CN101940626A - Chinese medicinal formula preparation for nourishing kidney, removing heat from liver, reducing glucose and regulating lipid and preparation method thereof - Google Patents
Chinese medicinal formula preparation for nourishing kidney, removing heat from liver, reducing glucose and regulating lipid and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal formula preparation for nourishing kidney, removing heat from liver, reducing glucose and regulating lipid and a preparation method thereof, which belong to the technical field of traditional Chinese medicines and health-care foods. The technical scheme is that: a Chinese medicinal formula comprises the following components in percentage by weight: 35 to 40 percent of tremella, 17 to 20.5 percent of mulberry leaf, 17 to 20.5 percent of mulberry, 7 to 9 percent of cassia seed, 8 to 12 percent of prepared tuber of multiflower knotweed and 6 to 8 percent of grosvener siraitia. By a scientific formula and a research on an extraction process, the glucose and lipid regulating functions of a medicinal and edible traditional Chinese medicine are improved, the application time of a western medicine and insulin are delayed, using amounts are reduced, complication is prevented and a modern Chinese medicinal preparation which tastes good and is convenient to store, carry and take is prepared; Chinese herbal medicines which have a wide medicine source, low cost, good synergetic curative effect and small side effect and serve as medicines and foods are selected as formula materials; and the formula has the advantages of reasonable composition, definite treating target, simple preparation process, sweet and slightly bitter preparation taste, convenient carrying, storage and application and suitability for long-term taking by diabetes patients.
Description
Technical field
The present invention relates to a kind of nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation and preparation method thereof, belong to Chinese medicine and health food technology field.
Background technology
(Diabetes Mellitus is because insulin secretion is absolute or relative deficiency DM) to diabetes, and body target tissue or target organ reduce the blood sugar level that causes to the sensitivity of insulin and raise, and can be the metabolic disease of feature with dyslipidemia.Infringement, dysfunction or depletion that hyperglycemia that continues and disorders of lipid metabolism can cause many organs.After one's own heart, the generation of acute complicationses such as the generation of chronic complicating diseases such as brain, extremity vascular, eye, kidney, nerve and ketoacidosis, non-ketosis hyperosmolality syndrome, hypoglycemic coma, severe infection.The serious threat human health brings heavy financial burden for society, family.Diabetes are mainly based on 1 type and type 2 diabetes mellitus, particularly type 2 diabetes mellitus accounts for the 90-95% of diabetes sum, polydipsia, polyphagia, polyuria and " three-many-one-little " syndrome such as lose weight are not true to type, outer unusual easy the failing to pinpoint a disease in diagnosis of lipid metabolism that merge of dehematize carbohydrate metabolism disturbance more.Western medical treatment about type 2 diabetes mellitus is treated based on diet control, motion, blood sugar monitoring, diabetes education and blood sugar lowering, lipid-regulation medicine.At present, western medicine mainly is oral antidiabetic drug and insulin injection, and oral drugs comprise: Drugs Promoting Insulin Secretion, biguanides, a-glycosidase inhibitor, glitazone medicine etc.; Insulinize comprises: the application of ultrashort effect insulin analog, short-acting insulin, intermediate-acting insulins, protamine zine insulin, premix insulin and insulin pump etc.Though current Western medicine has advantage aspect the blood sugar control effect, the painful prolonged application that greatly influences diabetics of its side effect, former inefficacy, secondary inefficacy and long term injections medicine still can not effectively be controlled the generation of chronic complicating diseases.How to improve curative effect, the side effect and the injection that reduce Western medicine are painful, postpone its application time, reduce its consumption, and what delay complication is the key issue that needs us to solve.Given this, find according to a large amount of documents and clinical research, science reinforcement Chinese herbal treatment is one a effective way, particularly diabetics can be with the Chinese medicine of medicine-food two-purpose as treatment means throughout one's life, not only delay injection of insulin, reduce the Western medicine consumption, reduce the Western medicine side effect, but the also generation of complication prevention.
Summary of the invention
The object of the invention provides a kind of nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation and preparation method thereof, improve diabetics sugar, lipid metabolism and delaying complications of diabetes, this magistral medicines source extensively, medicine-food two-purpose, with low cost, coordinating effect good, side effect is little, diabetic is taken for a long time, solves the problems referred to above that background technology exists.
