CN101856416A - 治疗鸡大肠杆菌病的中草药口服液 - Google Patents
治疗鸡大肠杆菌病的中草药口服液 Download PDFInfo
- Publication number
- CN101856416A CN101856416A CN 201010193969 CN201010193969A CN101856416A CN 101856416 A CN101856416 A CN 101856416A CN 201010193969 CN201010193969 CN 201010193969 CN 201010193969 A CN201010193969 A CN 201010193969A CN 101856416 A CN101856416 A CN 101856416A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- oral liquid
- chinese herbal
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 28
- 239000007788 liquid Substances 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 238000011282 treatment Methods 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 241000206469 Pulsatilla Species 0.000 claims abstract description 3
- 241000411851 herbal medicine Species 0.000 claims description 15
- 241000756943 Codonopsis Species 0.000 claims description 11
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 10
- 239000009806 pulsatillae Substances 0.000 claims description 9
- 239000008589 Cortex Fraxini Substances 0.000 claims description 7
- 239000009636 Huang Qi Substances 0.000 claims description 7
- 235000009604 Chrysanthemum X morifolium Nutrition 0.000 claims description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 241000001522 Terminalia chebula Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 239000000284 extract Substances 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 3
- 241000050051 Chelone glabra Species 0.000 abstract 1
- 241000099774 Cuscuta salina Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241001106477 Paeoniaceae Species 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 241001534869 Terminalia Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 description 22
- 230000002401 inhibitory effect Effects 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 208000001848 dysentery Diseases 0.000 description 10
- 241000588724 Escherichia coli Species 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 241000191967 Staphylococcus aureus Species 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 241000194017 Streptococcus Species 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 241000193830 Bacillus <bacterium> Species 0.000 description 5
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 5
- 241000193998 Streptococcus pneumoniae Species 0.000 description 5
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 5
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 5
- 229940093265 berberine Drugs 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000002949 hemolytic effect Effects 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 241000186216 Corynebacterium Species 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 206010013023 diphtheria Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 4
- 229960004949 glycyrrhizic acid Drugs 0.000 description 4
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 4
- 235000019410 glycyrrhizin Nutrition 0.000 description 4
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000000242 pagocytic effect Effects 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- YLRXAIKMLINXQY-ZDUSSCGKSA-O (S)-magnoflorine Chemical compound C1=C(OC)C(O)=C2C3=C(O)C(OC)=CC=C3C[C@@H]3[N+](C)(C)CCC1=C23 YLRXAIKMLINXQY-ZDUSSCGKSA-O 0.000 description 3
