CN101947301A - Medicine composition for preventing and treating vital myocarditis and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese patent drug taking plant as raw material, in particular to a medicine composition for preventing and treating vital myocarditis. The medicine composition is composed of active ingredients and pharmaceutically acceptable auxiliary materials; wherein the active ingredients are prepared by the following crude drugs by weight percent: 15-50% of radix fici simplicissimae, 15-50% of astragalus mongholicus, 5-25% of radix ophiopogonis, 5-25% of schisandra chinensis, 5-25% of rhodiola rosea, 5-25% of radix curcumae and 5-10% of radix glycyrrhizae preparata. The medicine of the invention adopts seven medicinal herbs, has the functions of invigorating blood circulation, promoting the circulation of qi, tonifying qi, promoting the secretion of body fluid and nourishing the blood and tranquilization and can improve qi-yin deficiency syndrome caused by vital myocarditis.

Description

A kind of pharmaceutical composition of preventing and treating viral myocarditis and preparation method thereof

Invention field

The present invention relates to a kind of medical configuration product, specifically be a kind of be the Chinese patent medicine of raw material with the plant.

Background technology

Viral myocarditis (VMC) is meant the myocardium acute or chronic inflammatory disease that various viruses cause, in recent years, the morbidity of primary disease is in rising trend in the China and even the world, and the incidence rate of VMC is 1.06% in Sweden 1975-1984 12747 routine postmortems; The incidence rate of the child of sudden death and youngster report is up to 17%-12%.In myocarditis treatment experiment, the 2333 routine patients that heart failure takes place in 2 years recently have 9.6% to reach myocarditic pathology standard, to the chronic viral myocarditis, think that at present it mostly occurs after acute, serious symptom myocarditis, with scar tissue is the cardiomyopathy of main pathological manifestations, and the cardiac muscle that causes of Bing Du continuous action and autoimmune mechanism damages repeatedly also and can cause chronic VMC in addition.Modern medicine to VMC still based on comprehensive and supporting treatment, still there is not specific treatment, though adopt multiple treatments such as immunosuppressant, interferon and myocardial cell nutrient, but curative effect is still satisfied inadequately, the formation of viral myocarditis is extremely complicated process with development, Chinese medicine VMC has accumulated experience for many years, presents certain advantage.Therefore, seek that a kind of can to bring into play the popular again viral myocarditis method of preventing and treating of tcm characteristic be desirability.Develop real the craving for of Chinese medicine compound of the treatment viral myocarditis that gains universal acceptance for extensive patients.

State knows that office discloses the Chinese medicine compound of a large amount of control VMC, as: the CN1907458 patent application discloses: Radix Angelicae Sinensis 30～60, Radix Notoginseng powder 2.5～5, Rhizoma Wenyujin Concisum 30～60, Lignum Dalbergiae Odoriferae 13～26, the be significantly improved effect of blood stasis hemorheological property of Radix Paeoniae Rubra 30～60, Fructus Crataegi 45～90, alleviate its blood plasma sticking, coagulate, poly-state; The CN1994435 patent application discloses the Chinese herbal medicine cold tea formulation for the treatment of acute viral myocarditis by a kind of, form by batchings such as Jin Genhua, Fructus Forsythiae, Folium Isatidis, Rhizoma Osmundae, Radix Pseudostellariae, Radix Ophiopogonis, the Radix Rehmanniae, Radix Puerariae, Radix Sophorae Flavescentis, Herba Lophatheri, Gypsum Fibrosum, method for making summer, Herba Hedyotis cantonensis, Radix Glycyrrhizae Preparata, Radix Glycyrrhizae, Radix Ginseng, green tea, glucoses, be mainly used in the prevention and the treatment pyretic toxicity invade diseases such as heart type new trouble disorder acute viral myocarditis, pericarditis, endocarditis, viral influenza, parotitis, rubella; The CN101406673 patent application discloses the oral liquid of opening a kind of special for treating vital myocarditis of children, configuration forms through clinic tests and repeated verification to be primarily aimed at the child who suffers from viral myocarditis, with Radix Ginseng, the Radix Astragali, Fructus Jujubae is monarch drug, and supplementing QI and nourishing YIN, relieving restlessness clears away heart-fire; Radix Salviae Miltiorrhizae, Plumula Nelumbinis, RADIX CURCUMAE, Radix Glycyrrhizae are ministerial drug, can strengthen the supplementing QI and nourishing YIN effect, and have to calm the nerves and decide intelligence, the effect of invigorating spleen for diuresis; The Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, Radix Ginseng Rubra strongly invigorating primordial QI, nourishing qi to stop, Radix Platycodonis, the Folium Ginkgo benefit heart are astringed the lung, removing dampness antidiarrheal, Fructus Schisandrae Chinensis, Poria, Fructus Trichosanthis clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens is moisturized laxation and is the adjuvant thing.Full side share has supplementing QI and nourishing YIN, calms the nerves and throbs with fear surely, regulating the flow of QI to dissipate blood stasis, the effect of spleen invigorating heart tonifying.

