CN101919761A - Medical hydrogel incision dressing and preparation method thereof - Google Patents
Medical hydrogel incision dressing and preparation method thereof Download PDFInfo
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- CN101919761A CN101919761A CN2009101083195A CN200910108319A CN101919761A CN 101919761 A CN101919761 A CN 101919761A CN 2009101083195 A CN2009101083195 A CN 2009101083195A CN 200910108319 A CN200910108319 A CN 200910108319A CN 101919761 A CN101919761 A CN 101919761A
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- pad pasting
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Abstract
The invention relates to a medical hydrogel incision dressing and a preparation method thereof. The medical hydrogel incision dressing mainly comprises four layers of structures of a fixed membrane, a polyurethane membrane, a hydrogel layer and a release membrane, wherein one surface of the polyurethane membrane is adhered on the fixed membrane; one surface of the hydrogel layer is adhered on the other surface of the polyurethane membrane; and the release film is covered on the other surface of the hydrogel layer. The medical hydrogel incision dressing can be used for forming a transparent membrane to be convenient for doctors to observe the condition of an incision, bloc bacteria and provide a wet healing environment for the incision to shorten the healing time of the incision; the dressing cannot be adhered on the incision, is simple and convenient to replace, can be helpful to relieve pains of the incision and is suitable for various operation incisions and skin scratches caused by various traumas; and in addition, in the invention, the adherence and the fixing of the hydrogel and the fixed membrane are realized through the polyurethane membrane, thereby incision infections caused by using additive adhesives are avoided.
Description
[technical field]
The present invention relates to a kind of medical dressing, be specifically related to a kind of medical hydrogel incision dressing that is applicable to the skin abrasion that all kinds of operative incisions and various wound cause and preparation method thereof.
[background technology]
Skin is important multi-functional organ of human body.Skin contacts with external environment, plays the barrier action of protection body, and it mainly is to prevent losing of moisture, electrolyte and plasma protein, resists the antibacterial intrusion, prevents that poisonous substance from entering, and keeps out mechanical injuries, prevents that ultraviolet radiation is to the injury of human body etc.In addition, also have physiologic functions such as sensation, secretion, drainage and thermoregulation.Therefore, be that the skin abrasion that operative incision or various wound cause all should obtain nursing as early as possible, make skin recovery organization and function, incision dressing plays an important role in this respect.
Ideal incision dressing should possess following characteristics: 1. cover and the protection otch; 2. stronger water absorption is arranged, can absorb the transudate of otch; Not with the otch adhesion, can not cause secondary damage; 4. soft comfortable, can alleviate incision pain; 5. can prevent infection of incisional wound.
The incision dressing that uses in now clinical mainly is a gauze, and its raw material sources mainly are Cotton Gossypiis, and such dressing only can play and cover and the effect of protection otch, and can cause pain and secondary damage by the adhesion wound when changing.Adhesive-bonded fabric dressing is the succedaneum of gauze dressing, but its water absorption is poor, and does not have antibiotic analgesic effect.The Sun Zhaoli of Norman Bethune Medical University, Changchun, Jilin Province etc. has invented a kind of medical high molecular medicine dressing that is used for the medical surgery otch, this dressing is the carrier of adjuvant with high-molecular polyivnyl alcohol formal porous material, with physics mode in conjunction with antibiotic and analgesic drug product, utilize subsidiary adhesive plaster to stick at cut surface, can absorb the otch transudate, the medicine that is loaded with continues local release and infiltration is played sterilization and analgesic effect to otch.Yet, lose the moisture that it absorbed easily after the polyvinyl formal porous material is exposed in the air, thereby allow the hardening of polyvinyl formal porous material, cause patient's discomfort, even wound is caused secondary damage.
[summary of the invention]
For fear of at least one weak point of above-mentioned dressing, the invention provides a kind of hydrogel incision dressing that is applicable to the skin abrasion that all kinds of operative incisions and various wound cause and preparation method thereof.
Medical hydrogel incision dressing provided by the invention comprises: fixing pad pasting; Polyurethane film, surface thereof is attached on the fixing pad pasting; Hydrogel layer is on surface thereof another surface attached to polyurethane film; And mould release membrance, it covers another surface of hydrogel layer.
According to one preferred embodiment of the present invention, fixedly the surface size of pad pasting greater than the surface size of hydrogel layer.
According to one preferred embodiment of the present invention, the surface size of polyurethane film is identical with the surface size of hydrogel layer.
According to one preferred embodiment of the present invention, mould release membrance is further attached to the fixing zone that is not covered by hydrogel layer of pad pasting.
According to one preferred embodiment of the present invention, the surface size of mould release membrance is identical with the surface size of fixing pad pasting.
