CN101940708A - Traditional Chinese medicinal preparation for curing malignant pleural effusion - Google Patents
Traditional Chinese medicinal preparation for curing malignant pleural effusion Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal preparation for curing malignant pleural effusion, which is body resistance-strengthening and expectoration-eliminating decoction. The malignant pleural effusion is the common complication of cancers, and intrathoracic chemotherapy can prolong control time but has bad unwanted effects. The traditional Chinese medicinal preparation can promote the repairing of the normal tissue of a human body and reduce damages of chemotherapeutic agents to the normal tissue, has the functions of strengthening effects and reducing toxic and side effects and therefore guarantees the smooth completion of the intrathoracic chemotherapy. The traditional Chinese medicinal preparation consists of the following medicaments of: codonopsis pilosula, astragalus membranaceus, prepared rhizome of rehmannia, Chinese angelica, bulbus fritillariae cirrhosae, poria cocos, semen lepidii, liquorice, dried orange peel, trichosanthes kirilowii maxim, grifola, rhizoma alismatis, the root of paris polyphylla, solanum lyratum and the like. Clinical application proves that: the traditional Chinese medicinal preparation has the characteristics of strengthening curing effect, reducing side effect, promoting the repairing of the normal tissue cells and protecting medullary hematopoiesis, increasing appetite, improving the quality of life, well controlling the cancers and the like and can be used as the medicament applied to the intrathoracic chemotherapy synchronously.
Description
Technical field
The present invention relates to a kind of Chinese drugs agentia for the treatment of malignant pleural effusion---set upright the dissipating fluid-retention soup that eliminates the phlegm.
Background technology
In recent years, cancer morbidity increases gradually, and malignant pleural effusion is the common complication of cancer patient, and majority belongs to the result of progression of disease or recurrence.Also can be used as the clinical manifestation of cancer patient.Malignant pleural effusion is often pointed out prognosis mala.Malignant pleural effusion is more common in pulmonary carcinoma, breast carcinoma, lymphoma, leukemia etc., secondly also sees ovarian cancer, gastroenteric tumor, mesothelioma of pleura etc.Malignant pleural effusion can cause serious malaise symptoms, as dyspnea, dysphagia, chest pain, cough, heating, causes the respiratory and circulatory function obstacle when serious, causes dead.
Though simple thoracic cavity discharge opeing can alleviate pressure symptom immediately, the controllable time is shorter, and most patient's hydrothorax increase sharply.
Though and chemotherapy can prolong the control time in the thoracic cavity, but untoward reaction is bigger, and the patient who has often is forced to therapy discontinued and reduces therapeutic effect.
At present the technology that alleviates chemotherapy side effect in the thoracic cavity that adopts in the world is based on symptomatic treatment, local application, as: intrathoracic injection dexamethasone, lignocaine etc.; Intravenous injection antiemetic, antibiotic etc.; Parenteral alimentation is supported; If the above bone marrow depression of moderate (leukopenia), then use granulocyte colony-stimulating factor etc.Chemotherapy side effect has certain treatment and inhibitory action in the thoracic cavity though these methods are to alleviating, and alleviates patient's misery; But, be temporary transient, can not reduce chemotherapeutics to the infringement of human normal tissue, promote the recovery of normal structure, still can not guarantee finishing smoothly of chemotherapy in the thoracic cavity.
And Chinese medicine is to execute smelting so that organic conception is dialectical.On the traditional Chinese medical science document, have and manyly discuss about carcinoma.Use both traditional Chinese medicines and western medicines in treatment in recent years, the Chinese medicine advantage demonstrates fully, and since nearly half a century, the therapy of combining Chinese and Western medicine malignant tumor is to be common method of treatment.Clinical application for many years the present invention reaches efficacy enhancing and toxicity reducing and reduces chemotherapy side effect.It also is Chinese drugs agentia as synchronous applications in the chemotherapy of thoracic cavity.
