CN101904969B - Traditional Chinese medicine composition for treating proliferative diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating proliferative diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating proliferative diseases and a preparation method thereof, and the traditional Chinese medicine composition is mainly prepared by the following pharmaceutical raw materials in parts by weight: 20-30 parts of philippine flemingia root, 15-25 parts of doubleteeth pubescent angilica root, 5-15 parts of manchurian wildginger, 13-25 parts of divaricate saposhnikovia root, 12-25 parts of largeleaf gentian root, 10-25 parts of Yunnan manyleaf Paris rhizome and 10-25 parts of cassia bark. The traditional Chinese medicine composition for treating the proliferative diseases is mainly used for treating cervical/lumbar hyperosteogeny, breast hyperplasia, hand and foot hyperosteogeny, lumbar disc herniation, phlebitis, rheumatism and rheumatoid arthritis, frozen shoulder, lumbar muscle strain, sciatica, paralysis of limbs, thoracic obstruction, gout, stroke-induced hemiplegia, traumatic swelling and pain and other painful symptoms of the neck, the shoulders, the waist and the legs.
Description
Technical field
The invention belongs to Chinese medicine and health promoting product field, more specifically, the present invention relates to a kind of Chinese medicine composition for the treatment of proliferative disease and preparation method thereof.
Background technology
Hyperosteogeny belongs to traditional Chinese medical science arthromyodynia [modern Chinese medicine is named arthromyodynia and is " rheumatism " (People's Health Publisher: " practical traditional Chinese medical science rheumatology ", 2006)] category more.The traditional Chinese medical science thinks that mostly " rheumatism " is to cause flesh bone, joint meridians impatency because of evil invasion and attack human bodies such as wind, cold, wet, heat, and QI-blood circulation is not smooth, i.e. the reason of so-called " stagnation of QI and blood may bring about pain, general rule are not bitterly ".According to the United Nations health organization statistics, more than 3,800 ten thousand rheumatism patients (China has more than 900～1,000 ten thousand people approximately) are arranged at present in the world approximately, and wherein 1/3 people is with disability, and 1/10 will disable, and be called as " not dead cancer ".The neck, lumbar vertebra slight illness, prolapse of lumbar intervertebral disc, osteoarthrosis pain vertebra, the osteopathia such as (being hyperplastic osteoarthritis) that are caused by cervical vertebra, lumbar vertebra hyperosteogeny, Secondary cases hyperosteogeny are commonly encountered diseases, frequently-occurring disease, the patient accounts for surgical patient's 1/3～1/2, be more common in the middle-aged and elderly people more than 40 years old, also be found in below 40 years old the blue or green middle age and be engaged in for a long time write, the worker that bows such as drawing.
Because the hyperosteogeny pathogeny is complicated, lack the radical cure medicine, become one of international difficult medical problem.According to the brainstrust statistics of the academic seminar of the international traditional Chinese medical science rheumatism of the first, the people more than 55 years old, osteoarthrosis X line is taken the photograph sheet has bony spur person to account for 85%, this type of patient is adopted doctor trained in Western medicine operation or non-operation (traction, physical therapy, have Western medicine etc.) treatment more both at home and abroad at present; The Chinese medicine orally taken for curing of employing or Chinese and western medicine Comprehensive Treatment method are also arranged, but effect is all unsatisfactory; Especially adopt central outer preferably liniment type of effect of Comprehensive Treatment and plaster dosage form medicine few.
Summary of the invention
The objective of the invention is to overcome the defective of prior art, a kind of Chinese medicine composition of eutherapeutic treatment proliferative disease is provided.
For achieving the above object, the present invention has taked following technical scheme:
A kind of Chinese medicine composition for the treatment of proliferative disease mainly is to be made by following bulk drugs: 20～30 parts of Radix Flemingiae Philippinensiss, 15～25 parts of Radix Angelicae Pubescentiss, 5～15 parts of Herba Asaris, 13～25 parts of Radix Saposhnikoviaes, 12～25 parts of Radix Gentianae Macrophyllae, 10～25 parts of Rhizoma Paridis, 10～25 parts in the Cortex Cinnamomi heart.
Preferably, the weight portion of each crude drug is in this Chinese medicine composition: 25 parts of Radix Flemingiae Philippinensiss, 20 parts of Radix Angelicae Pubescentiss, 9 parts of Herba Asaris, 18 parts of Radix Saposhnikoviaes, 18 parts of Radix Gentianae Macrophyllae, 15 parts of Rhizoma Paridis, 15 parts in the Cortex Cinnamomi heart.