According to one preferred embodiment of the present invention, fixedly pad pasting is provided with adhesive phase, and polyurethane film and mould release membrance are attached on the adhesive phase.
According to one preferred embodiment of the present invention, fixedly pad pasting and polyurethane film are transparent, and hydrogel layer is the crosslinking with radiation hydrogel of polyvinyl alcohol and polyethylene glycol oxide.
The preparation method of medical hydrogel incision dressing provided by the invention may further comprise the steps: a. is poured on hydrogel solution on one surface of polyurethane film; B. crosslinking with radiation hydrogel solution is to form hydrogel layer; C. take out the composite construction of hydrogel layer and polyurethane film, cut then; D. with another surface attachment of polyurethane film on fixing pad pasting; E. utilize mould release membrance to cover hydrogel layer.
According to one preferred embodiment of the present invention, step a further comprises: with polyvinyl alcohol and polyethylene glycol oxide powder in mass ratio 1: 9-7: 3 ratio is mixed; With mixed-powder and water in mass ratio 1: 9-1: 3 ratio is mixed, and carries out pre-wetted; Pressurizeing under the pressure of 0.05MPa and under 110-112 ℃ the temperature and heating, to form hydrogel solution.
According to one preferred embodiment of the present invention, in steps d, fixedly pad pasting is provided with adhesive phase, another surface attachment of polyurethane film is on adhesive phase, fixedly the surface size of pad pasting is greater than the surface size of hydrogel layer, in step e, mould release membrance is attached to the fixing zone that is not covered by hydrogel layer of pad pasting.
Incision dressing of the present invention has permeability similar to normal skin and barrier action, can prevent too much water evaporates and lose, make otch keep suitable humidity, form a kind of microenvironment that helps wound healing, for organizing the newborn good ecological environment of creating, simultaneously can alleviate patient's pain, improving postoperative scar and vesicle forms, alleviate the wound pigmentation, absorption speed is very fast, excellent biological compatibility is arranged, be applicable to the skin abrasion that all kinds of operative incisions and various wound cause.Incision dressing of the present invention can be transparent membranoid substance, so one of its characteristics are the transparencys, when clinical practice, does not need to open the healing state that dressing can be observed otch, helps clinical observation.In addition, the present invention by polyurethane film realize hydrogel and fixedly the adhesion of pad pasting fix, avoided adding the infection that binding agent causes otch because of use.
[description of drawings]
Fig. 1 is the decomposing schematic representation according to medical hydrogel incision dressing of the present invention;
Fig. 2 is the cross sectional representation according to medical hydrogel incision dressing of the present invention.
[specific embodiment]
As depicted in figs. 1 and 2, medical hydrogel incision dressing 10 according to the present invention mainly comprises fixedly pad pasting 11, polyurethane film 12, hydrogel layer 13 and mould release membrance 14 four-layer structures.Wherein, a surface attachment of polyurethane film 12 is on fixing pad pasting 11.One surface attachment of hydrogel layer 13 is on another surface of polyurethane film 12.Mould release membrance 14 covers another surface of hydrogel layer 13.In the present embodiment, fixedly the surface size of pad pasting 11 is greater than the surface size of hydrogel layer 13, the surface size of polyurethane film 12 is identical with the surface size of hydrogel layer 13, the surface size of mould release membrance 14 equals the fixedly surface size of pad pasting 11, makes mould release membrance 14 further attached to the fixing zone that is not covered by hydrogel layer 13 of pad pasting 11 thus.Polyurethane film 12 and mould release membrance 14 can be in several ways on the surface attached to fixing pad pasting 11, and for example fixedly pad pasting 11 is provided with adhesive phase, and polyurethane film 12 and mould release membrance 14 are attached on this adhesive phase.
Fixedly pad pasting 11 can be fixed on cut surface, and it can select good air permeability and the good material of mechanical strength for use, and incision dressing 10 can be covered on the otch easily, forms an airtight environment, isolates extraneous antibacterial.The main effect of polyurethane film 12 is with fixedly pad pasting 11 and hydrogel layer 13 be adhesively fixeds.It is directly bonding to find that through a large amount of experimental studies of the inventor hydrogel layer 13 and adhesive phase are difficult to, but hydrogel layer 13 can carry out excellent bonds with polyurethane film 12.In addition, polyurethane film 12 has avoided binding agent directly to contact with hydrogel layer 13, prevents that binding agent from causing the infection of otch.Hydrogel layer 13 water absorption rate height can reach 370%, can absorb the too much sepage of otch, also can provide moisture content to dry otch, for otch provides the wet union environment, quicken the healing of otch.Hydrogel adhesion otch can help to alleviate incision pain, intercepts antibacterial.Sticking and the property of hydrogel layer 12 and skin is better, and smooth surface can be removed from otch when change dressings more easily, and does not damage remaining epithelium and fresh granulation tissue in the otch, thereby the secondary damage when avoiding change dressings more alleviates the misery that the patient changes dressings.Mould release membrance 14 mainly is to prevent that incision dressing 10 is contaminated before use, and it applies at incision dressing 10 can be from incision dressing 10 sur-face peelings before on the otch.