Summary of the invention
The present invention seeks to, a kind of Chinese drugs agentia for the treatment of malignant pleural effusion is provided---set upright the dissipating fluid-retention soup that eliminates the phlegm.It can promote the reparation of human normal tissue from the integral body etiological treatment of starting with, and reduces the infringement of chemotherapeutics to normal structure, plays energization potentiation, alleviates the effect of toxicity, thereby guarantees finishing smoothly of chemotherapy in the thoracic cavity.
Malignant pleural effusion belongs to " hydrothorax " category on Chinese medicine, this disease is because positive QI-insufficiency, qi-blood disharmony, stagnation of QI causing phlegm retention, blood stasis poison are poly-, obstinate disease and then cause lung spleen kidney three dirty functional disorders, and qiactivity of triple energizer is unfavorable, so that diseases caused by retention of fluid stops poly-forming.Chemotherapeutics mostly is hot product on Chinese medicine, it is in the kill tumor cell, and normal structure also sustains damage, and its common untoward reaction is nauseating, vomiting, pain, constipation, leukopenia etc., thus the carrying out of influence treatment.
Malignant pleural effusion and intracavity patients undergoing chemotherapy, being diagnosed as vital QI being weakened and pathogen being violent, dirty functional disorder, qi depression to blood stasis, expectorant on Chinese medicine coagulates and wetly ties in poly-, scorchingly hot, disease meeting color is simple and unadorned, cough and asthma, irritable feverish sensation in the chest, severe palpitation, discomfort in the throat, the tired lack of appetite of body, constipation are urinated red, pale tongue with white fur, thready and rapid pulse or a little less than.
Interior-deficiency is that tumor is basic, the present invention has determined the treatment general principle of " strengthening vital QI to eliminate pathogenic factors " on this basis, simultaneously in conjunction with pathological characteristics such as " void, expectorant, the stasis of bloods, stagnate, wet, poison " that showed in tumor invasion, the diagnosis and treatment process, drafted benefiting QI and nourishing blood, the Therapeutic Method such as building spleen, promoting diuresis to eliminate damp pathogen, dissipating phlegm and resolving masses, heat-clearing and toxic substances removing of regulating the flow of vital energy.
Based on above-mentioned principle, medicament composing prescription of the present invention by its weight ratio is:
Radix Codonopsis 13～18 grams, the Radix Astragali 28～32 grams, Radix Rehmanniae Preparata 13～18 restrain, Radix Angelicae Sinensis 13～18 restrains,
Bulbus Fritillariae Cirrhosae 8～12 grams, Poria 13～18 grams, Semen Lepidii (Semen Descurainiae) 8～12 restrain, Radix Glycyrrhizae 8～12 restrains,
Pericarpium Citri Reticulatae 8～12 grams, Fructus Trichosanthis 13～18 grams, Polyporus 8～12 restrain, Rhizoma Alismatis 8～12 restrains,
Rhizoma Paridis 8～12 grams, Herba Solani Lyrati 8～12 grams.
Potion on the one is decocted in water for oral dose.
We's medicine treatment mechanism: benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen, promoting diuresis to eliminate damp pathogen, dissipating phlegm and resolving masses.
Press modern pharmacological research, in conjunction with Chinese medicine and pharmacy:
The Radix Astragali: sweet, warm; Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Contain astragaloside, lymphatic temperament, coumarin, Saponin, daucosterol, astragalus polysaccharides, sterol etc.The Radix Astragali has immunostimulant and tumor-inhibiting action to the s-180 tumor-bearing mice, and the enhancing human body immunity function is arranged in addition, the anti-ageing effect of waiting for a long time.
Radix Codonopsis: sweet, flat; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Contain Saponin, micro-alkaloid, several amino acids and inorganic elements.Decoct can prolong mean survival time, the enhancing human body immunity function of cyclophosphamide to the Lewis lung cancer and the lung metastasis tumor-bearing mice thereof of mouse subcutaneous transplanting, checks tumor development; Have the chemotherapeutic sensitivity effect, regulate effects such as hemopoietic function, leukocyte increasing, blood pressure lowering, rising blood glucose in addition.