Preferably, this Chinese medicine composition also comprises following bulk drugs: 15～25 parts of Herba Taxillis, 15～25 parts of the Cortexs Eucommiae, 15～25 parts of Radix Achyranthis Bidentataes, 15～25 parts of Rhizoma Chuanxiongs, 15～25 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Paeoniaes, 10～25 parts of Radix Rehmanniaes, Radix Ginseng 5～15,20～30 parts in Poria, 5～15 parts in Radix Glycyrrhizae.
More preferably, the weight portion of each crude drug is in this Chinese medicine composition: 25 parts of Radix Flemingiae Philippinensiss, 20 parts of Radix Angelicae Pubescentiss, 9 parts of Herba Asaris, 18 parts of Radix Saposhnikoviaes, 18 parts of Radix Gentianae Macrophyllae, 15 parts of Rhizoma Paridis, 15 parts in the Cortex Cinnamomi heart, 18 parts of Herba Taxillis, 18 parts of the Cortexs Eucommiae, 18 parts of Radix Achyranthis Bidentataes, 18 parts of Rhizoma Chuanxiongs, 18 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniaes, 15 parts of Radix Rehmanniaes, 10 parts of Radix Ginsengs, 25 parts in Poria, 9 parts in Radix Glycyrrhizae.
The present invention also provides the preparation method of the Chinese medicine composition of above-mentioned treatment proliferative disease, may further comprise the steps:
Get the raw materials in weight portion medicine and make coarse powder and put and mix in the tube of filtering, after getting 53～60 degree Chinese liquor and soaking 12～36h, continue with the speed percolation of 53～60 degree Chinese liquor by 2～4mL/min, the collection percolate promptly gets the active component of the Chinese medicine composition for the treatment of proliferative disease.
The active component of Chinese medicine composition is added each 5 parts of Mentholum, Camphoras, and stirring and dissolving leaves standstill, and filters, and concentrated packing promptly gets the outer medicated wine of wiping.
The present invention also provides the preparation method of the Chinese medicine composition of another kind of above-mentioned treatment proliferative disease, may further comprise the steps:
(1) get the raw materials in weight portion medicine, standby;
(2) extract flemiphilippinin C, D and isoflavone in the Radix Flemingiae Philippinensis according to a conventional method; Extract the volatile oil of Radix Angelicae Pubescentis, Herba Asari, Radix Saposhnikoviae, the Cortex Cinnamomi heart; Standby;
(3) medicinal residues with Radix Flemingiae Philippinensis, Radix Angelicae Pubescentis, Herba Asari, Radix Saposhnikoviae, the Cortex Cinnamomi heart mix with all the other crude drug, and water decocts secondary, and each 1.5-2.5 hour, filter, merging filtrate is condensed into thick paste;
(4) flemiphilippinin C, the D that obtain of blend step (2), the thick paste that isoflavone, volatile oil and step (3) obtain promptly gets the active component of the Chinese medicine composition for the treatment of proliferative disease.
Perhaps:
(1) get the raw materials in weight portion medicine, standby;
(2) extract flemiphilippinin C, D and isoflavone in the Radix Flemingiae Philippinensis according to a conventional method; Extract the volatile oil of Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart; Standby;
(3) medicinal residues with Radix Flemingiae Philippinensis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart mix with all the other crude drug, and water decocts secondary, and each 1.5～2.5 hours, filter, merging filtrate is condensed into thick paste;
(4) flemiphilippinin C, the D that obtain of blend step (2), the thick paste that isoflavone, volatile oil and step (3) obtain promptly gets the active component of the Chinese medicine composition for the treatment of proliferative disease.
Polyacrylic acid joined in the glycerol stir, add the active component of above-mentioned Chinese medicine composition, mix the back and add cross-linking agent and stir evenly, evenly coat on the non-woven fabrics, add a cover protective layer, promptly get outer emplastrum.
Chinese medicine composition of the present invention prepares decoction after can also directly decocting, and also active component can be added various conventional adjuvant required when preparing different dosage form, is prepared into peroral dosage form commonly used.
