CN101829160B - Functional composition with functions of controlling blood sugar and enhancing nutrition - Google Patents
Functional composition with functions of controlling blood sugar and enhancing nutrition Download PDFInfo
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- CN101829160B CN101829160B CN2010101715126A CN201010171512A CN101829160B CN 101829160 B CN101829160 B CN 101829160B CN 2010101715126 A CN2010101715126 A CN 2010101715126A CN 201010171512 A CN201010171512 A CN 201010171512A CN 101829160 B CN101829160 B CN 101829160B
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Abstract
The invention discloses a functional composition with functions of controlling blood sugar and enhancing nutrition, which is prepared from main materials and a common carrier, wherein the main materials consist of functional sugars, composite vitamins, mineral substance, dietary fiber and high sweetener; and the functional sugars comprise L-arabinose and trehalose, the weight content of the L-arabinose is 10 to 80 percent, and the weight content of the trehalose is 10 to 50 percent. The functional composition uses two functional sugars as main sugar-reducing substances and is added with multiple composite vitamins, the mineral substance, the dietary fiber and the high sweetener, so the invention provides the functional composition with convenient use, good mouthfeel, safety, effectiveness and practicability of controlling blood sugar and enhancing nutrition for diabetes patients. The functional composition can well supplement nutrient substances required for the human body when the diabetes patients can feel relieved to enjoy a proper amount of sweet food.
Description
Technical field
The present invention relates to a kind of diabetes patient's of being applicable to functional composition with blood sugar control and enhancing Nutrition.
Background technology
Along with development of Chinese economy, the raising of people's living standard and the change of dietary habit cause the sickness rate of diabetes and high sugared disease significantly to improve.Survey data according to health ministry shows that China's national diabetes number of patients in 2010 is 9,200 ten thousand, and the prediabetes patient 1.48 hundred million, and having surmounted India becomes the maximum country of global diabetes patient.This part patient must reduce the intake to trophism sugar source in daily life, also just means the reduction of quality of life to be subjected to and should the healthy again contradiction of mouthfeel to perplex deeply.Simultaneously, clinical research shows, the hyperglycemia state of diabetics and low insulin level may cause intravital vitamin and mineral when picked-up, absorption and transhipment obstacle to take place, and cause these nutrient substance levels low.And they are to promote insulin secretion, improve tissue to insulin sensitivity, impel the principal element that blood glucose descends in the body.So just must search out a kind of easy to use, good mouthfeel, be applicable to diabetes patient's blood sugar control safely and effectively, strengthen the functional composition of nutrition.
Chinese patent 01818856.7 discloses a kind of Remedies for diabetes, is used to improve the Food ﹠ Drink of diabetic conditions, it is characterized by to contain L-arabinose and sucrose as active component, and wherein L-arabinose is 0.5～90% with respect to the ratio of sucrose.This invention has pointed out that L-arabinose has had the effect that blood sugar level after meal increases that suppresses, and also the effectiveness of its blood sugar lowering level and treatment diabetes is verified.Yet it does not consider the demand of diabetes patient aspect balanced in nutrition.And that Chinese patent 200810163384.3 discloses is a kind of by non-glucides such as multiple sugar alcohols, adds the sugar-free nutrition of material such as minerals and vitamins and strengthens the sweet food prescription.Its main uses is the diet that place of sucrose is used for diabetes patient or fat-reducing personage, does not have the effect of any symptom of treatment.
Summary of the invention
The purpose of this invention is to provide a kind of easy to use, good mouthfeel, be applicable to diabetes patient's blood sugar control and strengthen the functional composition of nutrition safely and effectively.
A kind of functional composition that has blood sugar control and strengthen Nutrition provided by the invention, make by major ingredient and common carrier that functional sugar, compound vitamin, mineral, dietary fiber and high sweetener are formed, wherein said functional sugar is L-arabinose and trehalose, and the percetage by weight content of each component is:
L-arabinose 10～80%
Trehalose 10～50%
Compound vitamin 0.01～5%
Mineral 0.01～5%
Dietary fiber 1～30%
High sweetener 0.01～1%
Surplus is a common carrier.