Polyporus: sweet, light, flat; Return kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen.Contain water solublity polysaccharide chemical compound, ergosterol, 24 carbonic acid, biotin, crude protein, chitin etc.The water-soluble part and the various extract of polyporus extract can suppress murine sarcoma s-180, cervical cancer U-14 and hepatocarcinoma.The Polyporus agent subcutaneous injection of boiling medicine can strengthen mice reticuloendothelial system phagocytic function and can strengthen cellular immune function.Diuresis still arranged, protect the liver, effect such as antibiotic.
Bulbus Fritillariae Cirrhosae: sweet, bitter, be slightly cold; Return lung, heart channel.Bulbus Fritillariae Cirrhosae has the inhibitory action water extract that human cervical carcinoma JTC-26 cell is had inhibitory action to tumor cell.Eliminating phlegm and relieving cough, analgesia, calmness, blood pressure lowering, spasmolytic, effect such as antibiotic are still arranged.
Fructus Trichosanthis: sweet, cold; Return lung, stomach, large intestine channel.Removing heat from the lung and dissipating phlegm, the promoting the circulation of QI the chest stuffiness relieving.Contain triterpene saponin, organic acid and its esters, resin, saccharide and pigment etc.Its decoct has certain inhibitory action to ehrlich ascites carcinoma, sarcoma, can kill the mouse ascites cancerous cell.Still eliminate the phlegm, antibiotic, antiulcer, coronary artery dilating, increase coronary flow, anticoagulant, enhancing hypoxia-bearing capability, blood fat reducing, blood pressure lowering, rush down inferior effect.
Radix Rehmanniae Preparata: sweet, tepor; Return liver, kidney channel.Nourishing the blood and yin, vital essence replenishing and marrow benifiting.Contain Dihuang polysaccharide, Radix Rehmanniae oligosaccharide, iridoid, monoterpene and glycoside, several amino acids, trace element and organic acid.Obvious immune antitumor activity is arranged, promote lymphocyte activity, direct killing tumor cell.Still protect the liver, effects such as blood sugar lowering, anti-hypertrophy, antiinflammatory, antifungal, anti-radiation.
Rhizoma Alismatis: sweet, light, cold; Return kidney, urinary bladder channel.Relieving stranguria by diuresis, eliminating dampness by diuresis antidiarrheal.Contain volatile oil, alkaloid, choline, alisol, plant sterol, agedoite, organic acid, protein, polysaccharide etc.Can increase urine amount, carbamide and muriatic output, delay carbamide and content of cholesterol in the rabbit blood are reduced, the animal progression of atherosclerosis is slowed down.Also have blood pressure lowering, blood sugar lowering, effect such as antibiotic.
Poria: sweet, light, flat, GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing.Contain pachymic acid, eburicoic acid, loose Siberian cocklebur acid, pachyman, pachymaran, ergosterol, choline, histidine, lecithin and potassium salt etc.Multiple carcinoma to laboratory animal has inhibition and killing activity, and malignant tumor such as nasopharyngeal carcinoma, gastric cancer are had therapeutical effect, and can stop the mouse cervical cancer lung to shift.The leukopenia effect that strengthens cellular immune function, antagonism caused by cyclophosphamide is still arranged, also have heart tonifying, calmness, hypnosis, hepatoprotective, antiulcer, diuresis and antibacterial action.
Radix Angelicae Sinensis: sweet, hot, warm; Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.Contain vitamin B
12And folic acid etc.The anti-pernicious anemia of energy, hepatoprotective prevents that liver glycogen from reducing.The energy coronary blood flow increasing has inhibitory action to hemolytic chain bacterium, disease bacillus, Bacillus typhi, bacillus pyocyaneus etc.
