CN101933937A - Application of low molecular citrus pectin in clinic lead discharge and heavy metal discharge - Google Patents
Application of low molecular citrus pectin in clinic lead discharge and heavy metal discharge Download PDFInfo
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- CN101933937A CN101933937A CN2010102261135A CN201010226113A CN101933937A CN 101933937 A CN101933937 A CN 101933937A CN 2010102261135 A CN2010102261135 A CN 2010102261135A CN 201010226113 A CN201010226113 A CN 201010226113A CN 101933937 A CN101933937 A CN 101933937A
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Abstract
The invention relates to a new application of low molecular citrus pectin, in particular to the application of low molecular citrus pectin for treating and preventing lead and heavy metal poisoning in prepared medicines, foods and health care products. The low molecular citrus pectin is a compound prepared from soluble dietary fiber and galacturonic acid, the polysaccharide derivative is used as a metal ion absorbent (chelating agent), has absorption action on heavy metal ions, can remove heavy ions, such as Zn2+, Cu2+, Cd2+, Ag+, Cr3+, Ni2+, Hg2+, Pb2+ and the like. The low molecular citrus pectin is different from common chemical chelating agents; proved by animal and clinic experiments, lead, mercury and arsenic are discharged out of human bodies during toxin discharge, and the key level of calcium, magnesium, zinc or other minerals can not be influenced. The natural chelating function of the low molecular citrus pectin is a most ideal and successful solution for heavy metal pollution in the human body at present. Thus, the low molecular citrus pectin has the function of preventing various diseases and especially has special functions of clearing away harmful cells and discharging toxins in the human body.
Description
Technical field
The present invention relates to a kind of new purposes of low molecular citrus pectin, relate in particular to low molecular citrus pectin treatment and prevention lead and the application of heavy metal poisoning in medicine, food and the health product of preparation.
Background technology
Natural citrus pectin is a kind of polysaccharides compound (a long-chain carbohydrate), also is a kind of dietary fiber.It obtains by extracting in the peel of natural citrus fruit such as Fructus Citri Limoniae, Fructus Citri grandis, Fructus Citri tangerinae and Fructus Citri tangerinae and the sarcocarp.The long-chain product of this polysaccharide has many branches, has adhesion function.Natural pectin is soluble fiber, can not be by intestinal absorption after eating.Although some are arranged in big enteral fermentation, natural citrus pectin does not generally have very effective function for human body.
Low molecular citrus pectin, its structural formula is as follows:
Low molecular citrus pectin is that a kind of that extraction obtains from natural pectin product is the polysaccharide of Main Ingredients and Appearance with the galactose, and molecular weight is little, no antigen, and good water solubility is entered blood circulation by gastrointestinal absorption easily.Pectin molecule amount after the processing is significantly less than natural pectin, and molecular structure also obtains changing because of methyl reduces.It has with malignant phenotype's cell affine, and adhesion characteristics kills and wounds the function of mutant cell specifically, and mutant cell promptly was eliminated before not forming.This less polysaccharide group can also be combined in tightly on the cancer cell membrane surface can with the bonded specific part of galactose, form a kind of special complex, and stop gathering and mutant cell between mutant cell to adhere to contiguous cell and tissue.
The applicant has applied for that patent name is: the application (number of patent application is 200610050803.3) that low molecular citrus pectin is used for raise immunity discloses obviously improving appetite of low molecular citrus pectin, increases immunologic function and regulates immunologic derangement; Energy cholesterol reducing prevention of arterial is atherosis.
Patent name is: the application (200610051667.X) that low molecular citrus pectin is used for the blood sugar regulation blood fat and improves fatty liver discloses low molecular citrus pectin can delay sugar and the absorption of fat in digestive tract, influence the metabolism of cholic acid, changed the activity of lipid metabolism enzyme indirectly, can also promote sugar and fat metabolism in vivo, thereby blood sugar lowering and blood fat, in absorption and after entering blood circulation, can promote the sugar in liver and other organ and the activity of lipolytic enzyme in vivo, and the sugar in reduction liver and other organ and the activity of lipese, thereby reach blood sugar lowering and blood fat, the purpose of treatment diabetes and fatty liver.
