CN101850038A - Transdermal medicament delivery patch preparation for treating coronary heart disease and method for preparing same - Google Patents
Transdermal medicament delivery patch preparation for treating coronary heart disease and method for preparing same Download PDFInfo
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- CN101850038A CN101850038A CN201010100656A CN201010100656A CN101850038A CN 101850038 A CN101850038 A CN 101850038A CN 201010100656 A CN201010100656 A CN 201010100656A CN 201010100656 A CN201010100656 A CN 201010100656A CN 101850038 A CN101850038 A CN 101850038A
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Abstract
The invention discloses a transdermal medicament delivery patch preparation for treating coronary heart disease and a method for preparing the same, and relates to a medicament for treating the coronary heart disease and the method for preparing the same. The transdermal medicament delivery patch preparation for treating coronary heart disease is prepared by processing ginseng, root of red-rooted salvia, radix pseudo-ginseng, pilose asiabell root, szechuan lovage rhizome, cattail pollen, pubescent holly root, tuber fleeceflower root, fiveleaf gynostemma herb, Chinese angelica, peach seed, hawthorn, motherwort herb, malaytea scurfpea fruit, glossy privet fruit and safflower serving as raw materials by a specific process. The transdermal medicament delivery patch preparation is a pure Chinese medicinal preparation and has the advantages of no chemical additive, no toxic or side effects, no harm to a human body, good therapeutic effect by external medicament administration and suitability for patients with coronary heart disease.
Description
Technical field
The present invention relates to medicament for the treatment of coronary heart disease and preparation method thereof, say it is a kind of transdermal medicament delivery patch preparation for the treatment of coronary heart disease and preparation method thereof in detail.
Background technology
We know that coronary heart disease is the abbreviation of coronary atherosclerotic heart disease, is referred to as ischemic heart desease now.It is the atherosis and myocardial ischemia-anoxemia that causes coronarius that basic pathology changes.The order of severity and cardiac damage characteristics according to hypoxic-ischemic often are divided into latent coronary heart disease, angina pectoris, myocardial infarction and arrhythmia etc.Coronary heart disease is the modal a kind of disease of old people still not, also is the very common deadly cause of disease.Sickness rate raises with age growth, and the blood pressure during hypertension increases degree and also is directly proportional with evidence of coronary heart diseases.Angina pectoris, myocardial infarction are two kinds of common coronary heart disease.Coronary heart disease is one of key factor of world today's threat human health.Because serious disabling property has brought white elephant for many families.This disease is unsatisfactory by modes such as oral administrations, and poor stability, side effect are strong, and the Chinese medicine Study on Coronary Heart Disease has obtained remarkable progress in recent years, and numerous clinical practices has also proved that Chinese medicine can effectively treat coronary heart disease simultaneously.
Summary of the invention
The technical problem that the present invention solves is, the solution chemical drugs is oral, toxic and side effects is big, big to the human body infringement, the problem of oral administration therapeutic effect difference provides a kind of pure Chinese medicinal preparation, do not add any chemical addition agent, have no side effect, harmless to human body, transdermal medicament delivery patch preparation of the treatment coronary heart disease that the external application drug treatment is effective and preparation method thereof.
Technical solution of the present invention is:
The transdermal medicament delivery patch preparation raw material of treatment coronary heart disease contains Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Codonopsis, Rhizoma Chuanxiong, Pollen Typhae, Radix Ilicis Pubescentis, Radix Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Radix Angelicae Sinensis, Semen Persicae, Fructus Crataegi, Herba Leonuri, Fructus Psoraleae, Fructus Ligustri Lucidi, Flos Carthami.