Pericarpium Citri Reticulatae: hot, bitter, warm; Return spleen, lung meridian.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Contain volatile oil, main component is limonene, citral, nobiletin, hesperidin, inositol, vitamin B etc. in the volatile oil.Digestive tract there is demulcent stimulation, is beneficial to the discharge of stomach, intestinal gas, can promote the secretion of gastric juice, help digestion; Can stimulate respiratory mucosa, make secretion increasing; The sputum dilution is easy to discharge; Can the diastole bronchus and antiasthmatic effect is arranged.
Herba Solani Lyrati: sweet, bitter, cold; Return liver, stomach warp.Heat-clearing and toxic substances removing, expelling wind and removing dampness jaundice eliminating, inducing diuresis to remove edema.Contain alkaloid, tomatidenol, solasodine, soladulcine, α-solamarine, β-solamarine, solamargine etc. are arranged.Antitumor action is arranged, can suppress white mice ehrlich carcinoma, fusocelluar sarcoma and S-180.Still there is the antibody that promotes human body to form and effects such as proteinic synthetic, antiinflammatory, antibacterial, antifungal and diuresis.
Rhizoma Paridis: bitter, be slightly cold; Return Liver Channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.Contain paridin, steroid saponin and phenols etc.Hepatoma carcinoma cell, murine sarcoma-37 and mice-180 and Emhorn ascites all there is the inhibition inhibitory action.
Semen Lepidii (Semen Descurainiae): hot, bitter, cold.Return lung, bladder, large intestine channel.Inducing diuresis to remove edema, eliminating pathogen from the lung for relieving asthma.Can treat breast abdomen hydrops, dysuria, sputum-rich yellow-thick, fullness in the chest asthma.Modern pharmacological research shows that Semen Lepidii (Semen Descurainiae) has cardiotonic, and can blood lipid regulation.
Radix Glycyrrhizae: sweet, flat.Return spleen, the heart, lung meridian.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Contain glycyrrhizin, be the sweet ingredient of calcium, potassium salt and the Radix Glycyrrhizae of glycyrrhizic acid; Produce enoxolone and glucuronic acid after the glycyrrhizic acid hydrolysis; Also contain liquiritin and agedoite, mannitol etc.Radix Glycyrrhizae has stronger Detoxication and corticoid effect.Can alleviate the pipe smooth muscle spasm, suppress the caused gastric acid secretion of histamine, ulcer surface is also had protective effect.Has the antiinflammatory anti-allergy action.Can protect the throat of inflammation and the mucosa of trachea, abirritate helps cough-relieving, can be used as the expectorant of protectiveness.
In the side: the Radix Astragali, the sweet temperature compensation gas of Radix Codonopsis, spleen invigorating lung benefiting; Radix Angelicae Sinensis, Radix Rehmanniae Preparata nourishing YIN and benefiting blood, liver and kidney tonifying; Four medicines share and are monarch, the merit of playing benefiting QI and nourishing blood, strengthening the body resistance altogether.Polyporus, Poria, Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, dissipating phlegm and resolving masses; Fructus Trichosanthis moistening the lung and resolving phlegm, promoting the circulation of QI the chest stuffiness relieving; Bulbus Fritillariae Cirrhosae lung moistening eliminating stagnation, clearing heat, eliminating phlegm, relieving cough; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, alleviating distention in middle-JIAO, drying dampness to eliminate phlegm; Semen Lepidii (Semen Descurainiae) eliminating the pathogens from the lung cough-relieving, inducing diuresis to remove edema; More than seven medicines mutually 5, the merit that dissipating fluid-retention eliminates the phlegm is remarkable, is ministerial drug.Herba Solani Lyrati heat-clearing and toxic substances removing, inducing diuresis to remove edema; The Rhizoma Paridis heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
From modern pharmacological research, medicament of the present invention has following effect: the first, and directly antitumor action stops growth of cancer cells to shift.The second, strengthen host immune function, by the effector lymphocyte of activating immune system and the secreted factor thereof, kill and wound or suppress tumor cell.The 3rd, have the back mutation effect, but the generation of prophylaxis of tumours, and the chemotherapeutic sensitivity effect is arranged.The 4th, broad spectrum antibacterial function can be prevented and treated the secondary infection that causes owing to the infringement of natural immunity barrier in the therapeutic process.The 5th, sedation and analgesia, the relieving restlessness that clears away heart-fire improves sleep, adjusts the best immune state of human body.The 6th, contain abundant vitamin, crude fibre, improving appetite, the stool of removing heat by catharsis guarantees the supply of human body nutritional labeling.The 7th, diuresis, antitussive, promotion sputum are discharged, and slow down the generation of hydrothorax.The 8th, regulate hemopoietic function, leukocyte increasing.The 9th, the liver protecting promotes protein synthesis.The tenth, the effect of class adrenal cortex, thereby performance anti-inflammatory properties.
