CN101829158A - Pig blood composition and pig blood chewable tablet made therefrom - Google Patents
Pig blood composition and pig blood chewable tablet made therefrom Download PDFInfo
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Abstract
The invention discloses a pig blood composition, mainly comprising the following components: 20-40 parts of pig blood, 10-20 parts of ultrafine black fungus powder, 0.5-2 parts of vitamin B2 and 3-12 parts of vitamin C. The pig blood is made into pig blood paste by embedding pig blood solution added with sodium citrate b for anticoagulation using hydroxypropyl beta-cyclodextrin, ; or boiling the pig blood solution added with sodium citrate for anticoagulation in a boiling water bath into a coagulated block and then filtering, taking the coagulated block and crushing into paste, then adding hydroxypropyl beta-cyclodextrin into the coagulated block (the mass of the added hydroxypropyl beta-cyclodextrin is 1/2 the mass of the coagulated block), and processing by ultrasonic of 20-40KHz for 10-20min. The ultrafine black fungus powder has a fineness higher than 300 meshes. The invention also discloses a pig blood chewable tablet made from the pig blood composition. The hydroxypropyl beta-cyclodextrin is taken as the wall material, and an embedding technique is combined with an ultrasonics technique so that an offensive smell of pig blood can be effectively hidden.
Description
(1) technical field
The present invention relates to a kind of Sanguis sus domestica compositions of the iron deficiency anemia that can be used for preventing to lack nutrition and cause and the Sanguis sus domestica chewable tablet of making thereof.
(2) background technology
Ferrum is trace element essential in the human body, during iron deficiency, iron deficiency or iron deficiency anemia can occur in the body, and particularly the harm of bringing for child, child, gestation, lactication, the women of menstrual phase more than 4 months is very serious.By the standard of World Health Organization (WHO), anemia person accounts for 30% of world population.People study and inquire into its cause of disease and prophylactico-therapeutic measures always for many years, and wherein filling a vacancy is an important effective way improving iron deficiency anemia.
For a long time, first-selected always clinically FeSO
4Preparation for treating iron deficiency anemia, but FeSO
4Poor chemical stability, very easily be oxidized to trivalent iron salt and be difficult for being absorbed by human body, and tangible GI irritation effect arranged, often with gastrointestinal irritation and the side effect such as grade of rust flavor and bioavailability is low, the problem of poor chemical stability, and ferrum (II) can produce the endogenous free radical in vivo, the problems such as cell membrane damage that cause the peroxidating of cell membrane lipid to cause.Sanguis sus domestica chewable tablet of the present invention is to adopt Sanguis sus domestica as raw material, after the processing of embedding fishy smell elimination process, be equipped with the chewable tablet that improves nutritional anemia that has that Auricularia submicron powder and other adjuvants make, to the Sanguis sus domestica chewable tablet raw materials used and technology we do following introduction.
Sanguis sus domestica: sweet in the mouth, hardship, warm in nature, the effect of detoxifcation bowel relieving, blood tonification and beautification is arranged.Sanguis sus domestica is rich in vitamin B
2, nutritional labeling such as vitamin C, protein, ferrum, phosphorus, calcium, nicotinic acid.According to surveying and determination, contain protein 19 grams in every hectogram Sanguis sus domestica, be higher than the content of beef, thin pork and egg, and very easily digest and assimilate.Plasma protein in the Sanguis sus domestica produces a kind of detoxifcation, bowel relieving analyte after being decomposed by the intravital gastric acid of people, can with invade the intravital dust of people, poisonous metal microgranule generation combination reaction, be easy to toxin and excrete; The people of long-term contact poisonous and harmful dust, particularly every day steering vehicle the driver, should eat Sanguis sus domestica more.The content of Sanguis sus domestica fat is few, only contains 0.4 gram in every hectogram, is 1/10th of the contained fat mass of thin pork, belongs to low in calories, low fat, high-protein food.Also contain abundant trace element in the Sanguis sus domestica, as sodium, potassium, calcium, phosphorus, ferrum, zinc, copper and cobalt etc.Particularly the content of ferrum is very abundant, and every hectogram iron content is up to 45 milligrams, and is higher 2 times than Hepar Sus domestica, higher 18 times than egg, higher 20 times than Carnis Sus domestica; Ferrum in the Sanguis sus domestica is heme iron, and not only content exceeds any food, and very easily is absorbed by the body, and it can reach 37% at enteral absorbance, and is suitable with the absorbance of the basis (heme iron) of commercially available many iron supplement agent.To anemia and the pale complexion person has the improvement effect, be the desirable food of eliminating toxin and beautifying the skin.