Its preparation method is (percentage by weight):
1, get Radix Ginseng 9%-20%, Radix Salviae Miltiorrhizae 21%-45%, Radix Notoginseng 19%-38%, Radix Codonopsis 19%-38%, purify oven dry and pulverize, it is stand-by to get Chinese medicine powder;
2, get Rhizoma Chuanxiong 12%-24%, Pollen Typhae 12%-24%, Radix Ilicis Pubescentis 12%-24%, Radix Polygoni Multiflori 12%-24%, Herb Gynostemmae Pentaphylli 9%-17%, Radix Angelicae Sinensis 12%-24% clean oven dry and are ground into granule, Chinese medicinal granule is stand-by;
3, get Semen Persicae 7%-15%, Fructus Crataegi 23%-37%, Herba Leonuri 11%-20%, Fructus Psoraleae 15%-28%, Fructus Ligustri Lucidi 11%-20%, Flos Carthami 7%-15% clean, it is stand-by to mix Chinese medicine;
4, get the Chinese medicine powder 6%-11% of the first step, the Chinese liquor 89%-94% that adds 35 °-40 ° soaks filtration after 7 days, gets filtrate;
5, get the filtrate 65%-75% in the 4th step, add pure water 25%-35%, it is stand-by to get medicated wine;
6, get the Chinese medicinal granule 5%-8% in second step, add 40 °-50 ° Chinese liquor 92%-95%, soak filtration on the 7th, get filtrate;
7, get the filtrate 70%-80% in the 6th step, add pure water 20%-30%, it is stand-by to get medicated wine;
8, get the mixing Chinese medicine 3%-5% in the 3rd step, add pure water 95%-97%, at a simmer to moisture content residue 50%, filter supernatant;
9, get the supernatant 70%-80% in the 8th step, added 35 ° of-40 ° of Chinese liquor 20%-30% precipitations 7, it is stand-by to get medicated wine;
10, get the 5th step medicated wine 18%-22%, add the 7th step medicated wine 38%-42%, add the 9th step medicated wine 38%-42%, must mix medicated wine;
11, with the tenth the step make the centrifugal filter of mixing medicated wine, add filter pressing, must close liquid medicated wine;
That 12, got for the 11 step closes liquid medicated wine 48%-50%, adds the ethyl cellulose powder of 2%-4%, adds glycerol 48%-50%, heats to 40 ℃-50 ℃, stirs 1-2 hour, must the emulsifiable paste body;
13, the emulsifiable paste body and function that the 12 step was made is crossed colloid mill homogenizing twice, the encapsulation manufactured goods.
The invention has the beneficial effects as follows that Radix Ginseng all has excited earlier back to suppress to the heart of multiple animal, and is excited in a small amount, a large amount of effects that suppress, it is similar to cardiotonic glycoside to action of the heart, can improve myocardial contraction, and heavy dose then weakens contractility and decreased heart rate.Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind, heart tonifying is strengthened myocardial contraction, improves cardiac function, do not increase myocardial oxygen consumption, coronary artery dilating increases myocardial flow, the expansion peripheral blood vessel, blood flow increases, cerebral blood flow descends, and prolongs hemorrhage and clotting time, suppresses platelet and gathers, change hemorheology and learn characteristic, microcirculation improvement.Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, contact vascular smooth muscle spasm, expansion coronary vasodilator, coronary blood flow increasing, the myocardial ischemia-anoxemia that the antagonism pituitrin causes, alleviate the myocardial infarction lesion degree that arteria coronaria causes, expansion of cerebral vascular easily sees through blood brain barrier, it is more to distribute in the brain, suppress platelet and gather, microcirculation improvement, antithrombotic forms.Flos Carthami promoting blood circulation to remove obstruction in the collateral, eliminating stasis to stop pain, low dose of have slight excitation to heart, and heart beating is strong, but heart is had inhibitory action when heavy dose of, makes decreased heart rate, and myocardial contraction weakens; Flos Carthami water jacquard weave pigment has the effect of coronary blood flow increasing and myocardial nutrition blood flow, improves the supply-demand relationship of myocardial ischemia-anoxemia, and dilating coronary blood vessel increases blood flow; Carthamus yellow