The present invention proves through clinical practice: having to increase curative effect, attenuating side reaction; promote the reparation of normal tissue cell; hemopoietic function of bone marrow there is protective effect; the energy stimulating appetite; the quality of making the life better; thereby control characteristics such as tumor better, it can be used as in the thoracic cavity medicine of synchronous applications in the chemotherapy.
The specific embodiment
The present invention is by modern pharmacological research, in conjunction with Chinese medicine and pharmacy, has drafted benefiting QI and nourishing blood, the Therapeutic Method such as building spleen, promoting diuresis to eliminate damp pathogen, dissipating phlegm and resolving masses, heat-clearing and toxic substances removing of regulating the flow of vital energy.Its medicament composing prescription by its weight ratio is:
Radix Codonopsis 13～18 grams, the Radix Astragali 28～32 grams, Radix Rehmanniae Preparata 13～18 restrain, Radix Angelicae Sinensis 13～18 restrains,
Bulbus Fritillariae Cirrhosae 8～12 grams, Poria 13～18 grams, Semen Lepidii (Semen Descurainiae) 8～12 restrain, Radix Glycyrrhizae 8～12 restrains,
Pericarpium Citri Reticulatae 8～12 grams, Fructus Trichosanthis 13～18 grams, Polyporus 8～12 restrain, Rhizoma Alismatis 8～12 restrains,
Rhizoma Paridis 8～12 grams, Herba Solani Lyrati 8～12 grams.
Potion on the one is decocted in water for oral dose.
In order to improve drug effect and therapeutic effect, earlier with said medicine (being potion), decoct 15～20 minutes taking-up medicinal liquids with water 1500ml, add water 1500ml again and decocted 15～20 minutes, take out medicinal liquid again, with the medicinal liquid merging of secondary, three decoction being taken warmly of a bu.
The clinical practice situation:
The patient is totally 80 examples, wherein: pulmonary carcinoma 40 examples, mammary cancer 17 examples, gastric cancer 4 examples, colorectal cancer 6 examples, ovarian cancer 2 examples, esophageal carcinoma 2 examples, hepatocarcinoma 2 examples, lymphoma 5 examples; Divide 2 groups at random, treatment group (the intracavity chemotherapy is used medicine of the present invention) 40 examples, matched group (simple intracavity chemotherapy) 40 examples.Wherein male 42 examples, women 38 examples; Minimal ages 16 years old, maximum 75 years old age, 50 years old mean age.
Curative effect determinate standard: hydrothorax changes with reference to the WHO required standard.Alleviate fully (CR): hydrops disappears, remission, and B ultrasonic confirms to keep more than 4 weeks; Part is alleviated (PR): hydrops significantly reduces (more than 50%), and symptom takes a turn for the better, and keeps more than 4 weeks; Invalid (NC): symptom does not have improvement, and hydrothorax does not have minimizing or recurrence in 4 weeks.