But because the formation of viral myocarditis is extremely complicated with evolution, its pathogeny and treatment mechanism still do not have final conclusion at present, so needs are brought into play the advantage of Chinese medicine, develop the Chinese patent medicine of too many levels, multi-level, many target spots.

Summary of the invention

Technical problem to be solved of the present invention provides a kind of pharmaceutical composition of preventing and treating viral myocarditis, and this pharmaceutical composition has that crude drug is common, cheapness and the simply outstanding advantage of preparation technology.

The present invention realizes that the technical scheme of above-mentioned purpose is:

A kind of control viral myocarditis pharmaceutical composition, this medicine is made up of active component and acceptable accessories, it is characterized in that described active component is that crude drug is made by following percentage by weight: Herba Fici Simplicissimae 15～50%, the Radix Astragali 15～50%, Radix Ophiopogonis 5～25%, Fructus Schisandrae Chinensis 5～25%, Radix Rhodiolae 5～25%, Radix Curcumae 5～25%, Radix Glycyrrhizae Preparata 5～10%.

Pharmaceutical composition of the present invention, wherein, the optimum ratio of described crude drug is: Herba Fici Simplicissimae 17%～33%, the Radix Astragali 23%～41%, Radix Ophiopogonis 9%～16%, Fructus Schisandrae Chinensis 10%～20%, Radix Rhodiolae 9%～16%, Radix Curcumae 9%～16%, Radix Glycyrrhizae Preparata 6%～9%; The best proportioning of described crude drug is the Radix Astragali 25%, Herba Fici Simplicissimae 20%, Radix Ophiopogonis 15%, Fructus Schisandrae Chinensis 10%, Radix Rhodiolae 10%, Radix Curcumae 15%, Radix Glycyrrhizae Preparata 10%.

The preparation method of the active component in the pharmaceutical composition of the present invention is made up of following steps:

Get crude drug with water boiling and extraction 2～4 times by proportioning, add 8～12 times in water at every turn, decoct 1～3h, merge decoction liquor then, filter, be concentrated into relative density and be 1.10～1.50 extractum and get final product.

In this preparation method, the technological parameter of water boiling and extraction preferably: with water boiling and extraction 3 times, add 10 times in water at every turn, decoct 3h.

Pharmaceutical composition of the present invention can be various common solid orally ingestibles, as granule, tablet or capsule.

