CN101869561A - 含有他克莫司的改良释放组合物 - Google Patents

含有他克莫司的改良释放组合物 Download PDF

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Publication number
CN101869561A
CN101869561A CN201010194179A CN201010194179A CN101869561A CN 101869561 A CN101869561 A CN 101869561A CN 201010194179 A CN201010194179 A CN 201010194179A CN 201010194179 A CN201010194179 A CN 201010194179A CN 101869561 A CN101869561 A CN 101869561A
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CN
China
Prior art keywords
composition according
tacrolimus
acid
cellulose
solid
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Pending
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CN201010194179A
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English (en)
Chinese (zh)
Inventor
P·赫尔姆
T·诺灵
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LIFE PERIOD PHARMACEUTICS AS
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LIFE PERIOD PHARMACEUTICS AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
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    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201010194179A 2003-08-29 2004-08-30 含有他克莫司的改良释放组合物 Pending CN101869561A (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
DKPA200301232 2003-08-29
DKPA200301232 2003-08-29
DKPA200301837 2003-12-11
DKPA200301837 2003-12-11
US52979303P 2003-12-15 2003-12-15
US60/529,793 2003-12-15
DKPA200400079 2004-01-21
DKPA200400079 2004-01-21
DKPA200400467 2004-03-23
DKPA200400463 2004-03-23
DKPA200400467 2004-03-23
DKPA200400463 2004-03-23

Related Parent Applications (1)

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CNA2004800283537A Division CN1859910A (zh) 2003-08-29 2004-08-30 含有他克莫司的改良释放组合物

Publications (1)

Publication Number Publication Date
CN101869561A true CN101869561A (zh) 2010-10-27

Family

ID=42994769

Family Applications (2)

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CN2004800283344A Expired - Lifetime CN1859909B (zh) 2003-08-29 2004-08-30 含有他克莫司的固态分散体
CN201010194179A Pending CN101869561A (zh) 2003-08-29 2004-08-30 含有他克莫司的改良释放组合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2004800283344A Expired - Lifetime CN1859909B (zh) 2003-08-29 2004-08-30 含有他克莫司的固态分散体

Country Status (8)

Country Link
US (1) US8591946B2 (enExample)
JP (1) JP4903568B2 (enExample)
CN (2) CN1859909B (enExample)
AT (1) ATE531368T1 (enExample)
DK (2) DK1663216T3 (enExample)
ES (1) ES2376238T3 (enExample)
PT (2) PT1663216E (enExample)
SI (2) SI1663216T1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
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CN103889456A (zh) * 2011-10-18 2014-06-25 普渡制药公司 丙烯酸类聚合物制剂
CN107595799A (zh) * 2017-10-30 2018-01-19 无锡福祈制药有限公司 一种复方肠溶口崩片及其制备方法
CN108514545A (zh) * 2011-07-28 2018-09-11 来普卡公司 包含17-羟基孕酮酯的口服组合物和相关方法
CN113825495A (zh) * 2018-10-11 2021-12-21 阿利维奥治疗学股份有限公司 用于智能释放的不可注射水凝胶调配物
CN117049933A (zh) * 2023-08-11 2023-11-14 西北大学 一种可热塑成型的复合钨系延期药及其制备方法