has blood coagulation resisting function, reduces platelet and gathers effect.Semen Persicae blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, the active substance of water decoction-alcohol sedimentation gained can make the vein blood vessel flow increase, and vasodilator effect is arranged, and suppress blood coagulation and hemolytic effect in addition.The hemostasis of Radix Notoginseng dissipating blood stasis, subduing swelling and relieving pain, there are coronary artery dilating, resisting fatigue, improving memory, defying age, antioxidation, blood fat reducing and cholesterol, antiplatelet to gather and antithrombotic effect, the propagation of pluripotential hemopoietic stem cell is had obvious facilitation.The Fructus Crataegi removing food stagnancyization stagnates, convergence dysentery relieving, blood circulation promoting and blood stasis dispelling, can the treatment of vascular disease, and have blood vessel dilating, coronary blood flow increasing, improve the heart vigor, the stimulating central nervous system system, bring high blood pressure down and cholesterol, vessel softening and diuresis and sedation.Pollen Typhae hemostasis blood stasis dispelling is significantly increased the blood flow effect to arteria coronaria, and the open loop that strengthens blood capillary, the effect of blood fat reducing arteriosclerosis are arranged, and can strengthen cholesterol metabolism, inhibition platelet in vivo and gather and thrombosis.Radix Codonopsis Fructus Alpiniae Oxyphyllae, calmness, hypnosis, convulsion, have strengthen myocardial contraction, strengthen cardiac output, shock, blood pressure regulation, the effect that resists myocardial ischemia, change hemorheology and learn.Radix Ilicis Pubescentis blood circulation and channel invigorating, reducing swelling and alleviating pain, heat-clearing and toxic substances removing are used for coronary heart disease, angina pectoris, myocardial infarction, thromboangiitis obliterans, increase coronary flow and lasting.The Radix Polygoni Multiflori the kidney invigorating and essence nourishing, have promote hemopoietic function, blood fat reducing and atherosclerosis, slow down heart rate and coronary artery dilating, effect such as resist myocardial ischemia.Herb Gynostemmae Pentaphylli heat-clearing and toxic substances removing, eliminating phlegm and stopping cough have excitation to heart, and platelet is had depolymerisation, and the nervus centralis effect of regulating is arranged, can blood fat reducing, blood pressure lowering, arteriosclerosis and antithrombotic form.Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema have anti-platelet aggregation, improve coronary circulation and protection cardiac function.Fructus Psoraleae strengthens myocardium nutrient blood blood flow, and myocardial ischemia due to the pituitrin is had protective effect.The Fructus Ligustri Lucidi nourishing the liver and kidney is used for the treatment of coronary heart disease, hypertension, hyperlipidemia.Chinese angelica blood supplementing, invigorate blood circulation, menstruction regulating and pain relieving, intestine moistening, arrhythmia arranged, strengthen coronary flow, the myocardium antioxygen consumption of protection, blood fat reducing, atherosclerosis disease, suppress the effect that platelet is gathered, can form by antithrombotic.Pure Chinese medicinal preparation does not add any chemical addition agent, has no side effect, and is harmless to human body, and the external application drug treatment is effective.The present invention is applicable to patients with coronary heart disease.
The specific embodiment
Embodiment 1
A kind of transdermal medicament delivery patch preparation for the treatment of coronary heart disease, raw material contains Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Codonopsis, Rhizoma Chuanxiong, Pollen Typhae, Radix Ilicis Pubescentis, Radix Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Radix Angelicae Sinensis, Semen Persicae, Fructus Crataegi, Herba Leonuri, Fructus Psoraleae, Fructus Ligustri Lucidi, Flos Carthami.