Pharmaceutical composition of the present invention by Herba Fici Simplicissimae not warm not dry, nature and flavor are gentle and can air making-up and spleen enlivening, the sweet temperature compensation gas lift of Radix Astragali sun, the two is monarch drug altogether; YIN nourishing and the production of body fluid promoting relieving restlessness Radix Ophiopogonis, the Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, kidney calming is a ministerial drug; Radix Rhodiolae activating blood circulation and dissipating phlegm, Radix Curcumae blood-activating and qi-promoting help improving the resistance of the heart arteries and veins stasis of blood and are adjuvant drug altogether; The Radix Glycyrrhizae Preparata QI invigorating is in harmonious proportion, and five kinds of Chinese medicine is messenger drug altogether, blood-activating and qi-promoting, and the through focus of guiding monarch drug is with tonifying QI to produce body fluid, nourishing blood to tranquillize the mind.

The inventor is through years of researches and practice summary, find that viral myocarditis stage of attack symptom is similar to the symptom of traditional Chinese medical science deficiency of both QI and YIN cardiopalmus, therefore according to the pathogeny of the pathogenesis and the modern medicine of viral myocarditis, according to the dialectical of the traditional Chinese medical science and logos prescription, make the medicine that effectively prevents viral myocarditis with modern pharmaceutical technology, prove that through zoopery and clinical case contrast can effectively improve viral myocarditis syndrome of deficiency of both qi and yin occurs: severe palpitation, vexed, sensation of oppression over the chest with shortness of breath, spiritlessness and weakness, moving then all diseases aggravation, insomnia and dreamful sleep, spontaneous sweating, the few tongue thready and rapid pulse of dry pharynx red tongue.In addition, prepare the used medical material of pharmaceutical composition of the present invention and be common medical material, moderate cost, material is easy to get, and preparation technology is simple, is suitable for industrialization production.

To prove the technique effect that the present invention has by zoopery below.

1, pharmacodynamic experiment

For verifying medicine of the present invention in the pharmacological action aspect the control viral myocarditis, for its clinical use provides scientific basis, the spy carries out following pharmacodynamic experiment.

1.1 experiment material

1.1.1 experimental subject

Male SPF level BALB/C Mus (Nanfang Medical Univ's Experimental Animal Center provides, the quality certification number: Guangdong probatio inspectionem pecuoarem word the 2008th～0015) 60, and body weight 180 ± 10g.

1.1.2 experiment condition

Whole rat adaptabilities are fed 3d before the experiment, 18～24 ℃ of room temperatures, and relative humidity 65%, night, light and shade replaced 12h, and all rat sub-cage rearings, are freely drunk water the standard feed free choice feeding by 10/cage.

1.1.3 be subjected to the reagent product

Be subjected to reagent product 1: take off dissolved in distilled water that the granule of stating embodiment 1 adds 2 times of bulking values, shake all.

Be subjected to reagent product 2: take off dissolved in distilled water that the tablet of stating embodiment 2 adds 2 times of bulking values, shake all.

Be subjected to reagent product 3: take off dissolved in distilled water that the capsule of stating embodiment 3 adds 2 times of bulking values, shake all.

Be subjected to reagent product 4: take off dissolved in distilled water that the granule of stating embodiment 4 adds 2 times of bulking values, shake all.

1.2 experimental technique

1.2.1 experiment grouping

Group technology: divide 4 groups in blank group, viral myocarditis model group, 1 group in Chinese medicine, 2 groups in Chinese medicine, 3 groups in Chinese medicine and Chinese medicine, 10 every group at random according to body weight with 60 of BALB/C Mus.Viral myocarditis model group, 1 group in Chinese medicine, 2 groups in Chinese medicine, 3 groups in Chinese medicine and 4 groups of BALB/C Mus of Chinese medicine lumbar injection TCD5010-6CVB3m virus 0.1ml, set up the VMC animal model, high protein diet, clean room is raised, normal group BALB/C Mus lumbar injection Eagles nutritional solution.