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- KYEAXNAYHSCLMT-CVVGWEDFSA-N Magnoflorine Natural products C[C@H]1OC=C2[C@@H]3[C@@H]1CN4CCc5c([nH]c6ccccc56)[C@@H]4[C@@H]3OC2=O KYEAXNAYHSCLMT-CVVGWEDFSA-N 0.000 description 3
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- QNHQEUFMIKRNTB-UHFFFAOYSA-N aesculetin Natural products C1CC(=O)OC2=C1C=C(O)C(O)=C2 QNHQEUFMIKRNTB-UHFFFAOYSA-N 0.000 description 3
- 229930013930 alkaloid Natural products 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000003212 astringent agent Substances 0.000 description 3
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 3
- 229960003321 baicalin Drugs 0.000 description 3
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 3
- -1 demethyl wogonin Chemical compound 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- ILEDWLMCKZNDJK-UHFFFAOYSA-N esculetin Chemical compound C1=CC(=O)OC2=C1C=C(O)C(O)=C2 ILEDWLMCKZNDJK-UHFFFAOYSA-N 0.000 description 3
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 235000013594 poultry meat Nutrition 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 3
- 241000712461 unidentified influenza virus Species 0.000 description 3
- NOEGNKMFWQHSLB-UHFFFAOYSA-N 5-hydroxymethylfurfural Chemical compound OCC1=CC=C(C=O)O1 NOEGNKMFWQHSLB-UHFFFAOYSA-N 0.000 description 2
- JLUQTCXCAFSSLD-NXEZZACHSA-N Anemonin Chemical compound C1=CC(=O)O[C@]11[C@@]2(C=CC(=O)O2)CC1 JLUQTCXCAFSSLD-NXEZZACHSA-N 0.000 description 2
- JLUQTCXCAFSSLD-UHFFFAOYSA-N Anemonin Natural products C1=CC(=O)OC11C2(C=CC(=O)O2)CC1 JLUQTCXCAFSSLD-UHFFFAOYSA-N 0.000 description 2
- FBMORZZOJSDNRQ-GLQYFDAESA-N Atractylenolide III Chemical compound C=C([C@@H]1C2)CCC[C@]1(C)C[C@@]1(O)C2=C(C)C(=O)O1 FBMORZZOJSDNRQ-GLQYFDAESA-N 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 241000588832 Bordetella pertussis Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 239000004378 Glycyrrhizin Substances 0.000 description 2
- 240000002045 Guettarda speciosa Species 0.000 description 2
- 235000001287 Guettarda speciosa Nutrition 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 244000236658 Paeonia lactiflora Species 0.000 description 2
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 2
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 2
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 description 2
- RBBVPNQTBKHOEQ-KKSFZXQISA-O Phellodendrine Chemical compound C1CC2=CC(OC)=C(O)C=C2[C@H]2[N@+]1(C)CC(C=C(C(=C1)O)OC)=C1C2 RBBVPNQTBKHOEQ-KKSFZXQISA-O 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
- INYYVPJSBIVGPH-QHRIQVFBSA-N Sinomenine Chemical compound C([C@@H]1N(CC2)C)C3=CC=C(OC)C(O)=C3[C@@]32[C@@H]1C=C(OC)C(=O)C3 INYYVPJSBIVGPH-QHRIQVFBSA-N 0.000 description 2
- HKOIDIVCPUDLBS-UHFFFAOYSA-N Skullcapflavone II Natural products Oc1cccc(O)c1C2=CC(=O)c3c(O)c(O)c(O)c(O)c3O2 HKOIDIVCPUDLBS-UHFFFAOYSA-N 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- HIMJIPRMECETLJ-UHFFFAOYSA-N Wogonin Natural products COc1cc(O)c(O)c2C(=O)C=C(Oc12)c3ccccc3 HIMJIPRMECETLJ-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000002155 anti-virotic effect Effects 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- UGIVASYMZSZAMP-UHFFFAOYSA-N chebulagic acid Natural