Bone matrix hyperplasia is a kind of degenerative osteoarthritis, be clinical common chronic disease, with arthralgia, moving obstacle, flaccidity soft unfavorable be feature, and confidential relation is arranged with climate change, meet and coldly then increase the weight of, getting warm then disease subtracts, sickness rate with cervical vertebra and lumbar vertebra is the highest, belongs to the category of motherland's medical science " rheumatism involving the bone ", the formation of primary disease, motherland's medical science is thought oldaged physically weak, internal organs void declines, asthenia of essence and blood, or because of prolonged illness, consume healthy energy, wind-cold damp pathogen is taken advantage of a weak point, and injects meridians, stays in the joint, QI and blood numbness resistance, muscles and bones is impaired and fall ill.According to above-mentioned theory of Chinese medical science foundation, thus with wind-damp dispelling, stopping numbness pain, liver and kidney tonifying, legislation fills blood.Chinese medicine composition of the present invention is a monarch drug with Radix Flemingiae Philippinensis, Radix Angelicae Pubescentis, gets its wind-cold damp pathogen between the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and muscles and bones of dispelling.Minister is searched rheumatism of muscles and bones, removing obstruction in the collateral to relieve pain with the diffusing yin channel wind and cold of Herba Asari; Radix Saposhnikoviae is dispeled the wind wet to win; Radix Gentianae Macrophyllae removes rheumatism Shujin bone; Rhizoma Paridis, Cortex Cinnamomi heart warming the interior are dispeled cold promoting blood circulation.Assistant is with Herba Taxilli, Radix Achyranthis Bidentatae, Cortex Eucommiae invigorating the liver and kidney, strengthening bone and muscle, wind-damp dispelling; Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Paeoniae nourshing blood and promoting blood circulation, promptly so-called " wind is controlled blood earlier, and the blood sector-style is from going out ".Radix Ginseng, Poria, Radix Glycyrrhizae air making-up and spleen enlivening, reinforcing body resistance, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is messenger drug.All medicine compatibilities are expelled pathogenetic factors and reinforced antipathogenetic qi, and giving consideration to both the incidental and fundamental is a QI and blood foot and rheumatism is removed, and Liver and kidney is strong, and arthralgia pain more.
Beneficial effect of the present invention is as follows:
The Chinese medicine composition that the present invention treats proliferative disease is to be raw material with pure rare Chinese medicine, and prescription is efficiently tight, has effects such as wind dispelling is active, mass dissipating and swelling eliminating, blood circulation promoting and blood stasis dispelling, removing damp and stopping pain through refining liquid externally applied liniment or the unguentum that forms; Cure mainly neck-shoulder pain, lumbago and leg pain diseases such as cervical vertebra, lumbar vertebra hyperosteogeny, cyclomastopathy, trick hyperosteogeny, lumbar intervertebral disc protrusion pain, phlebitis, rheumatism and rheumatoid arthritis, scapulohumeral periarthritis, lumbar muscle strain, sciatica, hand and foot numbness, the thoracic obstruction, gout, apoplexy, hemiplegia, treating swelling and pain by traumatic injury.
The specific embodiment
The preparation that embodiment 1 Chinese medicine composition beyond the region of objective existence of the present invention is wiped medicated wine
May further comprise the steps:
(1) get Radix Flemingiae Philippinensis 500g, Radix Angelicae Pubescentis 450g, Herba Taxilli 450g, Cortex Eucommiae 450g, Radix Achyranthis Bidentatae 450g, Herba Asari 180g, Radix Gentianae Macrophyllae 360g, Poria 600g, Rhizoma Paridis 360g, Cortex Cinnamomi heart 360g, Radix Saposhnikoviae 450g, Rhizoma Chuanxiong 450g, Radix Ginseng 150g, Radix Glycyrrhizae 180g, Radix Angelicae Sinensis 450g, Radix Paeoniae 360g, Radix Rehmanniae 360g, standby;
(2) above-mentioned medical material is made coarse powder and put and mix in the tube of filtering, after getting 60 degree Chinese liquor and soaking 24h, continue press 3mL/min speed percolation with 60 degree Chinese liquor, collect percolate and be concentrated into about 1000mL, adding Mentholum, each 100g of Camphora dissolve, and leave standstill filtration;
(3) add Chinese liquor to 1000mL, stir evenly packing and get final product.