Its preparation method is (percentage by weight):
1, get Radix Ginseng 9%, Radix Salviae Miltiorrhizae 21%, Radix Notoginseng 32%, Radix Codonopsis 38%, purify oven dry and pulverize, it is stand-by to get Chinese medicine powder;
2, get Rhizoma Chuanxiong 12%, Pollen Typhae 24%, Radix Ilicis Pubescentis 12%, Radix Polygoni Multiflori 24%, Herb Gynostemmae Pentaphylli 16%, Radix Angelicae Sinensis 12% and clean oven dry and be ground into granule, Chinese medicinal granule is stand-by;
3, get Semen Persicae 7%, Fructus Crataegi 37%, Herba Leonuri 11%, Fructus Psoraleae 18%, Fructus Ligustri Lucidi 20%, Flos Carthami 7% and clean, it is stand-by to mix Chinese medicine;
4, get the Chinese medicine powder 6% of the first step, the Chinese liquor 94% that adds 35 °-40 ° soaks filtration after 7 days, gets filtrate;
5, get the filtrate 65% in the 4th step, add pure water 35%, it is stand-by to get medicated wine;
6, get the Chinese medicinal granule 5% in second step, add 40 °-50 ° Chinese liquor 95%, soak filtration on the 7th, get filtrate;
7, get the filtrate 70% in the 6th step, add pure water 30%, it is stand-by to get medicated wine;
8, get the mixing Chinese medicine 3% in the 3rd step, add pure water 97%, at a simmer to moisture content residue 50%, filter supernatant;
9, get the supernatant 70% in the 8th step, added 35 ° of-40 ° of Chinese liquor, 30% precipitation 7, it is stand-by to get medicated wine;
10, get the 5th step medicated wine 18%, add the 7th step medicated wine 42%, add the 9th step medicated wine 40%, must mix medicated wine;
11, with the tenth the step make the centrifugal filter of mixing medicated wine, add filter pressing, must close liquid medicated wine;
That 12, got for the 11 step closes liquid medicated wine 48%, adds 4% ethyl cellulose powder, adds glycerol 48%, heats to 40 ℃-50 ℃, stirs 1-2 hour, must the emulsifiable paste body;
13, the emulsifiable paste body and function that the 12 step was made is crossed colloid mill homogenizing twice, the encapsulation manufactured goods.
Embodiment 2
The preparation method of the transdermal medicament delivery patch preparation of treatment coronary heart disease is (percentage by weight):
1, get Radix Ginseng 20%, Radix Salviae Miltiorrhizae 30%, Radix Notoginseng 19%, Radix Codonopsis 31%, purify oven dry and pulverize, it is stand-by to get Chinese medicine powder;
2, get Rhizoma Chuanxiong 24%, Pollen Typhae 12%, Radix Ilicis Pubescentis 24%, Radix Polygoni Multiflori 12%, Herb Gynostemmae Pentaphylli 9%, Radix Angelicae Sinensis 19% and clean oven dry and be ground into granule, Chinese medicinal granule is stand-by;
3, get Semen Persicae 15%, Fructus Crataegi 23%, Herba Leonuri 13%, Fructus Psoraleae 28%, Fructus Ligustri Lucidi 11%, Flos Carthami 10% and clean, it is stand-by to mix Chinese medicine;
4, get the Chinese medicine powder 11% of the first step, the Chinese liquor 89% that adds 35 °-40 ° soaks filtration after 7 days, gets filtrate;
5, get the filtrate 75% in the 4th step, add pure water 25%, it is stand-by to get medicated wine;
6, get the Chinese medicinal granule 8% in second step, add 40 °-50 ° Chinese liquor 92%, soak filtration on the 7th, get filtrate;
7, get the filtrate 75% in the 6th step, add pure water 25%, it is stand-by to get medicated wine;
8, get the mixing Chinese medicine 4% in the 3rd step, add pure water 96%, at a simmer to moisture content residue 50%, filter supernatant;
9, get the supernatant 75% in the 8th step, added 35 ° of-40 ° of Chinese liquor, 25% precipitation 7, it is stand-by to get medicated wine;
10, get the 5th step medicated wine 22%, add the 7th step medicated wine 40%, add the 9th step medicated wine 38%, must mix medicated wine;
11, with the tenth the step make the centrifugal filter of mixing medicated wine, add filter pressing, must close liquid medicated wine;
That 12, got for the 11 step closes liquid medicated wine 49%, adds 2% ethyl cellulose powder, adds glycerol 49%, heats to 40 ℃-50 ℃, stirs 1-2 hour, must the emulsifiable paste body;
13, the emulsifiable paste body and function that the 12 step was made is crossed colloid mill homogenizing twice, the encapsulation manufactured goods.
