CN101912638A - Nano silver-carrying-silicon dioxide catheter and production method thereof - Google Patents
Nano silver-carrying-silicon dioxide catheter and production method thereof Download PDFInfo
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- CN101912638A CN101912638A CN2010102414662A CN201010241466A CN101912638A CN 101912638 A CN101912638 A CN 101912638A CN 2010102414662 A CN2010102414662 A CN 2010102414662A CN 201010241466 A CN201010241466 A CN 201010241466A CN 101912638 A CN101912638 A CN 101912638A
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Abstract
The invention relates to a nano silver-carrying-silicon dioxide catheter and a production method thereof, which belongs to a medical urethral catheterization device and the production method thereof. The invention mainly aims at solving the technical difficult problem that the existing catheter is easy to produce bacteria on the surface and further causes complications. The technical scheme of the invention is as follows: the nano silver-carrying-silicon dioxide catheter is prepared by a nano silver-carrying-silicon dioxide antibacterial agent and silica gel or latex, and the mixture ratio is that nano-silver-carrying-silicon dioxide is added in each 100ml of the silica gel or the latex. The method for producing the nano silver-carrying-silicon dioxide catheter comprises the following steps: 1) producing the nano silver-carrying-silicon dioxide antibacterial agent; and 2) producing the catheter: A) material preparation: firstly weighing raw materials according to the mixture ratio of adding 0.05-2g of the nano silver-carrying-silicon dioxide antibacterial agent into each 100ml of the silica gel or the latex, then pouring into a stirring machine for uniformly stirring, and monitoring the viscosity; B) impregnation; C) plasticization; D) lip curling, powdering and demolding; and E) removing powder, and finally carrying out inspection and packaging.
Description
Technical field
The present invention relates to a kind of nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) catheter and production method thereof, it belongs to a kind of medical urethral catheterization utensil and production method.
Background technology
Catheter is as Urology Surgery a kind of implants in vivo commonly used, and clinical practice is very extensive.And catheter dependency urinary tract infection (CAUTIs) is a kind of common complication of indwelling catheter.Catheter implants, along with the prolongation of indwelling time, antibacterial can form one deck biomembrane (BBF) on the catheter surface, and the antibacterial that is present in the biomembrane is put by the gentle slow release of special resistance mechanism, cause the repeated infection of patient's urinary system and even whole body, prolongedly do not heal.Simultaneously, because antibacterials are difficult to enter biomembrane, even use a large amount of anti-infectives also to be difficult to cure, it also can produce drug resistance for a long time, becomes intractable infection clinically.Because present catheter is made by silica gel or latex, very easily on its surface generation antibacterial, thereby cause complication, therefore, thereby existing catheter exists the defective that easily produces antibacterial initiation complication on its surface.
Summary of the invention
Exist the technological difficulties that easily produce antibacterial initiation complication thereby the objective of the invention is to solve existing catheter, and a kind of nano silver-carrying-silicon dioxide (nanometer Ag-SiO with long-term, stable and safe antibacterial action is provided on its surface
2) catheter and production method thereof.
The present invention solves the problems of the technologies described above the technical scheme that adopts to be: nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) catheter, wherein: this catheter is by nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial and silica gel or latex make, its proportioning is to add nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel or the latex
2) antibacterial 0.05-2 gram.
