CN101902993A - 支架 - Google Patents

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CN101902993A
CN101902993A CN2008801221288A CN200880122128A CN101902993A CN 101902993 A CN101902993 A CN 101902993A CN 2008801221288 A CN2008801221288 A CN 2008801221288A CN 200880122128 A CN200880122128 A CN 200880122128A CN 101902993 A CN101902993 A CN 101902993A
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bin
support
mast
junction surface
connecting section
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杰森·T·兰兹
丹尼尔·格雷格里奇
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Boston Scientific Scimed Inc
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Boston Scientific Scimed Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541Adjacent bands are arranged out of phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91583Adjacent bands being connected to each other by a bridge, whereby at least one of its ends is connected along the length of a strut between two consecutive apices within a band
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Abstract

一种支架(10)具有柱杆带(20)和连接部(40),其中所述柱杆带具有长的(30)和短的柱杆(32、34),在短柱杆之间设置有接合部。各接合部界定出储存器(12),其中柱杆带的储存器基本上沿圆周方向对齐。各连接部具有臂(42、46),其中各臂具有反向的U形联接段(44)。所述反向联接段具有位于一个柱杆带上的一峰部与相邻柱杆带上纵向邻近的谷部之间的共用部(50)。

Description

支架
技术领域
本发明涉及一种用于植入身体脉管(通常为血管)内的内用假体器械。更具体地,本发明涉及一种管状可扩张支架,其具有改进的结构和改进的药物保持/输送能力。
技术背景
支架(stent、grafts,stent-grafts)、静脉过滤器、可扩张框架和类似可植入医疗器械,在下文统称为支架,它们是可径向扩张的内用假体,通常为能够植入血管内并且在经皮肤导入后径向扩张的血管内植入物。支架可植入各种体腔或者各种脉管内,如血管系统、泌尿管路、胆管、输卵管、冠状血管、次生脉管等。支架可用于支撑身体脉管并防止在血管系统内进行血管成形术之后的再狭窄。它们可以是自扩张的,例如当安装到球囊上时由内部径向力扩张,或者是自扩张和球囊可扩张的组合(混合式可扩张)。
可以制造出支架的方法包括由管状原料切削或蚀刻出设计图样,由平面片材经切削或蚀刻然后将其卷起,或者由一种或多种交织的金属丝或编织带制成。
用于支架的公知构造材料包括聚合物、有机织物和生物相容金属。已用于构造支架和/或其组件的金属和/或这些金属的合金包括但不限于不锈钢、金、银、钽、钛、铬、钴和镍钛诺之类的形状记忆合金。
在努力与血管再狭窄和其它疾病作斗争中,已采用支架将各种治疗剂直接输送到支架展开位置。一些支架采用诸如沟、槽、孔、腔室之类的各种结构作为治疗剂和/或其它物质的储存器。
仍需要具有改善的结构性能特征的药物输送支架,例如具有改善的挠曲性、结构整体性、抗压缩性等。还需要使得这些支架具有更理想的药物输送特性。
上面提及和/或描述的技术无意构成承认任何专利、公开或本文中提及的其他信息是相对于本发明的“现有技术”。另外,这一部分不应被解释成已经做过检索或者不存在37C.F.R.§1.56(a)所定义的相关信息的含义。
在本申请中任何地方提到的所有美国专利以及申请和所有其它公开文件,通过引证将它们整体合并在此。
不作为对发明范围的限制,本发明的某些要求保护的实施例的简要概述说明如下。所概述的本发明实施例的详细说明及/或本发明的补充实施例可以在下面的发明的具体实施方式中找到。
仅为符合37C.F.R.1.72的目的提供说明书中的技术内容的摘要。该摘要不用于解释权利要求书的范围。
发明内容
本发明实施方式涉及支架结构,用于输送如药物之类的治疗剂时所述支架结构提供改善的药物输送特性。药物输送储存器在整个支架结构上独特的排列和配置方式提供改善的药物输送特性,而不牺牲支架的性能。
本发明的实施方式包括支架,所述支架具有改善的挠曲性,还具有结构强度以允许支架穿越哺乳动物内弯曲的路线。在一些实施方式中,本发明支架设有长柱杆和短柱杆的柱杆带,其中柱杆对在接合部处互相连接。柱杆带内的接合部沿圆周方向偏置。
在一些实施方式中,所述支架在柱杆带之间设置有连接部,连接部具有朝向相反的U形联接段,其中各联接段从相邻柱杆带的接合部延伸。
本发明的支架中提供的结构特征的组合提供了结构改善的、高挠曲性的支架。
