CN101843293A - Animal-breeding feed additive and preparation and application thereof - Google Patents
Animal-breeding feed additive and preparation and application thereof Download PDFInfo
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- CN101843293A CN101843293A CN200910010868A CN200910010868A CN101843293A CN 101843293 A CN101843293 A CN 101843293A CN 200910010868 A CN200910010868 A CN 200910010868A CN 200910010868 A CN200910010868 A CN 200910010868A CN 101843293 A CN101843293 A CN 101843293A
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Abstract
The invention discloses an animal-breeding feed additive and preparation and application thereof, and the feed additive is the organic solvent extract of jerusalem artichoke leaves. The main component of the jerusalem artichoke leaf extract is phenol compound, and the main important physiologically active component of the jerusalem artichoke leaf extract is chlorogenic acid compound. The jerusalem artichoke leaf extract is extracted by organic solvent. The invention increases the quality of feed by adding the jerusalem artichoke leaf extract into the feed; when the feed prepared with the feed additive is used for feeding animals, the feeding cost is low, the absorption is quick, and the effect is good.
Description
Technical field
The present invention relates to feed addictive, specifically a kind of animal-breeding feed additive and preparation and application.
Background technology
At present, at the medium-term and long-term medicated feed additives such as antibiotic, somatotropin, disinfectant, anticorrisive agent, antioxidant that use of poultry and livestock feed, directly and affected indirectly human beings'health.The harm of these conventional feed additives mainly contains: the one, in feed, add antibiotic, somatotropin, disinfectant, anticorrisive agent, antioxidant etc. for a long time, the microorganism drug resistance constantly strengthens in the fowl carcass, drug effect descends, dose increases, drug residue increases in the fowl carcass, behind human edible such livestock product, may cause the human DNA structure to change, cause distortion, the canceration of normal tissue cell, harm humans health; The 2nd, the microorganism drug resistance strengthens in the fowl carcass, in case infect the mankind, patient is yielded to no remedy, and the mankind are caused very big threat; The 3rd, in feed, add somatropin, the fowl dirty swine is rapidly long, but deterioration in quality is of low nutritive value.In China, a large amount of uses of antibiotics have had a strong impact on the outlet of livestock product in the feed.
Summary of the invention
In order to overcome the deficiency of above-mentioned feed addictive, the present invention extracts active ingredient with organic solvent from the jerusalem artichoke leaf, add the active ingredient in the jerusalem artichoke leaf extract in feed feeding animals, and it is low to reach the cost of feeding, and absorbs advantages such as fast, effective.
For achieving the above object, the technical solution adopted in the present invention is:
A kind of animal-breeding feed additive, described additive are the extractive with organic solvent of jerusalem artichoke leaf.
Contain nutritional labelings such as various trace elements and amino acid in the jerusalem artichoke leaf, the main component of described jerusalem artichoke leaf extract is a phenolic compound, but also contains other compositions; Wherein the important physical active component mainly is the chlorogenic acid compound, but also has other compounds; Wherein the chlorogenic acid compound mainly contains three classes, is respectively caffeoyl guinic acid (chlorogenic acid), feruloyl quinic acid and cynarin.
Chlorogenic acid is distributed widely in the plant, mainly is present in honeysuckle, folium cortex eucommiae, tealeaves, fresh coffee beans etc., also is rich in the chlorogenic acid compound in the composite family Helianthus plant jerusalem artichoke, and it has following effect:
The one, the effect of preventing and curing diseases: chlorogenic acid has antibacterial action more widely, has stronger antibacterial and anti-inflammation functions, and it is added in the feed, can reduce fowl and raise the probability of catching an illness, thereby play the effect of preventing and curing diseases;
The 2nd, increase the speed of growth, improve the meat quality;
The 3rd, improve the immunity of fowl poultry: chlorogenic acid can be removed interior free yl, improves immunity of organisms;
The 4th, improve the fertility of fowl poultry.