A kind of production nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) method of catheter, it comprises the following steps:
1) makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial
Weigh 5g nano silicon (nanometer SiO
2) powder joins the silver nitrate (AgNO that 100ml concentration is 0.001～0.1mol/L
3) in the solution, adjust the pH value of solution, make in its scope that remains on 6-8, under 50 ℃ of dark conditions, carry out adsorption reaction, the response time is 4 hours; Reaction is carried out centrifugalize to reactant liquor after finishing, and isolated solid material is dissolved in the deionized water washs, and cyclic washing does not have silver ion several times in washing liquid; With the solid material of washing under 100 ℃ temperature dry 12 hours; Then, the solid material that makes is inserted in the Muffle furnace again, be heated to 400 ℃ from room temperature, programming rate is 10 ℃/min, insulation 1h, and furnace cooling promptly makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial solid material (SLS);
2) make catheter
A, batching: at first by adding nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel or the latex
2) antibacterial 0.05-2 gram takes by weighing raw material, then with silica gel or latex and nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial drops into and to stir in the blender and monitor viscosity, so that viscosity is adjusted to 50MPas, subsequently glue is pumped into filter vat and filters, after the deaeration of deaeration storage barrel negative pressure of vacuum, it is standby to send into maceration tank again;
B, dipping: mould is cleaned with water after guide rail reaches the maceration tank dipping solution to desired height, and maceration tank overflow and pouring drippage purgation glue are all gone into accumulator tank, and blowback filtration again, deaeration recycle;
C, plasticizing: the pipe die behind dipping enters the plasticizing stove, dryness finalization plasticizing under 220 ℃ of-250 ℃ of temperature;
D, volume lip, dusting and the demoulding: after going out to plastify the pipe die cooling of stove, through volume lip, dusting, enter ejection phase, manually take off finished product, mould recirculation after cleaning with water uses;
E, shedding: finished product changes check and packing at last through the powder remover shedding.
Because the present invention has adopted technique scheme, the character of utilizing the active chemical attribute of Ag+ and from carrier, slowly discharging easily, when making catheter implant to contact with antibacterial, can slowly release Ag+, the latter is mainly by electric transmission system relevant with breathing production capacity on the destroy microorganisms film, material transfer system or other albumen relevant with metabolic activity in cells or the activity of enzyme, cause somatic cells death or growth to be suppressed, thereby reach long-term, stable and safe antibacterial effect.Therefore, compare with background technology, the present invention has for a long time, the advantage of stable and safe antibacterial effect.
In order to verify above-mentioned beneficial effect, the present invention external bacteriostasis property detection, zoopery, electron microscopic observation and Study of cytotoxicity have been carried out.
1, nanometer Ag-SiO
2The external bacteriostasis property check and analysis of catheter
Experimental result shows: the transmission electron microscope of (1) nanometer silver finished product shows nanometer Ag-SiO
2Powder distribution is even, good dispersion, and mean diameter is 46nm, does not have visible clustering phenomena; (2) nanometer Ag-SiO
2Powder is good to staphylococcus aureus and colibacillary biocidal property, antibacterial zone (the antibacterial outer most edge is to the beeline between the inner edge of bacterial growth on the plain agar culture dish) to two kinds of antibacterials is respectively 6.2 ± 0.8mm and 5.0 ± 0.5mm, and common medical catheter to the antibacterial zones of two kinds of antibacterials all less than 0.5mm.With reference to the bioassay standard of antibacterial ring in the drug sensitive test, think nanometer Ag-SiO
2Powder has antibacterial action, and common medical catheter does not have antibiotic effect.
2, zoopery
By the experiment of 4 weeks, the rabbit mucous membrane of urethra is carried out HE dyeing, SABC monitoring [interleukin 10 (IL-10) and tumor necrosis factor-a (TNF-a)], the result shows: nanometer Ag-SiO
2Catheter has antibiotic property, applying nano Ag-SiO
2Catheter can significantly reduce the incidence rate of catheter dependency urinary tract infection.
3, electron microscopic observation
Zoopery is preceding under the JEM-1011 transmission electron microscope, to nanometer Ag-SiO
2The catheter surface composition is observed, and can see the Ag+ about 10nm; 4 weeks were tested the back under the JEM-1011 transmission electron microscope, to nanometer Ag-SiO
2The catheter surface composition is observed once more, still can see the Ag+ about 10nm.Nanometer Ag-SiO is described
2The anti-microbial property of catheter has long-lasting.
4, Study of cytotoxicity
Adopt the relative rate of increase of absorbance, cell of MTT colorimetric method for determining, to nanometer Ag-SiO
2Catheter carries out toxicity research, and the result shows: nanometer Ag-SiO
2Infection catheter lixiviating solution cytotoxicity is 0 grade or 1 grade, does not have or low cytotoxicity, meets medical apparatus and instruments biological assessment standard-required.