Summary of the invention
In order further to develop the purposes of low molecular citrus pectin, the purpose of this invention is to provide the new application of low molecular citrus pectin.
Specifically, first purpose of the present invention provides the application that low molecular citrus pectin is used for preparing the medicine of arranging heavy metal element.
The heavy metal element that relates in particular to be in copper, zinc, ferrum, cobalt, nickel, manganese, cadmium, hydrargyrum, tungsten, molybdenum, gold, silver, arsenic and the lead one or more.
The most effectively heavy metal element be in lead, arsenic, hydrargyrum and the cadmium one or more.
Specifically, second purpose of the present invention provides the application that low molecular citrus pectin is used for preparing the health product of arranging heavy metal.
The heavy metal element that relates in particular to be in copper, zinc, ferrum, cobalt, nickel, manganese, cadmium, hydrargyrum, tungsten, molybdenum, gold, silver, arsenic and the lead one or more.
The most effectively heavy metal element be in lead, arsenic, hydrargyrum and the cadmium one or more.
Specifically, the 3rd purpose of the present invention provides low molecular citrus pectin and is used to prepare the Application in Food of arranging heavy metal.
The heavy metal element that relates in particular to be in copper, zinc, ferrum, cobalt, nickel, manganese, cadmium, hydrargyrum, tungsten, molybdenum, gold, silver, arsenic and the lead one or more.
The most effectively heavy metal element be in lead, arsenic, hydrargyrum and the cadmium one or more.
The low molecular citrus pectin Citrus are complexs that a kind of water soluble dietary fiber galacturonic acid is formed, and this polysaccharide derivates can be removed Zn as metal ion adsorbent (intercalating agent), heavy metal ion is had good adsorption
2+, Cu
2+, Cd
2+, Ag
+, Cr
3+, Ni
2+, Hg
2+, Pb
2+Etc. heavy metal ion.The advantage of low molecular citrus pectin maximum of the present invention is that it is different with general chelating agent, confirms it is deleading when toxin expelling is plain through animal and clinical experiment, hydrargyrum, and arsenic excretes, and can not influence other as calcium, magnesium, the critical levels of zinc or mineral.Its natural chelating function is that the most successful the most desirable solution heavy metal is polluted scheme in vivo at present.Therefore, have the multiple function of diseases of prevention, the eliminating to harmful cell removing and vivotoxin has specific function especially.
Description of drawings
Fig. 1 is that 5-12 year hospitalized child low molecular citrus pectin treatment (5 grams/time, 3 times/day) is preceding, back serum lead concentration measurement (microgram/decilitre. graphite oven atomic absorption).
Fig. 2 is that 5-12 year hospitalized child low molecular citrus pectin treatment (5 grams/time, 3 times/day) is preceding, back twenty-four-hour urine lead excretion level (microgram/decilitre).
Fig. 3 measures in the serum mean time variation percentage ratio (n=7) of excretory lead in the lead and twenty-four-hour urine for 5-12 year child accepts 15 gram/sky MCP treatment 2-4 after week.
Fig. 4 is that the MCP monosaccharide of HPAEC-PAD behind methanol is analyzed.The calculating of the monosaccharide relative quantity that obtains from analysis (mole %) is respectively galactose 6.6%, rhamnose 2.2%, arabinose 1.3%, xylose 0.5%, glucose 0.3%, fucose 0.1%, galacturonic acid 88.2% and glucuronic acid 0.4%.Inositol is as an internal standard.
Fig. 5 is that element is drained result's (since percentage ratio change of 0 day) in first day urine.
Fig. 6 is that element is drained result's (since percentage ratio change of 0 day) in the 7th day urine.
The specific embodiment
Below in conjunction with accompanying drawing the specific embodiment of the present invention is made a detailed explanation.
Lead poisoning is a problem that the whole world gives more sustained attention, and the easiest The Long-term Effect that is subjected to plumbous exposure of child presses for a safety and effective heavy metal chelant overcomes heavy metal and lead joint touches, i.e. the challenge of facing their every day.