Embodiment 3
The preparation method of the transdermal medicament delivery patch preparation of treatment coronary heart disease is (percentage by weight):
1, get Radix Ginseng 16%, Radix Salviae Miltiorrhizae 45%, Radix Notoginseng 20%, Radix Codonopsis 19%, purify oven dry and pulverize, it is stand-by to get Chinese medicine powder;
2, get Rhizoma Chuanxiong 15%, Pollen Typhae 15%, Radix Ilicis Pubescentis 14%, Radix Polygoni Multiflori 15%, Herb Gynostemmae Pentaphylli 17%, Radix Angelicae Sinensis 24% and clean oven dry and be ground into granule, Chinese medicinal granule is stand-by;
3, get Semen Persicae 10%, Fructus Crataegi 25%, Herba Leonuri 20%, Fructus Psoraleae 15%, Fructus Ligustri Lucidi 15%, Flos Carthami 15% and clean, it is stand-by to mix Chinese medicine;
4, get the Chinese medicine powder 9% of the first step, the Chinese liquor 91% that adds 35 °-40 ° soaks filtration after 7 days, gets filtrate;
5, get the filtrate 70% in the 4th step, add pure water 30%, it is stand-by to get medicated wine;
6, get the Chinese medicinal granule 9% in second step, add 40 °-50 ° Chinese liquor 93%, soak filtration on the 7th, get filtrate;
7, get the filtrate 80% in the 6th step, add pure water 20%, it is stand-by to get medicated wine;
8, get the mixing Chinese medicine 5% in the 3rd step, add pure water 95%, at a simmer to moisture content residue 50%, filter supernatant;
9, get the supernatant 80% in the 8th step, added 35 ° of-40 ° of Chinese liquor, 20% precipitation 7, it is stand-by to get medicated wine;
10, get the 5th step medicated wine 20%, add the 7th step medicated wine 38%, add the 9th step medicated wine 42%, must mix medicated wine;
11, with the tenth the step make the centrifugal filter of mixing medicated wine, add filter pressing, must close liquid medicated wine;
That 12, got for the 11 step closes liquid medicated wine 50%, adds 2% ethyl cellulose powder, adds glycerol 48%, heats to 40 ℃-50 ℃, stirs 1-2 hour, must the emulsifiable paste body;
13, the emulsifiable paste body and function that the 12 step was made is crossed colloid mill homogenizing twice, the encapsulation manufactured goods.
Using method: this preparation is made plaster, be affixed on the heart outer skin.Once a day, about one time four hours.
Use the over one hundred routine patients with coronary heart disease of this plaster preparation for treating, effective percentage reaches 88%, and therapeutic effect is good.
Claims (2)
1. transdermal medicament delivery patch preparation for the treatment of coronary heart disease, it is characterized in that: raw material contains Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Codonopsis, Rhizoma Chuanxiong, Pollen Typhae, Radix Ilicis Pubescentis, Radix Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Radix Angelicae Sinensis, Semen Persicae, Fructus Crataegi, Herba Leonuri, Fructus Psoraleae, Fructus Ligustri Lucidi, Flos Carthami.