Description of drawings
Fig. 1 is nanometer Ag-SiO of the present invention
2The sem photograph of catheter surface texture;
Fig. 2 is nanometer Ag-SiO of the present invention before the zoopery
2The transmission electron microscope picture of catheter surface composition; Red arrow is labeled as the Ag+ of 10nm among the figure;
Fig. 3 is 4 weeks experiment back nanometer Ag-SiO of the present invention
2The transmission electron microscope picture of catheter surface composition; Red arrow is labeled as the Ag+ of 10nm among the figure;
Fig. 4 is on the escherichia coli culture medium, nanometer Ag-SiO of the present invention
2The external bacteriostasis property of catheter and common medical catheter detects figure; Red arrow is labeled as nanometer Ag-SiO among the figure
2Catheter, visible tangible antibacterial ring around it;
Fig. 5 is on the staphylococcus aureus culture medium, nanometer Ag-SiO of the present invention
2The external bacteriostasis property of catheter and common medical catheter detects figure; Red arrow is labeled as nanometer Ag-SiO among the figure
2Catheter, visible tangible antibacterial ring around it;
Fig. 6 is for using nanometer Ag-SiO of the present invention
2Catheter carries out the rabbit zoopery, rabbit mucous membrane of urethra HE colored graph;
Fig. 7 carries out the rabbit zoopery, rabbit mucous membrane of urethra HE colored graph for using common medical catheter;
Fig. 8 is for using nanometer Ag-SiO of the present invention
2Catheter carries out the rabbit zoopery, the expression colored graph of rabbit mucous membrane of urethra IL-10;
Fig. 9 carries out the rabbit zoopery, the expression colored graph of rabbit mucous membrane of urethra IL-10 for using common medical catheter;
Figure 10 is for using nanometer Ag-SiO of the present invention
2Catheter carries out the rabbit zoopery, the expression colored graph of rabbit mucous membrane of urethra TNF-α;
Figure 11 carries out the rabbit zoopery, the expression colored graph of rabbit mucous membrane of urethra TNF-α for using common medical catheter;
Figure 12 is a structural representation of the present invention; 1-conduction hole among the figure, 2-air bag, 3-airsac tube, 4-drainage tube, 5-syringe pipe.
The specific embodiment
Embodiment 1
As shown in figure 12, the nano silver-carrying-silicon dioxide (nanometer Ag-SiO in the present embodiment
2) catheter, its catheter is by nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial and silica gel makes, its proportioning is to add nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 0.05 gram.
Present embodiment is produced nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) method of catheter, it comprises the following steps:
1) makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial
Weigh 5g nano silicon (nanometer SiO
2) powder joins the silver nitrate (AgNO that 100ml concentration is 0.001mol/L
3) in the solution, adjust the pH value of solution, make in its scope that remains on 6-8, under 50 ℃ of dark conditions, carry out adsorption reaction, the response time is 4 hours; Reaction is carried out centrifugalize to reactant liquor after finishing, and isolated solid material is dissolved in the deionized water washs, and cyclic washing does not have silver ion several times in washing liquid; With the solid material of washing under 100 ℃ temperature dry 12 hours; Then, the solid material that makes is inserted in the Muffle furnace again, be heated to 400 ℃ from room temperature, programming rate is 10 ℃/min, insulation 1h, and furnace cooling promptly makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial solid material (SLS);
2) make catheter
A, batching: at first by adding nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 0.05 gram takes by weighing raw material, then with silica gel and nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial drops into and to stir in the blender and monitor viscosity, so that viscosity is adjusted to 50MPas, subsequently glue is pumped into filter vat and filters, after the deaeration of deaeration storage barrel negative pressure of vacuum, it is standby to send into maceration tank again;
B, dipping: mould is cleaned with water after guide rail reaches the maceration tank dipping solution to desired height, and maceration tank overflow and pouring drippage purgation glue are all gone into accumulator tank, and blowback filtration again, deaeration recycle; Desired height is meant the dipping solution height of determining catheter according to the different model of catheter;
C, plasticizing: the pipe die behind dipping enters the plasticizing stove, dryness finalization plasticizing under 220 ℃ of-250 ℃ of temperature;
D, volume lip, dusting and the demoulding: after going out to plastify the pipe die cooling of stove, through volume lip, dusting, enter ejection phase, manually take off finished product, mould recirculation after cleaning with water uses;
E, shedding: finished product changes check and packing at last through the powder remover shedding.