Purpose 1: this clinical research is to determine whether with the oral child's blood lead poisoning that can reduce by 5 to 12 years old effectively of low molecular citrus pectin.
Method: measure the hospitalized child that the serum lead level is higher than 20 microgram/decilitres by GFAAS, do not give any chelating and/or antidote in preceding 3 months, the low molecular citrus pectin that restrain every day 15 divides to give for 3 times.Collected the 0th day, and 14 days, 21 days, carried out the sampling Graphite Furnace Atomic Absorption analysis with 28 days serum and twenty-four-hour urine liquid.
Result: studies show that originally (P=0.0016's level of serum lead sharply descends; Average plumbous (the P=0.0007 that significantly increases that changes in the urine that reaches collection in 161%, 24 hour; Average increase by 132%).
Conclusion: need a gentleness, the heavy metal chelant of safety, particularly, very important to the child of high strength contact heavy metal in the long-range circumstances.Low molecular citrus pectin application safety and effectively remarkable result, not untoward reaction, observed having no adverse reaction in the report that was used in the adult in the past shows that low molecular citrus pectin can become a such preparation.Further research remains to be confirmed that its benefit is rational.
Materials and methods
This research is in China, Hangzhou, and children's hospital of Zhejiang University carries out.7 patients that meet research standard enter this research.All patient's blood lead concentrations all＞20 microgram/decilitres, do not use any chelating agen and/or antidote in 3 months in advance.Father/mother or each child guardian sign Informed Consent Form, participate in the development test of the clinical hospital of this open-label supervision.
The patient accepts the low molecular citrus pectin of 15 grams every day, divides and takes for 3 times.There are not other any chelatings or antidote to use simultaneously in 3 months between observation=k-phase b.Total lead in urine excretion of blood lead concentration and 24 hours periods is with sampling Graphite Furnace Atomic Absorption.
Spectrum (GFAAS) is measured; Before low molecular citrus pectin begins to use is the 0th day, leaves hospital after patient is normal once in a week afterwards.Wherein two patients left hospital after 2 weeks; 3 patients left hospital after 3 weeks; Leave hospital discharged patient's Pb-B＜20 microgram/decilitres after 24 weeks.
Patient's while in hospital, estimate therapeutic process, comprise subjective symptom: any new symptom, take place in the deterioration of reveal any symptoms or improvement;
Comprise potential untoward reaction, as headache, diarrhoea is backflowed or other gastrointestinal upset cardiopalmus, or liquid holdup.Take general hemanalysis and monitoring untoward reaction; The result is not included in this report, because of not finding abnormal result.In this children's research,, do not give any special diet according to their condition.Carry out the analysis of MCP monosaccharide with methanol high performance anion exchange chromatography method and pulse Amperometric Detection Coupled (HPAECPAD).With wearing peace DX-500 system (Dai An company, Sani Wei Er, California), the PA-20 post comprising CarboPac carries out with 0.5 ml/min.Neutral and acid monosaccharide separates by single and uses the mobile phase operation, with the sodium hydroxide balance of 14mM 13 minutes, is the sodium hydroxide operation 30 minutes of 100mM then in the sodium acetate gradient of 0-120mM.This mobile phase turned back to the 14mM sodium hydroxide 40 minutes in next time before the injection.Other condition is identical with former report.
The result
Table 1 has been summed up at the blood lead concentration for the treatment of with low molecular citrus pectin before and after.Plumbous significantly minimizing in all 7 patient bloods.
Fig. 1 has shown that the blood lead concentration is in the variation of measurement in 0 day and excretory peak period in therapeutic process.Adopting paired sample to carry out statistical analysis with average finds differences and is showing very much (P=.0016).
Table 2 is summed up in the patient process and to be measured to excretory peak period 24 hours total lead in urine excretions and excretory peak from the 0th day.