The jerusalem artichoke leaf extract can obtain with organic solvent extraction, also can obtain by additive method, perhaps the combination of this several method.Be specially: the jerusalem artichoke leaf is joined in the organic solvent of 5～50 times of volumes of jerusalem artichoke leaf and extract, filter the extraction back, and filtrate is removed extractant, the jerusalem artichoke leaf extract.
Described organic solvent is one or more in ethanol, methyl alcohol, ethyl acetate, propyl alcohol, butanols, acetone and the chloroform; The whole leaf of jerusalem artichoke leaf can be extracted or extracts in the pure back of grinding of powder; Described filtrate removes that extractant can adopt that decompression concentrates, vacuum evaporation or spray-drying; Extraction can be finished with equipment known in the art, and as countercurrent extraction device, extraction also can be carried out in other various types of equipment.
The extractive with organic solvent of described jerusalem artichoke leaf makes an addition in the animal-breeding feed, improves the quality of feed, and its addition is 0.01%～10% of an animal-breeding feed weight.
This feed addictive is applicable to and adds in livestock and poultry and the aquatic feeds, as: bird breeding feed, domestic animals breeding feed or aquaculture of aquatic animal feed, edible for bird, domestic animals or aquatic livestock; Described aquaculture of aquatic animal feed is the fresh water animals breeding feed; Domestic animals comprise pig, ox, sheep, horse, donkey, mule, cat, dog, rabbit, deer, fox and ermine etc.; Bird comprises chicken, duck, goose, pigeon etc.; Aquatic livestock comprises fish, shrimp, shellfish, crab, soft-shelled turtle etc.
The present invention has following advantage:
1. the present invention adds the jerusalem artichoke leaf extract in the feed to, is mixed with green, environmental protection, non-harmful feed.The jerusalem artichoke leaf extract can be mixed with feed with other feed addictives, and is edible for fowl poultry and aquatic livestock, also can be only with this a kind of feed addictive.
2. the feed addictive that contains the jerusalem artichoke leaf extract provided by the invention can be used for improving feed quality.Animal edible behind this feed addictive, honey stomach, body weight increases, resistance against diseases improves, meat and fur quality improve, remarkable in economical benefits increases.
3. the present invention is by adding the quality that the jerusalem artichoke leaf extract improves feed in feed; Feed animal with this feed addictive formula feed, the cost of feeding is low, absorbs fast, effective.
The specific embodiment
Chlorogenic acid compounds in the embodiment 1 alcohol extract jerusalem artichoke leaf
Accurately take by weighing the jerusalem artichoke leaf 4g of drying and crushing, with the volumetric concentration 80% ethanol water refluxing extraction of 20 times of volumes 12 hours, filtered ultrasonic 30 minutes of cooling back, and filtrate is preserved standby; Filter residue adds volumetric concentration 80% ethanol water of 15 times of volumes again, refluxing extraction 8h, and filter ultrasonic 30 minutes of cooling back; Merging filtrate spends the night with volumetric concentration 70% ethanol alcohol precipitation.Filter, filtrate decompression is concentrated into the medicinal extract shape, gets the jerusalem artichoke leaf extract.
Active ingredient in the embodiment 2 ethyl acetate extraction jerusalem artichoke leaves
With jerusalem artichoke leaf drying and crushing, jerusalem artichoke leaf and ethyl acetate are in 1g: the 15ml ratio is mixed, and filter normal temperature lixiviate 〉=12 hour, and filtrate decompression concentrates removes organic solvent, the extract concentrated extract, this is the jerusalem artichoke leaf extract.
The evaluation of chlorogenic acid compounds in the embodiment 3 jerusalem artichoke leaves
Use high performance liquid chromatography and electrospray ionization mass spectrometry (MS-ESI) that the chemical composition in the embodiment 1 jerusalem artichoke leaf extract is identified.
The ultraviolet spectra of chlorogenic acid standard items shows as at 230～240nm and 325nm place absorption maximum, and the sample of jerusalem artichoke leaf extract separates through liquid chromatogram, finds to exist the multiple compound that has similar UV absorption to the chlorogenic acid standard items; Further identify, differentiate to belong to caffeoyl guinic acid (chlorogenic acid), feruloyl quinic acid and dicaffeoylquinic acid compound by electrospray ionization mass spectrometry.
The feed addictive that embodiment 4 contains the jerusalem artichoke leaf extract makes an addition to the preliminary test of feeding Tilapia mossambica in the feed
Test material and method: fingerling is the Sarotherodon sp seedling, selects a reservoir to test.With specification is Sarotherodon sp 150 tails about the 230g/ tail, is divided into 3 groups at random, every group of 2 repetitions, and promptly every group 25 tails, putting into specification respectively is 1m
3Small-sized net cage in, small-sized net cage is fixed in big production net cage (6m
3) between, making to be " one " font between big small-sized net cage, the feed addictive that the embodiment of the invention 1 is made adds in the Sarotherodon sp feed (seeing Table 1) by the addition of mass concentration 1 ‰, 2 ‰, and it is identical with the daily management condition that science is thrown something and fed.Calculate all test data averages (seeing Table 2) behind the adult fish, the rate of body weight gain of each group of test [counterpoise before rate of body weight gain (%)=100% * (counterpoise before counterpoise one examination of examination back)/examination]
Table 1 packet design
The weightening finish information slip unit of table 2 Tilapia mossambica: g
The rate of body weight gain of test group all is higher than control group, uses each group of additive of the present invention that great disease does not all take place simultaneously, shows that the feed addictive that contains the jerusalem artichoke leaf extract of the present invention has improved the growth performance of Tilapia mossambica.
The feed addictive that embodiment 5 contains the jerusalem artichoke leaf extract makes an addition to the preliminary test of feeding chicken in the feed
The feed addictive that contains the jerusalem artichoke leaf extract that take by weighing quality respectively and be 0,200g, 400g, the embodiment of the invention 2 of 600g makes adds in the feed of 1000kg, mixes, stirs, and divides every day and feeds chicken 3 times.The chicken feed desire is vigorous behind this feed addictive of feeding, and the effect that is produced is as shown in table 3.
Table 3 adds the growth of chicken behind the feed addictive contain the jerusalem artichoke leaf extract and butchers situation
As can be seen along with the increase that contains jerusalem artichoke leaf extract feed addictive addition, also corresponding the obtaining of the body weight of chicken increases in the present embodiment table 3, and the death rate descends, and resistance against diseases strengthens; The decline of drip loss and shearing force improves meat matter.
The chicken that eats the feed addictive that contains the jerusalem artichoke leaf extract is similar with the testing result that all the other eat the livestock and poultry that contain jerusalem artichoke leaf extract feed addictive, and eating effect all makes moderate progress to a certain extent.
The feed addictive that embodiment 6 contains the jerusalem artichoke leaf extract makes an addition to the preliminary test of feeding pig in the feed
Select to deliver 48 of healthy active piggys for sale with the child care of criticizing, according to body weight and the close principle of sex ratio, piggy is divided into two groups of A, B, wherein the A group is control group, if 2 repetition groups, the B group is test group, if 2 repetition groups, 12 of every groups, male and female half and half, the parted hair numbering: A organizes the ordinary maize-dregs of beans type daily ration of feeding, and does not add the feed addictive that contains the jerusalem artichoke leaf extract, the feed addictive that contains the jerusalem artichoke leaf extract that the embodiment of the invention 2 of B group interpolation 1% on the basis of A group basal diet makes.Fed 30 days.
After adding this feed addictive in the feed, every pig average daily gain is 691g, and the test group average daily gain improves 18.52% than control group; Feedstuff-meat ratio is 3.02, has reduced by 8.2% than control group; Diarrhea rate is 21.25%, has reduced by 16.4% than control group, and concrete result of the test sees Table 4,5,6.The result that feeds shows that product of the present invention can improve digestibility and the utilization rate of piglet to roughage, obviously increases daily gain, reduces feedstuff-meat ratio, increases economic benefit, improves breeding performonce fo animals, strengthens immunity of organisms.
Table 4 each test group pig body weight and weightening finish
The feedstuff-meat ratio situation of each test group pig of table 5
Table 6 a piggy diarrhoea number of days and diarrhea rate
*Diarrhea rate=diarrhoea number of days/total number of days.
Jerusalem artichoke leaf role, according to zoopery, can reduce following some:
1. to the influence of animal viscera weight change: 1) increased the extractum hepatis content in the liver cell; 2) form and the function of kidney have been strengthened; 3) can repair big intestinal mucosal injury; 4) improve the hyperfunction of small intestine digestive function; 4) relevant with sex hormone endocrine dysfunction is hyperfunction; 5) testis proportion increases; 6) thymus gland proportion increases;
2. to the influence of the physiological function of animal: 1) diuresis; 2) reduce blood fat; 3) hyperhepatia effect; 4) promote the metabolism effect; 5) strengthening by means of tonics effect.
Claims (7)
1. animal-breeding feed additive, it is characterized in that: the Main Ingredients and Appearance of described additive is the extractive with organic solvent of jerusalem artichoke leaf.
2. the preparation method of the described feed addictive of claim 1 is characterized in that: the jerusalem artichoke leaf is joined in the organic solvent of 5～50 times of volumes of jerusalem artichoke leaf and extract, filter the extraction back, and filtrate is removed extractant, the jerusalem artichoke leaf extract.
3. preparation method according to claim 2 is characterized in that: described organic solvent is one or more in ethanol, methyl alcohol, ethyl acetate, propyl alcohol, butanols, acetone and the chloroform.
4. preparation method according to claim 2 is characterized in that: described filtrate removes that extractant can adopt that decompression concentrates, vacuum evaporation or spray-drying.
5. the application of the described additive of claim 1 in animal-breeding feed, it is characterized in that: the extractive with organic solvent of the described jerusalem artichoke leaf of claim 1 is made an addition in the animal-breeding feed, improve the quality of feed, its addition is 0.01%～10% of an animal-breeding feed weight.
6. application according to claim 5 is characterized in that: described animal-breeding feed is bird breeding feed, domestic animals breeding feed or aquaculture of aquatic animal feed, and is edible for bird, domestic animals or aquatic livestock.
7. application according to claim 6 is characterized in that: described aquaculture of aquatic animal feed is the fresh water animals breeding feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910010868A CN101843293A (en) | 2009-03-25 | 2009-03-25 | Animal-breeding feed additive and preparation and application thereof |
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| CN200910010868A CN101843293A (en) | 2009-03-25 | 2009-03-25 | Animal-breeding feed additive and preparation and application thereof |
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| CN200910010868A Pending CN101843293A (en) | 2009-03-25 | 2009-03-25 | Animal-breeding feed additive and preparation and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106562113A (en) * | 2016-11-02 | 2017-04-19 | 通化师范学院 | Chinese herbal medicine-based feed additive combination for Salvelinus malma and preparation method and use thereof |
| CN114847405A (en) * | 2022-05-06 | 2022-08-05 | 山东益得来生物科技有限公司 | Jerusalem artichoke extract for promoting feather development and application thereof |
| WO2024098654A1 (en) * | 2022-11-07 | 2024-05-16 | 桂林风鹏生物科技有限公司 | Feed additive for replacing feed antibiotic and preparation method therefor |
-
2009
- 2009-03-25 CN CN200910010868A patent/CN101843293A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106562113A (en) * | 2016-11-02 | 2017-04-19 | 通化师范学院 | Chinese herbal medicine-based feed additive combination for Salvelinus malma and preparation method and use thereof |
| CN114847405A (en) * | 2022-05-06 | 2022-08-05 | 山东益得来生物科技有限公司 | Jerusalem artichoke extract for promoting feather development and application thereof |
| CN114847405B (en) * | 2022-05-06 | 2023-09-22 | 山东益得来生物科技有限公司 | Jerusalem artichoke extract for promoting feather development and application thereof |
| WO2024098654A1 (en) * | 2022-11-07 | 2024-05-16 | 桂林风鹏生物科技有限公司 | Feed additive for replacing feed antibiotic and preparation method therefor |
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Application publication date: 20100929 |