CN101928435A - Macromolecular sustained-release multifunctional reinforced film and preparation method thereof - Google Patents
Macromolecular sustained-release multifunctional reinforced film and preparation method thereof Download PDFInfo
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- CN101928435A CN101928435A CN2010102624073A CN201010262407A CN101928435A CN 101928435 A CN101928435 A CN 101928435A CN 2010102624073 A CN2010102624073 A CN 2010102624073A CN 201010262407 A CN201010262407 A CN 201010262407A CN 101928435 A CN101928435 A CN 101928435A
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Abstract
The invention discloses a macromolecular sustained-release multifunctional reinforced film and a preparation method thereof. The film comprises 0.05 to 2.50 percent of polyvinyl pyrrolidone, 0 to 2.0 percent of polyquaternium, 0.1 to 10.0 percent of sodium laureth sulfate, 0.1 to 6.0 percent of macromolecular acrylic polymer, 0.3 to 6.0 percent of glycerin, 0.02 to 0.10 percent of tea tree oil, 0.1 to 6.0 percent of cocamidopropyl betaine, 0.3 to 6.0 percent of polyoxyethylene rapeseed oil amide, 1.0 to 5.0 percent of lauryl sulfate triethanolamine salt, 0.3 to 3.0 percent of propylene glycol, 0 to 30 percent of ethanol, 0 to 2.0 percent of cellulose hydroxyethyl ether, 0 to 2.0 percent of dimethyl siloxane polyether and the balance of deionized water. The film can isolate various chemical substances and visible spots with long effect, and has the effects of nourishing, sterilizing and protecting the skin.
Description
Technical field
The present invention relates to polymeric material field, be specifically related to one group of compound and preparation method thereof, more specifically relate to a kind of object and human body skin surface sustained-release multifunctional reinforced film and preparation method thereof of being used for.
Background technology
Slow controlled-release technology promptly slowly spreads, discharges the effect that reaches long-acting slow-release by effective constituent in its internal system.At present, the slow controlled-release technology of using comparative maturity is slowly controlled-release technologies of microcapsule, secondly is the macromolecular sustained-release technology.
The slow controlled-release technology of microcapsule is to adopt microcapsule with nucleus parcel, dispersion, slowly dissolves, breaks, discharges under specific environment, thereby reach the long-acting slow-release effect.Proposed to be applicable to that from November, 1936 Atlantic Ocean seashore fishery (Atlantic Coast Fishers) patent application that preparation contains Oils,glyceridic,cod-liver gelatin microcapsule so far in whiteruss, be widely used in fields such as biological medicine, agricultural chemicals, food, makeup, initial purpose just is used for prolong drug action time in vivo.Except that indivedual makeup; the slow controlled-release technology of microcapsule also is not widely used in developing the functional product that is applied to skin surface and body surface; to improve the timeliness of functional ingredient; this mainly owing to microcapsulary because its granulating characteristics, can't overcome himself and body surface and skin surface bonded stability, burnish resistance, stability and the long defective of holding time.
The principle of the slow controlled-release technology of macromolecular sustained-release technology and microcapsule is similar, is to disperse or dissolve effective constituent with high molecular polymer as carrier, by effective constituent within it portion slowly spread, discharge the effect that reaches long-acting slow-release.At present, this technology has been used to fields such as spices, scent, does not obtain good stability and possesses the polymer carrier of good biocompatibility and can't be successfully applied to human body skin surface and body surface owing to still there are the effective technology means.
Summary of the invention
The objective of the invention is to develop a kind of be applied to body surface and human body skin surface, can the multiple chemical substance that is corrosive of long-acting isolation, and chemical stability is strong, good biocompatibility and safe macromolecular sustained-release multifunctional reinforced film.
Each moiety of macromolecular sustained-release film and degree involved in the present invention are: Polyvinylpyrolidone (PVP) 0.05%～2.50%, polyquaternium 0～2.00%, Tegosept M 0～0.1%, propylben 0%～0.05%, laureth sodium sulfovinate 0.1%～10.0%, high molecular weight acrylic polymkeric substance 0.1%～6.0%, glycerol 0.3%～6.0%, tea tree oil 0.02%～0.10%, AMONYL 380LC 0.1%～6.0%, Polyoxyethylatad Rape Oil acid amides 0.3%～6.0%, lauryl sulfate triethanolamine salt 1.0%～5.0%, propylene glycol 0.3%～3.0%, ethanol 0%～30.0%, natrosol 0～2.0%, dimethyl siloxane polyethers 0～2.0%, flavouring agent 0.05%～0.50%, surplus is deionized water.