Medication: early the 8:00 gastric infusion is once to test after the 21st day every day.Wherein, Chinese medicine gavages and be subjected to reagent product 11ml/100g (body weight) 1 group of every day, Chinese medicine gavages and be subjected to reagent product 21ml/100g (body weight) 2 groups of every day, and Chinese medicine gavages and be subjected to reagent product 31ml/100g (body weight) 3 groups of every day, and Chinese medicine gavages and be subjected to reagent product 41ml/100g (body weight) 4 groups of every day; Blank group and model group are given rat oral gavage with 1ml/100g (body weight) distilled water.After irritating the stomach fortnight, 2% pentobarbital sodium is in right amount with mouse anesthesia, peel off carotid artery, test mouse core blood discharge amount is plucked eyeball and is got blood, put to death, win heart, use the normal saline flushing of pre-cooling immediately, the flushing back is in operation on ice, cut cardiac muscle along the ventricle major axis, place formaldehyde fixed liquid to use for om observation.

1.2.2 observation index: the observation of HE colored light sem observation myocardial tissue structure, myocardial collagen fiber, the mensuration of mouse core blood discharge amount, Plasma ANP assay, plasma A LD assay

1.2.4 data statistics utilizes SPSS13.0 software to carry out data statistic analysis, the result is with mean ± standard deviation

Expression, the result carries out significance analysis with the independent sample t check, significant difference P＜0.05, concrete outcome is stated table 1～table 4 as follows.

1.3 result

1.3.1 the general situation of rat is observed

The peace and quiet of blank group mice expression, vivaciously active, fur is bright and clean neat, and eyes have god, and to the food sensitivity, escape reaction is fast, moves freely, and is quick on the draw.

Model group mice hair is withered, and food-intake reduces, and 2 all body weight slightly increase before experiment, and reducing appears in 2 weeks of experiment back.The rat slow movement reacts insensitive, the difficulty of creeping, the movable minimizing.2 of dead mouses.

It is lighter relatively that medicine of the present invention is respectively organized symptom, and ingest actively, and mice is active, and body weight continues to increase, and fur is smooth glossy.

1.3.2 light microscopic is observed mouse cardiac muscle cellular morphology structure down

Lumbar injection TCD5010-6CVB3m virus causes the chronic VMC model of BALB/C mice.The mouse cardiac muscle structural deterioration, cardiac muscle fiber fracture presents in various degree degeneration, necrosis, and matter has more widely the inflammatory infiltration based on lymphocyte and mononuclear cell between cardiac muscle.Visible its myocardium pathological changes of pathological section that the treatment group is respectively organized after the medication all obviously is lighter than model group, and wherein treatment group has as can be seen suppressed excessive fibroblast formation significantly, and simultaneously visible new vessels increases, and focus is obviously evacuated.

1.3.3 each group of Chinese medicine compound is to the influence of chronic VMC myocardial collagen fiber content

Table 1, each group of Chinese medicine compound are to the painted surface density influence of the scarlet collagen specificity of chronic VMC picric acid sky wolf

Annotate: with the blank group than △ P＜0.05

With model group than * P＜0.05

Virus is invaded the damage that causes behind the heart, is filled and is formed scar tissue by the fibroblast hypertrophy.The scarlet collagen specificity coloration result of picric acid sky wolf is as seen: blank group mouse cardiac muscle tissue can be seen type i collagen and arrange in order, is evenly distributed between cardiac muscle in the matter, and type i collagen is very thin, and yellow skin, refracted light are not strong, similarly are the gold thread that sketches the contours on myocardial cell membrane.The thick type i collagen of the visible hypertrophy of model group is overlapping repeatedly, arranges unorderedly, and the diameter thickness inequality has very strong birefringent light, and is then painted darker in the place that fibrosis is heavy, around the normal blood vessel painted obviously.The treatment by Chinese herbs group is respectively organized content near normal group, rarely seen focal collagen fiber that increase, with model group than difference remarkable (p＜0.05).

