CN101940636B - Chinese medicinal preparation for treating closed fracture and preparation method thereof - Google Patents
Chinese medicinal preparation for treating closed fracture and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal preparation for treating closed fracture and a preparation method thereof. The Chinese medicinal preparation comprises the following raw materials in part by weight: 5 parts of safflower, 5 parts of frankincense, 5 parts of myrrh, 5 parts of pseudoginseng root, 5 parts of rhubarb, 5 parts of pawpaw, 5 parts of ground beetle, 5 parts of pyrite, 5 parts of crab, 5 parts of dragon's bone, 5 parts of dahurian angelica root, 4 parts of borneol, 5 parts of Chinese taxillus twing, 5 parts of nux vomica and 5 parts of acanthopanax bark, wherein the preparation method comprises the following steps of: 1, a preparation method of the pyrite: wrapping the pyrite with iron wires, burning the pyrite by using charcoal until the pyrite is red-hot, placing the red-hot pyrite into a pot filled with rice vinegar, repeating the step for 7 times, and grinding the product to obtain powder; 2, a preparation method of the nux vomica: boiling the nux vomica and green beans together, preferably stopping the boiling until the green beans blossom, removing the green beans by filtration, taking the nux vomica out, soaking the nux vomica in cold water, removing bark and hairs, cutting the nux vomica into slices and drying the nux vomica; and 3, mixing the well prepared pyrite and nux vomica and other Chinese medicaments, and grinding the mixture to obtain powder. The Chinese medicinal preparation has the characteristics of good treatment effect and low cost, and capability of accelerating the healing of closed fracture.
Description
Technical Field
The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine preparation for treating closed fracture and a preparation method thereof.
Background
Fracture refers to a disease in which bone is partially or completely broken due to trauma or pathology. The main clinical manifestations are: local pain and tenderness of fracture, local swelling and ecchymosis, complete loss of functional parts of limbs, and deformity and abnormal movement of limbs due to complete bone.
Classification according to whether the fracture is communicated with the outside:
(1) open fracture: the rupture of the skin and mucosa near the fracture, the rupture of the bladder or urethra caused by the fracture of pubic bone at the fracture site and the rupture of rectum caused by the fracture of coccyx are all open fractures. Such fractures are contaminated due to communication with the outside.
(2) Closed fracture: the skin or mucosa of the fracture is intact and not communicated with the outside. Such fractures are free of contamination. Classification by degree of fracture:
(1) complete fracture: the integrity or continuity of the bone is completely interrupted, and the tubular bone is fractured to form far, near or more than two fracture sections. Horizontal, oblique, spiral and comminuted fractures are all complete fractures.
(2) Incomplete fractures: the integrity or continuity of bones is only partially interrupted, and the fractures of the skull, the scapula and the long bone, the fracture of the branch of children and the like are incomplete fractures.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine preparation for treating closed fracture and a preparation method thereof.
The preparation method comprises the following steps: the weight portions of the components are 5 portions of safflower, 5 portions of frankincense, 5 portions of myrrh, 5 portions of pseudo-ginseng, 5 portions of rhubarb, 5 portions of pawpaw, 5 portions of ground beetle, 5 portions of native copper, 5 portions of Szechwan seaweeds, 5 portions of keel, 5 portions of angelica dahurica, 4 portions of borneol, 5 portions of mistletoe, 5 portions of nux vomica and 5 portions of cortex acanthopanacis,
wherein, (1) the native copper preparation method:
wrapping Pyritum with iron net, placing into a basin filled with rice vinegar, repeating the above steps for 7 times, and grinding into fine powder;
(2) the preparation method of nux vomica comprises the following steps:
decocting semen Strychni and semen Phaseoli Radiati in water, filtering to remove semen Phaseoli Radiati, taking out semen Strychni, soaking in cold water, removing coat, slicing, and sun drying;
(3) grinding the other materials with Pyritum and semen Strychni into fine powder.
The preparation method of the nux vomica further comprises the following steps: frying semen Strychni in oleum Sesami to black yellow, taking out, cooling, removing coat, slicing, and sun drying.
The invention has the characteristics of good treatment effect, low cost and capability of accelerating the healing of closed fracture.
