CN101912410A - Medicament for vaginal irrigation - Google Patents
Medicament for vaginal irrigation Download PDFInfo
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- CN101912410A CN101912410A CN 201010258444 CN201010258444A CN101912410A CN 101912410 A CN101912410 A CN 101912410A CN 201010258444 CN201010258444 CN 201010258444 CN 201010258444 A CN201010258444 A CN 201010258444A CN 101912410 A CN101912410 A CN 101912410A
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- medicament
- vagina
- policresulen
- vaginal
- medicine
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Abstract
The invention provides a medicament for vaginal irrigation, which is policresulen solution of which the concentration expressed in percentage by weight is 4 to 8 percent. The invention also provides the application of the medicament. The medicament has the advantage that: the pH value of the medicament is closer to the acid environment in vagina, wherein the pH value of a healthy vagina of a human body is about 4.0 to 4.6 and the healthy vagina is in weak acid, so that the medicament can reduce stimulation to the human body and protect the physiological environment of the vagina; in addition, the medicament is directly used for vaginal irrigation, can effectively prevent kinds of pathogenic bacteria, fungi and the like, so that the medicament has good treatment effect on diseases such as cervicitis, vaginal infections (such as leucorrhoea increasing caused by bacteria, trichomonad and mould, and the like) or pruritus vulvue and the like.
Description
Technical field
The present invention relates to a kind of medicine that is directly used in vaginadouche, specifically, relate to a kind of policresulen solution that is directly used in vaginadouche.
Background technology
Policresulen has broad-spectrum antibacterial action, comprises common gram positive bacteria, gram negative bacteria, mycete and virus etc., and wherein Gardnerella Vaginatis, anaerobe, infusorian and candidiasis are particularly responsive to it; But Doderlein Vaginal Flore (vagina lactobacillus flora) is unaffected substantially.Its pharmacological mechanism is: by peracid and protein coagulation action kill antibacterial, mycete and infusorian, optionally cause necrosis or pathological tissues and columnar epithelium albuminous degeneration, cause that vasoconstriction and plasma protein solidify and stop blooding.At present, policresulen does not still have and causes chemical sproof report.Policresulen has necrosis or pathological tissues and optionally solidifies the eliminating effect, can promote the covering again of tissue regeneration and epithelium; Healthy squamous epithelial cancer is then unaffected, and columnar epithelial cell endochylema with nucleus swelling may take place after contacting this product, the coming seconds shrinkage.
Policresulen solution is one of dosage form at present commonly used, and it is a rufous liquid, and pH value is less than 1, is 36% (weight) in the concentration of metacresol-6-sulfonic acid dimer, and relative density is 1.13～1.17.This policresulen solution is used for the treatment of the hemostasis of using after pressure ulcer, official's neck polypectomy or the cut sections for microscopic examination that pessulum causes, condyloma acuminatum and quicken electric coagulation therapy after wound healing; The prevention of mastitis (burning of cracked nipple); The topical therapeutic of skin wound and pathological changes (as burn, limbs ulcer, decubital ulcer, chronic inflammatory disease etc.) can quicken coming off of slough, stops blooding and promotes agglutination and be used for the treatment of condyloma acuminatum; Also can be used for treating inflammation, oral ulcer and the post tonsillectomic hemostasis of oral mucosa and gums.
But the acidity of above-mentioned policresulen solution is strong excessively, and is bigger to the stimulation of human body, therefore can only be used for local calcination treatment, and can not be directly used in vaginadouche.
Summary of the invention
The object of the present invention is to provide a kind of medicine that can be directly used in vaginadouche.
Another object of the present invention is to provide the application of described medicine.
To achieve these goals, the medicine that is used for vaginadouche of the present invention, it is the policresulen solution of concentration expressed in percentage by weight 4～8% (in metacresol-6-sulfonic acid dimer).Preferably concentration expressed in percentage by weight is the policresulen solution of 6% (in metacresol-6-sulfonic acid dimer).