然而,本发明一附加的目标是提供还具有改善的药物输送特性的支架。通过为支架设置药物输送储存器来实现这个目标,所述储存器位于所述柱杆带接合部和所述连接部内(有时还位于所述柱杆内),并由这些柱杆带接合部、连接部和柱杆形成。在一些实施方式中,所述储存器中的至少一部分围绕所述支架以圆周向对齐的列设置。
储存器可以是适于容纳一定量治疗剂(如药物或药物/聚合物基体)的任意类型的表面结构。在一些实施方式中,一个或多个储存器仅延伸通过所述支架的部分厚度,仅有单个开口在支架的内表面(腔内)或外表面(腔外)上。在一些实施方式中,一个或多个储存器为通孔,所述通孔延伸穿过支架体的整个厚度。各储存器贯穿其厚度可以具有恒定的或变化的截面面积。各储存器的开口可以具有不同的大小或形状。
文后所附权利要求书精确地指出了这些和其它体现了本发明特征的实施方式,并构成了本文的一部分。然而,为了进一步理解本发明、通过其使用而得到的其优点和目的,可参考构成本文另一部分的附图以及所附的描述性内容,其中阐示和描述了本发明的实施方式。
附图说明
下面参考附图对本发明作详细说明。
图1示出了本发明一实施方式的平面图。
图2示出了本发明一实施方式的平面图。
图3示出了本发明一实施方式的平面图。
具体实施方式
尽管本发明可用许多不同形式来实施,但本文详细描述的是特定的实施方式。这种描述是本发明原理的范例,而无意将本发明限制于所阐述的特定的实施方式。
为了公开的目的,图中相同的附图标记表示相同的结构,除非另有说明。
本发明的至少一个实施方式涉及支架10,该支架的例子示于图1。支架10的结构由多个柱杆带20和连接部40组成。
各柱杆带20形成具有交替的峰部22和谷部24的闭合路径。相邻的柱杆带20由至少一个连接部40连接。
各柱杆带20包括多个长柱杆30、多个第一短柱杆32和第二短柱杆34、和多个接合部36。各接合部36位于第一短柱杆32和第二短柱杆34之间并连接该第一短柱杆32和第二短柱杆34。在图1至图3所示的实施方式中,在各柱杆带20内,各第一短柱杆32与各第二短柱杆34在纵向和圆周向上相互偏离。各长柱杆30连接至第一短柱杆32的峰部22,并连接至第二短柱杆34的谷部24。
在图1至图3的各实施方式中,各接合部36界定出单个接合部储存器12,其中一个柱杆带20的全部接合部储存器12基本上沿圆周方向对齐。然而,在一些实施方式中,一个接合部界定出多个接合部储存器,例如1、2、3、4或更多个接合部储存器。
在一些实施方式中,连接部40包括从一柱杆带20上的接合部36延伸的第一臂42和从相邻柱杆带20上的接合部36延伸的第二臂46。第一臂42的至少一部分包括第一U形联接段44,且第二臂46的至少一部分包括第二U形联接段48。各第一U形联接段44朝第一方向敞口而各第二U形联接段48朝基本上与第一方向相反的第二方向敞口。虽然可以改变联接段开口的朝向,并且可以是任意方向,但在图1至图3所示的实施方式中,各联接段44和48基本上沿圆周方向敞口,或者说基本上以与支架10的纵轴线垂直的方向敞口。
第一U形联接段44的至少一部分和第二U形联接段48的至少一部分具有共用部50。各连接部40的共用部50位于一柱杆带20上的其中一个峰部22与相邻柱杆带20上的纵向邻近的谷部24之间。在一些支架10具有在相邻柱杆带20之间的多个连接部40的实施方式中,任意两个柱杆带20之间的共用部50基本上在圆周方向上对齐。
如需要,可以使柱杆带20或单一连续相对于支架的纵轴线成一角度,以使得所述柱杆带具有螺旋状或类螺旋状构造。在这样的实施方式中,一对柱杆带40之间的那些连接部40的共用部50相对于所述纵轴线也可以是斜的或者说成一角度。
在图2所示的实施方式中,各长柱杆30上界定出至少一个柱杆储存器14。在一些实施方式中,一个或多个长柱杆30上界定出多个柱杆储存器14。在一个长柱杆30上的柱杆储存器14的数量可以在一至约十二之间变化,这取决于长柱杆30的长度。在一些实施方式中,所述柱杆储存器14的数量为至少三个至九个之间。在图2所示的实施方式中,在各长柱杆30中的其中一个柱杆储存器14与给定柱杆带20的接合部储存器12基本上在圆周方向对齐。在长柱杆30上有多个柱杆储存器14的情况下,优选地,附加的储存器14互相等距离隔开,并且均匀地分布在该与接合部储存器12圆周向对齐的中间储存器的任意侧。
支架的不同组件(柱杆、连接部、储存器等)可以具有不同的物理特征,诸如长度、宽度、厚度等,各个组件的物理特征也可以不同。然而,在图2所示的实施方式中,各长柱杆30具有长柱杆宽度31,第一和第二短柱杆32/34各自具有短柱杆宽度33。长柱杆宽度31大于短柱杆宽度33。或者,在图1至图3所示的实施方式中,长柱杆宽度31与短柱杆宽度33基本相同。
在一些实施方式中,如图1和图2所示,连接部40的各个臂42和46具有臂宽度45。该臂宽度小于所述长柱杆宽度31或小于所述短柱杆宽度33。在至少一实施方式中,例如如图3所示,臂42和46的宽度45沿其长度可以不同,特别是如果存在连接部储存器16而要求更大的宽度区域47以容纳所需的储存器16的截面面积。
在一些实施方式中,如图1和图2所示,各连接部40的共用部50上界定出单个连接部储存器16。如图示中可见,给定的连接部储存器16的截面积51大于接合部储存器12的截面积53或柱杆储存器14的截面积55(截面积51、53和55用阴影示出)。
在一些实施方式中,如在图3所示的支架10中,第一U形联接段44至少在靠近共用部50的一部分上界定出至少一个连接部储存器16,第二U形联接段48至少在靠近共用部50的一部分上界定出至少一个连接部储存器16。在所示实施方式中,各连接部储存器的截面积51小于或基本上等于各接合部储存器12的截面积53。
在图3所示的实施方式中,第一U形联接段44和第二U形联接段48各自界定出第一多个连接部储存器16a。第一臂42上靠近第一U形联接段44的区域和第二臂46上靠近第二U形联接段48区域中各自界定出第二多个连接部储存器16b。所述第一多个连接部储存器16a多于所述第二多个连接部储存器16b。
