CN101861318A - 合成吗啉代低聚物的方法 - Google Patents

合成吗啉代低聚物的方法 Download PDF

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Publication number
CN101861318A
CN101861318A CN200880116219A CN200880116219A CN101861318A CN 101861318 A CN101861318 A CN 101861318A CN 200880116219 A CN200880116219 A CN 200880116219A CN 200880116219 A CN200880116219 A CN 200880116219A CN 101861318 A CN101861318 A CN 101861318A
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China
Prior art keywords
morpholino
group
protected
ring nitrogen
compound
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Pending
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CN200880116219A
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English (en)
Chinese (zh)
Inventor
克里斯蒂娜·玛丽·约瑟芬·福克斯
马修·代尔·里乌斯
德怀特·D·怀勒
李永福
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Sarepta Therapeutics Inc
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AVI Biopharma Inc
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Publication date
Application filed by AVI Biopharma Inc filed Critical AVI Biopharma Inc
Publication of CN101861318A publication Critical patent/CN101861318A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880116219A 2007-11-15 2008-11-14 合成吗啉代低聚物的方法 Pending CN101861318A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98819207P 2007-11-15 2007-11-15
US98820007P 2007-11-15 2007-11-15
US60/988,192 2007-11-15
US60/988,200 2007-11-15
PCT/US2008/012804 WO2009064471A1 (en) 2007-11-15 2008-11-14 Method of synthesis of morpholino oligomers

Publications (1)

Publication Number Publication Date
CN101861318A true CN101861318A (zh) 2010-10-13

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CN200880116219A Pending CN101861318A (zh) 2007-11-15 2008-11-14 合成吗啉代低聚物的方法

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EP (1) EP2207779B1 (https=)
JP (3) JP5512533B2 (https=)
KR (1) KR101617472B1 (https=)
CN (1) CN101861318A (https=)
BR (1) BR122019021332A8 (https=)
CA (2) CA2704261C (https=)
DK (1) DK2207779T3 (https=)
ES (1) ES2479393T3 (https=)
HR (1) HRP20140646T1 (https=)
IL (1) IL205776A0 (https=)
MX (1) MX2010004955A (https=)
RU (1) RU2606627C2 (https=)
WO (1) WO2009064471A1 (https=)

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CN102702265A (zh) * 2012-05-14 2012-10-03 天津特安化学科技有限公司 一种固相合成磷酰二胺吗啉代寡核苷酸及方法
CN108350005A (zh) * 2015-08-05 2018-07-31 卫材R&D管理有限公司 用于制备均一低聚物的手性试剂
CN109937042A (zh) * 2016-09-20 2019-06-25 科罗拉多州立大学董事会法人团体 使用亚磷酰胺化学法合成主链修饰的吗啉代寡核苷酸和嵌合体
TWI737736B (zh) * 2016-05-24 2021-09-01 美商薩羅塔治療公司 製備磷醯二胺嗎啉代寡聚物之方法
TWI738784B (zh) * 2016-05-24 2021-09-11 美商薩羅塔治療公司 製備寡聚物之方法
WO2022006871A1 (en) * 2020-07-10 2022-01-13 Changzhou Syntheall Pharmaceuticals Co., Ltd. Processes for preparing oligonucleotides

