CN101843823B - Anti-flu injection and preparation method thereof - Google Patents
Anti-flu injection and preparation method thereof Download PDFInfo
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- CN101843823B CN101843823B CN201010189539.8A CN201010189539A CN101843823B CN 101843823 B CN101843823 B CN 101843823B CN 201010189539 A CN201010189539 A CN 201010189539A CN 101843823 B CN101843823 B CN 101843823B
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Abstract
The invention relates to an anti-flu injection and a preparation method thereof. The anti-flu injection is prepared from main raw materials of 30-50g of garlic, 15-25g of fistular onion stalk, 30-50g of Chinese cinquefoil herb and 1-3ml of pig's bile, and auxiliary materials of 95% of alcohol, 0.5% of procaine aqueous solution, 4% of sodium hydroxide solution and distilled water. The anti-flu injection has good disinfection, antivirus and immunity-improving effects, small toxic or side effects, fast action and low cost. The anti-flu injection is favorable medicament against flu and pestilence.
Description
Technical field the present invention relates to a kind of anti-flu injection, the invention still further relates to the preparation method of this anti-flu injection.
The tracheitis that background technology is caused by influenza, enteritis, the syndromes such as dysentery are comparatively common clinically, especially agnogenic various pestilence, typhoid fever miscellaneous diseases are also more and more.At present, this class disease does not have specific Therapeutic Method, and medicine used is substantially all that performance is perfect not, and therapeutic effect is poor, and side effect is large, and cost is high.
Summary of the invention technical problem to be solved by this invention is: a kind of anti-flu injection and preparation method thereof is provided.By selecting suitable compound ratio, reach treatment fruit good, side effect is little, the object reducing costs.
Technical scheme of the present invention is as follows:
An anti-flu injection, is characterized in that: primary raw material forms: Bulbus Allii 30-50 gram, Bulbus Allii Fistulosi 15-25 gram, Herba Potentillae Chinensis 30-50 gram, Fel Sus domestica 1-3 milliliter.Auxiliary material: 95% ethanol, 0.5% procaine aqueous solution, 4% sodium hydroxide solution, distilled water.
Preferred composition of raw materials is as follows: 40 grams, Bulbus Allii, 20 grams of Bulbus Allii Fistulosi, 40 grams of Herba Potentillae Chinensis, 2 milliliters of Fel Sus domestica.
The preparation method of anti-flu injection, is characterized in that, step is as follows:
(1) get in proportion Bulbus Allii, Bulbus Allii Fistulosi is smashed to pieces.
(2) speed is used vapor distillation by (1), and temperature is controlled at 95-101 ℃.85 milliliters of liquid are slipped in collection.
(3) fresh pig bile is condensed into half amount, is cooled to 5-18 ℃, make abundant precipitation, filter, filtrate adds 2-3 and doubly measures 95% ethanol.
(4) (3) mixture is stirred to 3-5 minute, standing 10-15 minute, filters, filtrate recovered alcohol, and adding distil water is made into 100% bile dope.
(5) get (4) gained bile dope and add (2) gained to slip in liquid, obtain clear and bright liquid.
(6) Herba Potentillae Chinensis of ratio is added to water 300-500 milliliter and decoct 3 times, remain 100 milliliters of medicinal liquids at every turn, collecting decoction, filters, and is condensed into syrupy shape.
(7) add 95% ethanol and process (6) to without precipitation, then distill ethanol and obtain decorating film.Add (5) clear and bright liquid, mix.
(8) (7) mixture is added to the procaine hydrochloride of its 0.5% weight, stir, with 4% sodium hydroxide solution, be neutralized to pH value to 8.5.
(9) filter (8) liquid, subpackage 2-3 milliliter, sterilizing.
Prescription key component of the present invention is according to traditional medicine and modern medicine analysis, and the property of medicine and pharmacological action are as follows:
Bulbus Allii: meridian distribution of property and flavor: gas is special, acrid in the mouth is peppery.Function cures mainly: circulation of qi promoting removing food stagnancy, parasite killing removing toxic substances.For flu, bacillary dysentery, amebic dysentery, enteritis, eating accumulation, carbuncle skin infection.Function cures mainly:
(1) antibacterial, effect sterilizes, kills the virus.