The specific implementation mode is as follows:
example 1
The preparation method comprises the following steps:
the weight portions of the components are 5 portions of safflower, 5 portions of frankincense, 5 portions of myrrh, 5 portions of pseudo-ginseng, 5 portions of rhubarb, 5 portions of pawpaw, 5 portions of ground beetle, 5 portions of native copper, 5 portions of Szechwan seaweeds, 5 portions of keel, 5 portions of angelica dahurica, 4 portions of borneol, 5 portions of mistletoe, 5 portions of nux vomica and 5 portions of cortex acanthopanacis,
wherein, (1) the native copper preparation method:
wrapping Pyritum with iron net, placing into a basin filled with rice vinegar, repeating the above steps for 7 times, and grinding into fine powder;
(2) the preparation method of nux vomica comprises the following steps:
decocting semen Strychni and semen Phaseoli Radiati in water, filtering to remove semen Phaseoli Radiati, taking out semen Strychni, soaking in cold water, removing coat, slicing, and sun drying;
(3) grinding the other materials with Pyritum and semen Strychni into fine powder.
The preparation method of the nux vomica comprises the following steps: frying semen Strychni in oleum Sesami to black yellow, taking out, cooling, removing coat, slicing, and sun drying.
Example 2
The treatment effect of the present invention will be further described below with reference to clinical data such as acute toxicity test, long-term toxicity test, pharmacodynamic test, etc. of the present invention:
first, acute toxicity test
(I) test Material
1. Medicine preparation: the preparation of the invention.
2. Animals: the Kunming white mouse has the weight of 20 +/-2 g and can be used for both male and female, is provided by the animal room of the university of traditional Chinese medicine of Heilongjiang, and has the animal qualification number: medical letter No. 09-2-2
(II) methods and results
12 mice are taken, half of each male and female mouse are divided into 3 groups, 4 mice are taken in each group, the gavage is carried out for 0.5 ml/mouse, the concentration is 0.2g/ml, 0.4g/ml and 0.6g/ml (maximum concentration), the mice are continuously observed for 7 days, and the LD50 is not detected. Taking 20 mice, each half of the mice, carrying out intragastric administration for 3 times/day by using the powder of the invention with the maximum concentration of 0.667g/ml and the maximum volume of 0.8ml, continuously observing for 7 days after administration, ensuring that the activity, diet, excrement and fur of the mice are normal and the death and adverse reaction of the mice are not seen, and calculating the maximum tolerance and safety multiple of the mice.
(III) conclusion
Gavage is carried out for 3 times according to the maximum concentration of 0.667g/ml and the maximum volume of 0.8ml, and the maximum tolerance of the powder mouse is 80 g/kg; the daily dosage of the traditional Chinese medicine is 914 times of that of an adult, and no death occurs in 7 days of 20 mice, and no adverse reaction occurs. The test shows that: the powder of the invention is safe and reliable for oral administration.
Second, Long term toxicity test
(I) test Material
1. Medicine preparation: the invention relates to a powder.
2. Reagent: glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase, alkaline phosphatase, total cholesterol, creatinine, urea nitrogen, glucose, total bilirubin, total protein and albumin determination kit, Beijing Zhongsheng bioengineering technology company.
3. Animals: wistar rats weighing 130 ± 10g were provided by the animal house of the university of traditional Chinese medicine, Heilongjiang. Certificate number: the medical letter No. 09-3-3.
4. The instrument comprises the following steps: hitachi 7020 full-automatic biochemical analyzer, Shanghai Changcheng-Kangren medical science Co., Ltd.
(II) methods and results
Taking 80 rats with half male and female, randomly dividing into 4 groups, each group containing 20 rats, administrating with stomach empty in the morning every day with the volume of 10ml/kg, and administrating distilled water to the control group, wherein the low dose group of the powder is 1.0g/kg, and the concentration is 0.10 g/ml; the medium dose group is 2.2g/kg, and the concentration is 0.22 g/ml; the high dose group was 4.4g/kg at a concentration of 0.44g/ml, and the weight was weighed once a week, the dose was adjusted according to the weight, and the administration was continued for 90 days while observing the behavior, diet, and feces of the animals daily. After the administration is finished, half of animals (female and male halves) are taken from each group for hematology and blood biochemical examination; performing histopathological examination on heart, liver, spleen, lung, kidney, brain, uterus, and testis; the rest animals were stopped and kept for two weeks, and hematology and hematochemistry were observed for recovery period. The result shows that the invention has no obvious influence on the hemoglobin content, the red blood cell count, the white blood cell classification, the blood platelet and the blood coagulation time of the rat compared with the control group,
the clinical test of 60 cases in the present example shows the following data:
clinical patients: the group has 60 patients with the age of 60 years at the maximum and 20 patients at the minimum, the number of the patients is 50% at the maximum in 35-45 years, the treatment course has the longest period of 60 days and the shortest period of 30 days, wherein the treatment course has 20 patients from 30 days to 40 days, 20 patients from 41 days to 50 days and 20 patients from 51 days to 60 days, and the clinical manifestations are different: closed fracture, complete or partial interruption, no skin and flesh damage and steel plate fixation;
diagnostic criteria: the diagnosis is made by referring to the relevant contents of the 1993 version of the guidelines on clinical research of Chinese medicine, and all cases are diagnosed by the modern detection means such as laboratory and CT.