The preparation of the outer emplastrum of embodiment 2 Chinese medicine compositions of the present invention
May further comprise the steps:
(1) get Radix Flemingiae Philippinensis 500g, Radix Angelicae Pubescentis 450g, Herba Taxilli 450g, Cortex Eucommiae 450g, Radix Achyranthis Bidentatae 450g, Herba Asari 180g, Radix Gentianae Macrophyllae 360g, Poria 600g, Rhizoma Paridis 360g, Cortex Cinnamomi heart 360g, Radix Saposhnikoviae 450g, Rhizoma Chuanxiong 450g, Radix Ginseng 100g, Radix Glycyrrhizae 180g, Radix Angelicae Sinensis 450g, Radix Paeoniae 360g, Radix Rehmanniae 360g, standby;
(2) Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart are extracted volatile oil, it is standby together that Radix Flemingiae Philippinensis extracts flemiphilippinin C, D and isoflavone;
(3) medicinal residues with Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart, Radix Flemingiae Philippinensis mix all the other medical materials, and water decocts secondary, and each 2 hours, filter, merging filtrate is condensed into thick paste;
(4) in polyacrylic acid: glycerol=7: 5 (V: ratio V), the 210ml polyacrylic acid joined in the glycerol stir, the flemiphilippinin C, the D that add step (2), the thick paste of isoflavone and volatile oil, step (3), and a small amount of Mentholum, Camphora mix the back and add 30g cross-linking agent AlCl
3And Al (OH)
3(ratio is 19: 13) stirs evenly; Evenly coat on the non-woven fabrics, add a cover protective layer at last, promptly get the plaster that contains Chinese medicine composition of the present invention.
The preparation of embodiment 3 Chinese medicine composition decoctions of the present invention
May further comprise the steps:
(1) get Radix Flemingiae Philippinensis 25g, Radix Angelicae Pubescentis 20g, Herba Asari 9g, Radix Saposhnikoviae 18g, Radix Gentianae Macrophyllae 18g, Rhizoma Paridis 15g, Cortex Cinnamomi heart 15g, Herba Taxilli 18g, Cortex Eucommiae 18g, Radix Achyranthis Bidentatae 18g, Rhizoma Chuanxiong 18g, Radix Angelicae Sinensis 18g, Radix Paeoniae 15g, Radix Rehmanniae 15g, Radix Ginseng 10g, Poria 25g, Radix Glycyrrhizae 9g, standby;
(2) above-mentioned medical material is soaked in water 0.5～1h fries in shallow oil twice, mixes after respectively being condensed into 150ml, promptly.
The preparation that embodiment 4 Chinese medicine composition beyond the region of objective existences of the present invention are wiped medicated wine
(1) it is standby to get 20 parts of Radix Flemingiae Philippinensiss, 17 parts of Radix Angelicae Pubescentiss, 5 parts of Herba Asaris, 15 parts of Radix Saposhnikoviaes, 12 parts of Radix Gentianae Macrophyllae, 10 parts of Rhizoma Paridis, 10 parts in the Cortex Cinnamomi heart;
(2) above-mentioned medical material is made coarse powder and put and mix in the tube of filtering, after getting 60 degree Chinese liquor and soaking 24h, continue press 3mL/min speed percolation with 60 degree Chinese liquor, collect percolate and be concentrated into about 1000mL, adding Mentholum, each 100g of Camphora dissolve, and leave standstill filtration;
(3) add Chinese liquor to 1000mL, stir evenly packing and get final product.
The preparation that embodiment 5 Chinese medicine composition beyond the region of objective existences of the present invention are wiped medicated wine
(1) gets 30 parts of Radix Flemingiae Philippinensiss, 24 parts of Radix Angelicae Pubescentiss, 13 parts of Herba Asaris, 25 parts of Radix Saposhnikoviaes, 25 parts of Radix Gentianae Macrophyllae, 25 parts of Rhizoma Paridis, 25 parts in the Cortex Cinnamomi heart;
(2) above-mentioned medical material is made coarse powder and put and mix in the tube of filtering, after getting 60 degree Chinese liquor and soaking 24h, continue press 3mL/min speed percolation with 60 degree Chinese liquor, collect percolate and be concentrated into about 1000mL, adding Mentholum, each 100g of Camphora dissolve, and leave standstill filtration;
(3) add Chinese liquor to 1000mL, stir evenly packing and get final product.