products OC1C2c3c(OC1=O)c(O)c(O)cc3C(=O)OC4C(OC(=O)c5cc(O)c(O)c(O)c5)OC6COC(=O)c7cc(O)c(O)c(O)c7c8c(O)c(O)c(O)cc8C(=O)OC4C6OC(=O)C2(O)C(=O)O UGIVASYMZSZAMP-UHFFFAOYSA-N 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 244000053095 fungal pathogen Species 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 239000001685 glycyrrhizic acid Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- YKQOSKADJPQZHB-RGYSVOEGSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(6r,9s,12r,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydr Chemical compound CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C([C@@H](C)O)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-RGYSVOEGSA-N 0.000 description 2
- ZFKKRRMUPBBYRS-UHFFFAOYSA-N norwogonin Chemical compound OC=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 ZFKKRRMUPBBYRS-UHFFFAOYSA-N 0.000 description 2
- 229960000988 nystatin Drugs 0.000 description 2
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 2
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 230000004223 radioprotective effect Effects 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- GMQFOKBGMKVUQZ-UHFFFAOYSA-N scullcapflavone II Chemical compound COC1=CC=CC(O)=C1C1=CC(=O)C2=C(O)C(OC)=C(OC)C(OC)=C2O1 GMQFOKBGMKVUQZ-UHFFFAOYSA-N 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- YGVHOSGNOYKRIH-UHFFFAOYSA-N 1,3,6-tri-O-galloyl-2,4-O-chebuloyl-beta-D-glucopyranose Natural products O1C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(C2OC(=O)C=3C=C(O)C(O)=C(O)C=3)OC(=O)C(C3=4)=CC(O)=C(O)C=4OC(=O)C(O)C3C(CC(O)=O)C(=O)OC2C1COC(=O)C1=CC(O)=C(O)C(O)=C1 YGVHOSGNOYKRIH-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- WRYLYDPHFGVWKC-UHFFFAOYSA-N 4-terpineol Chemical compound CC(C)C1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-UHFFFAOYSA-N 0.000 description 1
- 241001119624 Aesculus chinensis Species 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000561734 Celosia cristata Species 0.000 description 1
- HGJXAVROWQLCTP-YABCKIEDSA-N Chebulagic acid Chemical compound O([C@H]1[C@H]2[C@H]3OC(=O)C4=CC(O)=C(O)C(O)=C4C4=C(O)C(O)=C(O)C=C4C(=O)OC[C@@H](O1)[C@H]3OC(=O)[C@@H](CC(O)=O)[C@@H]1[C@@H](C(OC=3C(O)=C(O)C=C(C1=3)C(=O)O2)=O)O)C(=O)C1=CC(O)=C(O)C(O)=C1 HGJXAVROWQLCTP-YABCKIEDSA-N 0.000 description 1
- 229920002052 Chebulagic acid Polymers 0.000 description 1
- YGVHOSGNOYKRIH-FJPMMHPYSA-N Chebulinic acid Chemical compound C([C@@H]1[C@H]2OC(=O)[C@@H](CC(O)=O)[C@@H]3[C@@H](C(OC=4C(O)=C(O)C=C(C3=4)C(=O)O[C@@H]([C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)O1)[C@H]2OC(=O)C=1C=C(O)C(O)=C(O)C=1)=O)O)OC(=O)C1=CC(O)=C(O)C(O)=C1 YGVHOSGNOYKRIH-FJPMMHPYSA-N 0.000 description 1
- 229920000585 Chebulinic acid Polymers 0.000 description 1
- MHDANAFDVQLLPY-UHFFFAOYSA-N Chebulinic acid Natural products OC(C1C(CC(=O)O)C(=O)OC2C(COC(=O)c3cc(O)c(O)c(O)c3)OC(OC(=O)c4cc(O)c(O)c(O)c4)C(OC(=O)c5cc(O)c(O)c(O)c15)C2OC(=O)c6cc(O)c(O)c(O)c6)C(=O)O MHDANAFDVQLLPY-UHFFFAOYSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241000193449 Clostridium tetani Species 0.000 description 1