2. the preparation method of the transdermal medicament delivery patch preparation of treatment coronary heart disease according to claim 1 is characterized in that (percentage by weight):
1, get Radix Ginseng 9%-20%, Radix Salviae Miltiorrhizae 21%-45%, Radix Notoginseng 19%-38%, Radix Codonopsis 19%-38%, purify oven dry and pulverize, it is stand-by to get Chinese medicine powder;
2, get Rhizoma Chuanxiong 12%-24%, Pollen Typhae 12%-24%, Radix Ilicis Pubescentis 12%-24%, Radix Polygoni Multiflori 12%-24%, Herb Gynostemmae Pentaphylli 9%-17%, Radix Angelicae Sinensis 12%-24% clean oven dry and are ground into granule, Chinese medicinal granule is stand-by;
3, get Semen Persicae 7%-15%, Fructus Crataegi 23%-37%, Herba Leonuri 11%-20%, Fructus Psoraleae 15%-28%, Fructus Ligustri Lucidi 11%-20%, Flos Carthami 7%-15% clean, it is stand-by to mix Chinese medicine;
4, get the Chinese medicine powder 6%-11% of the first step, the Chinese liquor 89%-94% that adds 35 °-40 ° soaks filtration after 7 days, gets filtrate;
5, get the filtrate 65%-75% in the 4th step, add pure water 25%-35%, it is stand-by to get medicated wine;
6, get the Chinese medicinal granule 5%-8% in second step, add 40 °-50 ° Chinese liquor 92%-95%, soak filtration on the 7th, get filtrate;
7, get the filtrate 70%-80% in the 6th step, add pure water 20%-30%, it is stand-by to get medicated wine;
8, get the mixing Chinese medicine 3%-5% in the 3rd step, add pure water 95%-97%, at a simmer to moisture content residue 50%, filter supernatant;
9, get the supernatant 70%-80% in the 8th step, added 35 ° of-40 ° of Chinese liquor 20%-30% precipitations 7, it is stand-by to get medicated wine;
10, get the 5th step medicated wine 18%-22%, add the 7th step medicated wine 38%-42%, add the 9th step medicated wine 38%-42%, must mix medicated wine;
11, with the tenth the step make the centrifugal filter of mixing medicated wine, add filter pressing, must close liquid medicated wine;
That 12, got for the 11 step closes liquid medicated wine 48%-50%, adds the ethyl cellulose powder of 2%-4%, adds glycerol 48%-50%, heats to 40 ℃-50 ℃, stirs 1-2 hour, must the emulsifiable paste body;
13, the emulsifiable paste body and function that the 12 step was made is crossed colloid mill homogenizing twice, the encapsulation manufactured goods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010100656A CN101850038A (en) | 2010-01-18 | 2010-01-18 | Transdermal medicament delivery patch preparation for treating coronary heart disease and method for preparing same |
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| CN201010100656A CN101850038A (en) | 2010-01-18 | 2010-01-18 | Transdermal medicament delivery patch preparation for treating coronary heart disease and method for preparing same |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610893A (en) * | 2013-12-06 | 2014-03-05 | 李明莉 | Traditional Chinese medicine for treating coronary disease |
| CN106511911A (en) * | 2016-12-30 | 2017-03-22 | 湖州长兴益健医疗科技有限公司 | Traditional Chinese medicine patch for treating coronary heart disease and preparation method thereof |
| CN113101314A (en) * | 2021-04-23 | 2021-07-13 | 王洪强 | Composition for preventing and treating coronary heart disease and cardiovascular and cerebrovascular diseases and application method thereof |
-
2010
- 2010-01-18 CN CN201010100656A patent/CN101850038A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610893A (en) * | 2013-12-06 | 2014-03-05 | 李明莉 | Traditional Chinese medicine for treating coronary disease |
| CN103610893B (en) * | 2013-12-06 | 2015-11-18 | 李明莉 | A kind of Chinese medicine for the treatment of coronary heart disease |
| CN106511911A (en) * | 2016-12-30 | 2017-03-22 | 湖州长兴益健医疗科技有限公司 | Traditional Chinese medicine patch for treating coronary heart disease and preparation method thereof |
| CN113101314A (en) * | 2021-04-23 | 2021-07-13 | 王洪强 | Composition for preventing and treating coronary heart disease and cardiovascular and cerebrovascular diseases and application method thereof |
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Open date: 20101006 |