Technical process involved in the present invention is:
(1) preparation DS solution
In deionized water, slowly add the laureth sodium sulfovinate, at room temperature be stirred to its complete dispersing and dissolving, get A solution; In propylene glycol, add ethanol, add 2,4,4 '-three chloro-yl diphenyl ethers again, at room temperature mix to it and dissolve fully, get B solution; Solution B is slowly added in the solution A, stir and get DS solution after five minutes.
(2) preparation CS solution
In deionized water, slowly add laureth sodium sulfovinate, tea tree oil, AMONYL 380LC, Polyoxyethylatad Rape Oil acid amides and lauryl sulfate triethanolamine salt in order successively, at room temperature mix to its complete dispersing and dissolving, get solution C; In propylene glycol, add ethanol, Tegosept M, propylben and glycerol, at room temperature mix to its complete dispersing and dissolving, get solution D; Solution D is slowly added in the solution C, stir and get CS solution after five minutes.
(3) preparation FS solution
In deionized water, slowly add Polyvinylpyrolidone (PVP), polyquaternium, evenly stirred continuously and healthily 30-40 minute, until complete dispersing and dissolving, get solution E, the dimethyl siloxane polyethers is heated to 40 ℃, slowly put into solution E, be stirred well to its complete dispersing and dissolving, get FS solution.
(4) preparation BS solution
In deionized water, slowly add natrosol, evenly stirred continuously and healthily 60 minutes, behind its complete dispersing and dissolving, under the state that keeps stirring, slowly add the high molecular weight acrylic polymkeric substance, equally behind its complete dispersing and dissolving, slowly add laureth sodium sulfovinate, AMONYL 380LC, Polyoxyethylatad Rape Oil acid amides, lauryl sulfate triethanolamine salt, glycerol, ethanol successively, optionally add flavouring agent, continue at the uniform velocity to be stirred to its complete dispersing and dissolving, get BS solution.
(5) preparation finished product
After keeping in BS solution, slowly adding FS solution, CS solution, DS solution successively under the state that stirs, fully stirring 15 minutes, add ethanol and deionized water, fully stirred again 60 minutes, leave standstill and promptly got the finished product in 12 hours.
When macromolecular sustained-release film of the present invention is applied to body surface and human body skin surface; can form one deck cryptomorphic ecological protection film on its surface fast; and have excellent biological compatibility and chemical stability; this rete can combine closely with skin or body surface, and to the effect of playing prolongation action time of the functional ingredient of its load (as sterilization, nourish to become to grade).
After macromolecular sustained-release film of the present invention is applied to the human body skin surface; can reach a few hours isolates various corrosive chemicals (comprising solid-state or fluent meterials such as strong acid, highly basic); and various visible spots (comprising paint, greasy dirt, metallic dust, tackiness agent etc.), protection skin is not subjected to the corrosion or the adhesion of chemical substance or spot.For there being spot to be attached to film surface, soil release both can have been saved water with less water, protected environment again.Simultaneously, the sterilization of rete internal burden and nourish composition and can continue a few hours and work.
The related product of the present invention can play effective provide protection with relevant practitioners' such as maintenance, chemical industry, automobile making, aircraft manufacturing and maintenance, shipbuilding and maintenance, paint spraying, bio-pharmaceuticals Occupational health protection to army rear service guarantee, mechanical workout, starts the new situation of Occupational health protection.
The present invention has filled up will delay the blank that controlled-release technology is applied to body surface and human body skin surface, by different effective constituent is added in the slow-released system, the wide development application prospect is arranged at numerous areas such as public health and Occupational health protection, PCO, cosmetic skin care and pharmaceutical industrieies.
Embodiment
The present invention is further elaborated with test below in conjunction with embodiment, but these embodiment and test example never are any limitation of the invention.
Embodiment 1
Prescription one: Polyvinylpyrolidone (PVP) 0.50%, polyquaternium 0.1%, Tegosept M 0.06%, propylben 0.01%, laureth sodium sulfovinate 2.5%, 2,4,4 '-three chloro-yl diphenyl ethers 0.3%, high molecular weight acrylic polymkeric substance 1%, glycerol 1.33%, tea tree oil 0.06%, AMONYL 380LC 1.33%, Polyoxyethylatad Rape Oil acid amides 2%, lauryl sulfate triethanolamine salt 3.33%, propylene glycol 0.79%, ethanol 10%, natrosol 0.7%, dimethyl siloxane polyethers 0.8%, spices 0.15%, all the other are deionized water.According to the product that technical process is made, be applied to skin surface after, greater than 5h, product is nontoxic non-stimulated to effective isolation time of the various chemical substances that are corrosive.