- 108010065152 Coagulase Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- XDVZNDLANFJOQR-UHFFFAOYSA-N Coptisine Natural products O=Cc1c2OCOc2ccc1C=C3/NCCc4cc5OCOc5cc34 XDVZNDLANFJOQR-UHFFFAOYSA-N 0.000 description 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- FBMORZZOJSDNRQ-UHFFFAOYSA-N Demethoxy,B,HCl-Adriamycin Natural products C1C2C(=C)CCCC2(C)CC2(O)C1=C(C)C(=O)O2 FBMORZZOJSDNRQ-UHFFFAOYSA-N 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 208000009386 Experimental Arthritis Diseases 0.000 description 1
- CRSFLLTWRCYNNX-UHFFFAOYSA-N Fraxin Natural products OC=1C(OC)=CC=2C=CC(=O)OC=2C=1OC1OC(CO)C(O)C(O)C1O CRSFLLTWRCYNNX-UHFFFAOYSA-N 0.000 description 1
- 229920000296 Glucogallin Polymers 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 108010006464 Hemolysin Proteins Proteins 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010022678 Intestinal infections Diseases 0.000 description 1
- MXTLAHSTUOXGQF-UHFFFAOYSA-O Jatrorrhizine Chemical compound COC1=CC=C2C=C3C(C=C(C(=C4)O)OC)=C4CC[N+]3=CC2=C1OC MXTLAHSTUOXGQF-UHFFFAOYSA-O 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 241000589902 Leptospira Species 0.000 description 1
- 229930194248 Licoflavone Natural products 0.000 description 1
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000192041 Micrococcus Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- PTPHDVKWAYIFRX-UHFFFAOYSA-N Palmatine Natural products C1C2=C(OC)C(OC)=CC=C2C=C2N1CCC1=C2C=C(OC)C(OC)=C1 PTPHDVKWAYIFRX-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 206010071301 Perihepatitis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241001312524 Streptococcus viridans Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- LNOHXHDWGCMVCO-UHFFFAOYSA-N Wogonoside Natural products C1=C(O)C(C(C=C(O2)C=3C=CC=CC=3)=O)=C2C(OC)=C1OC1OC(C(O)=O)C(O)C(O)C1O LNOHXHDWGCMVCO-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- GUAFOGOEJLSQBT-UHFFFAOYSA-N aesculetin dimethyl ether Natural products C1=CC(=O)OC2=C1C=C(OC)C(OC)=C2 GUAFOGOEJLSQBT-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229940089837 amygdalin Drugs 0.000 description 1
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003263 anti-adenoviral effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- GDVRUDXLQBVIKP-UHFFFAOYSA-N beta-D-glucogallin Natural products OC1C(O)C(O)C(CO)OC1OC(=O)C1=CC(O)=C(O)C(O)=C1 GDVRUDXLQBVIKP-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- LUXPUVKJHVUJAV-UHFFFAOYSA-M coptisine, chloride Chemical compound [Cl-].C1=C2C=C(C3=C(C=C4OCOC4=C3)CC3)[N+]3=CC2=C2OCOC2=C1 LUXPUVKJHVUJAV-UHFFFAOYSA-M 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- FPJQGFLUORYYPE-UHFFFAOYSA-N epiberberine Chemical compound C1=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C2OCOC2=C1 FPJQGFLUORYYPE-UHFFFAOYSA-N 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229960003760 florfenicol Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- CRSFLLTWRCYNNX-QBNNUVSCSA-N fraxin Chemical compound OC=1C(OC)=CC=2C=CC(=O)OC=2C=1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CRSFLLTWRCYNNX-QBNNUVSCSA-N 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- KGHSLXLLBHRMML-VKISENBKSA-N glucogallin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](OC)O[C@H]1OC(=O)C1=CC(O)=C(O)C(O)=C1 KGHSLXLLBHRMML-VKISENBKSA-N 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 239000000399 hydroalcoholic extract Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 description 1