Fig. 2 has shown when treatment from twenty-four-hour urine excretion variation in the 0th day.Adopt average paired sample statistical analysis
Discovery has highly significant meaning (p=.0007).Report has no adverse reaction.3 below 5 years old (2.5-3.5 year) with the low molecular citrus pectin treatment, but is not included in this research, because they are outside age criterion.They have similar result, also do not have the untoward reaction report.
Fig. 3 shows that patient organizes the lead content average percent variation in the urine of blood and collection in 24 hours.
Fig. 4 has shown the monosaccharide chromatography, shows the galacturonic acid of low molecular citrus pectin composition 88.2%.The low-molecular-weight of other low molecular citrus pectin monosaccharide, debranching enzyme, stream low fat degree and sugar II of low Mus season (10%) are consistent with the pectin structure that M reported in the past.
Table 1 serum lead concentration data
24 hours plumbous data of draining of table 2 urine
In sum, low molecular citrus pectin of the present invention is a kind of soluble fiber, adopts the most modern enzymatic degradation technology to obtain small molecule structure, directly enters the blood of human body circulation, and Plumbum removing is effective, speed is fast.Can effectively reduce blood lead, and drive away the lead in skeleton and the tissue, stop Plumbum absorption.High selectivity.Only get rid of harmful heavy metal ions such as lead, and do not influence the absorption metabolism of human body beneficial's metal ion.
This clinical research is to determine whether with the oral heavy metal toxicity that can be lowered into effectively in the human urine of low molecular citrus pectin.
1 low molecular citrus pectin to urine in the excretory influence of poisonous element:
Method:
10 patients take in 15 gram low molecular citrus pectins every day, and 7 days by a definite date, the 8th day to 20 grams
Collecting urine specimen in 24 hours measures: beginning in the 0th day the 1st day, the 7th day.
Analyze column element down with icp ms (ICP-MS): calcium, magnesium, zinc, aluminum, arsenic, cadmium, calcium, hydrargyrum and lead.
The result;
As shown in Figure 5, first twenty-four-hour urine arsenic is drained and is being shown increase (above 35% of average baselining (0 day); P＜0.05), hydrargyrum and cadmic drainage remarkable (55% and 135%; P＜0.1)
As shown in Figure 6, the 8th day, cadmium was drained and is being shown increase (45%, p＜0.05).In addition, plumbous drainage, show showing very much increase (426%, P=0.05)
Calcium, magnesium, ferrum, selenium, zinc element does not have to show and changes.
Method:
The human clinical trial studies 8 routine patients
Health total mercury amount benchmark is measured the method that is to use dimercapto-1-propane sulfonic acid (two mercaptos, third sulphur) to select.
Low molecule citrus pectin oral dose every day is 15 grams,
After low molecule citrus pectin treatment, measure health total mercury amount with identical two mercaptos, the third sulphur selection method.
The result:
Take in 15 gram citrus pectin table explanations every day:
The result that low molecule citrus pectin treatment back reduces mercury content in the body sums up
All experimenters show mercury content and are showing and descend.Average drop range is 72.17%, scope 38.13%-84.83% (P=0.0313), without any side effect.
Claims (9)
1. low molecular citrus pectin is used for preparing the application of the medicine of arranging heavy metal element.
2. low molecular citrus pectin according to claim 1 is used for preparing the application of the medicine of arranging heavy metal element, it is characterized in that: heavy metal element be in copper, zinc, ferrum, cobalt, nickel, manganese, cadmium, hydrargyrum, tungsten, molybdenum, gold, silver, arsenic and the lead one or more.
3. low molecular citrus pectin according to claim 2 is used for preparing the application of the medicine of arranging heavy metal element, it is characterized in that: heavy metal element be in lead, arsenic, hydrargyrum and the cadmium one or more.
4. low molecular citrus pectin is used for preparing the application of the health product of arranging heavy metal.
5. low molecular citrus pectin according to claim 4 is used for preparing the application of the health product of arranging heavy metal element, it is characterized in that: heavy metal element be in copper, zinc, ferrum, cobalt, nickel, manganese, cadmium, hydrargyrum, tungsten, molybdenum, gold, silver, arsenic and the lead one or more.