1.3.4 each group of Chinese medicine compound is to the influence of chronic VMC cardiac output

Table 2, Chinese medicine compound are respectively organized the influence to chronic VMC Mus cardiac output

Annotate: compare △ P＜0.01 with the blank group

Compare * P＜0.01 with model group

The result shows: the blood discharge amount of blank group mice is about 1.3ml/min.Model group and blank group be than difference remarkable (p＜0.01), and each compares treatment with model group and significant difference is all arranged (p＜0.05).Blood discharge amount the be significantly improved effect of Chinese medicine compound to experimental mice with viral myocarditis is described.

1.3.5 each group of Chinese medicine compound is to the influence of chronic VMC Plasma ANP content

The method of exempting from is put in employing, according to the operating instruction of test kit, utilizes the r automatic counter for counting to measure and respectively organizes mice plasma ANP content, the results are shown in Table four:

Table 3, Chinese medicine compound are respectively organized the influence to chronic VMC Plasma ANP content

Annotate: compare △ P＜0.01 with the blank group

Compare * P＜0.01**P＜0.05 with model group

Table 3 result shows: compare with the blank group, the chronic VMC Mus of model group Plasma ANP content significantly increases (p＜0.01), compare with model group, treatment group ANP content (p＜0.05 that obviously descends, p＜0.01), 1 group in Chinese medicine is particularly remarkable, illustrates that chronic VMC model can significantly increase Plasma ANP content, and the prompting Chinese medicine compound can significantly reduce its content.

1.3.6 Chinese medicine compound is to the influence of chronic VMC plasma A LD content

Table 4, Chinese medicine compound are to the influence of chronic VMC plasma A LD content

Annotate: compare △ P＜0.01 with the blank group

Compare * * P＜0.01**P＜0.05 with model group

Table 4 result shows: compare with the blank group, the chronic VMC Mus of model group plasma A LD content significantly increases (p＜0.01), compare with model group, treatment group ALD content (p＜0.05 that obviously descends, p＜0.01), 1 group in Chinese medicine is particularly remarkable, illustrates that chronic VMC model can significantly increase plasma A LD content, and the prompting Chinese medicine compound can significantly reduce its content.

Conclusion

The medicine of different proportionings is got in this experiment, has finished four of representative zooperies.A large amount of work has been done early stage by our seminar, uses various biological means from a plurality of aspects such as cardiac electrophysiology, immunology, biochemistry the mechanism of Chinese medicine compound control VMC to be researched and analysed.This experimental result shows, medicine of the present invention all can obviously be intervened chronic viral myocarditis cardiac insufficiency neuroendocrine factor at the medicine of different proportionings, especially intervene renin angiotensin aldosterone system, thereby suppressed the hyper-proliferative of matter and vascular smooth muscle collagen fiber between cardiac muscle, reached the final purpose of improving cardiac function.The result shows that Chinese medicine compound has arrhythmia, prolongs myocardium effective refractory period, and the human body immunity improving function is improved the effect of myocardial metabolism control myocardial damage.

The specific embodiment

Example 1: granule

The prescription: Radix Astragali 25g, Herba Fici Simplicissimae 20g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 10g, Radix Rhodiolae 10g, Radix Curcumae 15g, Radix Glycyrrhizae Preparata 10g.

Preparation method: get crude drug water extraction 3 times by prescription, add 10 times of decoctings at every turn and boil 3h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.50 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings, pulverized 65 mesh sieves and got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, made wetting agent system soft material with 95% ethanol, crossing 16 mesh sieves granulates, drying, granulate is distributed into 10 grams, one bag.

Instructions of taking: each 10g, every day 3 times, warm boiled water.

Example 2: tablet

The prescription: Radix Astragali 17g, Herba Fici Simplicissimae 14g, Radix Ophiopogonis 8g, Fructus Schisandrae Chinensis 18g, Radix Rhodiolae 8g, Radix Curcumae 8g, Radix Glycyrrhizae Preparata 5g

Preparation method: get crude drug water extraction 3 times by prescription, add 12 times of decoctings at every turn and boil 1h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.49 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings, pulverized 65 mesh sieves and got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, made wetting agent system soft material with 95% ethanol, crossing 16 mesh sieves granulates, drying, the conventional method tabletting is made tablet.

