CN101918041A - 用于肿瘤诊断和治疗的氯毒素剂的系统性给药 - Google Patents

用于肿瘤诊断和治疗的氯毒素剂的系统性给药 Download PDF

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Publication number
CN101918041A
CN101918041A CN2008801112420A CN200880111242A CN101918041A CN 101918041 A CN101918041 A CN 101918041A CN 2008801112420 A CN2008801112420 A CN 2008801112420A CN 200880111242 A CN200880111242 A CN 200880111242A CN 101918041 A CN101918041 A CN 101918041A
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tumor
catilan
xaa
agent
cys
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艾利森·奥尼尔
道格拉斯·B·雅各比
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Transmolecular Inc
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Transmolecular Inc
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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CN2008801112420A 2007-10-12 2008-10-10 用于肿瘤诊断和治疗的氯毒素剂的系统性给药 Pending CN101918041A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97971407P 2007-10-12 2007-10-12
US60/979,714 2007-10-12
PCT/US2008/079547 WO2009049184A2 (en) 2007-10-12 2008-10-10 Systemic administration of chlorotoxin agents for the diagnosis and treatment of tumors

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CN101918041A true CN101918041A (zh) 2010-12-15

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CN2008801112420A Pending CN101918041A (zh) 2007-10-12 2008-10-10 用于肿瘤诊断和治疗的氯毒素剂的系统性给药

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US (1) US20100215575A1 (https=)
EP (1) EP2211913A4 (https=)
JP (1) JP2011500601A (https=)
CN (1) CN101918041A (https=)
AU (1) AU2008310664A1 (https=)
CA (1) CA2702314A1 (https=)
WO (1) WO2009049184A2 (https=)

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US8227439B2 (en) * 2008-05-15 2012-07-24 Morphotek, Inc. Treatment of metastatic tumors
JP5858932B2 (ja) 2010-02-04 2016-02-10 モルフォテック， インコーポレイテッド クロロトキシンポリペプチドおよびコンジュゲートならびにその使用
JP2013532126A (ja) 2010-05-11 2013-08-15 フレッド ハッチンソン キャンサー リサーチ センター クロロトキシン変異体、コンジュゲート、およびそれらを使用する方法
CN101804197B (zh) * 2010-05-21 2012-05-23 魏华 一种用于癌症骨转移的药物组合物及其用途
US8524239B2 (en) 2010-07-09 2013-09-03 The United States of America as represented by the Secrectary, Department of Health and Human Services Photosensitizing antibody-fluorophore conjugates
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
CN102552943A (zh) * 2010-12-31 2012-07-11 复旦大学 一种氯代毒素修饰的肿瘤靶向磁共振造影剂及其制备方法和应用
WO2012096926A2 (en) * 2011-01-10 2012-07-19 President And Fellows Of Harvard College Method for delivering agents into cells using bacterial toxins
DK2729806T3 (en) * 2011-07-08 2017-05-15 Sloan-Kettering Inst For Cancer Res APPLICATIONS OF MARKED HSP90 INHIBITORS
PT2794626T (pt) 2011-12-22 2018-01-12 Glycomimetics Inc Compostos de antagonistas de e-selectina
WO2013108869A1 (ja) * 2012-01-20 2013-07-25 国立大学法人岡山大学 がんの治療又は予防剤
EP2817341A4 (en) 2012-02-23 2015-12-02 Harvard College MICROBIAL MODIFIED TOXIN RECEPTOR FOR THE DISTRIBUTION OF AGENTS IN CELLS
CA2891514C (en) 2012-12-07 2020-08-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
CN105008393A (zh) 2012-12-10 2015-10-28 弗莱德哈钦森癌症研究中心 用于筛选的方法
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
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ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
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US11090358B2 (en) 2015-09-09 2021-08-17 Fred Hutchinson Cancer Research Center Cartilage-homing peptides
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
WO2017181149A1 (en) * 2016-04-15 2017-10-19 Blaze Bioscience, Inc. Methods of treating breast cancer
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US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
AU2018210157B2 (en) 2017-01-18 2022-10-06 Fred Hutchinson Cancer Center Peptide compositions and methods of use thereof for disrupting TEAD interactions
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
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CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
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WO2003101474A1 (en) * 2002-05-31 2003-12-11 Transmolecular, Inc. Combination chemotherapy with chlorotoxin
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
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US8227439B2 (en) * 2008-05-15 2012-07-24 Morphotek, Inc. Treatment of metastatic tumors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106573054A (zh) * 2014-06-02 2017-04-19 利康公司 酞菁探针及其用途
CN112999347A (zh) * 2014-06-02 2021-06-22 乐天医药生技股份有限公司 酞菁探针及其用途

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EP2211913A4 (en) 2010-12-22
EP2211913A2 (en) 2010-08-04
AU2008310664A1 (en) 2009-04-16
US20100215575A1 (en) 2010-08-26
WO2009049184A9 (en) 2009-11-19
CA2702314A1 (en) 2009-04-16
JP2011500601A (ja) 2011-01-06
WO2009049184A2 (en) 2009-04-16

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