连接部储存器16的具体形态和排列不限于图1至图3所示的那些配置/样式。连接部储存器(以及接合部储存器和柱杆储存器)的分布、大小、形状和形态可以改动,以提供一种或多种药物或其它治疗剂的所需的分布/排出特征。
治疗剂可以是药物或其它医药制品,如非遗传药剂、遗传药剂、细胞材料等。适当的非遗传治疗剂的一些例子包括但不限于,如肝素之类的抗血栓剂、肝素衍生物、血管细胞生长促进剂、生长因子抑制剂、紫杉醇(Paclitaxel)等。如药剂包括遗传治疗剂,所述遗传治疗剂可包括但不限于:DNA、RNA和它们各自的衍生物和/或组分;刺猬蛋白等。如治疗剂包括细胞材料,所述细胞材料可包括但不限于:人源细胞和/或非人源细胞,以及它们各自的组分和/或衍生物。如治疗剂包括聚合物剂,该聚合物剂可以是聚苯乙烯-聚异丁二烯-聚苯乙烯三嵌段共聚物(SIBS)、聚氧乙烯、硅橡胶和/或任意其它合适的基质。
本文示出并说明的支架10可由任意生物相容材料制成,该生物相容材料包括一种或多种聚合物、一种或多种金属或聚合物与金属的组合物。合适的材料的例子包括也是生物相容的生物可降解材料。生物可降解表示一种材料会经历作为正常的生物学过程的一部分,裂解或分解成为无危害化合物。合适的生物可降解材料包括聚乳酸、聚乙醇酸(PGA)、胶原或其他结缔蛋白或天然材料、聚己酸内酯、透明质酸、粘合蛋白、这些材料的共聚物、及其复合物和组合物以及其它生物可降解材料的组合物。其它可使用的聚合物包括聚酯和聚碳酸酯共聚物。合适金属的例子包括但不限于不锈钢、钛、钽、铂、钨、金、以及任何上述金属的合金。合适的合金的例子包括但不限于铂铱合金、包括埃尔吉洛伊(Elgiloy)和菲诺克斯(Phynox)的钴铬合金、MP35N合金和例如镍钛诺(Nitinol)的镍钛合金。
支架10可由诸如超塑性的镍钛诺或者弹簧钢之类的形状记忆材料制成,或由塑性可变形的材料制成。在使用形状记忆材料的情况下,所述支架可设为记忆形状,然后变形为直径减小形状。当将所述支架加热至转换温度并且移除所有对它的限制,支架10可自行回复至其记忆形状。
支架10的制造方法包括由管状原料切削或蚀刻出设计图样,由平面片材经切削或蚀刻然后将其卷起,或者由一种或多种交织的金属丝或织带制成。也可使用本领域已知的或将来开发出来的其它任何合适的技术来制造本文公开的支架10。
在一些实施方式中,支架10,或其输送系统,可包括一个或多个可以被成像模式,诸如X光、MRI、超声等检测到的区域、带、涂层、部件等。在一些实施方式中,支架的至少一部分是至少部分射线透不过的。
上述公开的内容是用于阐述而非穷举的。本说明书对于本领域普通技术人员暗示了有许多变化方式和替代方式。个别附图中显示的以及以上描述的各个元件在需要时可以组合或为了组合而作改动。所有这些替代方式和变化方式意欲包含在权利要求书的范围内,其中术语“包括”意味着“包含但不限于”。
此外,从属权利要求中出现的具体特征可以用本发明范围内的其它方式互相合并,从而应当承认本发明,还明确地涉及其它具有从属权利要求特征的任意可能组合的实施例。例如,为了权利要求的公布,下列任何从属权利要求应当可以采用多项从属形式的另一种写法,即其从属于所有的、具有该从属权利要求所引用的全部前提条件的在先权利要求,如果该多项从属的格式在法律范围内是可接受的格式的话(例如,每个直接从属于权利要求1的权利要求,应当换成从属于所有在先的权利要求的写法)。如果法律限制多项从属权利要求的格式,下列从属权利要求应当分别采用另一种写法,即从属于在先的、具有前提条件的权利要求的各单一的从属权利要求格式,而不是以下从属权利要求中所列出的具体权利要求。
本发明的描述到此为止。本技术领域的技术人员可认识到与在此描述的具体实施例的其他等价物,也意欲将其包含在所附权利要求的范围之内。

Claims (15)

1.一种支架,包括:
多个柱杆带,各柱杆带形成具有交替的峰部和谷部的闭合路径,其中相邻的所述柱杆带由多个连接部连接,
各柱杆带包括多个长柱杆、多个短柱杆和多个接合部,各接合部位于第一短柱杆和第二短柱杆之间并连接该第一和第二短柱杆,各长柱杆与第一短柱杆的峰部相连并与第二短柱杆的谷部相连,
各接合部上仅界定出单个接合部储存器,一柱杆带的所有接合部储存器沿圆周方向对齐,
各连接部包括从一柱杆带上的接合部延伸的第一臂和从相邻柱杆带上的接合部延伸的第二臂,所述第一臂的至少一部分包括第一U形联接段并且所述第二臂的至少一部分包括第二U形联接段,各第一U形联接段以第一方向敞口而各第二U形联接段以与所述第一方向基本上相反的第二方向敞口,所述第一U形联接段的至少一部分和所述第二U形联接段的至少一部分具有共用部,所述共用部位于一柱杆带上其中一个所述峰部与相邻柱杆带的纵向相邻的谷部之间。
2.如权利要求1所述的支架,其中各第一短柱杆与各第二短柱杆在纵向和圆周向上偏离。
3.如权利要求1所述的支架,其中各长柱杆上界定出至少一个柱杆储存器。
4.如权利要求3所述的支架,其中在各柱杆带中,所述至少一个柱杆储存器与所述接合部储存器基本上沿圆周方向对齐。
5.如权利要求3所述的支架,其中各长柱杆上界定出多个柱杆储存器,其中所述多个柱杆储存器中的至少一个与所述接合部储存器基本上沿圆周方向对齐。
6.如权利要求5所述的支架,其中各所述多个柱杆储存器沿所述长柱杆的长度互相基本上等距离地隔开。
7.如权利要求6所述的支架,其中各长柱杆上界定出至少三个柱杆储存器至九个柱杆储存器。
8.如权利要求1所述的支架,其中各长柱杆具有长柱杆宽度,且各短柱杆具有短柱杆宽度,所述长柱杆宽度大于所述短柱杆宽度。
9.如权利要求1所述的支架,其中各长柱杆具有长柱杆宽度,各短柱杆具有短柱杆宽度,且各臂具有臂宽度,所述臂宽度小于所述长柱杆宽度或所述短柱杆宽度。