- 235000008718 isoliquiritigenin Nutrition 0.000 description 1
- DXDRHHKMWQZJHT-FPYGCLRLSA-N isoliquiritigenin Chemical compound C1=CC(O)=CC=C1\C=C\C(=O)C1=CC=C(O)C=C1O DXDRHHKMWQZJHT-FPYGCLRLSA-N 0.000 description 1
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 description 1
- 229930013397 isoquinoline alkaloid Natural products 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 1
- QUCQEUCGKKTEBI-UHFFFAOYSA-N palmatine Chemical compound COC1=CC=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C1OC QUCQEUCGKKTEBI-UHFFFAOYSA-N 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 208000008494 pericarditis Diseases 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- QJVXKWHHAMZTBY-GCPOEHJPSA-N syringin Chemical compound COC1=CC(\C=C\CO)=CC(OC)=C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 QJVXKWHHAMZTBY-GCPOEHJPSA-N 0.000 description 1
- QJVXKWHHAMZTBY-KSXIZUIISA-N syringin Natural products COc1cc(C=CCO)cc(OC)c1O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O QJVXKWHHAMZTBY-KSXIZUIISA-N 0.000 description 1
- 229930183580 tangshenoside Natural products 0.000 description 1
- NUPTUAXNMUIMFS-MIHIQLSESA-N terchebin Chemical compound C([C@@H]1[C@H]2OC(=O)C=3[C@H]4C5=C(C(O[C@@H]([C@H](OC(=O)C=6C=C(O)C(O)=C(O)C=6)O1)[C@H]2OC(=O)C=1C=C(O)C(O)=C(O)C=1)=O)C=C(C(=C5OC4(O)C(O)(O)C(=O)C=3)O)O)OC(=O)C1=CC(O)=C(O)C(O)=C1 NUPTUAXNMUIMFS-MIHIQLSESA-N 0.000 description 1
- ULYXEEKCDUUGNM-UHFFFAOYSA-N terchebin Natural products Oc1cc(cc(O)c1O)C(=O)OCC2OC(OC(=O)c3cc(O)c(O)c(O)c3)C4OC(=O)C5CC(=O)C(=O)C(=O)C5c6c(O)c(O)c(O)cc6C(=O)OC2C4OC(=O)c7cc(O)c(O)c(O)c7 ULYXEEKCDUUGNM-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- JFJZZMVDLULRGK-URLMMPGGSA-O tubocurarine Chemical compound C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CCN3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 JFJZZMVDLULRGK-URLMMPGGSA-O 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- XLTFNNCXVBYBSX-UHFFFAOYSA-N wogonin Chemical compound COC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=CC=C1 XLTFNNCXVBYBSX-UHFFFAOYSA-N 0.000 description 1
- LNOHXHDWGCMVCO-NTKSAMNMSA-N wogonin 7-O-beta-D-glucuronide Chemical compound C1=C(O)C(C(C=C(O2)C=3C=CC=CC=3)=O)=C2C(OC)=C1O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LNOHXHDWGCMVCO-NTKSAMNMSA-N 0.000 description 1
Abstract
本发明涉及一种治疗鸡大肠杆菌病的中草药口服液，它是由下述重量配比的原料制成的药剂：白头翁4-6份，黄连须2-4份，黄芩2-4份，黄柏1-3份，秦皮1-3份，白芍1-3份，乌梅1-3份，诃子1-2份，党参1-3份，黄芪1-3份，甘草1-2份。上述原料经过：粉碎，配料，水煮浸提，浓缩，封装，制成本发明口服液。本发明中草药口服液对治疗鸡大肠杆菌病有很好的效果。
Description
技术领域
本发明涉及养鸡用的中草药制剂，具体涉及一种治疗鸡大肠杆菌病的中草药口服液。
背景技术
近年来，大肠杆菌病已成为制约养鸡业发展的一大疾病，发病率和死亡率居高不下，造成了严重的经济损失。目前治疗鸡大肠杆菌病主要采用抗菌消炎类西药，虽然具有一定的疗效，但存在易产生抗药性和有不良副作用的问题，并且残留在鸡肉、蛋内的化学药物，也给人类的健康带来潜在威胁。中草药具有天然、使用安全、无毒副作用、无化学物质残留、不易产生抗药性等特点，用于养鸡业的疾病防治，具有广阔的应用前景。目前市售的用于治疗鸡大肠杆菌病的中草药制剂虽然种类很多，但实际使用效果不尽人意。
发明内容
本发明的目的在于针对上述问题，提供一种能够有效治疗鸡大肠杆菌病的中草药口服液。
本发明的技术方案是：一种治疗鸡大肠杆菌病的中草药口服液，它的原料重量配比是：白头翁4-6份，黄连须2-4份，黄芩2-4份，黄柏1-3份，秦皮1-3份，白芍1-3份，乌梅1-3份，诃子1-2份，党参1-3份，黄芪1-3份，甘草1-2份。
本发明治疗鸡大肠杆菌病的中草药口服液的优选原料重量比是：白头翁5份，黄连须3份，黄芩2.5份，黄柏2份，秦皮2份，白芍2份，乌梅1.5份，柯子1.5份，党参2份，黄芪2份，甘草1.5份。
本发明采用如下生产工艺：选料→粉碎→配料→拌匀→水煮浸提→浓缩→封装→成品。
本发明组方中各组分的药理功效是：
1、白头翁功效：白头翁主要含白头翁皂甙A、B、C、D，并含有鼠李糖、白头翁素、23-羟基白桦酸、胡萝卜素等。白头翁煎剂及其皂甙在体外和体内都能抑制溶组织阿米巴原虫生长；白头翁新鲜茎叶榨取的汁液在体外对金黄色葡萄球菌、绿脓杆菌、舒氏痢疾杆菌、弗氏痢疾杆菌及宋内氏痢疾杆菌有抑制作用；白头翁酒精浸液在试管中对枯草杆菌及金黄色葡萄球菌也有抑制作用，对实验动物小鼠流感病毒感染有轻度抑制作用；白头翁素对白喉杆菌、葡萄球菌、链球菌、大肠杆菌、结核杆菌等有抑制作用。