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BRPI0414000B8 (pt) 2003-08-29 2021-05-25 Lifecycle Pharma As composição farmacêutica sólida oral de liberação prolongada contendo tacrolimus na forma de uma dispersão sólida, forma de dosagem, e, uso da composição farmacêutica
KR100678824B1 (ko) * 2005-02-04 2007-02-05 한미약품 주식회사 용해성이 증가된 무정형 타크로리무스 고체분산체 및 이를포함하는 약제학적 조성물
CN101175481A (zh) * 2005-03-17 2008-05-07 伊兰制药国际有限公司 纳米颗粒免疫抑制化合物的可注射的组合物
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US12083103B2 (en) 2007-05-30 2024-09-10 Veloxis Pharmaceuticals, Inc. Tacrolimus for improved treatment of transplant patients
PL2167033T4 (pl) 2007-05-30 2018-08-31 Veloxis Pharmaceuticals A/S Podawana raz dziennie doustna postać dawkowania zawierająca takrolimus
US8349033B2 (en) * 2007-05-31 2013-01-08 The Penray Companies, Inc. Diesel fuel, diesel fuel additive, and associated method for using the same
PL2200588T3 (pl) 2007-09-25 2019-09-30 Solubest Ltd. Kompozycje zawierające lipofilowe związki aktywne i sposób ich wytwarzania
CL2008000374A1 (es) 2008-02-05 2008-04-04 Igloo Zone Chile S A Composicion farmaceutica que comprende un polvo para suspension oral de tacrolimus o una de sus sales, hidratos o solvatos y excipientes farmaceuticamente aceptables; procedimiento de preparacion de dicha composicion farmaceutica; y uso para la preve
US8222272B2 (en) * 2008-04-11 2012-07-17 Roxane Laboratories, Inc. Pharmaceutical formulation and process comprising a solid dispersion of macrolide (tacrolimus)
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US8632805B2 (en) * 2008-06-20 2014-01-21 Mutual Pharmaceutical Company, Inc. Controlled-release formulations, method of manufacture, and use thereof
US7794750B2 (en) * 2008-06-20 2010-09-14 Mutual Pharmaceutical Company, Inc. Controlled-release formulations, method of manufacture, and use thereof
CA2729948C (en) * 2008-07-08 2021-11-23 Lifecycle Pharma A/S Tacrolimus for improved treatment of transplant patients
KR101174183B1 (ko) 2008-11-28 2012-08-16 주식회사 삼양바이오팜 생체이용률이 향상된 타크로리무스 제제 및 상기 제제의 제조방법
SG10201710156RA (en) * 2009-12-07 2018-01-30 Raptor Therapeutics Inc 4-methylpyrazole formulations
EP2521537A2 (en) * 2010-01-04 2012-11-14 Wockhardt Limited Pharmaceutical composition for modified delivery of actives
WO2011100975A2 (en) * 2010-02-17 2011-08-25 Lifecycle Pharma A/S Stabilized tacrolimus composition
EP2560618A1 (en) * 2010-04-22 2013-02-27 Ratiopharm GmbH Melt-granulated fingolimod
CA2797042A1 (en) * 2010-04-22 2011-10-27 Ratiopharm Gmbh Fingolimod in the form of a solid solution
US9168246B2 (en) 2013-06-27 2015-10-27 Veloxis Pharmaceutical A/S Regimen for suppressing organ rejection
EP3193877A4 (en) * 2014-08-07 2018-04-04 Pharmacyclics LLC Novel formulations of a bruton's tyrosine kinase inhibitor
CN105828827A (zh) 2014-11-21 2016-08-03 杭州领业医药科技有限公司 一种含他克莫司的药物组合物及其制备方法
MX381589B (es) * 2015-10-23 2025-03-12 Basf Se Formulaciones con liberación controlada de perfumes para aplicación dérmica.
CN107126419B (zh) * 2016-02-26 2020-06-19 石药集团中诺药业（石家庄）有限公司 一种奥贝胆酸片剂及其制备方法
CN106309395B (zh) * 2016-09-22 2019-09-20 沈阳药科大学 一种他克莫司缓释片及其制备方法
US10752642B1 (en) 2019-04-30 2020-08-25 George Mason University Macrocyclic lactones
EP4101469A4 (en) * 2020-02-03 2024-05-29 Senju Pharmaceutical Co., Ltd. USE OF A POLYETHER COMPOUND
US11666560B2 (en) 2020-09-24 2023-06-06 George Mason University Anti-fibrotic agent
US20220296572A1 (en) 2021-03-03 2022-09-22 Sana Biotechnology, Inc. Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions
CN114469847B (zh) * 2021-12-29 2024-08-13 北京鑫开元医药科技有限公司 他克莫司栓剂及其制备方法和用途

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ATE531368T1 (de) 2011-11-15
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DK1663216T3 (da) 2012-02-20
ES2376238T3 (es) 2012-03-12
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CN1859909B (zh) 2011-04-06

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