Embodiment 2
Prescription two: Polyvinylpyrolidone (PVP) 0.4%, polyquaternium 0.1%, Tegosept M 0.06%, propylben 0.01%, laureth sodium sulfovinate 1.5%, 2,4,4 '-three chloro-yl diphenyl ethers 0.3%, high molecular weight acrylic polymkeric substance 1%, glycerol 1.33%, tea tree oil 0.06%, AMONYL 380LC 1.0%, Polyoxyethylatad Rape Oil acid amides 2%, lauryl sulfate triethanolamine salt 2.33%, propylene glycol 0.59%, ethanol 6%, natrosol 0.5%, dimethyl siloxane polyethers 0.8%, spices 0.15%, all the other are deionized water.According to the product that technical process is made, be applied to skin surface after, greater than 3h, product is nontoxic non-stimulated to effective isolation time of the various chemical substances that are corrosive.
The isolation chemical classes determination test of test example 1 macromolecular sustained-release film
Supply test agent: adopt the product of producing according among the embodiment 1.
Test method: the volunteer cleans up hand earlier, treats that hand is dry and comfortable fully, and the 1.5mL given the test agent evenly is applied in the both hands skin surface, can test behind 1～2min.Draw the 2mL fluid drips in (or putting into beaker with suction pipe with weighing 2g pressed powder, with key pressed powder is transferred to) volunteer's hand skin surface, outwell liquid after stopping 2min, should outwell liquid (pressed powder) immediately, and towel off and wipe away the back and wash with big water gaging if uncomfortable situation occurs.Observe the damaged situation of skin and record volunteer's personal feeling.Every kind of solid or solution are tested with 3 people.
Test result: see Table 1.
Conclusion: given the test agent not only has isolation effect preferably to various strong acid, highly basic, simultaneously, the solution and the solid of severe corrosive is all had stronger isolating and protecting effect.
Table 1 macromolecular sustained-release film is to the isolation effect of various chemical substances
The isolating and protecting aging test of test example 2 macromolecular sustained-release films
Supply test agent: adopt the product of producing according in embodiment 1 and the embodiment 2.
Test method: the volunteer evenly smears sample behind the hand skin surface, stops respectively and measures the effect that it isolates chemical substance behind 2h, 3h, 4h, 5h and the 6h.Each test is 3 people.Observe the damaged situation of skin and record volunteer's personal feeling.
Test result: see Table 2 and table 3.
Conclusion: after given the test agent is applied in skin surface, can continue more than 3～5h to various strong acid and strong bases and mordant liquid and solid isolation time.
Table 2 macromolecular sustained-release film isolating and protecting aging test result (1)
Table 3 macromolecular sustained-release film isolating and protecting aging test result (2)
The toxicological experiment (one) of test example 3 macromolecular sustained-release films
The acute skin irritation test
Supply test agent: adopt the product of producing according among the embodiment 1.
Animal subject: rabbit is planted by New Zealand, and 3, body weight 2.4～2.8Kg is provided by laboratory animal field, the south of the River, curry favour mountain, Wuxi.
Test method: 24h before the test, rabbit backbone both sides are cut by hair, must not injured skin.Unhairing scope left and right sides Ge Yue 3cm * 3cm.Drip this product 0.5mL on the two-layer gauze of 2.5cm * 2.5cm size and apply ointment or plaster at the left side skin surface next day, covers with the non-stimulated oilpaper of one deck then, fixed with non-stimulated gauze again, and right side unhairing district skin is as the blank group.The time of applying ointment or plaster is 4 hours.After the off-test, remove the residual thing that tried with warm water.Remove respectively and tried behind the thing 1,24,48 hour, observe the local skin reaction, carry out skin irritation reaction scoring.
Test-results: by table 4 as seen, this sample is to intact skin stimulation test of rabbit, and stimulus intensity belongs to nonirritant.
Table 4 rabbit skin irritant test result
The toxicological experiment (two) of test example 4 macromolecular sustained-release films
Acute oral toxicity test
Supply test agent: adopt the product of producing according among the embodiment 1.
Test method:, get the ICR mouse of 20 about 18～22g of body weight and test according to 2.3.1 bar in " disinfection technology standard " (Ministry of Health 2006).Mouse fasting overnight is 16 hours before the test, can't help water.Adopt and irritate the stomach and intestine mode, tried thing by 20ml/kgBW, per os is once irritated stomach, and poisoning dosage is 5000mg/kg BW.Observed 14 days continuously, observe and write down performance and the death condition that animal poisons.
Table 5 acute oral toxicity test result
Test-results: animal no abnormality seen in the process of the test, test-results sees Table 5
Conclusion: this sample LD
50＞5000mg/kgBW, true border is nontoxic.