6. low molecular citrus pectin according to claim 5 is used for preparing the application of the health product of arranging heavy metal element, it is characterized in that: heavy metal element be in lead, arsenic, hydrargyrum and the cadmium one or more.
7. low molecular citrus pectin is used to prepare the Application in Food of arranging heavy metal.
8. low molecular citrus pectin according to claim 7 is used to prepare the Application in Food of arranging heavy metal element, it is characterized in that: heavy metal element be in copper, zinc, ferrum, cobalt, nickel, manganese, cadmium, hydrargyrum, tungsten, molybdenum, gold, silver, arsenic and the lead one or more.
9. low molecular citrus pectin according to claim 8 is used to prepare the Application in Food of arranging heavy metal element, it is characterized in that: heavy metal element be in lead, arsenic, hydrargyrum and the cadmium one or more.
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| CN102380348A (en) * | 2011-09-21 | 2012-03-21 | 湖南大学 | Pectin modified magnetic nano-adsorbent and preparation method and application thereof |
| CN103005468A (en) * | 2012-11-06 | 2013-04-03 | 天津科技大学 | Preparation method of crataegus pinnatifida insoluble dietary fiber-calcium and zinc chelate |
| WO2013127146A1 (en) | 2012-02-28 | 2013-09-06 | 江南大学 | Lactobacillus plantarum able to relieve lead toxicity and use thereof |
| RU2642674C1 (en) * | 2017-02-21 | 2018-01-25 | Федеральное бюджетное учреждение науки "Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора) | Method for increase of organism resistance to combined toxic action of nanoparticles of copper, zinc and lead oxides |
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| RU2694844C1 (en) * | 2018-03-29 | 2019-07-17 | Федеральное бюджетное учреждение науки "Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора) | Method for increasing body resistance to general toxic and genotoxic action of a combination of aluminum, titanium and silicon oxide nanoparticles |
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| RU2784169C1 (en) * | 2021-12-08 | 2022-11-23 | Федеральное бюджетное учреждение науки "Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора) | Method of increasing the resistance of the body to the harmful effects of a toxic combination polluting the workspace air and the surrounding atmosphere with relation to the activities of blister copper manufacture |
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2010
- 2010-07-13 CN CN2010102261135A patent/CN101933937A/en active Pending
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380348A (en) * | 2011-09-21 | 2012-03-21 | 湖南大学 | Pectin modified magnetic nano-adsorbent and preparation method and application thereof |
| WO2013127146A1 (en) | 2012-02-28 | 2013-09-06 | 江南大学 | Lactobacillus plantarum able to relieve lead toxicity and use thereof |
| CN103005468A (en) * | 2012-11-06 | 2013-04-03 | 天津科技大学 | Preparation method of crataegus pinnatifida insoluble dietary fiber-calcium and zinc chelate |
| RU2642674C1 (en) * | 2017-02-21 | 2018-01-25 | Федеральное бюджетное учреждение науки "Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора) | Method for increase of organism resistance to combined toxic action of nanoparticles of copper, zinc and lead oxides |
| RU2694844C1 (en) * | 2018-03-29 | 2019-07-17 | Федеральное бюджетное учреждение науки "Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора) | Method for increasing body resistance to general toxic and genotoxic action of a combination of aluminum, titanium and silicon oxide nanoparticles |
| CN109007822A (en) * | 2018-08-07 | 2018-12-18 | 青岛明月海藻生物科技有限公司 | A kind of absorption, the diet fiber composition for excluding internal heavy metal and its preparation method and application |
| CN112220850A (en) * | 2019-07-14 | 2021-01-15 | 北京恒润泰生医药科技有限公司 | Pomelo flesh water extract powder, preparation, mercury discharging function and application thereof |
| RU2784169C1 (en) * | 2021-12-08 | 2022-11-23 | Федеральное бюджетное учреждение науки "Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора) | Method of increasing the resistance of the body to the harmful effects of a toxic combination polluting the workspace air and the surrounding atmosphere with relation to the activities of blister copper manufacture |
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Application publication date: 20110105 |