In the component of above-mentioned functions compositions:
Described compound vitamin comprises vitamin B
1, vitamin B
2, vitamin B
3, vitamin B
5, vitamin B
6, vitamin B
9, vitamin B
12, in vitamin C and the vitamin D one or more.
Described mineral comprises one or more in zinc lactate, yeast rich in selenium and the Rich chromium yeast.
Described dietary fiber comprises one or more in oat beta-glucan, polydextrose and the soybean water-soluble dietary fiber.
Described high sweetener comprises one or more in sucralose, acesulfame potassium and the stevioside.
Described common carrier comprises one or more in filler, binding agent and the lubricant.
This functional composition is mainly made by L-arabinose and two kinds of functional sugars of trehalose.L-arabinose can optionally influence the saccharase in the small intestinal, thereby suppresses the absorption of sucrose.It is reported, in sucrose, add 2% L-arabinose, can suppress the absorption of 40% sucrose.If the L-arabinose addition reaches 4%, blood glucose value is not raise fully.Can bring into play maximum effect but L-arabinose is preferably taken in just together with sucrose, feed sucrose is eaten after 2 hours does not again have effect substantially.And the blood sugar level that trehalose can make alloxan cause the hyperglycemia mice descends, and mice is had no side effect substantially.Lumbar injection has stronger hypoglycemic activity than low dosage F4 (one of high pure component of trehalose).
This functional composition also comprises an amount of multiple compound vitamin and mineral, mainly is the compositions of vitamin B, C, D and selenium, chromium, zinc.Diabetics is often with the shortage of multivitamin and mineral.This mainly is because undue strict diet control often causes the Deficiency of Intake of multiple nutrients material, diabetes merge the absorbtivity minimizing that the gastrointestinal function obstacle can cause nutrient substance simultaneously, and the hypertonicity diuresis due to the hyperglycemia state can cause the discharge of nutrient substance to increase in addition.
Have research report to point out, often there are shortages such as vitamin B1, B2, B6, C, D in type 1 diabetes patient.In the type 2 diabetes mellitus patient, lack comparatively common with vitamin B group, beta-carotene and vitamin C, D.Vitamin B group plays an important role in carbohydrate metabolism as the coenzyme of key enzyme, can reduce diabetic neuropathy, and reduces homocysteine level, reduces the onset risk of diabetics cardiovascular complication.Vitamin C has the removing oxygen-derived free radicals, the function of protection endotheliocyte, the occurrence risk of reduction diabetics nerve and vascular complication.Vitamin D can suppress the autoimmune response of pancreatic beta cell, reduces insulin resistant, and the D that is deficient in vitamin may cause that insulin secretion reduces.
Simultaneously research worker is found, trace element and diabetes confidential relation, wherein shortage the working to diabetes of elements such as chromium, zinc, selenium arranged.Chromium can activate insulin, helps the conversion of glucose, and chromium also acts on the phosphatase in the glucose metabolism, if lack chromium, the activity of this kind of enzyme just descends.If the medium-term and long-term chromium that lacks of diet must influence carbohydrate tolerance, be unfavorable for the control of the diabetes state of an illness.Zinc can influence endocrine multiple function, and zinc and insulin are combined into complex, plays the hypoglycemic effect of regulating and prolonging insulin, and zinc deficiency easily causes immunologic function to reduce, and the infectious disease that is easy to get can increase the weight of the diabetes state of an illness.Selenium is the active component that constitutes glutathion peroxidase, and it can prevent that the beta Cell of islet oxidation from destroying, and makes its function normal, promotes sugar part metabolism, blood sugar lowering and glucose in urine, improves the symptom of diabetics.
In this functional composition, can be according to different dosage forms and consumption, adjust every day various vitamin and the intake of mineral reach the scope (specifically can with reference to " regulation (trying) is declared and evaluated to nutrient prime replenisher ") of effective and safe.
Also comprise multiple composite dietary in this functional composition.Find that according to current research often ingesting contains confectionery in a large number, and eats crude fibre food less, very easily suffers from diabetes, its ill probability can reach and increase by 2.5 times at ordinary times.If but only control to contain the confectionery thing worth choosing, must take in fibre-bearing food, blood glucose, glucose in urine just can reduce.HFD can reduce the demand of human body to insulin, oat beta-glucan, polydextrose, soybean water-soluble dietary fiber etc. can increase the stickiness of chyme, increase satiety, reduce saccharide by the speed of little intestinal absorption, can increase toleration, certain hypoglycemic activity is arranged glucose, also can the blood fat reducing level, reduce low density lipoprotein, LDL content, help the overweight people and lose weight.