Curative effect compares: treatment group: CR30 example (75%), PR6 example (15%), NC4 example (10%); Total effective rate (CR+PR) 90%.Matched group: CR16 example (40%), PR13 example (32.5%), NC11 example (27.5%), total effective rate (CR+PR) 72.5%.Statistical procedures is alleviated between two groups fully and total effective rate all has significant difference (P＜0.05).Adopt the therapeutic effect of the treatment group of chemotherapy in the medicine mating cavity of the present invention obviously to be better than matched group.
Untoward reaction: criterion: set up observation index (specific as follows) according to the calibration standard of WHO antitumor drug toxicity:
Two groups of untoward reaction statistical conditions are as follows: (concrete condition sees the following form)
As can be seen from the above table, the side reaction of treatment group significantly is lower than matched group, and significant difference (P＜0.05) is arranged between two groups.
Model case:
Patient Wang, woman, 21 years old; Uncomfortable in chest, suppress and breathe heavily; Through the breast CT inspection, be diagnosed as huge tumor and a large amount of hydrothorax in right side in the mediastinum, row thoracentesis closed drainage and intracavity chemotherapy are taken medicament of the present invention simultaneously.Symptom is obviously improved, check after 10 days, and hydrothorax disappears, and lump obviously dwindles in the mediastinum.Do not have obviously secondary anti-during the treatment.It is malignant lymphoma that sample alive is got in back lump puncture in CT guiding inferior mediastinum.Hydrothorax does not take place afterwards again.
Patient field: man, 41 years old; Cough, uncomfortable in chest, spitting of blood is month surplus; Through the breast CT inspection, be diagnosed as a large amount of hydrops in pulmonary carcinoma and the thoracic cavity, taking out the inspection of hydrothorax row exfoliative cytology is adenocarcinoma.Row thoracentesis closed drainage and intracavity chemotherapy are obeyed medicament of the present invention simultaneously.Symptom is obviously improved, check after 10 days, hydrothorax complete obiteration, 3 months catabasises.Existing healthy existence.
Therefore the present invention has can increase curative effect, lower side reaction, promotes the reparation of normal tissue cell; hemopoietic function of bone marrow there is protective effect, energy stimulating appetite, the quality of making the life better; thereby control characteristics such as tumor better, it can be used as in the thoracic cavity medicine of synchronous applications in the chemotherapy.
List of references:
1, " Chinese medicine " He Zhiguang chief editor, People's Health Publisher June in 1989 the 3rd edition
2, " practical Internal Medicine-Oncology " Zhou Ji emits the chief editor, People's Health Publisher February in 2005 the 2nd edition
3, the new medical college in " Chinese medicine voluminous dictionary " Jiangsu is compiled, Shanghai People's Press May in 1975 1 edition
4, " typhoid fever heart method gist " Hao Wanshan chief editor, People's Health Publisher May in 2004 the 3rd edition
5, " pharmacology of Chinese medical formulae " Wang Yiqi chief editor, People's Health Publisher June in 2005 the 1st edition
6, " clinical tumor conventional Chinese medicine guide " Tang Xianping chief editor, scientific and technical literature publishing house in August, 2006
7, " Internal Medicine-Oncology therapy of combining Chinese and Western medicine " Wang Juxiang chief editor, People's Health Publisher February in 2009 1 edition
Claims (1)
1. Chinese drugs agentia for the treatment of malignant pleural effusion, it is characterized in that: medicament composing prescription by its weight ratio is:
Radix Codonopsis 13～18 grams, the Radix Astragali 28～32 grams, Radix Rehmanniae Preparata 13～18 restrain, Radix Angelicae Sinensis 13～18 restrains,
Bulbus Fritillariae Cirrhosae 8～12 grams, Poria 13～18 grams, Semen Lepidii (Semen Descurainiae) 8～12 restrain, Radix Glycyrrhizae 8～12 restrains,
Pericarpium Citri Reticulatae 8～12 grams, Fructus Trichosanthis 13～18 grams, Polyporus 8～12 restrain, Rhizoma Alismatis 8～12 restrains,
Rhizoma Paridis 8～12 grams, Herba Solani Lyrati 8～12 grams.