10.如权利要求1所述的支架,其中圆周方向上相邻的连接部的所述共用部基本上沿圆周方向对齐。
11.如权利要求10所述的支架,其中各共用部上界定出单个连接部储存器,各连接部储存器具有连接部储存器面积,各接合部储存器具有接合部储存器面积,所述连接部储存器面积大于所述接合部储存器面积。
12.如权利要求1所述的支架,其中所述第一U形联接段的至少一部分上界定出至少一个连接部储存器,并且所述第二U形联接段的至少一部分上界定出至少一个连接部储存器。
13.如权利要求12所述的支架,其中各连接部储存器具有连接部储存器面积,各接合部储存器具有接合部储存器面积,所述连接部储存器面积不大于所述接合部储存器面积。
14.如权利要求13所述的支架,其中所述第一U形联接段的靠近所述共用部的区域上界定出第一连接部储存器,且所述第二U形联接段的区域上界定出第二连接部储存器。
15.如权利要求14所述的支架,其中所述第一U形联接段上和所述第二U形联接段上各界定出第一多个连接部储存器,并且
所述第一臂的靠近所述第一U形联接段的区域上以及所述第二臂的靠近所述第二U形联接段的区域上各界定出第二多个连接部储存器,
其中所述第一多个多于所述第二多个。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103391757A (zh) * 2011-03-03 2013-11-13 波士顿科学国际有限公司 低应变高强度支架

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8382821B2 (en) 1998-12-03 2013-02-26 Medinol Ltd. Helical hybrid stent
US20070219642A1 (en) * 1998-12-03 2007-09-20 Jacob Richter Hybrid stent having a fiber or wire backbone
US20040267349A1 (en) * 2003-06-27 2004-12-30 Kobi Richter Amorphous metal alloy medical devices
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US9039755B2 (en) 2003-06-27 2015-05-26 Medinol Ltd. Helical hybrid stent
US9155639B2 (en) * 2009-04-22 2015-10-13 Medinol Ltd. Helical hybrid stent
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
WO2008002778A2 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
ATE508708T1 (de) 2006-09-14 2011-05-15 Boston Scient Ltd Medizinprodukte mit wirkstofffreisetzender beschichtung
US20080294236A1 (en) * 2007-05-23 2008-11-27 Boston Scientific Scimed, Inc. Endoprosthesis with Select Ceramic and Polymer Coatings
US8431149B2 (en) * 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
WO2009012353A2 (en) * 2007-07-19 2009-01-22 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
WO2009020520A1 (en) 2007-08-03 2009-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US20090118821A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118818A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
US20090118812A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7722661B2 (en) * 2007-12-19 2010-05-25 Boston Scientific Scimed, Inc. Stent
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US8114151B2 (en) * 2008-05-08 2012-02-14 Boston Scientific Scimed, Inc. Stent with tabs and holes for drug delivery
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
CN101732114B (zh) * 2008-11-04 2014-07-30 上海微创医疗器械(集团)有限公司 开有载药槽的冠状动脉血管支架
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
EP2391312B1 (en) 2009-02-02 2013-06-05 Cordis Corporation Flexible stent design