As shown in figure 12, the nano silver-carrying-silicon dioxide (nanometer Ag-SiO in the present embodiment
2) catheter, its catheter is by nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial and silica gel makes, its proportioning is to add nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 2 grams.
Present embodiment is produced nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) method of catheter, it comprises the following steps:
1) makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial
Weigh 5g nano silicon (nanometer SiO
2) powder joins the silver nitrate (AgNO that 100ml concentration is 0.1mol/L
3) in the solution, adjust the pH value of solution, make in its scope that remains on 6-8, under 50 ℃ of dark conditions, carry out adsorption reaction, the response time is 4 hours; Reaction is carried out centrifugalize to reactant liquor after finishing, and isolated solid material is dissolved in the deionized water washs, and cyclic washing does not have silver ion several times in washing liquid; With the solid material of washing under 100 ℃ temperature dry 12 hours; Then, the solid material that makes is inserted in the Muffle furnace again, be heated to 400 ℃ from room temperature, programming rate is 10 ℃/min, insulation 1h, and furnace cooling promptly makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial solid material (SLS);
2) make catheter
A, batching: at first by adding nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 2 gram takes by weighing raw material, then with silica gel and nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial drops into and to stir in the blender and monitor viscosity, so that viscosity is adjusted to 50MPas, subsequently glue is pumped into filter vat and filters, after the deaeration of deaeration storage barrel negative pressure of vacuum, it is standby to send into maceration tank again;
B, dipping: mould is cleaned with water after guide rail reaches the maceration tank dipping solution to desired height, and maceration tank overflow and pouring drippage purgation glue are all gone into accumulator tank, and blowback filtration again, deaeration recycle; Desired height is meant the dipping solution height of determining catheter according to the different model of catheter;
C, plasticizing: the pipe die behind dipping enters the plasticizing stove, dryness finalization plasticizing under 220 ℃ of-250 ℃ of temperature;
D, volume lip, dusting and the demoulding: after going out to plastify the pipe die cooling of stove, through volume lip, dusting, enter ejection phase, manually take off finished product, mould recirculation after cleaning with water uses;
E, shedding: finished product changes check and packing at last through the powder remover shedding.
Embodiment 3
As shown in figure 12, the nano silver-carrying-silicon dioxide (nanometer Ag-SiO in the present embodiment
2) catheter, its catheter is by nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial and silica gel makes, its proportioning is to add nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 1 gram.
Present embodiment is produced nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) method of catheter, it comprises the following steps:
1) makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial
Weigh 5g nano silicon (nanometer SiO
2) powder joins the silver nitrate (AgNO that 100ml concentration is 0.01mol/L
3) in the solution, adjust the pH value of solution, make in its scope that remains on 6-8, under 50 ℃ of dark conditions, carry out adsorption reaction, the response time is 4 hours; Reaction is carried out centrifugalize to reactant liquor after finishing, and isolated solid material is dissolved in the deionized water washs, and cyclic washing does not have silver ion several times in washing liquid; With the solid material of washing under 100 ℃ temperature dry 12 hours; Then, the solid material that makes is inserted in the Muffle furnace again, be heated to 400 ℃ from room temperature, programming rate is 10 ℃/min, insulation 1h, and furnace cooling promptly makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial solid material (SLS);
2) make catheter
A, batching: at first by adding nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 1 gram takes by weighing raw material, then with silica gel and nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial drops into and to stir in the blender and monitor viscosity, so that viscosity is adjusted to 50MPas, subsequently glue is pumped into filter vat and filters, after the deaeration of deaeration storage barrel negative pressure of vacuum, it is standby to send into maceration tank again;
B, dipping: mould is cleaned with water after guide rail reaches the maceration tank dipping solution to desired height, and maceration tank overflow and pouring drippage purgation glue are all gone into accumulator tank, and blowback filtration again, deaeration recycle; Desired height is meant the dipping solution height of determining catheter according to the different model of catheter;
C, plasticizing: the pipe die behind dipping enters the plasticizing stove, dryness finalization plasticizing under 220 ℃ of-250 ℃ of temperature;
D, volume lip, dusting and the demoulding: after going out to plastify the pipe die cooling of stove, through volume lip, dusting, enter ejection phase, manually take off finished product, mould recirculation after cleaning with water uses;
E, shedding: finished product changes check and packing at last through the powder remover shedding.