(2), blood fat reducing, cholesterol reducing, anticoagulant, prevention of arterial sclerosis and cerebral infarction.
(3) the liver protecting, prevents and treats hepatitis.
(4) function of tumor inhibition.
(5) remove free radical, improve immunity and anti-senescence function.
(6) blood sugar lowering, the dosis tolerata function of raising body to glucose grain.
Bulbus Allii Fistulosi: meridian distribution of property and flavor: acrid in the mouth, warm in nature.Attach to the lung and stomach meridians.。Function cures mainly: deliver cold expelling, activate yang, removing toxic substances, parasite killing.
Herba Potentillae Chinensis: meridian distribution of property and flavor: feeble QI, puckery, micro-hardship.Function cures mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For bloody dysentery stomachache, chronic dysentery is more than, bleeding hemorrhoids, carbuncle sore tumefacting virus.
Fel Sus domestica: main component is bile acids, bile pigments, mucin, lipid and inorganic matter etc.In bile acid, have chenodeoxy cholic acid (Cllenodeoxy-cholic acid), 3a-hydroxyl-6-oxygen-5 α-cholanic acid (3 α-Hydroxy-6-oxo-5 α-cholanic acid) and lithocholic acid (Llthocholic acid), they are almost completely combined with glycine and exist.Another containing hyocholic acid and
hyodeoxycholic Acid(Hyodeoxycholicacid).Fel Sus domestica is mainly containing Hyodeoxycholic Acid (hyodesoxycholic acid), still containing deoxycholic acid and several amino acids.Function cures mainly: lung benefiting, spleen reinforcing, moisturizes.Control and quench one's thirst, constipation, jaundice, pertussis, asthma, have loose bowels, dysentery, conjunctival congestion, sore throat, stare at ear, carbuncle.
Anti-flu injection of the present invention has good sterilizing and anti-virus poison, improves immunity, and toxic and side effects is little, instant effect, and cost is low.From 2007 in JIUYUE, 10 to 2009, with San the People's Hospital, Yao of the present invention Laizhou City treatment influenza syndrome 50 examples, and contrast with using levofloxacin-metronidazole 50 examples of infusing.Result shows effective percentage 96% of the present invention, the effective percentage 80% of levofloxacin-metronidazole transfusion.Diagnostic criteria is with reference to < < CDC influenza diagnostic criteria > >
Treatment group 1: medicine of the present invention, after 3-7 days, observe.
Matched group 2: levofloxacin-metronidazole, after 3-7 days, observe.
Every group is all carried out efficacy evaluation in treatment after 3-7 days.Two groups of front differences that there are no significant (P < 0.05) of (having a fever, cough, diarrhoea, biochemical indicator) aspect case source, Sex, Age, the course of disease, cardinal symptom for the treatment of, have comparability.Observe treatment front and back symptom, and body temperature, cough, the situations such as biochemical investigation are also observed and are had or not bad reflection.
Medicine of the present invention respectively with contrast organize between relatively, have significant difference.The aspects such as medicine of the present invention is being eliminated clinical symptoms, and toxic and side effects is little, and cost is low, low-hanging fruit are all better than other medicines.
Two groups of therapeutic outcomes see the following form:
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate | 3 days fevers | 7 days fevers |
| Treatment group | 50 | 41 | 48 | 2 | 96％ | 6 | 0 |
| Matched group | 50 | 36 | 40 | 10 | 80％ | 29 | 5 |
Medicine of the present invention respectively with contrast organize between relatively, have significant difference.The aspects such as medicine of the present invention is being eliminated clinical symptoms, and toxic and side effects is little, and cost is low, low-hanging fruit are all better than other medicines.
The specific embodiment, in order to understand better and to implement, further illustrates the present invention below in conjunction with Preparation Example.
Embodiment mono-:
The proportioning of raw material is as follows: 30 grams, Bulbus Allii, 15 grams of Bulbus Allii Fistulosi, 30 grams of Herba Potentillae Chinensis, 1 milliliter of Fel Sus domestica.