2、黄连须功效：黄连须含多种异喹啉类生物碱，以小檗碱含量最高，为5～8％，尚含黄连碱、甲基黄连碱、巴马亭、药根碱、表小檗碱及木兰花碱等；酸性成分有阿魏酸，氯原酸等；具有清热燥湿，泻火解毒等功效。小檗碱对实验动物有很广的抗菌谱，对大肠杆菌、金黄色葡萄球菌、溶血性链球菌、肺炎球菌、脑膜炎双球菌、痢疾杆菌、绿脓杆菌等均有较显著的抑制作用，对钩端螺旋体、阿米巴原虫、滴虫、锥虫、流感病毒及多种致病性真菌也有抑制作用，并能够增强白细胞的吞噬能力；另有对抗细菌毒素，降低金黄色葡萄球菌凝固酶、溶血素效价，降低大肠杆菌毒力等作用。
3、黄芩功效：黄芩主要含黄芩苷、黄芩素、汉黄芩苷、汉黄芩素、黄芩新素I、黄芩新素II、去甲汉黄芩素、7-甲氧基黄芩素、7-甲氧基去甲基汉黄芩素等，此外还有挥发油、苯乙醇糖苷类成分等，具有清热燥湿，泻火解毒，止血，安胎作用。黄芩具有抗菌作用，黄芩煎剂体外平板试验，对痢疾杆菌、伤寒杆菌、副伤寒杆菌、大肠杆菌、变形杆菌、绿脓杆菌、葡萄球菌、溶血性链球菌、肺炎双球菌有抑制作用，对伤寒混合疫苗致实验性发热家兔有解热作用；另有抗病毒作用。
4、黄柏功效：川黄柏主要含小檗碱，并含少量黄柏碱、木兰花碱、掌叶防已碱等多种生物碱以及内质、甾醇、粘液质等；关黄柏主要含小檗碱及少量木兰花碱、黄柏碱、掌叶防已碱等多种生物碱。小檗碱体外试验对金黄色葡萄球菌、肺炎球菌、白喉杆菌、草绿色链球菌、痢疾杆菌(宋内氏志贺菌除外)、溶血性链球菌、脑膜炎球菌、霍乱弧菌均有效或有较强的抑制作用；对枯草杆菌、百日咳杆菌、破伤风杆菌亦有抑制作用；关黄柏和川黄柏的乙醚浸提物对新型隐球菌和红色发癣菌具有较强的抑菌作用，其作用比制霉菌素强，但对白色念珠菌的抑制作用比制霉菌素弱；黄柏煎剂(1g/ml生药)0.3ml/只灌胃，连续7天，能增加小鼠脾空斑形成细胞数。
5、秦皮功效：秦皮含七叶树甙(七叶甙，马栗树皮甙，秦皮甲素)、七叶树内酯(马栗树皮素，七叶树素，秦皮乙素)、秦皮甙、丁香甙、香豆素及鞣质等，具有清热燥湿，收涩，明目等功效。体外试验证明，秦皮煎剂对大肠杆菌、表皮葡萄球菌、金黄色葡萄球菌、卡他球菌、绿脓杆菌等多种细菌具有抑制作用；七叶树甙和七叶树素有止咳、祛痰、平喘作用。
6、白芍功效：白芍主要含芍药甙、牡丹酚、芍药花甙、苯甲酸、挥发油、脂肪油、树脂、鞣质、糖、淀粉、粘液质、蛋白质、β-谷甾醇和三萜类。白芍水煎剂及白芍总甙对机体的细胞免疫、体液免疫及巨噬细胞功能均有调节作用；白芍提取物和白芍总甙对急性炎症水肿及佐剂关节炎有治疗作用；白芍煎剂有抗菌、抗病毒作用，且抗菌作用较强，抗菌谱广；白芍水提物可对实验动物大鼠胰腺淀粉酶活力有抑制作用，能提高动物对高温刺激的耐受力，对实验性消化系统溃疡有防治作用。
7、乌梅功效：乌梅主含枸缘酸、苹果酸、草酸、琥珀酸和延胡索酸，还含5-羟甲基-2-糠醛、苯甲醛、4-松油烯醇、苯甲醇和十六烷酸、苦杏仁甙；具有敛肺止咳，涩肠止泻，止血，生津等功效。乌梅在体外对多种致病菌有抑制作用，如痢疾杆菌、大肠杆菌、伤寒杆菌、副伤寒杆菌、百日咳杆菌、脑膜炎双球菌、结核杆菌等，对某些致病性真菌如絮状表皮癣菌、石膏样小芽胞菌等也有抑制作用。
8、诃子功效：诃子主要含诃子酸、诃黎勒酸、1，3，6-三没食子酰葡萄糖、原诃子酸、葡萄糖没食子鞣甙、没食子酸等，具有涩肠止泻、敛肺止咳、利咽开音等功效。诃子水煎剂(100％)对痢疾杆菌、绿脓杆菌、白喉杆菌作用较强，对金黄色葡萄球菌、大肠杆菌、肺炎球菌、溶血性链球菌、变形杆菌、鼠伤寒杆菌均有抑制作用；诃子提取物对流感病毒有灭活作用；诃子的醇提物口服或灌肠对消化系统粘膜有收敛作用。
9、党参功效：党参主要含甾醇、党参甙、党参多糖、党参内酯、生物碱和17种氨基酸，并含铁、锌、铜、锰、铬、钴、铝等11种微量元素和钾、钠、钙、磷、镁等14种无机盐。党参水醇浸膏与煎剂均能提升动物红细胞、血红蛋白、网织红细胞的数量，抑制血小板聚积的作用。党参能够增加腹腔巨噬细胞吞噬功能，提高淋巴细胞转化率、E-玫瑰花环形成率，还能增加动物体重，延缓衰老、耐缺氧、抗辐射等作用。
10、黄芪功效：黄芪含皂甙、黄酮、多糖、多种氨基酸、叶酸及硒、锌、铜等多种微量元素，具有增强机体免疫功能、保肝、利尿、降压、抗衰老、抗缺氧、抗辐射、抗应激、耐低温和耐高温作用。动物试验证明，能够增加网状内皮系统的吞噬功能，促进抗体形成，提高E-玫瑰花环率，促进T细胞的分化与成熟，增强NK细胞的细胞毒活性，诱导产生干扰素；对细菌脂多糖诱导的鸡外周血B淋巴细胞体外增殖也有明显的促进作用；有加强毛细血管抵抗力的作用，可对抗组织胺、氯仿造成的毛细血管渗透性增加的现象。黄芪在体外对痢疾杆菌、白喉杆菌、溶血性链球菌、肺炎双球菌、金黄色葡萄球菌等有较强的抗菌作用；对动物流感病毒、腺病毒等所致的细胞病变有抑制作用。
11、甘草功效：甘草主要含甘草酸、甘草甜素、24-羟基甘草次酸、甘草黄酮、甘草素、异甘草素、甘草多糖等成分，具有抗溃疡、促进胰腺分泌、保肝、降脂、调节巨噬细胞的吞噬功能等作用。甘草酸是天然解毒剂，可用于机体抗衰老、增强免疫力、维持水盐代谢平衡等；甘草多糖具有抗腺病毒3型、单纯疱疹病毒I型活性。
本发明组方依据：大肠杆菌病已成为制约养鸡业发展的一大疾病，鸡发病后，鸡冠变紫、变白，呼吸困难，腹泻，排黄白色和绿色粪便及急性败血症或亚急性心包炎、肝周炎、气囊炎等症状。故治疗上，宜以清热燥湿、凉血解毒、止痢为治则。方中白头翁、秦皮有清热解毒、凉血止痢等功效；黄连须、黄芩、黄柏有清热燥湿，泻火解毒，凉血止血等功效；乌梅、诃子具有涩肠止泻、敛肺止咳、生津止渴等功效；党参、黄芪、甘草有补中益气、生津止渴、扶正祛邪等功效，可调节机体免疫功能；白芍有平肝抑阳、养血敛阴等功效；甘草甘温益气、和中健脾，通行十二经络，调和诸药。方中诸药相和，共奏清热燥湿、凉血解毒、止痢、养阴生津的功效，适用于鸡大肠杆菌所引起的传染病。为方便在鸡病防治中的应用，制成口服液。
本发明治疗鸡大肠杆菌病的中草药口服液，是在进行了大量实际应用的基础上，依据传统医学古方，结合现代流行病学、病原学和免疫学的理论筛选而成，对由病原性大肠杆菌引起的一类肠道传染性疾病具有很好的治疗效果。
具体实施方式
结合实施例对本发明作进一步说明。
实施例：
1、分别称取原料(饮片)，白头翁200g，黄连须120g，黄芩100g，黄柏80g，秦皮80g，白芍80g，乌梅60g，柯子60g，党参80g，黄芪80g，甘草60g；
2、将上述原料分别粉碎成粗粉；
3、将上述原料粗粉混合，加水7000ml浸泡1小时，水开后文火煎煮30分钟，滤过；再每次加水5000ml煎煮二次，每次20分钟；
4、合并三次滤液，浓缩至约900ml，加入0.05％苯甲酸钠作为防腐剂，加水至1000ml，搅匀，滤过，灌装，灭菌，即制得本发明治疗鸡大肠杆菌病的中草药口服液。
利用本发明中草药口服液进行的一些试验情况如下：
1、人工感染鸡大肠杆菌病的疗效试验
280只45日龄伊莎褐蛋鸡随机分为7组，每组40只，分组及处理方法见表1。除健康对照组注射灭菌生理盐水1ml，其余各组每只雏鸡均注射大肠杆菌液(O78，6×108个/ml)1ml。攻毒36h后试验鸡(健康对照组除外)出现大肠杆菌病典型症状，开始按表1剂量给药，连用5d，观察给药后的临床变化，每天记录各组鸡的临床症状和死亡数。
表1试验动物分组及处理方法 (单位：只)
表2鸡大肠杆菌病人工感染试验的治疗结果 (单位：只、％)