The present invention seeks to realize by following technical scheme:
Nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation, prescription comprises Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae; The percentage by weight of each Chinese medicinal components is as follows: Tremella 35-40%, Folium Mori 17-20.5%, Fructus Mori 17-20.5%, Semen Cassiae 7-9%, Radix Polygoni Multiflori Preparata 8-12%, Fructus Momordicae 6-8%.
The preparation method of nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation comprises following operation:
1. the first step is pulverized Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae respectively, crosses 60 mesh sieves, and it is standby to get the minus sieve material; Each Chinese medicinal components percentage by weight is as follows: Tremella 35-40%, Folium Mori 17-20.5%, Fructus Mori 17-20.5%, Semen Cassiae 7-9%, Radix Polygoni Multiflori Preparata 8-12%, Fructus Momordicae 6-8%;
2. in second step, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata powder are mixed, add 6 times of amounts of weight ratio 60%-80% soak with ethanol 0.5 hour, twice of heating and refluxing extraction, each 2-3 hour, filter filtrate recycling ethanol, powdered extract gets alcohol extract, filters the back medicinal residues and enters the extraction of the 3rd step;
3. the 3rd step, the Fructus Momordicae powder mixed with medicinal residues after the above-mentioned filtration add 8 times of water gagings of weight ratio, extract 2 times, 2-3 hour at every turn, water extract concentrate drying must water extract; Filter back medicinal residues discard;
4. in the 4th step, the Tremella powder amount of increasing the weight of than 20 times of amount 80% ethanol, was soaked 0.5 hour, reflux 1 hour filters, and filtrate recycling ethanol discards and precipitates in the filtrate; Medicinal residues after the filtration add 40 times of water of weight ratio, fry in shallow oil 2 times, and 2-3 hour at every turn, to filter, filtrate concentrates, and adds ethanol to containing alcohol amount 60%-80%, and standing over night is got precipitation, gets the extract of precipitate with ethanol, and the medicinal residues after the filtration discard;
5. in the 5th step, the extract mixing with water extract, alcohol extract and precipitate with ethanol gets powder after drying, the pulverizing, and powder is made nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation.
The extract of precipitate with ethanol is materials such as tremella polysaccharide.
Preparation technology of the present invention can extract nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation effective ingredient, obtain the powder of effective ingredient at last, flour extraction is 20--30%, that is to say, the final effective ingredient powder weight of extracting is the 20--30% of Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae powder weight.
The effective ingredient powder that the present invention extracts with the corresponding medicinal supplementary product compatibility, can be made into capsule, tablet, pill, electuary and granule, is packaged as every bag of 5g.
Effect of the present invention: nourishing kidney liver heat removing, hypoglycemic fat-regulating, relieving constipation.Cure mainly: be mainly used in type 2 diabetes mellitus hyperglycemia, hyperlipidemia and diabetic constipation.Usage: every day 3 times, each 5-10g was in whenever 10-15 minute before the meal warm water delivery service.
The present invention is by scientific formula and Study on extraction, improve sugar, the fat regulating action of medicinal and edible Chinese medicine, delay Western medicine, insulin application time, reduce consumption, the generation of complication prevention, it is pleasant to make taste, preserves, carries, the modern Chinese medicine preparation of taking convenience.
The invention has the beneficial effects as follows: this invention is guidance with the theory of Chinese medical science, with the modern Chinese medicine pharmacological research is foundation, screening and the comparative study of prescription at all times by tens kinds of Chinese medicines, at onset diabetes mechanism, selected that the medicine source is extensive, with low cost, coordinating effect is good, side effect is little for use, be medicine be again that the food herbal variety is as formula material, this formula and prescription is reasonable, therapeutic goal is clear and definite, preparation technology is simple, preparation taste sweetness, little hardship, carry and preserve and use conveniently, diabetic is taken for a long time.Prove that by animal experiment study this side not only has good blood sugar lowering, blood lipid regulation effect, and hepatic and renal function is had good protective action.Said preparation not only is easy to promote at home, and in the world wide promotion prospect is arranged also, and world's diabetics extensive use will obtain good social benefit and economic benefit.
The specific embodiment
The invention will be further described by the following examples.