Embodiment 4
As shown in figure 12, the nano silver-carrying-silicon dioxide (nanometer Ag-SiO in the present embodiment
2) catheter, its catheter is by nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial and silica gel makes, its proportioning is to add nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 1.5 grams.
Present embodiment is produced nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) method of catheter, it comprises the following steps:
1) makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial
Weigh 5g nano silicon (nanometer SiO
2) powder joins the silver nitrate (AgNO that 100ml concentration is 0.05mol/L
3) in the solution, adjust the pH value of solution, make in its scope that remains on 6-8, under 50 ℃ of dark conditions, carry out adsorption reaction, the response time is 4 hours; Reaction is carried out centrifugalize to reactant liquor after finishing, and isolated solid material is dissolved in the deionized water washs, and cyclic washing does not have silver ion several times in washing liquid; With the solid material of washing under 100 ℃ temperature dry 12 hours; Then, the solid material that makes is inserted in the Muffle furnace again, be heated to 400 ℃ from room temperature, programming rate is 10 ℃/min, insulation 1h, and furnace cooling promptly makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial solid material (SLS);
2) make catheter
A, batching: at first by adding nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel
2) antibacterial 1.5 gram takes by weighing raw material, then with silica gel and nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial drops into and to stir in the blender and monitor viscosity, so that viscosity is adjusted to 50MPas, subsequently glue is pumped into filter vat and filters, after the deaeration of deaeration storage barrel negative pressure of vacuum, it is standby to send into maceration tank again;
B, dipping: mould is cleaned with water after guide rail reaches the maceration tank dipping solution to desired height, and maceration tank overflow and pouring drippage purgation glue are all gone into accumulator tank, and blowback filtration again, deaeration recycle; Desired height is meant the dipping solution height of determining catheter according to the different model of catheter;
C, plasticizing: the pipe die behind dipping enters the plasticizing stove, dryness finalization plasticizing under 220 ℃ of-250 ℃ of temperature;
D, volume lip, dusting and the demoulding: after going out to plastify the pipe die cooling of stove, through volume lip, dusting, enter ejection phase, manually take off finished product, mould recirculation after cleaning with water uses;
E, shedding: finished product changes check and packing at last through the powder remover shedding.
Nano silver-carrying-silicon dioxide (nanometer Ag-SiO in the foregoing description
2) weight of antibacterial is not limited to above-mentioned four points, nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) weight of antibacterial can also choose arbitrarily between 0.05-2 gram.
Silver nitrate (AgNO in the foregoing description
3) concentration of solution is not limited to above-mentioned four points, silver nitrate (AgNO
3) concentration of solution can also choose arbitrarily between 0.001～0.1mol/L.
Silica gel in the foregoing description can also replace with latex.
By Fig. 2 and Fig. 3 more as can be known, before zoopery and after the experiment of 4 weeks, nanometer Ag-SiO
2All there is the Ag+ of 10nm in the catheter surface composition, the long-lasting of its anti-microbial property is described.
More as can be known, use nanometer Ag-SiO by Fig. 6 and Fig. 7
2Catheter uses in the rabbit mucous membrane of urethra tissue of common medical catheter, and it is better that cell is arranged homogeneous, and the cell infiltration that a mucous epithelium and a matter are soaked into obviously reduces.
More as can be known, use nanometer Ag-SiO by Fig. 8 and Fig. 9
2Catheter uses in the rabbit mucous membrane of urethra tissue of common medical catheter, and the positive expression density of IL-10 is obviously high.IL-10 is the inflammation inhibitive factor, and it is expressed height and is negative correlation with inflammatory reaction.Result shown in the figure shows use nanometer Ag-SiO
2Inflammatory reaction due to the catheter is starkly lower than common medical catheter.
More as can be known, use nanometer Ag-SiO by Figure 10 and Figure 11
2Catheter uses in the rabbit mucous membrane of urethra tissue of common medical catheter, and the positive expression density of TNF-α is obviously low.TNF-α is that inflammation promotes the factor, and it is expressed height and is proportionate with inflammatory reaction.Result shown in the figure shows use nanometer Ag-SiO
2Inflammatory reaction due to the catheter is starkly lower than common medical catheter.