The taking method comprises the following steps: the medicine is taken 5 g each time and 3 times a day.
The treatment results are as follows:
48 cases are healed, which accounts for about 80 percent, has obvious effect, basically normal detection indexes of fracture parts,
the effective 7 cases, about 11.6 percent, change or disappear clinical symptoms at the fracture part,
and 5 invalid cases, accounting for 8.3%,
the total effective rate is 91.6%.
The Chinese medicinal preparation is contraindicated:
pregnant women, patients with high fever, hemorrhage, hypertension, and hyperosteogeny.
Claims (3)
1. A preparation method of a traditional Chinese medicine for treating closed fracture is characterized by comprising the following steps:
the weight portions of the components are 5 portions of safflower, 5 portions of frankincense, 5 portions of myrrh, 5 portions of pseudo-ginseng, 5 portions of rhubarb, 5 portions of pawpaw, 5 portions of ground beetle, 5 portions of native copper, 5 portions of Szechwan seaweeds, 5 portions of keel, 5 portions of angelica dahurica, 4 portions of borneol, 5 portions of mistletoe, 5 portions of nux vomica and 5 portions of cortex acanthopanacis,
wherein,
(1) the preparation method of the native copper comprises the following steps:
wrapping Pyritum with iron net, placing into a basin filled with rice vinegar, repeating the above steps for 7 times, and grinding into fine powder;
(2) the preparation method of nux vomica comprises the following steps:
decocting semen Strychni and semen Phaseoli Radiati, boiling semen Phaseoli Radiati, filtering to remove semen Phaseoli Radiati, taking out semen Strychni, soaking in cold water, removing coat, slicing, and sun drying;
(3) grinding the other materials with Pyritum and semen Strychni into fine powder.
2. The traditional Chinese medicine for treating closed fracture prepared by the preparation method of the traditional Chinese medicine for treating closed fracture according to claim 1.
3. The preparation method of the traditional Chinese medicine for treating closed fracture according to claim 1, characterized in that the preparation method of nux vomica is replaced by: frying semen Strychni in oleum Sesami to dark yellow, taking out, cooling, removing coat, slicing, and sun drying.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102824539B (en) * | 2012-08-27 | 2013-12-11 | 王菲菲 | Method of preparing traditional Chinese medicine lotion for treating burning red and purple black type closed fracture |
| CN102824523B (en) * | 2012-08-27 | 2014-01-22 | 许红梅 | Method of preparing traditional Chinese medicine lotion for treating headache type closed fracture |
| CN102824603B (en) * | 2012-08-27 | 2013-09-11 | 刘巧慧 | Preparation method of traditional Chinese medicine lotion for treating cough type closed fracture |
| CN102824604B (en) * | 2012-08-27 | 2014-01-15 | 王小丽 | Method for preparing Chinese medicinal lotion for treating meridian stasis type closed fracture |
| CN102824536B (en) * | 2012-08-27 | 2013-10-16 | 孙岚岚 | Method of preparing traditional Chinese medicine lotion for treating bump type closed fracture |
| CN102824537B (en) * | 2012-08-27 | 2013-10-16 | 张立美 | Method of preparing traditional Chinese medicine lotion for treating stomach anorexia type closed fracture |
| CN103285117B (en) * | 2013-07-08 | 2015-03-25 | 王德利 | Traditional Chinese medicinal combination for treating bone breakage, bone fracture and hairline fracture |
| CN103704817A (en) * | 2013-12-25 | 2014-04-09 | 王凯 | Wild blueberry juice beverage with cancer resistant effect and making method thereof |
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| CN101439127A (en) * | 2007-11-22 | 2009-05-27 | 高光贺 | Pharmaceutical product for treating fracture |
| CN101239131B (en) * | 2008-01-15 | 2010-12-01 | 孟宪铎 | Blood-stasis-dissipating blood-circulation-promoting fast fracture-setting medicament |
| CN101361872A (en) * | 2008-09-28 | 2009-02-11 | 庄仲 | Traditional Chinese medicine for quickly treating bone fracture and postoperative nonunion and delayed healing |
| CN101716266B (en) * | 2010-01-13 | 2011-04-06 | 孟照明 | Medicaments for treating fractures and preparation method thereof |
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