In an embodiment, nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation, comprise Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae, the percentage by weight of each Chinese medicinal components is as follows: Tremella 35-40%, Folium Mori 17-20.5%, Fructus Mori 17-20.5%, Semen Cassiae 7-9%, Radix Polygoni Multiflori Preparata 8-12%, Fructus Momordicae 6-8%.
The preparation method of nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation comprises following operation:
1. the first step is pulverized Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae respectively, crosses 60 mesh sieves, and it is standby to get the minus sieve material; Each Chinese medicinal components percentage by weight is as follows: Tremella 35-40%, Folium Mori 17-20.5%, Fructus Mori 17-20.5%, Semen Cassiae 7-9%, Radix Polygoni Multiflori Preparata 8-12%, Fructus Momordicae 6-8%.
2. second go on foot, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata powder are mixed, add 6 times of amounts of weight ratio 60%-80% soak with ethanol 0.5 hour, heating and refluxing extraction twice, each 2-3 hour, filter, filtrate recycling ethanol, powdered extract gets alcohol extract; Filter the back medicinal residues and enter the extraction of the 3rd step;
3. the 3rd step, the Fructus Momordicae powder mixed with medicinal residues after the above-mentioned filtration add 8 times of water gagings of weight ratio, extracts 2 times, each 2-3 hour, filtration fetch water extract and concentrate drying got water extract; Filtering the back medicinal residues discards;
4. in the 4th step, the Tremella powder amount of increasing the weight of than 20 times of amount 80% ethanol, was soaked 0.5 hour, reflux 1 hour filters, and filtrate recycling ethanol discards and precipitates in the filtrate; Medicinal residues after the filtration add 40 times of water of weight ratio, fry in shallow oil 2 times, and 2-3 hour at every turn, to filter, filtrate concentrates, and adds ethanol to containing alcohol amount 60%-80%, and standing over night is got precipitation, gets the extract of precipitate with ethanol, and the medicinal residues after the filtration discard.
5. in the 5th step, with the extract mixing of water extract, alcohol extract and precipitate with ethanol, drying gets powder after the pulverizing, and powder is made nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation.
The concrete numerical value of each embodiment component, the amount of preparing powder, color, flavor, quality results see the following form:
The present invention is according to Chinese medical theory record and clinical practice; screen from the kind of Chinese medicine integration of edible and medicinal herbs in conjunction with animal experiment study and to have the glycolipid metabolism of improvement effect medical herbs; formed nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation according to the traditional Chinese medical science principles of formulating prescriptions and Chinese medicine modern pharmacology mechanism of action; it is pleasant to utilize best preparation technology that prescription is made taste; preserve, carry, the modern Chinese medicine preparation of taking convenience; by the type 2 diabetes mellitus pharmacological experiment study; clear and definite its regulated the therapeutic effect of glycolipid, and the diabetic animal hepatic and renal function is had the certain protection effect.The current China and even the world are prevented and treated the significant and broad prospect of application of diabetes.
Claims (4)
1. a nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation is characterized by Chinese medicine preparation and comprises Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae; The percentage by weight of Chinese medicine preparation component: Tremella 35-40%, Folium Mori 17-20.5%, Fructus Mori 17-20.5%, Semen Cassiae 7-9%, Radix Polygoni Multiflori Preparata 8-12%, Fructus Momordicae 6-8%.
2. the preparation method of a nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation is characterized in that comprising following operation:
1. the first step was pulverized 60 mesh sieves with Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae respectively, and it is standby to get the minus sieve material; Each Chinese medicinal components percentage by weight is as follows: Tremella 35-40%, Folium Mori 17-20.5%, Fructus Mori 17-20.5%, Semen Cassiae 7-9%, Radix Polygoni Multiflori Preparata 8-12%, Fructus Momordicae 6-8%;
2. second go on foot, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata powder are mixed, add 6 times of amounts of weight ratio 60%-80% soak with ethanol 0.5 hour, heating and refluxing extraction twice, each 2-3 hour, filter, filtrate recycling ethanol, powdered extract gets alcohol extract; Filter the back medicinal residues and enter the extraction of the 3rd step;
3. the 3rd step, the medicinal residues after the Fructus Momordicae powder and second step filtered mix and add 8 times of water gagings of weight ratio, extract 2 times, and each 2-3 hour, filtration fetch water extract and concentrate drying got water extract; Filtering the back medicinal residues discards;
4. in the 4th step, the Tremella powder amount of increasing the weight of than 20 times of amount 80% ethanol, was soaked 0.5 hour, reflux 1 hour filters, and filtrate recycling ethanol discards and precipitates in the filtrate; Medicinal residues after the filtration add 40 times of water of weight ratio, fry in shallow oil 2 times, and 2-3 hour at every turn, to filter, filtrate concentrates, and adds ethanol to containing alcohol amount 60%-80%, and standing over night is got precipitation, gets the extract of precipitate with ethanol; Medicinal residues after the filtration discard;
5. in the 5th step, the extract mixing with water extract, alcohol extract and precipitate with ethanol gets powder after drying, the pulverizing, and powder is made nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation.