Instructions of taking: oral, one time 4,3 times on the one.

Example 3: capsule

The prescription: Radix Astragali 40g, Herba Fici Simplicissimae 30g, Radix Ophiopogonis 20g, Fructus Schisandrae Chinensis 15g, Radix Rhodiolae 16g, Radix Curcumae 16g, Radix Glycyrrhizae Preparata 6g

Preparation method: get crude drug water extraction 2 times by prescription, add 8 times of decoctings at every turn and boil 3h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.12 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings were pulverized 65 mesh sieves and were got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, make wetting agent system soft material with 95% ethanol, cross 16 mesh sieves and granulate drying, granulate, the gelatine capsule of packing into is made capsule.

Instructions of taking: oral, one time 4,3 times on the one.

Example 4: granule

The prescription: Radix Astragali 23g, Herba Fici Simplicissimae 15g, Radix Ophiopogonis 12g, Fructus Schisandrae Chinensis 9g, Radix Rhodiolae 6g, Radix Curcumae 5g, Radix Glycyrrhizae Preparata 5g

Preparation method: get crude drug water extraction 3 times by prescription, add 10 times of decoctings at every turn and boil 2h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.38 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings, pulverized 65 mesh sieves and got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, made wetting agent system soft material with 95% ethanol, crossing 16 mesh sieves granulates, drying, granulate is distributed into 10 grams, one bag.

Instructions of taking: each 10g, every day 3 times, warm boiled water.

Example 5: tablet

The prescription: Radix Astragali 35g, Herba Fici Simplicissimae 23g, Radix Ophiopogonis 9g, Fructus Schisandrae Chinensis 7g, Radix Rhodiolae 5g, Radix Curcumae 6g, Radix Glycyrrhizae Preparata 6g

Preparation method: get crude drug water extraction 3 times by prescription, add 12 times of decoctings at every turn and boil 1h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.49 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings, pulverized 65 mesh sieves and got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, made wetting agent system soft material with 95% ethanol, crossing 16 mesh sieves granulates, drying, the conventional method tabletting is made tablet.

Instructions of taking: oral, one time 4,3 times on the one.

Example 6: capsule

The prescription: Radix Astragali 20g, Herba Fici Simplicissimae 9g, Radix Ophiopogonis 7g, Fructus Schisandrae Chinensis 17g, Radix Rhodiolae 17g, Radix Curcumae 14g, Radix Glycyrrhizae Preparata 6g

Preparation method: get crude drug water extraction 4 times by prescription, add 12 times of decoctings at every turn and boil 2h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.26 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings were pulverized 65 mesh sieves and were got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, make wetting agent system soft material with 95% ethanol, cross 16 mesh sieves and granulate drying, granulate, the gelatine capsule of packing into is made capsule.

Instructions of taking: oral, one time 4,3 times on the one.

Example 7: granule

The prescription: Radix Astragali 30g, Herba Fici Simplicissimae 18g, Radix Ophiopogonis 6g, Fructus Schisandrae Chinensis 7g, Radix Rhodiolae 9g, Radix Curcumae 12g, Radix Glycyrrhizae Preparata 7g

Preparation method: get crude drug water extraction 3 times by prescription, add 10 times of decoctings at every turn and boil 2h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.38 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings, pulverized 65 mesh sieves and got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, made wetting agent system soft material with 95% ethanol, crossing 16 mesh sieves granulates, drying, granulate is distributed into 10 grams, one bag.

Instructions of taking: each 10g, every day 3 times, warm boiled water.