Fixedly the shape of pad pasting 11, polyurethane film 12, hydrogel 13 and mould release membrance 14 can be shapes such as rectangle, circle, ellipse, but combination in any between each shape.
In the present embodiment, fixedly pad pasting 11 and polyurethane film 12 are preferably transparent, hydrogel layer 13 is to be raw material with PEO (polyethylene glycol oxide) and PVA (polyvinyl alcohol), a kind of new medical hydrogel incision dressing that the process crosslinking with radiation forms, thus, incision dressing 10 can be transparent membranoid substance, does not need to open the healing state that dressing can be observed otch when clinical practice.
The present invention further provides a kind of method for preparing medical hydrogel incision dressing 10.Wherein, with polyvinyl alcohol and polyethylene glycol oxide powder in mass ratio 1: 9-7: 3 ratio is mixed, with mixed-powder and water in mass ratio 1: 9-1: 3 ratio is mixed, and carries out pre-wetted.Pressurizeing under the pressure of 0.05MPa and under 110-112 ℃ the temperature and heating, to form hydrogel solution.Then, hydrogel solution is poured on the surface of polyurethane film 12, utilizes gamma-ray radiation cross-linked hydrogel solution to form hydrogel layer 13.Take out the composite construction of hydrogel layer 13 and polyurethane film 12, cut then.With another surface attachment of polyurethane film 12 on fixing pad pasting 11.In the present embodiment, fixedly pad pasting 11 is provided with adhesive phase, and another surface attachment of polyurethane film 12 is on adhesive phase.Subsequently, utilize mould release membrance 14 to cover hydrogel layer 13.In the present embodiment, fixedly the surface size of pad pasting 11 is greater than the surface size of hydrogel layer 13, thereby mould release membrance 14 is attached to the fixing zone that is not covered by hydrogel layer 13 of pad pasting 11.
In the above-described embodiments, only the present invention has been carried out exemplary description, but those skilled in the art can carry out various modifications to the present invention after reading present patent application under the situation that does not break away from the spirit and scope of the present invention.
Claims (10)
1. medical hydrogel incision dressing, it is characterized in that: described medical hydrogel incision dressing comprises:
Fixing pad pasting;
Polyurethane film, a surface attachment of described polyurethane film is on described fixedly pad pasting;
Hydrogel layer, a surface attachment of described hydrogel layer is on another surface of described polyurethane film; And
Mould release membrance covers another surface of described hydrogel layer.
2. incision dressing according to claim 1 is characterized in that: the surface size of described fixedly pad pasting is greater than the surface size of described hydrogel layer.
3. incision dressing according to claim 2 is characterized in that: the surface size of described polyurethane film is identical with the surface size of described hydrogel layer.
4. incision dressing according to claim 3 is characterized in that: described mould release membrance is further attached to the zone that is not covered by described hydrogel layer of described fixedly pad pasting.
5. incision dressing according to claim 4 is characterized in that: the surface size of described mould release membrance is identical with the surface size of described fixedly pad pasting.
6. according to claim 4 or 5 described incision dressings, it is characterized in that: described fixedly pad pasting is provided with adhesive phase, and described polyurethane film and described mould release membrance are attached on the described adhesive phase.
7. incision dressing according to claim 1 is characterized in that: described fixedly pad pasting and described polyurethane film are transparent, and described hydrogel layer is the crosslinking with radiation hydrogel of polyvinyl alcohol and polyethylene glycol oxide.
8. the preparation method of a medical hydrogel incision dressing said method comprising the steps of:
A. hydrogel solution is poured on the surface of polyurethane film;
B. the described hydrogel solution of crosslinking with radiation is to form hydrogel layer;
C. take out the composite construction of described hydrogel layer and described polyurethane film, cut then;
D. with another surface attachment of described polyurethane film on fixing pad pasting;
E. utilize mould release membrance to cover described hydrogel layer.
9. preparation method according to claim 8 is characterized in that: described step a further comprises:
With polyvinyl alcohol and polyethylene glycol oxide powder in mass ratio 1: 9-7: 3 ratio is mixed;
With mixed-powder and water in mass ratio 1: 9-1: 3 ratio is mixed, and carries out pre-wetted;
Pressurizeing under the pressure of 0.05MPa and under 110-112 ℃ the temperature and heating, to form described hydrogel solution.