3. according to the preparation method of the described nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation of claim 2, what it is characterized in that described technology extraction is nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation effective ingredient, obtain the powder of effective ingredient at last, flour extraction is 20--30%, that is to say, the final effective ingredient powder weight of extracting is the 20--30% of Tremella, Folium Mori, Fructus Mori, Semen Cassiae, Radix Polygoni Multiflori Preparata, Fructus Momordicae powder weight.
4. according to the preparation method of the described nourishing kidney liver heat removing hypoglycemic fat-regulating Chinese medicine preparation preparation of claim 2, it is characterized in that the effective ingredient powder that extracts, with the corresponding medicinal supplementary product compatibility, can be made into capsule, tablet, pill, electuary and granule, be packaged as every bag of 5g.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010289695 CN101940626A (en) | 2010-09-25 | 2010-09-25 | Chinese medicinal formula preparation for nourishing kidney, removing heat from liver, reducing glucose and regulating lipid and preparation method thereof |
| CN2011101326283A CN102198174B (en) | 2010-09-25 | 2011-05-23 | Traditional Chinese medicine formulated preparation for nourishing kidney, removing heat from liver, reducing sugar and regulating fat, and preparation method thereof |
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| CN 201010289695 CN101940626A (en) | 2010-09-25 | 2010-09-25 | Chinese medicinal formula preparation for nourishing kidney, removing heat from liver, reducing glucose and regulating lipid and preparation method thereof |
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| CN101940626A true CN101940626A (en) | 2011-01-12 |
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| CN 201010289695 Pending CN101940626A (en) | 2010-09-25 | 2010-09-25 | Chinese medicinal formula preparation for nourishing kidney, removing heat from liver, reducing glucose and regulating lipid and preparation method thereof |
| CN2011101326283A Expired - Fee Related CN102198174B (en) | 2010-09-25 | 2011-05-23 | Traditional Chinese medicine formulated preparation for nourishing kidney, removing heat from liver, reducing sugar and regulating fat, and preparation method thereof |
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| CN2011101326283A Expired - Fee Related CN102198174B (en) | 2010-09-25 | 2011-05-23 | Traditional Chinese medicine formulated preparation for nourishing kidney, removing heat from liver, reducing sugar and regulating fat, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104547970A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Health traditional Chinese medicine for reducing blood pressure, promoting blood circulation and realizing high immunity and making method of health traditional Chinese medicine |
| CN112316060A (en) * | 2020-12-02 | 2021-02-05 | 曾凡伟 | Traditional Chinese medicine composition for protecting liver |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813910A (en) * | 2005-02-05 | 2006-08-09 | 北京北大维信生物科技有限公司 | Medicinal composition with blood sugar reducing action and its preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1227728A (en) * | 1998-03-01 | 1999-09-08 | 夏佩珊 | Flavouring nutritive health food capable of refreshing oneself, relieving summer heat and curing disease |
| CN1919036A (en) * | 2005-05-23 | 2007-02-28 | 吴跃飞 | Green health care animal foodstuff produced by living animal bioreactor and producing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1813910A (en) * | 2005-02-05 | 2006-08-09 | 北京北大维信生物科技有限公司 | Medicinal composition with blood sugar reducing action and its preparing method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547970A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Health traditional Chinese medicine for reducing blood pressure, promoting blood circulation and realizing high immunity and making method of health traditional Chinese medicine |
| CN112316060A (en) * | 2020-12-02 | 2021-02-05 | 曾凡伟 | Traditional Chinese medicine composition for protecting liver |
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| CN102198174B (en) | 2012-07-25 |
| CN102198174A (en) | 2011-09-28 |
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Open date: 20110112 |