By as can be known above-mentioned,
1, nanometer Ag-SiO of the present invention
2Catheter has antibiotic property;
2, nanometer Ag-SiO of the present invention
2The catheter anti-microbial property has long-lasting;
3, nanometer Ag-SiO of the present invention
2Catheter does not have or low cytotoxicity, meets medical apparatus and instruments biological assessment standard-required.
Claims (2)
1. nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) catheter, it is characterized in that: this catheter is by nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial and silica gel or latex make, its proportioning is to add nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel or the latex
2) antibacterial 0.05-2 gram.
2. described nano silver-carrying-silicon dioxide (nanometer Ag-SiO of production claim 1
2) method of catheter, it is characterized in that: it comprises the following steps:
1) makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial
Weigh 5g nano silicon (nanometer SiO
2) powder joins the silver nitrate (AgNO that 100ml concentration is 0.001～0.1mol/L
3) in the solution, adjust the pH value of solution, make in its scope that remains on 6-8, under 50 ℃ of dark conditions, carry out adsorption reaction, the response time is 4 hours; Reaction is carried out centrifugalize to reactant liquor after finishing, and isolated solid material is dissolved in the deionized water washs, and cyclic washing does not have silver ion several times in washing liquid; With the solid material of washing under 100 ℃ temperature dry 12 hours; Then, the solid material that makes is inserted in the Muffle furnace again, be heated to 400 ℃ from room temperature, programming rate is 10 ℃/min, insulation 1h, and furnace cooling promptly makes nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial solid material (SLS);
2) make catheter
A, batching: at first by adding nano silver-carrying-silicon dioxide (nanometer Ag-SiO in every 100ml silica gel or the latex
2) antibacterial 0.05-2 gram takes by weighing raw material, then with silica gel or latex and nano silver-carrying-silicon dioxide (nanometer Ag-SiO
2) antibacterial drops into and to stir in the blender and monitor viscosity, so that viscosity is adjusted to 50MPas, subsequently glue is pumped into filter vat and filters, after the deaeration of deaeration storage barrel negative pressure of vacuum, it is standby to send into maceration tank again;
B, dipping: mould is cleaned with water after guide rail reaches the maceration tank dipping solution to desired height, and maceration tank overflow and pouring drippage purgation glue are all gone into accumulator tank, and blowback filtration again, deaeration recycle;
C, plasticizing: the pipe die behind dipping enters the plasticizing stove, dryness finalization plasticizing under 220 ℃ of-250 ℃ of temperature;
D, volume lip, dusting and the demoulding: after going out to plastify the pipe die cooling of stove, through volume lip, dusting, enter ejection phase, manually take off finished product, mould recirculation after cleaning with water uses;
E, shedding: finished product changes check and packing at last through the powder remover shedding.
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| WO2018219035A1 (en) | 2017-05-31 | 2018-12-06 | 苏州度博迈医疗科技有限公司 | Antimicrobial silicone rubber, preparation method therefor and use thereof |
| CN111070504A (en) * | 2019-12-24 | 2020-04-28 | 广东亿康医疗器械有限公司 | Preparation method of latex catheter mold |
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| CN102613244A (en) * | 2012-03-11 | 2012-08-01 | 浙江大学 | Preparation method of mesoporous hollow spherical silver-loaded silicon dioxide antimicrobial |
| CN102613244B (en) * | 2012-03-11 | 2014-03-19 | 浙江大学 | Preparation method of mesoporous hollow spherical silver-loaded silicon dioxide antimicrobial |
| CN103266467A (en) * | 2013-06-13 | 2013-08-28 | 太仓协大申泰羊毛衫有限公司 | Preparation method of antibacterial wool fibers |
| CN107485732A (en) * | 2016-06-11 | 2017-12-19 | 桂林紫竹乳胶制品有限公司 | The preparation method of antimicrobial silicon sebific duct, composite antibacterial material and the material in silicone tube surface coating |
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| CN111070504B (en) * | 2019-12-24 | 2021-09-28 | 广东亿康医疗器械有限公司 | Preparation method of latex catheter mold |
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