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9301864B2 (en) 2010-06-08 2016-04-05 Veniti, Inc. Bi-directional stent delivery system
US8864811B2 (en) 2010-06-08 2014-10-21 Veniti, Inc. Bi-directional stent delivery system
KR20160103151A (ko) * 2010-08-02 2016-08-31 코디스 코포레이션 상이한 나선형 영역들을 갖는 가요성 나선형 스텐트
BR112013002720A2 (pt) * 2010-08-02 2016-05-31 Cordis Corp stent helicoidal flexível tendo região não helicoidal intermediária
EP2600802B1 (en) * 2010-08-02 2019-05-29 Cardinal Health Switzerland 515 GmbH Flexible helical stent having intermediate structural feature
CA2807022C (en) * 2010-08-02 2016-09-06 Cordis Corporation Flexible helical stent having intermediate structural feature
US9233014B2 (en) 2010-09-24 2016-01-12 Veniti, Inc. Stent with support braces
WO2012125184A1 (en) * 2011-03-16 2012-09-20 Boston Scientific Scimed, Inc. Stent and delivery system
CN106667630B (zh) 2012-05-14 2019-03-29 C·R·巴德公司 可均匀膨胀的支架
US20140121750A1 (en) * 2012-10-31 2014-05-01 Cook Medical Technologies Llc Fixation Process For Nesting Stents
USD723165S1 (en) 2013-03-12 2015-02-24 C. R. Bard, Inc. Stent
US10271975B2 (en) 2013-03-15 2019-04-30 Atrium Medical Corporation Stent device having reduced foreshortening and recoil and method of making same
WO2015007435A1 (en) * 2013-07-19 2015-01-22 Biotronik Ag Stent
US10835398B2 (en) 2017-11-03 2020-11-17 Covidien Lp Meshes and devices for treating vascular defects

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US5133732A (en) 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
CA1322628C (en) 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
US5425739A (en) 1989-03-09 1995-06-20 Avatar Design And Development, Inc. Anastomosis stent and stent selection system
US5221261A (en) 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5242399A (en) 1990-04-25 1993-09-07 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5139480A (en) 1990-08-22 1992-08-18 Biotech Laboratories, Inc. Necking stents
US5183085A (en) 1991-09-27 1993-02-02 Hans Timmermans Method and apparatus for compressing a stent prior to insertion
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
CA2380683C (en) 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
US5507771A (en) 1992-06-15 1996-04-16 Cook Incorporated Stent assembly
US5494029A (en) 1992-09-29 1996-02-27 Hood Laboratories Laryngeal stents
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5443477A (en) 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