This functional composition contains nutrient substance such as multivitamin and mineral, and its mouthfeel has certain abnormal flavour and bitterness.Can cover its bad mouthfeel by adding high sweetener, increase sugariness, make that said composition is easier to be accepted by diabetics.And the stability of high sweetener is high, and addition is lower, does not contain heat, and no hygroscopicity helps the stable of product quality.
Except that containing above major ingredient, this functional composition also can compound easily common carrier obtain solid oral dosage form.In case of necessity to wherein adding common carrier such as filler, binding agent and lubricant and obtain diluting the solid dosage forms of powder, conventional tablet, effervescent tablet and capsule form.Operable carrier is starch, carboxymethyl cellulose, maltodextrin, magnesium stearate etc.Use for convenience, the dilution powder can be made the bag packing of 5～10g, reconstitutes a bag in half an hour ante cibum at every turn and takes and get final product.Conventional tablet, effervescent tablet, capsule are generally 0.5～2g, carry and take convenient.The dosage of this functional composition also can be according to suitably decision such as dosage form, instructions of taking, use object and patient's age, body weight and symptom etc.
This functional composition with two kinds of functional sugars as main sugar reducing substance, added multiple compound vitamin, mineral, dietary fiber, compound high sweetener and common carrier and made, for diabetics provides a kind of easy to use, good mouthfeel, is applicable to blood sugar control and strengthen the functional composition of nutrition safely and effectively.When this functional composition makes the diabetes patient relievedly enjoy an amount of sweet food, also can replenish the nutrient substance of needed by human body well.
The specific embodiment
Following examples only are used to set forth the present invention, and protection scope of the present invention is not only to be confined to following examples.The those of ordinary skill of described technical field all can be realized purpose of the present invention according to above content disclosed by the invention and scope that each parameter is got.
Embodiment 1
The dilution powder powder formulation:
L arabinose 30% trehalose 10% oat beta-glucan 10%
Vitamin B
10.006% vitamin B
20.006%
Vitamin B
30.06% vitamin B
50.02%
Vitamin B
60.006% vitamin B
90.001%
Vitamin B
120.00002% vitamin C 0.6%
Vitamin D 0.00002% zinc lactate 0.8%
Yeast rich in selenium 0.2% Rich chromium yeast 0.2%
Sucralose 0.1% acesulfame potassium 0.2%
Maltodextrin to 100%
Technology: trace element and high sweetener mix homogeneously, add L-arabinose, trehalose and oat beta-glucan mix homogeneously again, add the maltodextrin mix homogeneously at last, device therefor is a V-Mixer.Pack with the powder automatic packaging machine.
Instructions of taking: get bag (5g) water at every turn and reconstitute and take.
Blood sugar decreasing effect checking: to do not take food the previous day supper and the same day breakfast adult men and women 10 people of the health dilution powder that use embodiment 1 to make at 10 in the morning, drink the sucrose solution that 100ml contains sugar 30% in half an hour.Before edible, edible back 30min, 60min, 120min measure the blood glucose value variation of tip blood respectively with the blood sugar detection device.In contrast, the dilution powder that does not use embodiment 1 to make 10 people only drinking sucrose solution also carry out same test.Edible previous crops is 0, the converted quantity after numeric representation is edible.
| Sucrose solution | Embodiment 1 | Contrast |
| Before edible | 0 | 0 |
| Edible back 30min | +29 | +48 |
| Edible back 60min | +19 | +27 |
| Edible back 120min | -2 | +8 |
As can be seen from the above table, blood glucose value has tangible rising in the control experiment before absorbing, and the prescription of embodiment 1 can be suppressed at the blood glucose value rising about 60%.The result shows that the prescription of taking embodiment 1 can suppress the rising of blood glucose significantly.