The preparation of the outer emplastrum of embodiment 6 Chinese medicine compositions of the present invention
(1) it is standby to get 28 parts of Radix Flemingiae Philippinensiss, 23 parts of Radix Angelicae Pubescentiss, 10 parts of Herba Asaris, 25 parts of Radix Saposhnikoviaes, 25 parts of Radix Gentianae Macrophyllae, 22 parts of Rhizoma Paridis, 22 parts in the Cortex Cinnamomi heart, 22 parts of Herba Taxillis, 22 parts of the Cortexs Eucommiae, 22 parts of Radix Achyranthis Bidentataes, 25 parts of Rhizoma Chuanxiongs, 25 parts of Radix Angelicae Sinensis, 18 parts of Radix Paeoniaes, 25 parts of Radix Rehmanniaes, Radix Ginseng 15,30 parts in Poria, 15 parts in Radix Glycyrrhizae;
(2) Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart are extracted volatile oil, it is standby together that Radix Flemingiae Philippinensis extracts flemiphilippinin C, D and isoflavone;
(3) medicinal residues with Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart, Radix Flemingiae Philippinensis mix all the other medical materials, and water decocts secondary, and each 2 hours, filter, merging filtrate is condensed into thick paste;
(4) in polyacrylic acid: glycerol=7: 5 (V: ratio V), the 210ml polyacrylic acid joined in the glycerol stir, the flemiphilippinin C, the D that add step (2), the thick paste of isoflavone and volatile oil, step (3), and a small amount of Mentholum, Camphora mix the back and add 30g cross-linking agent AlCl
3And Al (OH)
3(ratio is 19: 13) stirs evenly; Evenly coat on the non-woven fabrics, add a cover protective layer at last, promptly get the plaster that contains Chinese medicine composition of the present invention.
The clinical observation of test example 1 traditional Chinese medicine composition for treating cervical vertebra/lumbar vertebra hyperosteogeny of the present invention and lumbar intervertebral disc protrusion pain
1. physical data
Total patient's 802 examples of this test example, wherein male 384 examples, women 418 examples; Minimum 17 years old of age, maximum 84 years old; One-sided lumbago and skelalgia 610 examples, bilateral lumbago and skelalgia 192 examples; All patients all make a definite diagnosis after image instrument (CT and X line are taken the photograph sheet etc.) is checked.802 routine patients' age of onset distribution situation sees Table 1.
Routine cervical vertebra/lumbar vertebra hyperosteogeny of table 1802 and lumbar intervertebral disc protrusion pain patient age of onset distribution situation
2. Therapeutic Method
Take the Chinese medicine composition of embodiment 3, divide upper and lower noon 2 times oral.1 dose of every day, took for 6 weeks continuously.
3. therapeutic effect (seeing Table 2)
Routine cervical vertebra/lumbar vertebra hyperosteogeny of table 2802 and lumbar intervertebral disc protrusion pain patient treatment result
Can learn that from table 2 result use Chinese medicine composition of the present invention (embodiment three) treatment 802 examples, after 2 weeks of taking medicine, total effective rate can reach 88.7%; Continuous taking medicine to the 4th week, total effective rate can reach 96.8%; Continuous clothes are to the 6th week, and total effective rate can reach more than 99.5%.And this test example is not observed Chinese medicine composition of the present invention has anomalous effects to the heart, liver, renal function, blood system.Very effective and fool proof for proliferative diseases such as treatment hyperosteogenys.
The Chinese medicine composition of other embodiment also can effectively be treated proliferative diseases such as hyperosteogeny, and concrete data are omitted.
The test of pesticide effectiveness and the toxicological test of test example 2 Chinese medicine compositions of the present invention
One, Chinese medicine composition of the present invention is to the tumor-inhibiting action of Emhorn solid tumor mice
Test method: adopt Kunming mouse, divide 5 groups to experimentize at random, observe high, medium and low dosage group (high dose=12960mgkg of embodiment 3 respectively
-1, middle dosage=6480mgkg
-1, low dosage=3240mgkg
-1) to the tumour inhibiting rate of ehrlich carcinoma solid tumor in the body and the effect of ehrlich carcinoma rate elongation life cycle, and with 5-FU (dosage=18.75mgkg
-1) and the contrast of blank normal saline.Result of the test sees Table 3.
Table 3 Chinese medicine composition of the present invention to the tumor-inhibiting action of Emhorn solid tumor mice (
N=10)
Compare with the blank group,
△P＞0.05,
*P＜0.01,
* *P＜0.001.