DE4418845C5 (de) 1994-05-30 2012-01-05 Synova S.A. Verfahren und Vorrichtung zur Materialbearbeitung mit Hilfe eines Laserstrahls
US5531741A (en) 1994-08-18 1996-07-02 Barbacci; Josephine A. Illuminated stents
US5891108A (en) 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US5522882A (en) 1994-10-21 1996-06-04 Impra, Inc. Method and apparatus for balloon expandable stent-graft delivery
US5549662A (en) 1994-11-07 1996-08-27 Scimed Life Systems, Inc. Expandable stent using sliding members
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
WO1997009006A1 (en) 1995-09-01 1997-03-13 Emory University Endovascular support device and method of use
US5824037A (en) 1995-10-03 1998-10-20 Medtronic, Inc. Modular intraluminal prostheses construction and methods
US5741293A (en) 1995-11-28 1998-04-21 Wijay; Bandula Locking stent
US5824040A (en) 1995-12-01 1998-10-20 Medtronic, Inc. Endoluminal prostheses and therapies for highly variable body lumens
US6783543B2 (en) 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US5925061A (en) 1997-01-13 1999-07-20 Gore Enterprise Holdings, Inc. Low profile vascular stent
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6344055B1 (en) 1997-05-14 2002-02-05 Novo Rps Ulc Method for production of an expandable stent
US6231598B1 (en) * 1997-09-24 2001-05-15 Med Institute, Inc. Radially expandable stent
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6273908B1 (en) 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
US6156062A (en) 1997-12-03 2000-12-05 Ave Connaught Helically wrapped interlocking stent
US6179867B1 (en) 1998-01-16 2001-01-30 Advanced Cardiovascular Systems, Inc. Flexible stent and method of use
US6132461A (en) 1998-03-27 2000-10-17 Intratherapeutics, Inc. Stent with dual support structure
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
DE19916086B4 (de) 1998-04-11 2004-11-11 Inflow Dynamics Inc. Implantierbare Prothese, insbesondere Gefäßprothese (Stent)
KR100584310B1 (ko) 1998-04-30 2006-05-26 시노바 에스.에이 분사액체로 주입되는 레이저빔으로 소재를 가공하는방법과 장치
US20020038146A1 (en) 1998-07-29 2002-03-28 Ulf Harry Expandable stent with relief cuts for carrying medicines and other materials
US6206915B1 (en) 1998-09-29 2001-03-27 Medtronic Ave, Inc. Drug storing and metering stent
DE19855421C2 (de) 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6379381B1 (en) 1999-09-03 2002-04-30 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
ES2332869T3 (es) 1999-11-17 2010-02-15 Boston Scientific Limited Dispositivos microfabricados para la entrega de moleculas en fluidos portadores.