由表2可知，本发明中草药口服液高、中、低剂量组与感染对照组相比较，治愈率均差异极显著(P＜0.01)；本口服液高、中剂量组与硫酸粘杆菌素、氟苯尼考比较，治愈率呈显著差异(P＜0.05)；低剂量组的治愈率与硫酸粘杆菌素相比较差异不显著(P＞0.05)。
2、自然感染鸡大肠杆菌病的疗效试验
自然发病成年蛋鸡、雏鸡分别由河北省昌黎县、滦南县、卢龙县、青龙县各养殖户提供，根根据临床症状、剖检变化、动物接种试验和实验室检查结果，最后确诊为鸡大肠杆菌病。以各自感染鸡群为试验组，发病鸡群按0.5ml/只雏鸡、1ml/只成年蛋鸡的剂量将本中草药口服液混于水中饲喂，每日2次，投药5～7d为一个疗程。停药后继续观察3～5d，以临床症状消失，饮水、采食和精神状态恢复正常者判为治愈，再结合病理剖检抽测结果确定防治效果，统计治愈率。治疗结果见表3、表4。
表3中草药口服液对自然发病成年蛋鸡的治疗效果 (单位：只、％)
通过对7200只自然感染成年产蛋鸡的治疗，本发明口服液对成年产蛋鸡的大肠杆菌病有显著的治疗效果，平均治愈率为98.3％，一般经5～7d症状消失，恢复正常采食，产蛋率回升，经2～4周恢复到接近正常产蛋水平。
表4中草药口服液对自然发病雏鸡的治疗效果 (单位：只、％)
通过对12700只不同日龄雏鸡治疗观察，本发明口服液对雏鸡的大肠杆菌病有显著的治疗功效，平均治愈率为95.2％，一般经5～7d病雏康复，体重有不同程度增加，且投药全程未见鸡群有任何不良反应。
Claims (2)
1.一种治疗鸡大肠杆菌病的中草药口服液，其特征在于它是由下述重量配比的原料制成的药剂：白头翁4-6份，黄连须2-4份，黄芩2-4份，黄柏1-3份，秦皮1-3份，白芍1-3份，乌梅1-3份，诃子1-2份，党参1-3份，黄芪1-3份，甘草1-2份。
2.根据权利要求1所述的治疗鸡大肠杆菌病的中草药口服液，其特征在于它是由下述重量配比的原料制成的药剂：白头翁5份，黄连须3份，黄芩2.5份，黄柏2份，秦皮2份，白芍2份，乌梅1.5份，诃子1.5份，党参2份，黄芪2份，甘草1.5份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010193969 CN101856416B (zh) | 2010-06-03 | 2010-06-03 | 治疗鸡大肠杆菌病的中草药口服液 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010193969 CN101856416B (zh) | 2010-06-03 | 2010-06-03 | 治疗鸡大肠杆菌病的中草药口服液 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101856416A true CN101856416A (zh) | 2010-10-13 |
| CN101856416B CN101856416B (zh) | 2012-07-04 |
Family
ID=42942720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010193969 Expired - Fee Related CN101856416B (zh) | 2010-06-03 | 2010-06-03 | 治疗鸡大肠杆菌病的中草药口服液 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101856416B (zh) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579648A (zh) * | 2012-03-01 | 2012-07-18 | 辽宁凯为生物技术有限公司 | 一种防治禽大肠杆菌病的中药复方口服液提取工艺 |
| CN102716213A (zh) * | 2012-06-06 | 2012-10-10 | 四川金瑞克动物药业有限公司 | 连参止痢颗粒、其制备方法及应用 |
| CN102716199A (zh) * | 2012-06-15 | 2012-10-10 | 李良 | 治疗痢疾的石榴皮中药汤剂及制备方法 |
| CN102727848A (zh) * | 2012-06-20 | 2012-10-17 | 青岛绿曼生物工程有限公司 | 治疗家禽传染性法氏囊病的纯中药组合物及其制备方法 |
| CN103585578A (zh) * | 2013-11-06 | 2014-02-19 | 王双山 | 一种防治肉鸡大肠杆菌病的中药 |
| CN103655967A (zh) * | 2012-09-24 | 2014-03-26 | 天津瑞贝特科技发展有限公司 | 治疗仔猪痢疾的中药组合物及其制备方法 |
| CN104784309A (zh) * | 2015-03-10 | 2015-07-22 | 李博 | 一种防治鸭大肠杆菌病的中药组合物 |
| CN104800362A (zh) * | 2015-05-18 | 2015-07-29 | 河南金尔康生物科技有限公司 | 一种兽用中药组合物、中药散剂及其制备方法和应用 |
| CN104922530A (zh) * | 2015-07-16 | 2015-09-23 | 山东中牧兽药有限公司 | 一种防治鸡大肠杆菌病的药物组合物及其制备方法 |
| CN105213522A (zh) * | 2014-06-22 | 2016-01-06 | 骆红斌 | 一种治疗痢疾的药物 |
| CN105641261A (zh) * | 2014-11-11 | 2016-06-08 | 天津中敖生物科技有限公司 | 治疗仔猪黄痢的中药组合物及其制备方法 |
| CN113855748A (zh) * | 2021-11-10 | 2021-12-31 | 四川化工职业技术学院 | 一种复合植物源提取物及其制备方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369296A (zh) * | 2002-01-30 | 2002-09-18 | 王福田 | 一种治疗鸡瘟的鸡瘟宁及其制备方法 |
-
2010
- 2010-06-03 CN CN 201010193969 patent/CN101856416B/zh not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369296A (zh) * | 2002-01-30 | 2002-09-18 | 王福田 | 一种治疗鸡瘟的鸡瘟宁及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 《中国兽医杂志》 20020228 孙荣华 等 复方白头翁散对鸡大肠杆菌病的疗效 27-28 1-2 第38卷, 第2期 * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579648A (zh) * | 2012-03-01 | 2012-07-18 | 辽宁凯为生物技术有限公司 | 一种防治禽大肠杆菌病的中药复方口服液提取工艺 |
| CN102716213A (zh) * | 2012-06-06 | 2012-10-10 | 四川金瑞克动物药业有限公司 | 连参止痢颗粒、其制备方法及应用 |
| CN102716199A (zh) * | 2012-06-15 | 2012-10-10 | 李良 | 治疗痢疾的石榴皮中药汤剂及制备方法 |