Auricularia Auricularia auricula (L.exHook.) Underwood, belong to Basidiomycetes, Auriculariale, Auriculariaceae, Auricularia, be the medicinal and edible colloid fungus of China's preciousness, contained irony comes out at the top in edible fungi family in the Auricularia sporophore, and is higher 6 times than Tremella, than high nearly 7 times of the high Hepar Sus domestica of iron-holder in the animal foodstuff, higher 20 times than iron content is the highest in the vegetable Herba Apii graveolentis, higher 100 times than meat, be the hat of varieties of food items iron content.The content of ferrum is very high in the Auricularia, and the utilization that is absorbed by the body easily, is a kind of extraordinary natural blood-tonifying food, and is remarkable to gynaecopathia and iron deficiency anemia effect.
Vitamin C can promote the more ferrum of intestinal absorption, and with Fe
3+Be reduced into Fe
2+, can also help ferrum to transfer on the ferritin from the carrier transferrins, strengthen the activity of some iron enzyme.Vitamin B
12Adjusting material as organism metabolism has the ability that the human body hematopoietic function is in normal condition, and pernicious anemia takes place during shortage.
Vitamin B
2, be the important composition composition of many enzyme systems in the body, the B if body is deficient in vitamin
2, the matter and energy metabolism disorder can appear, vitamin B
2Also be to constitute erythrocytic important substance.Studies have shown that it is to promoting the effect that focuses on that is absorbed with of ferrum, the existing report B that is deficient in vitamin
2The anemia of pregnant woman iron deficiency anemia takes place easily.An amount of vitamin B
2Picked-up is highly profitable to the prevention status of iron deficiency in pregnant women.
Embedding techniques is a kind ofly to utilize natural or synthesized polymer material, and with solid, liquid, or even gaseous matter wraps up, and forms the technology of the fine particle with semi permeability or sealing cyst membrane.Embedding has reduced diffusion and the evaporation of core to environment, makes to be the flavor composition in the food, and particularly some micromolecular esters and terpenoid are farthest sheltered.Cyclodextrin (Cyclodextrin, be called for short CD) is the general name of a series of cyclic oligosaccharides of generating under the cyclodextrin glycosyltransferase effect that is produced by bacillus cereus of amylose, contains 6～12 D-glucopyranose units usually.Wherein study morely and what have important practical usage is the molecule that contains 6,7,8 glucose units, be called α-, β-and gamma-cyclodextrin.Each glucose unit is all with 1, and the 4-glycosidic bond is in conjunction with ring formation, and inner chamber is hydrophobic because the outer rim of cyclodextrin is hydrophilic, thereby it can provide a hydrophobic binding site as enzyme, as the various suitable objects of main body envelope.The effect of this optionally envelope is usually said molecular recognition, consequently forms the Subjective and Objective inclusion complex.Therefore, in fields such as catalysis, separation, food and medicine, cyclodextrin has been subjected to great attention and extensive use.
Superfine communication technique can make the variation of product aspect rerum natura and microstructure, and all can improve at extraction efficiency, dissolubility, absorption affinity, aspects such as solid perfume (or spice), drug effect and bioavailability.Because Auricularia cell wall key component chitin and beta glucan, strong but pliable in texture, be difficult for being digested by human body, the nutrient substance that is contained in the cell wall is difficult to see through cell wall, absorbed by human body, breaking cellular wall can make the functional components stripping of being rich in the Auricularia cell in water, improves the digestibility of Auricularia.When Auricularia is refine to micron, nano-grade size, functional component can directly be absorbed or be easier to rapid extraction.