AU2001252890B2 (en) 2000-03-02 2005-06-02 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
EP1132058A1 (en) 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US6379382B1 (en) 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US6395326B1 (en) 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
US6254632B1 (en) 2000-09-28 2001-07-03 Advanced Cardiovascular Systems, Inc. Implantable medical device having protruding surface structures for drug delivery and cover attachment
US6506437B1 (en) 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6558733B1 (en) 2000-10-26 2003-05-06 Advanced Cardiovascular Systems, Inc. Method for etching a micropatterned microdepot prosthesis
US6663664B1 (en) 2000-10-26 2003-12-16 Advanced Cardiovascular Systems, Inc. Self-expanding stent with time variable radial force
US6758859B1 (en) * 2000-10-30 2004-07-06 Kenny L. Dang Increased drug-loading and reduced stress drug delivery device
US10398830B2 (en) 2000-11-17 2019-09-03 Vactronix Scientific, Llc Device for in vivo delivery of bioactive agents and method of manufacture thereof
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6663662B2 (en) 2000-12-28 2003-12-16 Advanced Cardiovascular Systems, Inc. Diffusion barrier layer for implantable devices
US6635082B1 (en) 2000-12-29 2003-10-21 Advanced Cardiovascular Systems Inc. Radiopaque stent
US6790227B2 (en) * 2001-03-01 2004-09-14 Cordis Corporation Flexible stent
US6660034B1 (en) 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
ES2266148T5 (es) 2001-07-20 2012-11-06 Sorin Biomedica Cardio S.R.L. Stent
US20060224234A1 (en) 2001-08-29 2006-10-05 Swaminathan Jayaraman Drug eluting structurally variable stent
DE10150995A1 (de) 2001-10-08 2003-04-10 Biotronik Mess & Therapieg Implantat mit proliferationshemmender Substanz
AU2002339717A1 (en) 2001-10-18 2003-07-15 Advanced Stent Technologies, Inc. Stent for vessel support, coverage and side branch accessibility
EP1310242A1 (en) 2001-11-13 2003-05-14 SORIN BIOMEDICA CARDIO S.p.A. Carrier and kit for endoluminal delivery of active principles
US7014654B2 (en) * 2001-11-30 2006-03-21 Scimed Life Systems, Inc. Stent designed for the delivery of therapeutic substance or other agents
US6828696B2 (en) 2002-07-03 2004-12-07 Fusion Uv Systems, Inc. Apparatus and method for powering multiple magnetrons using a single power supply
US7951392B2 (en) 2002-08-16 2011-05-31 Boston Scientific Scimed, Inc. Microarray drug delivery coatings
US6878162B2 (en) * 2002-08-30 2005-04-12 Edwards Lifesciences Ag Helical stent having improved flexibility and expandability
US7163555B2 (en) 2003-04-08 2007-01-16 Medtronic Vascular, Inc. Drug-eluting stent for controlled drug delivery
US7722661B2 (en) * 2007-12-19 2010-05-25 Boston Scientific Scimed, Inc. Stent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103391757A (zh) * 2011-03-03 2013-11-13 波士顿科学国际有限公司 低应变高强度支架
CN103391757B (zh) * 2011-03-03 2016-01-20 波士顿科学国际有限公司 低应变高强度支架

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US7722661B2 (en) 2010-05-25
EP2231079A1 (en) 2010-09-29
US7922756B2 (en) 2011-04-12
US20100222868A1 (en) 2010-09-02
ATE550000T1 (de) 2012-04-15
EP2231079B1 (en) 2012-03-21
US20110190873A1 (en) 2011-08-04
US20090163991A1 (en) 2009-06-25

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