Preparation process is as follows:
(1) get 30 grams, Bulbus Allii,, 15 grams of Bulbus Allii Fistulosi are smashed to pieces.
(2) speed is used vapor distillation by (1), and temperature is controlled at 95-101 ℃.85 milliliters of liquid are slipped in collection.
(3) 1 milliliter of fresh pig bile is condensed into half amount, is cooled to 5-18 ℃, make abundant precipitation, filter, filtrate adds 2-3 and doubly measures 95% ethanol.
(4) (3) mixture is stirred to 3-5 minute, standing 10-15 minute, filters, filtrate recovered alcohol, and adding distil water is made into 100% bile dope.
(5) get (4) gained bile dope and add (2) gained to slip in liquid, obtain clear and bright liquid.
(6) Herba Potentillae Chinensis of 30 grams is added to water 300-500 milliliter and decoct 3 times, remain 100 milliliters of medicinal liquids at every turn, collecting decoction, filters, and is condensed into syrupy shape.
(7) add 95% ethanol and process (6) to without precipitation, then distill ethanol and obtain decorating film.Add (5) clear and bright liquid, mix.
(8) (7) mixture is added to the procaine hydrochloride of its 0.5% weight, stir, with 4% sodium hydroxide solution, be neutralized to pH value to 8.5.
(9) filter (8) liquid, subpackage 2-3 milliliter, sterilizing.
Using method: intramuscular injection, every day 1-2 time, each 2-3 milliliter.
Embodiment bis-:
The proportioning of raw material is as follows: 40 grams, Bulbus Allii, 20 grams of Bulbus Allii Fistulosi, 40 grams of Herba Potentillae Chinensis, 2 milliliters of Fel Sus domestica.
Preparation process is as follows:
(1) get 40 grams of Bulbus Alliis, 20 grams of Bulbus Allii Fistulosi are smashed to pieces.
(2) speed is used vapor distillation by (1), and temperature is controlled at 95-101 ℃.85 milliliters of liquid are slipped in collection.
(3) 2 milliliters of fresh pig bile are condensed into half amount, are cooled to 5-18 ℃, make abundant precipitation, filter, filtrate adds 2-3 and doubly measures 95% ethanol.
(4) (3) mixture is stirred to 3-5 minute, standing 10-15 minute, filters, filtrate recovered alcohol, and adding distil water is made into 100% bile dope.
(5) get (4) gained bile dope and add (2) gained to slip in liquid, obtain clear and bright liquid.
(6) 40 grams of Herba Potentillae Chinensis are added to water 300-500 milliliter and decoct 3 times, remain 100 milliliters of medicinal liquids at every turn, collecting decoction, filters, and is condensed into syrupy shape.
(7) add 95% ethanol and process (6) to without precipitation, then distill ethanol and obtain decorating film.Add (5) clear and bright liquid, mix.
(8) (7) mixture is added to the procaine hydrochloride of its 0.5% weight, stir, with 4% sodium hydroxide solution, be neutralized to pH value to 8.5.
(9) filter (8) liquid, subpackage 2-3 milliliter, sterilizing.
Using method is with embodiment mono-
Embodiment tri-:
The proportioning of raw material is as follows: 50 grams, Bulbus Allii, and 25 grams of Bulbus Allii Fistulosi, 50 grams of Herba Potentillae Chinensis, 3 milliliters of preparation processes of Fel Sus domestica are as follows:
(1) get 50 grams of Bulbus Alliis, 25 grams of Bulbus Allii Fistulosi are smashed to pieces.
(2) speed is used vapor distillation by (1), and temperature is controlled at 95-101 ℃.85 milliliters of liquid are slipped in collection.
(3) 3 milliliters of fresh pig bile are condensed into half amount, are cooled to 5-18 ℃, make abundant precipitation, filter, filtrate adds 2-3 and doubly measures 95% ethanol.
(4) (3) mixture is stirred to 3-5 minute, standing 10-15 minute, filters, filtrate recovered alcohol, and adding distil water is made into 100% bile dope.
(5) get (4) gained bile dope and add (2) gained to slip in liquid, obtain clear and bright liquid.