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WO2010141511A2 (en) 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
EP2499248B1 (en) 2009-11-13 2017-01-04 Sarepta Therapeutics, Inc. Antisense antiviral compound and method for treating influenza viral infection
KR20200133284A (ko) 2010-05-28 2020-11-26 사렙타 쎄러퓨틱스, 인코퍼레이티드 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
US10017763B2 (en) 2010-09-03 2018-07-10 Sarepta Therapeutics, Inc. dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
ES2607603T3 (es) 2010-09-30 2017-04-03 Nippon Shinyaku Co., Ltd. Derivado de ácido morfolino nucleico
AU2011326364B2 (en) 2010-11-12 2016-08-11 Sarepta Therapeutics, Inc. Antisense antibacterial compounds and methods
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US10100305B2 (en) 2011-07-15 2018-10-16 Sarepta Therapeutics, Inc. Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
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JP6496549B2 (ja) 2011-11-30 2019-04-03 サレプタ セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症における誘発されたエクソン包含
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US10563199B2 (en) 2015-09-16 2020-02-18 Nippon Shinyaku Co., Ltd. Antisense nucleic acid for treating amyotrophy
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US11142764B2 (en) 2015-12-23 2021-10-12 Board Of Regents, The University Of Texas System Antisense antibacterial compounds and methods
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KR20240006023A (ko) 2016-12-19 2024-01-12 사렙타 쎄러퓨틱스 인코퍼레이티드 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체
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PT3554552T (pt) 2016-12-19 2022-10-03 Sarepta Therapeutics Inc Conjugados de oligómero de skipping de exão para distrofia muscular
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CN102702265A (zh) * 2012-05-14 2012-10-03 天津特安化学科技有限公司 一种固相合成磷酰二胺吗啉代寡核苷酸及方法
CN108350005A (zh) * 2015-08-05 2018-07-31 卫材R&D管理有限公司 用于制备均一低聚物的手性试剂
CN113461733A (zh) * 2015-08-05 2021-10-01 卫材R&D管理有限公司 用于制备均一低聚物的手性试剂
CN108350005B (zh) * 2015-08-05 2024-02-06 卫材R&D管理有限公司 用于制备均一低聚物的手性试剂
AU2023226763B2 (en) * 2015-08-05 2025-09-18 Eisai R&D Management Co., Ltd. Chiral reagents for preparation of homogeneous oligomers
TWI737736B (zh) * 2016-05-24 2021-09-01 美商薩羅塔治療公司 製備磷醯二胺嗎啉代寡聚物之方法
TWI738784B (zh) * 2016-05-24 2021-09-11 美商薩羅塔治療公司 製備寡聚物之方法
CN109937042A (zh) * 2016-09-20 2019-06-25 科罗拉多州立大学董事会法人团体 使用亚磷酰胺化学法合成主链修饰的吗啉代寡核苷酸和嵌合体
WO2022006871A1 (en) * 2020-07-10 2022-01-13 Changzhou Syntheall Pharmaceuticals Co., Ltd. Processes for preparing oligonucleotides
CN116096724A (zh) * 2020-07-10 2023-05-09 常州合全药业有限公司 用于制备寡核苷酸的方法
CN116096724B (zh) * 2020-07-10 2025-10-31 常州合全药业有限公司 用于制备寡核苷酸的方法

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KR20100090681A (ko) 2010-08-16
WO2009064471A1 (en) 2009-05-22
CA2704261A1 (en) 2009-05-22
JP2014159432A (ja) 2014-09-04
JP6178744B2 (ja) 2017-08-09
DK2207779T3 (da) 2014-07-14
ES2479393T3 (es) 2014-07-24
CA2884340A1 (en) 2009-05-22
RU2606627C2 (ru) 2017-01-10
BRPI0819828A2 (pt) 2015-05-26
BRPI0819828A8 (pt) 2022-12-27
CA2704261C (en) 2015-05-26
AU2008321409A1 (en) 2009-05-22
BR122019021332A8 (pt) 2022-12-06
RU2010123958A (ru) 2011-12-20
JP5512533B2 (ja) 2014-06-04
JP2011503184A (ja) 2011-01-27
CA2884340C (en) 2017-07-25
KR101617472B1 (ko) 2016-05-02
EP2207779B1 (en) 2014-04-09
HK1144424A1 (en) 2011-02-18
MX2010004955A (es) 2010-06-30
JP2016196494A (ja) 2016-11-24
HRP20140646T1 (hr) 2014-09-26
BR122019021332A2 (https=) 2015-05-26
IL205776A0 (en) 2010-11-30
AU2008321409B2 (en) 2014-08-14
EP2207779A1 (en) 2010-07-21

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Application publication date: 20101013