10. preparation method according to claim 8, it is characterized in that: in described steps d, described fixedly pad pasting is provided with adhesive phase, another surface attachment of described polyurethane film is on described adhesive phase, the surface size of described fixedly pad pasting is greater than the surface size of described hydrogel layer, in described step e, described mould release membrance is attached to the zone that is not covered by described hydrogel layer of described fixedly pad pasting.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101083195A CN101919761A (en) | 2009-06-17 | 2009-06-17 | Medical hydrogel incision dressing and preparation method thereof |
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| CN2009101083195A CN101919761A (en) | 2009-06-17 | 2009-06-17 | Medical hydrogel incision dressing and preparation method thereof |
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| CN101919761A true CN101919761A (en) | 2010-12-22 |
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| CN2009101083195A Pending CN101919761A (en) | 2009-06-17 | 2009-06-17 | Medical hydrogel incision dressing and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488587A (en) * | 2011-11-18 | 2012-06-13 | 大连得达科技发展有限公司 | Medical polyurethane waterproof plaster |
| CN102847196A (en) * | 2012-07-31 | 2013-01-02 | 宁波宏搏高科医疗器械有限公司 | Wet wound surface dressing and preparation method thereof |
| CN103431947A (en) * | 2011-09-15 | 2013-12-11 | 英属维尔京群岛商科裕有限公司 | Dressing |
| CN103876895A (en) * | 2014-03-11 | 2014-06-25 | 朱新生 | Liquid absorption wound dressing enabling wound surface to be observable |
| CN105536027A (en) * | 2015-12-24 | 2016-05-04 | 南阳市汇博生物技术有限公司 | Scar treatment strip capable of lowering tissue tension and preparation method thereof |
| CN107638587A (en) * | 2017-09-25 | 2018-01-30 | 凯斯蒂南京医疗器械有限公司 | With tissue inducing function without scar regeneration medical dressing and preparation method thereof |
| CN107789658A (en) * | 2017-11-06 | 2018-03-13 | 山东蓝孚高能物理技术股份有限公司 | A kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing |
| CN108904135A (en) * | 2018-09-15 | 2018-11-30 | 深圳市浓华生物电子科技有限公司 | A kind of moisture film is cured the wound patch |
| CN113398313A (en) * | 2021-06-08 | 2021-09-17 | 上海大学 | Multilayer-structure composite dressing acting on wound surface and preparation method thereof |
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| CN2383500Y (en) * | 1999-08-13 | 2000-06-21 | 中国原子能科学研究院 | Hydrogel composite wound dressing |
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| CN201200547Y (en) * | 2008-06-02 | 2009-03-04 | 常勇刚 | Medical high-density pad pasting having core with dressing |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103431947A (en) * | 2011-09-15 | 2013-12-11 | 英属维尔京群岛商科裕有限公司 | Dressing |
| CN103431947B (en) * | 2011-09-15 | 2016-04-06 | 英属维尔京群岛商科裕有限公司 | Dressing |
| CN102488587A (en) * | 2011-11-18 | 2012-06-13 | 大连得达科技发展有限公司 | Medical polyurethane waterproof plaster |
| CN102847196A (en) * | 2012-07-31 | 2013-01-02 | 宁波宏搏高科医疗器械有限公司 | Wet wound surface dressing and preparation method thereof |
| CN102847196B (en) * | 2012-07-31 | 2014-04-16 | 宁波宏搏高科医疗器械有限公司 | Wet wound surface dressing and preparation method thereof |
| CN103876895A (en) * | 2014-03-11 | 2014-06-25 | 朱新生 | Liquid absorption wound dressing enabling wound surface to be observable |
| CN105536027A (en) * | 2015-12-24 | 2016-05-04 | 南阳市汇博生物技术有限公司 | Scar treatment strip capable of lowering tissue tension and preparation method thereof |
| CN107638587A (en) * | 2017-09-25 | 2018-01-30 | 凯斯蒂南京医疗器械有限公司 | With tissue inducing function without scar regeneration medical dressing and preparation method thereof |
| CN107789658A (en) * | 2017-11-06 | 2018-03-13 | 山东蓝孚高能物理技术股份有限公司 | A kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing |
| CN108904135A (en) * | 2018-09-15 | 2018-11-30 | 深圳市浓华生物电子科技有限公司 | A kind of moisture film is cured the wound patch |
| CN113398313A (en) * | 2021-06-08 | 2021-09-17 | 上海大学 | Multilayer-structure composite dressing acting on wound surface and preparation method thereof |
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Application publication date: 20101222 |