Chinese medicine composition of the present invention as can be seen from Table 3 strengthens along with the increase of dosage gradually to the tumor-inhibiting action of Emhorn solid tumor mice.
Two, Chinese medicine composition of the present invention is to the tumor-inhibiting action of S-180 sarcoma mice
Test method: set up S-180 sarcoma mice transplanted tumor model, it is blank group, embodiment 3 low dose group (3240mgkg that 60 mices are divided into 5 components at random
-1), dosage group (6480mgkg among the embodiment 3
-1), embodiment 3 high dose group (12960mgkg
-1), positive controls (cyclophosphamide 16.25mgkg
-1), treatment finishes the back and measures tumor tissues weight, the results are shown in Table 4.
Table 4 Chinese medicine composition of the present invention to the tumor-inhibiting action of S-180 sarcoma mice (
N=10)
Compare with the blank group,
△P＞0.05,
*P＜0.01,
* *P＜0.001.
Chinese medicine composition of the present invention as can be seen from Table 4 strengthens along with the increase of dosage gradually to the tumor-inhibiting action of S-180 sarcoma mice.
Three, Chinese medicine composition of the present invention is to the tumor-inhibiting action of liver-cancer solid tumor mice
Test method: after kunming mice transplanted the H22 hepatoma carcinoma cell, be divided into blank group (normal saline), positive (cyclophosphamide 16.25mgkg
-1) matched group, embodiment 3 low dose group (3240mgkg
-1), dosage group (6480mgkg among the embodiment 3
-1), embodiment 3 high dose group (12960mgkg
-1), the tumour inhibiting rate of observation hepatic ascites tumor and solid tumor.
Table 5 Chinese medicine composition of the present invention to the tumor-inhibiting action of liver-cancer solid tumor mice (
N=10)
Compare with the blank group,
△P＞0.05,
*P＜0.05,
*P＜0.01,
* *P＜0.001.
Can Chinese medicine composition of the present invention as can be seen the tumor-inhibiting action of liver-cancer solid tumor mice be strengthened gradually along with the increase of dosage from table 5.
Four, Chinese medicine composition of the present invention is to the influence of IL-1 in the joint fluid and TNF level
Test method: 24 rabbits are divided into 2 groups at random, be blank group and treatment group, each 12,24 knee joints, adopt the rabbit knee intracavity to inject the pathological model that papain causes osteoarthritis, knee joint is handled, 1,3,5 weeks extracted joint fluid respectively in the treatment back with Chinese medicine composition of the present invention (embodiment 2), adopt double-antibody sandwich enzyme linked immunosorbent assay (ELISA), measure the expression of IL-1 and TNF in the rabbit knee liquid respectively.
Table 6 Chinese medicine composition of the present invention is to the influence of IL-1 in the joint fluid and TNF level
Compare with matched group,
△P＞0.05,
*P＜0.05,
*P＜0.01,
* *P＜0.001.
The result shows: treatment 1 week of back, and can detect IL-1 and TNF in the knee joint endoprosthesis liquid and express, matched group peaked when 3 weeks, slightly fell after rise during 5 weeks.Treatment group numerical value and matched group fall more as follows, decline difference not statistically significant (P＞0.05) during 1 week, and decline difference has statistical significance (P＜0.01, P＜0.05) during 3,5 weeks.
Five, Chinese medicine composition of the present invention is to the influence of male's patients with ankylosing spondylitis bone density
Therapeutic Method: treat prescription 1 dose of decocting usefulness 3 every days of embodiment to 300ml, sooner or later respectively obey 150ml, took for 2 weeks.Per 2 weeks can have a rest 1 day.Matched group: oral sulfasalazine (SASP) sheet, the 1st every day 3 times in week, each 0.5g adds to every day 3 times the 2nd week, and each 1g keeps this dosage later on, advises polydipsia water.2 groups was 1 course of treatment with 3 months all, all treated 2 courses of treatment.
Table 7 Chinese medicine composition of the present invention is to the influence of male's patients with ankylosing spondylitis bone density
Compare with matched group,
*P＜0.05,
*P＜0.01.
The bone density of treatment group treatment back lumbar vertebra and neck of femur significantly increases (P＜0.05, P＜0.01), matched group there was no significant difference; All there is improvement 2 groups of treatment posterior spinal mobility index of correlation aspects, and the treatment group is better than matched group (P＜0.05).The bone density of pointing out this Chinese medicine composition can improve male's patients with ankylosing spondylitis is improved the activity of spinal column.