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| CN103110808A (en) * | 2013-02-28 | 2013-05-22 | 曹锋 | Traditional Chinese medicinal preparation capable of relieving side reaction of esophagus cancer radiotherapy |
| CN103251863A (en) * | 2013-05-12 | 2013-08-21 | 张磊 | Chinese medicinal decoction for treating stagnant pathogen of Shaoyang type pleural effusion |
| CN103704412A (en) * | 2013-12-31 | 2014-04-09 | 孙晓兵 | Milk tea electuary for curing pleural effusion conjunctivitis |
| CN103861017A (en) * | 2014-04-11 | 2014-06-18 | 胡海波 | Traditional Chinese medicinal composition for treating tuberculous pleural effusion and preparation method of composition |
| CN104056104A (en) * | 2014-06-26 | 2014-09-24 | 程子明 | Traditional Chinese medicine composition for treating malignant pleural effusion |
| CN104645178A (en) * | 2015-01-26 | 2015-05-27 | 阮秀云 | Drug for intrapleural hyperthermic perfusion therapy |
| CN104667088A (en) * | 2015-01-26 | 2015-06-03 | 阮秀云 | Preparation method of intrapleural hyperthermal infusion fluid |
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| CN110101800A (en) * | 2019-06-25 | 2019-08-09 | 复旦大学附属金山医院 | It is a kind of to treat malignant pleural effusion Chinese medicine composition and its application |
| CN111939239A (en) * | 2020-09-04 | 2020-11-17 | 陕西省中医医院 | Traditional Chinese medicine composition for treating malignant pleural effusion |
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| CN103251863A (en) * | 2013-05-12 | 2013-08-21 | 张磊 | Chinese medicinal decoction for treating stagnant pathogen of Shaoyang type pleural effusion |
| CN103251863B (en) * | 2013-05-12 | 2014-09-24 | 张磊 | Chinese medicinal decoction for treating stagnant pathogen of Shaoyang type pleural effusion |
| CN103704412A (en) * | 2013-12-31 | 2014-04-09 | 孙晓兵 | Milk tea electuary for curing pleural effusion conjunctivitis |
| CN103861017B (en) * | 2014-04-11 | 2016-05-25 | 刘梅 | Be used for the treatment of Chinese medicine composition of tuberculous pleural effusion and preparation method thereof |
| CN103861017A (en) * | 2014-04-11 | 2014-06-18 | 胡海波 | Traditional Chinese medicinal composition for treating tuberculous pleural effusion and preparation method of composition |
| CN104056104A (en) * | 2014-06-26 | 2014-09-24 | 程子明 | Traditional Chinese medicine composition for treating malignant pleural effusion |
| CN104645178A (en) * | 2015-01-26 | 2015-05-27 | 阮秀云 | Drug for intrapleural hyperthermic perfusion therapy |
| CN104667088A (en) * | 2015-01-26 | 2015-06-03 | 阮秀云 | Preparation method of intrapleural hyperthermal infusion fluid |
| CN105311599A (en) * | 2015-11-12 | 2016-02-10 | 青岛华仁技术孵化器有限公司 | Medicine for treating malignant pleural effusion with syndrome of phlegm-dampness due to spleen deficiency |
| US9668990B1 (en) | 2016-06-10 | 2017-06-06 | Gongwin Biopharm Holdings Co., Ltd. | Benzenesulfonamides compositions for treatment of malignant pleural effusions |
| US10182998B2 (en) | 2016-06-10 | 2019-01-22 | Gongwin Biopharm Holdings Co., Ltd. | Benzenesulfonamide compositions for treatment of malignant pleural effusions |
| CN110101800A (en) * | 2019-06-25 | 2019-08-09 | 复旦大学附属金山医院 | It is a kind of to treat malignant pleural effusion Chinese medicine composition and its application |
| CN111939239A (en) * | 2020-09-04 | 2020-11-17 | 陕西省中医医院 | Traditional Chinese medicine composition for treating malignant pleural effusion |
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