Embodiment 2
Tablet formulation:
L-arabinose 50% trehalose 20% oat beta-glucan 10%
Vitamin B
10.03% vitamin B
20.03%
Vitamin B
30.1% vitamin B
50.15%
Vitamin B
60.04% vitamin B
90.005%
Vitamin B
120.0001% vitamin C 3%
Vitamin D 0.0001% zinc lactate 1%
Yeast rich in selenium 1% Rich chromium yeast 0.5%
Sucralose 0.015% acesulfame potassium 0.02%
Starch 12% magnesium stearate 0.1% carboxymethyl cellulose to 100%
Technology: first three is planted primary raw material, 80% starch, carboxymethyl cellulose and crosses mix homogeneously behind 20 mesh sieves.In this mixture, add starch (10%) and high sweetener solution, stir into the mud shape and cross 16 mesh sieves.Then in 50-60 ℃ of drying, after 16 mesh sieves.Other raw materials are crossed 30 mesh sieves, add mix homogeneously in this granule again, tabletting, and every weight is 1g.
Instructions of taking: get 1～2 water at every turn and take.
Embodiment 3
Capsule formula:
L-arabinose 65% trehalose 20% oat beta-glucan 8%
Vitamin B
10.03% vitamin B
20.03%
Vitamin B
30.1% vitamin B
50.15%
Vitamin B
60.04% vitamin B
90.005%
Vitamin B
120.0001% vitamin C 3%
Vitamin D 0.0001% zinc lactate 1%
Yeast rich in selenium 1% Rich chromium yeast 0.5%
Sucralose 0.005% acesulfame potassium 0.01%
Magnesium stearate to 100%
Technology: trace element, high sweetener and magnesium stearate mix homogeneously, add L-arabinose, trehalose and oat beta-glucan mix homogeneously again, device therefor is a V-Mixer.By 20～30 mesh sieve secondaries, remix is even with above-mentioned powder.Select capsule for use No. 2, adopt the filled type automatic filling machine to carry out fill, the adjusting loading amount is 500mg.
Instructions of taking: get 1～3 water at every turn and take.
Claims (6)
1. functional composition that has blood sugar control and strengthen Nutrition, it is characterized in that: make by major ingredient and common carrier that functional sugar, compound vitamin, mineral, dietary fiber and high sweetener are formed, wherein said functional sugar is L-arabinose and trehalose, described mineral is one or more in zinc lactate, yeast rich in selenium and the Rich chromium yeast, described dietary fiber is one or more in oat beta-glucan, polydextrose and the soybean water-soluble dietary fiber, and the percetage by weight content of each component is:
L-arabinose 10～80%
Trehalose 10～50%
Compound vitamin 0.01～5%
Mineral 0.01～5%
Dietary fiber 1～30%
High sweetener 0.01～1%
Surplus is a common carrier.
2. a kind of functional composition that has blood sugar control and strengthen Nutrition according to claim 1, it is characterized in that: described compound vitamin is a vitamin B
1, vitamin B
2, vitamin B
3, vitamin B
5, vitamin B
6, vitamin B
9, vitamin B
12, in vitamin C and the vitamin D one or more.
3. a kind of functional composition that has blood sugar control and strengthen Nutrition according to claim 1, it is characterized in that: described high sweetener is one or more in sucralose, acesulfame potassium and the stevioside.
4. a kind of functional composition that has blood sugar control and strengthen Nutrition according to claim 1, it is characterized in that: described common carrier is one or more in filler, binding agent and the lubricant.
5. a kind of functional composition that has blood sugar control and strengthen Nutrition according to claim 4, it is characterized in that: described common carrier is starch, carboxymethyl cellulose, maltodextrin or magnesium stearate.
6. a kind of functional composition that has blood sugar control and strengthen Nutrition according to claim 1 is characterized in that: the dosage form of described functional composition is dilution powder, conventional tablet or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010101715126A CN101829160B (en) | 2010-05-06 | 2010-05-06 | Functional composition with functions of controlling blood sugar and enhancing nutrition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101715126A CN101829160B (en) | 2010-05-06 | 2010-05-06 | Functional composition with functions of controlling blood sugar and enhancing nutrition |
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| CN101829160A CN101829160A (en) | 2010-09-15 |
| CN101829160B true CN101829160B (en) | 2011-09-07 |
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