Can draw this Chinese medicine composition from above experimental result Emhorn solid tumor mice, S-180 sarcoma mice, liver-cancer solid tumor mice are all had good effect; Can significantly improve bone density.
The Chinese medicine composition of other embodiment also has the same function of test example 2, and concrete data are omitted.
More than be at the specifying of possible embodiments of the present invention, but this embodiment is not in order to limiting claim of the present invention, does not allly break away from equivalence of the present invention and implement or change, all should be contained in the claim of the present invention.
Claims (6)
1. Chinese medicine composition for the treatment of proliferative disease, it is characterized in that this Chinese medicine composition is made by following bulk drugs: 20～30 parts of Radix Flemingiae Philippinensiss, 15～25 parts of Radix Angelicae Pubescentiss, 5～15 parts of Herba Asaris, 13～25 parts of Radix Saposhnikoviaes, 12～25 parts of Radix Gentianae Macrophyllae, 10～25 parts of Rhizoma Paridis, 10～25 parts in the Cortex Cinnamomi heart, 15～25 parts of Herba Taxillis, 15～25 parts of the Cortexs Eucommiae, 15～25 parts of Radix Achyranthis Bidentataes, 15～25 parts of Rhizoma Chuanxiongs, 15～25 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Paeoniaes, 10～25 parts of Radix Rehmanniaes, Radix Ginseng 5～15,20～30 parts in Poria, 5～15 parts in Radix Glycyrrhizae.
2. the Chinese medicine composition of treatment proliferative disease according to claim 1, it is characterized in that the weight portion of each crude drug is in this Chinese medicine composition: 25 parts of Radix Flemingiae Philippinensiss, 20 parts of Radix Angelicae Pubescentiss, 9 parts of Herba Asaris, 18 parts of Radix Saposhnikoviaes, 18 parts of Radix Gentianae Macrophyllae, 15 parts of Rhizoma Paridis, 15 parts in the Cortex Cinnamomi heart, 18 parts of Herba Taxillis, 18 parts of the Cortexs Eucommiae, 18 parts of Radix Achyranthis Bidentataes, 18 parts of Rhizoma Chuanxiongs, 18 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniaes, 15 parts of Radix Rehmanniaes, 10 parts of Radix Ginsengs, 25 parts in Poria, 9 parts in Radix Glycyrrhizae.
3. the preparation method of the Chinese medicine composition of claim 1 or 2 described treatment proliferative diseases is characterized in that, may further comprise the steps:
Get the raw materials in weight portion medicine and make coarse powder and put in the percolator, after getting 53～60 degree Chinese liquor and soaking 12～36h, continue with the speed percolation of 53～60 degree Chinese liquor with 2～4mL/min, the collection percolate promptly gets the active component of the Chinese medicine composition for the treatment of proliferative disease.
4. the preparation method of the Chinese medicine composition of treatment proliferative disease according to claim 3 is characterized in that, the active component of Chinese medicine composition is added each 5 parts of Mentholum, Camphoras, and stirring and dissolving leaves standstill, and filters, and concentrates and promptly get outer wiping medicated wine.
5. the preparation method of the Chinese medicine composition of claim 1 or 2 described treatment proliferative diseases is characterized in that, may further comprise the steps:
(1) get the raw materials in weight portion medicine, standby;
(2) extract flemiphilippinin C, D and isoflavone in the Radix Flemingiae Philippinensis according to a conventional method; Extract the volatile oil of Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart; Standby;
(3) medicinal residues with Radix Flemingiae Philippinensis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Asari, Radix Saposhnikoviae, Rhizoma Chuanxiong, the Cortex Cinnamomi heart mix with all the other crude drug, and water decocts secondary, and each 1.5～2.5 hours, filter, merging filtrate is condensed into thick paste;
(4) flemiphilippinin C, the D that obtain of blend step (2), the thick paste that isoflavone, volatile oil and step (3) obtain promptly gets the active component of the Chinese medicine composition for the treatment of proliferative disease.
6. the preparation method of the Chinese medicine composition of treatment proliferative disease according to claim 5; it is characterized in that; polyacrylic acid joined in the glycerol stir; the active component that adds Chinese medicine composition; mixing back adding cross-linking agent stirs evenly; evenly coat on the non-woven fabrics, add a cover protective layer, promptly get outer emplastrum.
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