Claims (2)
1. macromolecular sustained-release multifunctional reinforced film, comprise: Polyvinylpyrolidone (PVP) 0.05%～2.50%, polyquaternium 0～2.0%, Tegosept M 0～0.1%, propylben 0%～0.05%, laureth sodium sulfovinate 0.1%～10.0%, high molecular weight acrylic polymkeric substance 0.1%～6.0%, glycerol 0.3%～6.0%, tea tree oil 0.02%～0.10%, AMONYL 380LC 0.1%～6.0%, Polyoxyethylatad Rape Oil acid amides 0.3%～6.0%, lauryl sulfate triethanolamine salt 1.0%～5.0%, propylene glycol 0.3%～3.0%, ethanol 0～30%, natrosol 0～2.0%, dimethyl siloxane polyethers 0～2.0%, surplus is deionized water.
2. the preparation method of the macromolecular sustained-release film described in right 2 is characterized in that its production technique is:
(1) preparation DS solution
In deionized water, slowly add the laureth sodium sulfovinate, at room temperature be stirred to its complete dispersing and dissolving, get A solution; In propylene glycol, add ethanol, add 2,4,4 '-three chloro-yl diphenyl ethers again, at room temperature mix to it and dissolve fully, get B solution; Solution B is slowly added in the solution A, stir and get DS solution after five minutes.
(2) preparation CS solution
In deionized water, slowly add laureth sodium sulfovinate, tea tree oil, AMONYL 380LC, Polyoxyethylatad Rape Oil acid amides and lauryl sulfate triethanolamine salt in order successively, at room temperature mix to its complete dispersing and dissolving, get solution C; In propylene glycol, add ethanol, Tegosept M, propylben and glycerol, at room temperature mix to its complete dispersing and dissolving, get solution D; Solution D is slowly added in the solution C, stir and get CS solution after five minutes.
(3) preparation FS solution
In deionized water, slowly add Polyvinylpyrolidone (PVP), polyquaternium, evenly stirred continuously and healthily 30-40 minute, until complete dispersing and dissolving, get solution E; The dimethyl siloxane polyethers is heated to 40 ℃, slowly puts into solution E, be stirred well to its complete dispersing and dissolving, get FS solution.
(4) preparation BS solution
In deionized water, slowly add natrosol, evenly stirred continuously and healthily 60 minutes, behind its complete dispersing and dissolving, under the state that keeps stirring, slowly add the high molecular weight acrylic polymkeric substance, equally behind its complete dispersing and dissolving, slowly add laureth sodium sulfovinate, AMONYL 380LC, Polyoxyethylatad Rape Oil acid amides, lauryl sulfate triethanolamine salt, glycerol, edible ethanol successively, optionally add flavouring agent, continue at the uniform velocity to be stirred to its complete dispersing and dissolving, get BS solution.
(5) preparation finished product
After keeping in BS solution, slowly adding FS solution, CS solution, DS solution successively under the state that stirs, fully stirring 15 minutes, add ethanol and deionized water, fully stirred again 60 minutes, leave standstill and promptly got the finished product in 12 hours.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102624073A CN101928435A (en) | 2010-08-25 | 2010-08-25 | Macromolecular sustained-release multifunctional reinforced film and preparation method thereof |
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| CN2010102624073A CN101928435A (en) | 2010-08-25 | 2010-08-25 | Macromolecular sustained-release multifunctional reinforced film and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104441899A (en) * | 2014-12-03 | 2015-03-25 | 华侨大学 | Preparation method of efficient and antibacterial composite film with water-meeting sensitivity |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1280631A (en) * | 1968-07-09 | 1972-07-05 | Smith & Nephew | Adhesive materials |
| CN1646675A (en) * | 2002-04-10 | 2005-07-27 | 萨尔沃那有限公司 | Targeted controlled delivery compositions activated by changes in pH or salt concentration |
| CN1929819A (en) * | 2004-01-30 | 2007-03-14 | 考里安国际公司 | Rapidly dissolving film for delivery of an active agent |
-
2010
- 2010-08-25 CN CN2010102624073A patent/CN101928435A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1280631A (en) * | 1968-07-09 | 1972-07-05 | Smith & Nephew | Adhesive materials |
| CN1646675A (en) * | 2002-04-10 | 2005-07-27 | 萨尔沃那有限公司 | Targeted controlled delivery compositions activated by changes in pH or salt concentration |
| CN1929819A (en) * | 2004-01-30 | 2007-03-14 | 考里安国际公司 | Rapidly dissolving film for delivery of an active agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104441899A (en) * | 2014-12-03 | 2015-03-25 | 华侨大学 | Preparation method of efficient and antibacterial composite film with water-meeting sensitivity |
| CN104441899B (en) * | 2014-12-03 | 2016-08-17 | 华侨大学 | Meet water sensitivity, the preparation method of high-efficiency antimicrobial laminated film |
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Open date: 20101229 |