(6) 50 grams of Herba Potentillae Chinensis are added to water 300-500 milliliter and decoct 3 times, remain 100 milliliters of medicinal liquids at every turn, collecting decoction, filters, and is condensed into syrupy shape.
(7) add 95% ethanol and process (6) to without precipitation, then distill ethanol and obtain decorating film.Add (5) clear and bright liquid, mix.
(8) (7) mixture is added to the procaine hydrochloride of its 0.5% weight, stir, with 4% sodium hydroxide solution, be neutralized to pH value to 8.5.
(9) filter (8) liquid, subpackage 2-3 milliliter, sterilizing.
Using method is with embodiment mono-.
Claims (1)
1. an anti-flu injection, is characterized in that, the proportioning of raw material is as follows: 40 grams, Bulbus Allii, 20 grams of Bulbus Allii Fistulosi, 40 grams of Herba Potentillae Chinensis, 2 milliliters of Fel Sus domestica;
Preparation process is as follows:
(1) get 40 grams of Bulbus Alliis, 20 grams of Bulbus Allii Fistulosi are smashed to pieces;
(2) speed is used vapor distillation by (1), and temperature is controlled at 95-101 ℃; 85 milliliters of liquid are slipped in collection;
(3) 2 milliliters of fresh pig bile are condensed into half amount, are cooled to 5-18 ℃, make abundant precipitation, filter, filtrate adds 2-3 and doubly measures 95% ethanol;
(4) (3) mixture is stirred to 3-5 minute, standing 10-15 minute, filters, filtrate recovered alcohol, and adding distil water is made into 100% bile dope;
(5) get (4) gained bile dope and add (2) gained to slip in liquid, obtain clear and bright liquid;
(6) 40 grams of Herba Potentillae Chinensis are added to water 300-500 milliliter and decoct 3 times, remain 100 milliliters of medicinal liquids at every turn, collecting decoction, filters, and is condensed into syrupy shape;
(7) add 95% ethanol and process (6) to without precipitation, then distill ethanol and obtain decorating film; Add (5) clear and bright liquid, mix;
(8) (7) mixture is added to the procaine hydrochloride of its 0.5% weight, stir, with 4% sodium hydroxide solution, be neutralized to pH value to 8.5;
(9) filter (8) liquid, subpackage 2-3 milliliter, sterilizing.
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| CN201010189539.8A CN101843823B (en) | 2010-05-27 | 2010-05-27 | Anti-flu injection and preparation method thereof |
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| CN201010189539.8A CN101843823B (en) | 2010-05-27 | 2010-05-27 | Anti-flu injection and preparation method thereof |
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| CN101843823B true CN101843823B (en) | 2014-04-09 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096698A (en) * | 1994-02-05 | 1994-12-28 | 谢时亮 | The compound method that is used for the anti-nasal drops that cures cold |
| CN1137892A (en) * | 1995-06-12 | 1996-12-18 | 冉红卫 | Preparation method of drug for curing common cold and its series product-ointment for curing common cold |
| WO2006057637A1 (en) * | 2004-11-24 | 2006-06-01 | Seo Hong Yoo | Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof |
-
2010
- 2010-05-27 CN CN201010189539.8A patent/CN101843823B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096698A (en) * | 1994-02-05 | 1994-12-28 | 谢时亮 | The compound method that is used for the anti-nasal drops that cures cold |
| CN1137892A (en) * | 1995-06-12 | 1996-12-18 | 冉红卫 | Preparation method of drug for curing common cold and its series product-ointment for curing common cold |
| WO2006057637A1 (en) * | 2004-11-24 | 2006-06-01 | Seo Hong Yoo | Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof |
| CN101065110A (en) * | 2004-11-24 | 2007-10-31 | 柳署弘 | Dried forms of aqueous solubilized bile acid dosage formulation, preparation and uses thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘直.猪胆汁的临床应用和实验研究.《中国生化药物杂志》.1989,(第02期),64-66. |
| 猪胆汁的临床应用和实验研究;刘直;《中国生化药物杂志》;19891231(第02期);64-66 * |
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Inventor after: Wang Suwen Inventor after: Gong Zhaorong Inventor before: Gong Zhaorong |
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