CN101899001A - N-(2-氨基-4-吡啶基)-苯甲酰胺衍生物及其应用 - Google Patents
N-(2-氨基-4-吡啶基)-苯甲酰胺衍生物及其应用 Download PDFInfo
- Publication number
- CN101899001A CN101899001A CN2009100519366A CN200910051936A CN101899001A CN 101899001 A CN101899001 A CN 101899001A CN 2009100519366 A CN2009100519366 A CN 2009100519366A CN 200910051936 A CN200910051936 A CN 200910051936A CN 101899001 A CN101899001 A CN 101899001A
- Authority
- CN
- China
- Prior art keywords
- amino
- pyridyl
- benzamide
- aminomethyl
- carbon atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (12)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100519366A CN101899001A (zh) | 2009-05-25 | 2009-05-25 | N-(2-氨基-4-吡啶基)-苯甲酰胺衍生物及其应用 |
PCT/CN2010/000712 WO2010135908A1 (zh) | 2009-05-25 | 2010-05-20 | N-(2-氨基-4-吡啶基)苯甲酰胺衍生物及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100519366A CN101899001A (zh) | 2009-05-25 | 2009-05-25 | N-(2-氨基-4-吡啶基)-苯甲酰胺衍生物及其应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101899001A true CN101899001A (zh) | 2010-12-01 |
Family
ID=43222130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009100519366A Pending CN101899001A (zh) | 2009-05-25 | 2009-05-25 | N-(2-氨基-4-吡啶基)-苯甲酰胺衍生物及其应用 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN101899001A (zh) |
WO (1) | WO2010135908A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102850236A (zh) * | 2011-06-27 | 2013-01-02 | 国药一心制药有限公司 | 新型苯甲酰胺类组蛋白去乙酰化酶抑制剂及其应用 |
WO2013170758A1 (zh) * | 2012-05-18 | 2013-11-21 | 国药一心制药有限公司 | 含稠环结构的苯甲酰胺类化合物及其作为抗肿瘤药物应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11335375A (ja) * | 1998-05-20 | 1999-12-07 | Mitsui Chem Inc | ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体 |
CN1284772C (zh) * | 2003-07-04 | 2006-11-15 | 深圳微芯生物科技有限责任公司 | 具有分化和抗增殖活性的苯甲酰胺类组蛋白去乙酰化酶抑制剂及其药用制剂 |
US20100152188A1 (en) * | 2005-08-05 | 2010-06-17 | Akella Satya Surya Visweswara Srinivas | Novel Heterocyclic Compounds |
CN101633638B (zh) * | 2008-06-20 | 2012-07-25 | 江苏国华投资有限公司 | 一类组蛋白去乙酰化酶抑制剂及其应用 |
-
2009
- 2009-05-25 CN CN2009100519366A patent/CN101899001A/zh active Pending
-
2010
- 2010-05-20 WO PCT/CN2010/000712 patent/WO2010135908A1/zh active Application Filing
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102850236A (zh) * | 2011-06-27 | 2013-01-02 | 国药一心制药有限公司 | 新型苯甲酰胺类组蛋白去乙酰化酶抑制剂及其应用 |
WO2013000395A1 (zh) * | 2011-06-27 | 2013-01-03 | 国药一心制药有限公司 | 新型苯甲酰胺类组蛋白去乙酰化酶抑制剂及其应用 |
US9040727B2 (en) | 2011-06-27 | 2015-05-26 | Shanghai Institute Of Pharmaceutical Industry | Histone deacetylase inhibitor of benzamides and use thereof |
CN102850236B (zh) * | 2011-06-27 | 2016-05-18 | 国药一心制药有限公司 | 新型苯甲酰胺类组蛋白去乙酰化酶抑制剂及其应用 |
WO2013170758A1 (zh) * | 2012-05-18 | 2013-11-21 | 国药一心制药有限公司 | 含稠环结构的苯甲酰胺类化合物及其作为抗肿瘤药物应用 |
CN103420917A (zh) * | 2012-05-18 | 2013-12-04 | 国药一心制药有限公司 | 含稠环结构的苯甲酰胺类化合物及其作为抗肿瘤药物应用 |
CN103420917B (zh) * | 2012-05-18 | 2015-08-19 | 国药一心制药有限公司 | 含稠环结构的苯甲酰胺类化合物及其作为抗肿瘤药物应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2010135908A1 (zh) | 2010-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU HENGYI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: JIANGSU GUOHUA INVESTMENT CO., LTD. Effective date: 20121210 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 226000 NANTONG, JIANGSU PROVINCE TO: 210038 NANJING, JIANGSU PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20121210 Address after: 210038, No. 1, Hengyi Road, Nanjing Economic Development Zone, Jiangsu, Nanjing Applicant after: Jiangsu Hengyi Pharmaceutical Co., Ltd. Applicant after: Shanghai Institute of pharmaceutical industry Address before: 226000, room 2, building 2805, Wangfu building, East Renmin Road, Nantong, Jiangsu Applicant before: Jiangsu Guohua Investment Co., Ltd. Applicant before: Shanghai Institute of pharmaceutical industry |
|
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20101201 |