication number Publication date
WO2009089119A3 (en) 2009-12-30
JP2011508785A (ja) 2011-03-17
WO2009089119A2 (en) 2009-07-16
EP2237787A4 (en) 2012-03-21
US8815522B2 (en) 2014-08-26
CA2711330A1 (en) 2009-07-16
KR20100111275A (ko) 2010-10-14
US20100004195A1 (en) 2010-01-07
AU2009204345A1 (en) 2009-07-16
EP2237787A2 (en) 2010-10-13

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Application publication date: 20110119