CN101951927A - 诱饵流感疗法 - Google Patents

诱饵流感疗法 Download PDF

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Publication number
CN101951927A
CN101951927A CN2009801016606A CN200980101660A CN101951927A CN 101951927 A CN101951927 A CN 101951927A CN 2009801016606 A CN2009801016606 A CN 2009801016606A CN 200980101660 A CN200980101660 A CN 200980101660A CN 101951927 A CN101951927 A CN 101951927A
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CN
China
Prior art keywords
glycan
umbrella topology
amino acids
topology glycan
decoy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801016606A
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English (en)
Chinese (zh)
Inventor
拉姆·萨西谢卡尔安
卡西克·维斯瓦那坦
阿尔特希·钱德拉赛卡安
拉胡尔·拉曼
阿拉温德·斯里尼瓦桑
S·拉古拉姆
维斯瓦那坦·萨西谢卡尔安
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of CN101951927A publication Critical patent/CN101951927A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Walking Sticks, Umbrellas, And Fans (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801016606A 2008-01-03 2009-01-02 诱饵流感疗法 Pending CN101951927A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1878308P 2008-01-03 2008-01-03
US61/018,783 2008-01-03
PCT/US2009/030056 WO2009089119A2 (en) 2008-01-03 2009-01-02 Decoy influenza therapies

Publications (1)

Publication Number Publication Date
CN101951927A true CN101951927A (zh) 2011-01-19

Family

ID=40853715

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801016606A Pending CN101951927A (zh) 2008-01-03 2009-01-02 诱饵流感疗法

Country Status (8)

Country Link
US (1) US8815522B2 (https=)
EP (1) EP2237787A4 (https=)
JP (1) JP2011508785A (https=)
KR (1) KR20100111275A (https=)
CN (1) CN101951927A (https=)
AU (1) AU2009204345A1 (https=)
CA (1) CA2711330A1 (https=)
WO (1) WO2009089119A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9278998B2 (en) 2009-07-02 2016-03-08 Massachusetts Institute Of Technology Compositions and methods for diagnosing and/or treating influenza infection
WO2011094445A1 (en) * 2010-01-27 2011-08-04 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
US20110257032A1 (en) * 2010-04-16 2011-10-20 Massachusetts Institute Of Technology Modular glycan arrays
WO2012040406A2 (en) 2010-09-21 2012-03-29 Massachusetts Institute Of Technology Influenza treatment and/or characterization; human-adapted ha polypeptides; vaccines
BR112013007946B1 (pt) 2010-10-04 2022-07-12 Massachusetts Institute Of Technology Composições farmacêuticas e imunogênicas compreendendo polipeptídeos de hemaglutinina
WO2014116723A1 (en) * 2013-01-22 2014-07-31 The Charles Stark Draper Laboratory, Inc. Multivalent liposome formulations
US10526375B2 (en) 2013-06-05 2020-01-07 Massachusetts Institute Of Technology Human Adaptation of H7 HA
KR101529654B1 (ko) 2013-11-15 2015-06-19 한국지질자원연구원 시추부 경사를 감안한 시추시스템 및 이를 이용한 심도 보정 방법
US20160256388A1 (en) * 2015-03-05 2016-09-08 Uri Galili Compositions and methods for treatment of respiratory tract infections
SG10201912866RA (en) 2015-06-25 2020-02-27 Univ Nanyang Tech Broad-spectrum anti-infective peptides
MX2020004151A (es) 2017-10-30 2020-08-13 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070184065A1 (en) * 2006-01-26 2007-08-09 Jan Holgersson Compositions and Methods for Inhibiting Viral Adhesion
US20070243629A1 (en) * 2003-10-20 2007-10-18 Glykos Finland Oy High Affinity Ligands for Influenza Virus and Methods for Their Production
CN101553502A (zh) * 2006-08-14 2009-10-07 麻省理工学院 血球凝集素多肽和其相关试剂和方法

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JP4651213B2 (ja) * 2001-03-27 2011-03-16 株式会社グライコメディクス インフルエンザウイルス・ヘマグルチニン結合性ペプチド
BE1017134A5 (nl) 2006-05-11 2008-03-04 Delaere Marc Borstel voor een schrob-,veeg- en/of boenmachine en sproei-inrichting voor het reinigen van meerdere door middel van groeven en/of voegen van elkaar gescheiden oppervlakten.
US20080241918A1 (en) * 2006-08-14 2008-10-02 Ram Sasisekharan Hemagglutinin polypeptides, and reagents and methods relating thereto

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243629A1 (en) * 2003-10-20 2007-10-18 Glykos Finland Oy High Affinity Ligands for Influenza Virus and Methods for Their Production
US20070184065A1 (en) * 2006-01-26 2007-08-09 Jan Holgersson Compositions and Methods for Inhibiting Viral Adhesion
CN101553502A (zh) * 2006-08-14 2009-10-07 麻省理工学院 血球凝集素多肽和其相关试剂和方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMES STEVENS等: "Glycan Microarray Analysis of the Hemagglutinins from Modern and Pandemic Influenza Viruses Reveals Different Receptor Specificities", 《JOURNAL OF MOLECULAR BIOLOGY》 *

Also Published As

Publication number Publication date
KR20100111275A (ko) 2010-10-14
EP2237787A4 (en) 2012-03-21
CA2711330A1 (en) 2009-07-16
US8815522B2 (en) 2014-08-26
WO2009089119A2 (en) 2009-07-16
EP2237787A2 (en) 2010-10-13
US20100004195A1 (en) 2010-01-07
JP2011508785A (ja) 2011-03-17
WO2009089119A3 (en) 2009-12-30
AU2009204345A1 (en) 2009-07-16

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Application publication date: 20110119