| CN102727848A (zh) * | 2012-06-20 | 2012-10-17 | 青岛绿曼生物工程有限公司 | 治疗家禽传染性法氏囊病的纯中药组合物及其制备方法 |
| CN102727848B (zh) * | 2012-06-20 | 2013-10-30 | 青岛绿曼生物工程有限公司 | 治疗家禽传染性法氏囊病的纯中药组合物及其制备方法 |
| CN103655967A (zh) * | 2012-09-24 | 2014-03-26 | 天津瑞贝特科技发展有限公司 | 治疗仔猪痢疾的中药组合物及其制备方法 |
| CN103585578A (zh) * | 2013-11-06 | 2014-02-19 | 王双山 | 一种防治肉鸡大肠杆菌病的中药 |
| CN105213522A (zh) * | 2014-06-22 | 2016-01-06 | 骆红斌 | 一种治疗痢疾的药物 |
| CN105641261A (zh) * | 2014-11-11 | 2016-06-08 | 天津中敖生物科技有限公司 | 治疗仔猪黄痢的中药组合物及其制备方法 |
| CN104784309A (zh) * | 2015-03-10 | 2015-07-22 | 李博 | 一种防治鸭大肠杆菌病的中药组合物 |
| CN104800362A (zh) * | 2015-05-18 | 2015-07-29 | 河南金尔康生物科技有限公司 | 一种兽用中药组合物、中药散剂及其制备方法和应用 |
| CN104922530A (zh) * | 2015-07-16 | 2015-09-23 | 山东中牧兽药有限公司 | 一种防治鸡大肠杆菌病的药物组合物及其制备方法 |
| CN113855748A (zh) * | 2021-11-10 | 2021-12-31 | 四川化工职业技术学院 | 一种复合植物源提取物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101856416B (zh) | 2012-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101856416B (zh) | 治疗鸡大肠杆菌病的中草药口服液 | |
| CN1369296A (zh) | 一种治疗鸡瘟的鸡瘟宁及其制备方法 | |
| CN102894192B (zh) | 防治仔猪腹泻的中草药饲料添加剂 | |
| CN103948786B (zh) | 一种治疗糖尿病的中药 | |
| CN104367874A (zh) | 一种治疗猪高热病的中药组合物 | |
| CN103800634B (zh) | 防治淡水鱼主要细菌性传染病的中草药饲料添加剂 | |
| CN102846804B (zh) | 治疗淡水鱼嗜水气单胞菌病的中草药制剂及其制备方法 | |
| CN103182018B (zh) | 治疗鸡大肠杆菌病、鸡沙门菌病的中草药饲料添加剂 | |
| CN114246878B (zh) | 一种中药提取物组合物及其制备方法和应用 | |
| CN104887890A (zh) | 一种治疗雏鸡白痢的药物组合物及其制备方法 | |
| CN102552656A (zh) | 一种用于治疗鸡大肠杆菌病的中药组合物 | |
| CN101940628B (zh) | 治疗畜禽实热证的中药复方药物 | |
| CN103721103A (zh) | 用于治疗猪丹毒的药物及其制备方法 | |
| CN102671088A (zh) | 一种治疗肺结核的中药组合物 | |
| CN101856415B (zh) | 治疗鸡呼吸道传染病的中草药口服液 | |
| KR101017929B1 (ko) | 항치루 조성물 및 그 제조 방법 | |
| CN106511675A (zh) | 一种用于防治家禽疾病的药及其制备方法 | |
| CN113876896B (zh) | 一种降尿酸和缓解痛风的三米饮中药配方组成及其制备工艺 | |
| CN101297856B (zh) | 治疗奶牛酒精阳性乳的中药制剂及其制备方法 | |
| CN104056242A (zh) | 一种治疗急性胆囊炎的中药组合物及其制备方法 | |
| CN103432245B (zh) | 治疗仔猪白痢的中草药口服液 | |
| CN102894200A (zh) | 用于增强羊抗菌抗病毒的食料添加剂及其制备方法 | |
| CN104352797A (zh) | 一种治疗晚期肺癌的中药及其应用 | |
| CN106729628A (zh) | 一种防治奶牛乳房炎的中药复方制剂及制备方法 | |
| CN101653567A (zh) | 防治仔猪黄白痢的中兽药口服液及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HEBEI KEHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: HEBEI SCIENCE + TECHNOLOGY NORMAL COLLEGE Effective date: 20130704 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 066600 QINHUANGDAO, HEBEI PROVINCE TO: 071100 BAODING, HEBEI PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130704 Address after: 071100 Huan Cheng Bei Road, Qingyuan County, Baoding City, Hebei Province Patentee after: HEBEI KEHENG BIOTECHNOLOGY Co.,Ltd. Address before: 066600 College of animal science and technology, Hebei Normal University of Science and Technology, Changli, Hebei, Qinhuangdao Patentee before: HEBEI NORMAL University OF SCIENCE & TECHNOLOGY |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20221024 Address after: 050000 Rooms 401 and 402, Building 13, Hebei (Fujian) SME Science Park, No. 580, Shitong Road, Luquan District, Shijiazhuang, Hebei Patentee after: SHIJIAZHUANG YANKE BIOTECHNOLOGY Co.,Ltd. Address before: Huancheng North Road, Qingyuan County, Baoding City, Hebei Province, 071100 Patentee before: HEBEI KEHENG BIOTECHNOLOGY Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120704 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |