CN101837062A - Lipid-lowering buccal tablets - Google Patents
Lipid-lowering buccal tablets Download PDFInfo
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- CN101837062A CN101837062A CN201010187692A CN201010187692A CN101837062A CN 101837062 A CN101837062 A CN 101837062A CN 201010187692 A CN201010187692 A CN 201010187692A CN 201010187692 A CN201010187692 A CN 201010187692A CN 101837062 A CN101837062 A CN 101837062A
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Abstract
The invention discloses lipid-lowering buccal tablets, which are characterized by comprising the following components in part by weight: bottle brush herb extract 20-30, rosa davurica extract 16-25, hawthorn extract 17 to 25, isomaltitol 12-17, sucrose 6-12, starch 5-8, magnesium stearate 4-7 and sodium essence 0.3-0.4. The health-care blood lipid lowering buccal tablets have the characteristics of high active ingredient content, easy administration, excellent mouthfeel and quick absorption, and a more convenient administration approach is provided for the clinic treatment, health care and treatment of hyperlipidemia.
Description
Technical field
The present invention relates to a kind of buccal tablet, relate in particular to a kind of health blood fat reducing buccal tablet.
Background technology
Along with improving constantly of people's living standard, the sickness rate of hyperlipemia is obvious ascendant trend, and hyperlipemia is again the key factor of bringing out coronary atherosclerotic heart disease (coronary heart disease), arteriosclerosis, fatty liver, diabetes, obesity etc. simultaneously.Therefore blood lipid-lowering medicine and the health care medicine of seeking high effect nontoxic have important practical sense.
At present a lot of to the drug research of hyperlipemia, Chinese medicine is being brought into play special advantages in this respect.From the nature and flavor of Chinese medicine, return through, effect, cure mainly and chemical constituent and pharmacological action, and in conjunction with formation, pathogenesis and the performance analysis of hyperlipidemia, the Chinese prescription of treatment hyperlipidemia is many to contain the drug for invigorating blood circulation and eliminating stasis of flavones ingredient, this type of medicine energy blood vessel dilating and hat tremulous pulse, coronary blood flow increasing; With the clearing away heat and promoting diuresis eliminating dampness by diuresis medicine that contains saponin and anthraquinone component is ministerial drug more, and this type of medicine can make enterokinesia increase, promote the drainage of cholesterol and reduce the absorption of cholesterol, and be auxilliary with sedative and relieving cough and resolving phlegm medicine and digestants.Although treatment by Chinese herbs has the medicine source abundant, untoward reaction is few, advantage that can the flexible prescription of giving treatment in accordance with the patient, but Chinese medicine fried and take a lot of people and be difficult to accept, though the product of various relevant Chinese patent medicines is arranged at present, but do not satisfy present allegro life requirement, therefore, the exploitation of the health blood fat reducing buccal tablet dosage form of conveniently taking becomes inevitable.
Summary of the invention
At the deficiencies in the prior art, the problem to be solved in the present invention provides a kind of health blood fat reducing buccal tablet and preparation method thereof.
Health blood fat reducing buccal tablet of the present invention, it is characterized in that described buccal tablet is made by the component of following weight portion: 20～30 parts of Herba Equiseti Arvinsis extract, 16～25 parts of piece berry extracts of thorn, 17～25 parts of Fructus Crataegi extracts, 12～17 parts of hydroxyl isomaltuloses, 6～12 parts of sucrose, 5～8 parts of starch, 4～7 parts of magnesium stearate, essence sodium 0.3-0.4 part.
Wherein: above-mentioned buccal tablet is preferably made by the component of following weight portion: 25 parts of Herba Equiseti Arvinsis extract, 20 parts of piece berry extracts of thorn, 20 parts of Fructus Crataegi extracts, 15 parts of hydroxyl isomaltuloses, 9 parts of sucrose, 6 parts of starch, 5 parts of magnesium stearate, 0.3 part in essence sodium.
Above-mentioned Herba Equiseti Arvinsis extract or Fructus Crataegi extract are produced by the logical biotechnology Co., Ltd of Qingyang health Baily, Xi'an Caulis et Folium Polygalae Tenuifoliae plant science and technology limited Company, the bio tech ltd in Xi'an or Sanjiang Biologica Engineering Co., Ltd., Xi-an City; Above-mentioned thorn piece berry extract is produced by source, the world, Shaanxi bio tech ltd.
Weight portion of the present invention can be the known mass units of field of medicaments such as μ g, mg, g, kg.
The dosage of the health blood fat reducing buccal tablet that the present invention relates to calculates with the amount that exists in the unit dosage form, and the Herba Equiseti Arvinsis extract that the present invention relates in unit dosage form, thorn piece berry extract and Fructus Crataegi extract total content are about 50～80mg.
The amount of the health blood fat reducing buccal tablet of the present invention that the adult takes, be 750-1500mg every day, divides and take for 8-10 time.
Health blood fat reducing buccal tablet provided by the invention is to prepare according to the method that those of ordinary skills know, and its basic preparation method is:
In weight portion, unit is a kilogram, takes by weighing respectively: 20～30 parts of Herba Equiseti Arvinsis extract, 16～25 parts of piece berry extracts of thorn, 17～25 parts of Fructus Crataegi extracts, 12～17 parts of hydroxyl isomaltuloses, 6～12 parts of sucrose, 5～8 parts of starch, 4～7 parts of magnesium stearate, essence sodium 0.3-0.4 part.
Wherein: above-mentioned Herba Equiseti Arvinsis extract or Fructus Crataegi extract are available from the logical biotechnology Co., Ltd of Qingyang health Baily, Xi'an Caulis et Folium Polygalae Tenuifoliae plant science and technology limited Company, the bio tech ltd in Xi'an or Sanjiang Biologica Engineering Co., Ltd., Xi-an City; Above-mentioned thorn piece berry extract is available from source, the world, Shaanxi bio tech ltd.
Above-mentioned Herba Equiseti Arvinsis extract, Fructus Crataegi extract or thorn piece berry extract are ground, make it fineness and reach the 350-400 order, then it is mixed with hydroxyl isomaltulose, sucrose, starch, water is evenly moistening, the mixture after moistening is sieved and drying, after sieve, granulate adds magnesium stearate, essence sodium, then with this mixture tabletting, every heavily about 200～220mg, extract component content is 100-160mg.
The present invention is by testing to have Herba Equiseti Arvinsis extract, Fructus Crataegi extract and the thorn piece berry extract of blood fat reducing function selected.Wherein contain acid and phenolic acid, flavone, glucosides, alkaloid, protein and aminoacid, indone, Herba Equiseti Arvinsis silicide and other compositions in the Herba Equiseti Arvinsis extract, pharmacological evaluation proves, Herba Equiseti Arvinsis extract have suppress the central nervous system, protect the liver, effects such as blood pressure lowering, blood fat reducing and diuresis, can be used for treating arteriosclerosis, hypertension, hyperlipidemia etc.Fructus Crataegi extract has blood fat reducing and function of resisting myocardial ischemia, Fructus Crataegi flavone wherein has effects such as the lipid metabolism of adjusting, reduction serum cholesterol, lipase wherein, have aid digestion, promote steatolysis, improve pepsin activity, promote protein to decompose and Absorption.A thorn piece berry extract has that spleen invigorating is regulated the flow of vital energy, nourishing blood for regulating menstruation, defying age, prevent and treat effect such as cardiovascular disease; Total flavonoids substance wherein has the effect of the cardiovascular and cerebrovascular disease due to prevention and treatment hyperlipidemia, the thrombosis, and has efficient, low toxicity, the little advantage of side effect.The present invention uses the buccal tablet dosage form that Herba Equiseti Arvinsis extract, a Fructus Crataegi extract and thorn piece berry extract active ingredient through port transmucosal is directly absorbed, the loss that has been produced when having avoided effective ingredient to absorb by organs such as human intestines and stomach and livers, improved the absorption rate of nutrition in the described extract, also provide another new route of administration more easily simultaneously for clinical treatment and health care prevention.
The specific embodiment
The present invention is further elaborated below in conjunction with embodiment, but described protection content is not limited only to this.
Embodiment 1:
In weight portion, unit is a kilogram, takes by weighing respectively: 22 parts of Herba Equiseti Arvinsis extract, 18 parts of piece berry extracts of thorn, 18 parts of Fructus Crataegi extracts, 17 parts of hydroxyl isomaltuloses, 12 parts of sucrose, 8 parts of starch, 4 parts of magnesium stearate, 0.3 part in essence sodium.
Above-mentioned Herba Equiseti Arvinsis extract, Fructus Crataegi extract or thorn piece berry extract are ground, make it fineness and reach the 350-400 order, then it is mixed with hydroxyl isomaltulose, sucrose, starch, water is evenly moistening, the mixture after moistening is sieved and drying, after sieve, granulate adds magnesium stearate, essence sodium, then with this mixture tabletting, every heavily about 200mg, the extract component total content is about 120mg.
Embodiment 2:
In weight portion, unit is a kilogram, takes by weighing respectively: 25 parts of Herba Equiseti Arvinsis extract, 20 parts of piece berry extracts of thorn, 20 parts of Fructus Crataegi extracts, 15 parts of hydroxyl isomaltuloses, 9 parts of sucrose, 6 parts of starch, 5 parts of magnesium stearate, 0.3 part in essence sodium.
Above-mentioned Herba Equiseti Arvinsis extract, Fructus Crataegi extract or thorn piece berry extract are ground, make it fineness and reach the 350-400 order, then it is mixed with hydroxyl isomaltulose, sucrose, starch, water is evenly moistening, the mixture after moistening is sieved and drying, after sieve, granulate adds magnesium stearate, essence sodium, then with this mixture tabletting, every heavily about 200mg, the extract component total content is about 130mg.
Embodiment 3:
In weight portion, unit is a kilogram, takes by weighing respectively: 30 parts of Herba Equiseti Arvinsis extract, 25 parts of piece berry extracts of thorn, 25 parts of Fructus Crataegi extracts, 12 parts of hydroxyl isomaltuloses, 9 parts of sucrose, 6 parts of starch, 7 parts of magnesium stearate, 0.4 part in essence sodium.
Above-mentioned Herba Equiseti Arvinsis extract, Fructus Crataegi extract or thorn piece berry extract are pulverized, make it fineness and reach the 350-400 order, then it is mixed with hydroxyl isomaltulose, sucrose, starch, water is evenly moistening, the mixture after moistening is sieved and drying, after sieve, granulate adds magnesium stearate, essence sodium, then with this mixture tabletting, every heavily about 220mg, the extract component total content is about 160mg.
Herba Equiseti Arvinsis extract of the present invention or Fructus Crataegi extract are available from the logical biotechnology Co., Ltd of Qingyang health Baily, Xi'an Caulis et Folium Polygalae Tenuifoliae plant science and technology limited Company, the bio tech ltd in Xi'an or Sanjiang Biologica Engineering Co., Ltd., Xi-an City; Thorn of the present invention piece berry extract is available from source, the world, Shaanxi bio tech ltd.
Claims (2)
1. health blood fat reducing buccal tablet, it is characterized in that described buccal tablet is made by the component of following weight portion: 20～30 parts of Herba Equiseti Arvinsis extract, 16～25 parts of piece berry extracts of thorn, 17～25 parts of Fructus Crataegi extracts, 12～17 parts of hydroxyl isomaltuloses, 6～12 parts of sucrose, 5～8 parts of starch, 4～7 parts of magnesium stearate, essence sodium 0.3-0.4 part.
2. health blood fat reducing buccal tablet according to claim 1, it is characterized in that described buccal tablet is made by the component of following weight portion: 25 parts of Herba Equiseti Arvinsis extract, 20 parts of piece berry extracts of thorn, 20 parts of Fructus Crataegi extracts, 15 parts of hydroxyl isomaltuloses, 9 parts of sucrose, 6 parts of starch, 5 parts of magnesium stearate, 0.3 part in essence sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101876927A CN101837062B (en) | 2010-05-31 | 2010-05-31 | Lipid-lowering buccal tablets |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101876927A CN101837062B (en) | 2010-05-31 | 2010-05-31 | Lipid-lowering buccal tablets |
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| Publication Number | Publication Date |
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| CN101837062A true CN101837062A (en) | 2010-09-22 |
| CN101837062B CN101837062B (en) | 2011-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101876927A Expired - Fee Related CN101837062B (en) | 2010-05-31 | 2010-05-31 | Lipid-lowering buccal tablets |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103766908A (en) * | 2014-03-03 | 2014-05-07 | 安徽科技学院 | Health chrysanthemum morifolium ramat buccal tablets and production method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097100A (en) * | 1993-07-09 | 1995-01-11 | 许双贵 | Dahurian rose fruit jelly and preparation method thereof |
| CN1293983A (en) * | 1999-10-25 | 2001-05-09 | 隋英祝 | Hypolipemic medicine and its preparing process and application |
-
2010
- 2010-05-31 CN CN2010101876927A patent/CN101837062B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097100A (en) * | 1993-07-09 | 1995-01-11 | 许双贵 | Dahurian rose fruit jelly and preparation method thereof |
| CN1293983A (en) * | 1999-10-25 | 2001-05-09 | 隋英祝 | Hypolipemic medicine and its preparing process and application |
Non-Patent Citations (5)
| Title |
|---|
| 《中华人民共和国卫生部药品标准新药转正标准》 19981231 国家药典委员会 山玫胶囊 197 1-2 , 1 * |
| 《中国药物与临床》 20070615 白瑶等 山玫胶囊对急性血瘀模型大鼠血液流变学及高血脂大鼠降脂作用的研究 447-449 1-2 第7卷, 第6期 2 * |
| 《中国食品添加剂》 20000630 Ms.Anette Radowski et al 异麦芽酮糖醇的性质和用途 45-53 1-2 , 第2期 2 * |
| 《吉林医药学院学报》 20091230 赵曼曼等 降血脂中药有效成分及提取方法研究进展 357-359 1-2 第30卷, 第6期 2 * |
| 《辽宁中医学院学报》 20051118 李熙灿等 问荆化学成分及其药理作用的研究进展 633-635 1-2 第7卷, 第6期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103766908A (en) * | 2014-03-03 | 2014-05-07 | 安徽科技学院 | Health chrysanthemum morifolium ramat buccal tablets and production method thereof |
| CN103766908B (en) * | 2014-03-03 | 2016-08-17 | 安徽科技学院 | A kind of health Chu chrysanthemum buccal tablet and production method thereof |
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| Publication number | Publication date |
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| CN101837062B (en) | 2011-08-31 |
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Granted publication date: 20110831 Termination date: 20140531 |