Medicine of the present invention is with 50% policresulen solution, adds water and stirs, and mix homogeneously makes through fill, check then; Its pH is about 1.5～5.0, and relative density is 0.99～1.05.
The present invention also provides the described application that is used for the medicine of vaginadouche at the medicine of preparation treatment vagina and official's NC.Described vagina and official's NC are cervicitis, vaginal infection (leucorrhoea grow in quantity that causes as antibacterial, infusorian and mycete) or pruritus vulvae etc.
The invention has the advantages that, because the acid-base value of the vaginal environment of health be faintly acid, so the pH value of medicine of the present invention more approaches intravaginal sour environment about 4.0～4.6, can reduce stimulation to health, and the physiological environment of protection vagina; In addition, medicine of the present invention is directly used in vaginadouche, can effectively suppress multiple pathogen, fungus etc., thereby diseases such as cervicitis, vaginal infection (leucorrhoea grow in quantity that causes as antibacterial, infusorian and mycete) or pruritus vulvae are had excellent curative.
The specific embodiment
Below further specify the present invention by specific embodiment, but be not used for limiting the scope of the invention.
Embodiment 1
In 120g concentration is in the policresulen solution of 50% (weight), adds the 880g distilled water, the back fill that stirs, check.Make concentration and be 6% policresulen solution, pH is 4.6.
Embodiment 2
In 80g concentration is in the policresulen solution of 50% (weight), adds the 920g distilled water, the back fill that stirs, check.Make concentration and be 4% policresulen solution, pH is 5.0.
Embodiment 3
In 160g concentration is in the policresulen solution of 50% (weight), adds the 840g distilled water, the back fill that stirs, check.Make concentration and be 8% policresulen solution, pH is 1.5.
Embodiment 4
The policresulen solution that makes with embodiment 1～3 is sample, measures its MIC to multiple vagina pathogen respectively
90, the result is shown in table 1～3.
The policresulen solution of table 1 embodiment 1 is to the MIC of vaginal pathogenic
90
The policresulen solution of table 2 embodiment 2 is to the MIC of vaginal pathogenic
90
The policresulen solution of table 3 embodiment 3 is to the MIC of vaginal pathogenic
90
From table 1～table 3 as can be seen, concentration is that 6%, 4% and 8% policresulen solution all has the effect of good inhibition vagina pathogen.But the concentration of embodiment 1 is 6% to be that 8% policresulen solution is compared with the concentration of embodiment 3, and its pH value is more near the human vagina, and to the zest minimum of human body, and both antibacterial activity in vitro are more or less the same; In addition, the concentration of embodiment 1 is 6% to be that 4% policresulen solution is compared with the concentration of embodiment 2, and external antibacterial activity is better, and in sum, the medicine that is used for vaginadouche of the present invention is 6% policresulen solution most preferably.
Though above with the general explanation and the specific embodiment, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (4)
1. a medicine that is used for vaginadouche is characterized in that, it is the policresulen solution of concentration expressed in percentage by weight 4～8%.
2. medicine according to claim 1 is characterized in that, it is the policresulen solution of concentration expressed in percentage by weight 6%.
3. claim 1 or the 2 described medicines application in the medicine of preparation treatment vagina and cervical disease.
4. application according to claim 3 is characterized in that, described cervical disease is cervicitis, vaginal infection or pruritus vulvae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010258444 CN101912410A (en) | 2010-08-17 | 2010-08-17 | Medicament for vaginal irrigation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010258444 CN101912410A (en) | 2010-08-17 | 2010-08-17 | Medicament for vaginal irrigation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101912410A true CN101912410A (en) | 2010-12-15 |
Family
ID=43320159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010258444 Pending CN101912410A (en) | 2010-08-17 | 2010-08-17 | Medicament for vaginal irrigation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101912410A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480151A (en) * | 2002-09-04 | 2004-03-10 | 黄振华 | Policresulen lotion |
-
2010
- 2010-08-17 CN CN 201010258444 patent/CN101912410A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480151A (en) * | 2002-09-04 | 2004-03-10 | 黄振华 | Policresulen lotion |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20101215 |