Example 8: capsule

The prescription: Radix Astragali 14g, Herba Fici Simplicissimae 14g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 16g, Radix Rhodiolae 16g, Radix Curcumae 13g, Radix Glycyrrhizae Preparata 6g

Preparation method: get crude drug water extraction 3 times by prescription, add 10 times of decoctings at every turn and boil 2h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.18 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings were pulverized 65 mesh sieves and were got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, make wetting agent system soft material with 95% ethanol, cross 16 mesh sieves and granulate drying, granulate, the gelatine capsule of packing into is made capsule.

Instructions of taking: oral, one time 4,3 times on the one.

Example 9: tablet

The prescription: Radix Astragali 14g, Herba Fici Simplicissimae 19g, Radix Ophiopogonis 12g, Fructus Schisandrae Chinensis 19g, Radix Rhodiolae 12g, Radix Curcumae 9g, Radix Glycyrrhizae Preparata 5g

Preparation method: get crude drug water extraction 3 times by prescription, add 12 times of decoctings at every turn and boil 1h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.16 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings, pulverized 65 mesh sieves and got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, made wetting agent system soft material with 95% ethanol, crossing 16 mesh sieves granulates, drying, the conventional method tabletting is made tablet.

Instructions of taking: oral, one time 4,3 times on the one.

Example 10: granule

The prescription: Radix Astragali 20g, Herba Fici Simplicissimae 9g, Radix Ophiopogonis 7g, Fructus Schisandrae Chinensis 17g, Radix Rhodiolae 17g, Radix Curcumae 14g, Radix Glycyrrhizae Preparata 6g

Preparation method: get crude drug water extraction 3 times by prescription, add 10 times of decoctings at every turn and boil 2h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.32 extractum, add the dextrin of 4 times of weight earlier by the weight of extractum, 80 ℃ of vacuum dryings were pulverized 65 mesh sieves and were got dry powder, added the Icing Sugar of 2 times of weight again by the weight of dry powder, make wetting agent system soft material with 95% ethanol, cross 16 mesh sieves and granulate drying, granulate is distributed into 10 grams, one bag.

Instructions of taking: each 10g, every day 2 times, warm boiled water.

Claims (5)

1. prevent and treat the viral myocarditis pharmaceutical composition for one kind, this pharmaceutical composition is made up of active component and acceptable accessories, it is characterized in that, described active component is made by following raw materials by weight percent medicine: Herba Fici Simplicissimae 15～50%, the Radix Astragali 15～50%, Radix Ophiopogonis 5～25%, Fructus Schisandrae Chinensis 5～25%, Radix Rhodiolae 5～25%, Radix Curcumae 5～25%, Radix Glycyrrhizae Preparata 5～10%.

2. a kind of control viral myocarditis pharmaceutical composition according to claim 1, it is characterized in that, the weight proportion of described crude drug is: Herba Fici Simplicissimae 17%～33%, the Radix Astragali 23%～41%, Radix Ophiopogonis 9%～16%, Fructus Schisandrae Chinensis 10%～20%, Radix Rhodiolae 9%～16%, Radix Curcumae 9%～16%, Radix Glycyrrhizae Preparata 6%～9%.

3. a kind of control viral myocarditis pharmaceutical composition according to claim 2 is characterized in that the weight proportion of described crude drug is: the Radix Astragali 25%, Herba Fici Simplicissimae 20%, Radix Ophiopogonis 15%, Fructus Schisandrae Chinensis 10%, Radix Rhodiolae 10%, Radix Curcumae 15%, Radix Glycyrrhizae Preparata 10%.

4. according to claim 1,2 or 3 described a kind of control viral myocarditis pharmaceutical compositions, it is characterized in that described pharmaceutical composition is granule, tablet or capsule.

5. preparation method as claim 1,2 or 3 described active ingredient in pharmaceutical, this method is made up of following steps:

Get crude drug with water boiling and extraction 2～4 times by proportioning, add 8～12 times in water at every turn, decoct 1～3h, merge decoction liquor then, filter, be concentrated into relative density and be 1.10～1.50 extractum and get final product.