Chewable tablet (chewable tablets) means to be chewed in the oral cavity or suckes the tablet that clothes are swallowed after sheet is dissolved, it is a kind of quick-effective preparation that development in recent years is got up, because its distinctive advantage, more and more be subjected to people's attention, " Chinese pharmacopoeia 2000 version (two ones) has been recorded this dosage form first.Chewable tablet has mouthfeel preferably, chews or do not chew the very fast disintegrate of Shi Junneng, compares with conventional tablet to have the following advantages: disintegration time weak point, good dispersing state, medicine stripping are rapid; Absorb fast, bioavailability is high, taking convenience, be not subjected to the restriction in time place, can swallow, chew, contain and suck or with taking after the aqueous dispersion, reduced medicine gastrointestinal is born, the patient of especially suitable children's, old man, paralytic and the difficulty of swallowing takes.In addition, some peculiar taste tablet is for covering the disagreeable taste sugar coating, the process complexity, yield rate is low, make chewable tablet after, saved the coating process, shortened the production cycle.
Chewable tablet is a tool pharmaceutical dosage form with broad prospects for development, has obtained the extensive concern of various countries new drug research mechanism and each big drugmaker, develops very rapid.Though the Chinese medicine extraction properties is various, the kind that can be prepared into chewable tablet is a lot, and the kind that can produce greatly seldom at present.Compare with Western medicine, the Chinese medicine chewable tablet still is that preparation technology is with all there is a big difference qualitatively in kind quantity.
(3) summary of the invention
It is raw material with the Sanguis sus domestica that the object of the invention is to provide a kind of, after utilizing the embedding techniques eliminating sargassum smell, be equipped with the Sanguis sus domestica compositions of Auricularia submicron powder and other adjuvants, and the Sanguis sus domestica chewable tablet made from this Sanguis sus domestica compositions, goods have no side effect, production technology is simple, and iron absorptivity height, mouthfeel are good, and cost is low.
For solving the problems of the technologies described above, the present invention adopts following technical scheme:
A kind of Sanguis sus domestica compositions, described compositions mainly is made up of following component: Sanguis sus domestica, Auricularia submicron powder, vitamin B
2, vitamin C; The proportion by weight of described each component is as follows:
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs.
Described Sanguis sus domestica is by adding the Sanguis sus domestica paste that sodium citrate anticoagulant pig blood is made with the hydroxypropyl embedding: will add sodium citrate anticoagulant pig blood and boil into the coagulated mass after-filtration in boiling water bath, get coagulated mass and break into pastel, add the hydroxypropyl that quality is a coagulated mass quality 1/2 then, under 30～50 ℃ of conditions of temperature, make Sanguis sus domestica with ultrasonic Treatment 10～20min of 20～40KHz and stick with paste, wherein the addition of sodium citrate is for adding 1/9 3.8% sodium citrate aqueous solution of pig blood quality; Described Auricularia submicron powder was the Auricularia powder of 300 mesh sieves.Comparatively concrete, described Auricularia submicron powder is with the coarse pulverization of dry Auricularia machinery, crosses 40 mesh sieves, pulverizes with super micron mill then, and the regulation and control rotation speed of fan is 10000～22000r/min, crosses 300 mesh sieves then and obtains Auricularia submicron powder.
The implication of " mainly " was during above-mentioned described compositions mainly was made up of following component: Sanguis sus domestica, Auricularia submicron powder, vitamin B
2, vitamin C is main active ingredient, but the present composition is not got rid of the situation of the pharmaceutic adjuvant that adds the acceptable necessity of human body.Compositions of the present invention also can only be made up of the component of following proportion by weight:
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs.
Sanguis sus domestica of the present invention is to be stuck with paste by the Sanguis sus domestica that adding sodium citrate anticoagulant pig blood is made with the hydroxypropyl embedding, and the Sanguis sus domestica effective ingredient was 2/3 of a Sanguis sus domestica paste quality in the coagulated mass of Sanguis sus domestica during Sanguis sus domestica was stuck with paste.
Based on described Sanguis sus domestica, Auricularia submicron powder, vitamin B
2, vitamin C, the proportion by weight of described each component is preferably:
25～35 parts of Sanguis sus domestica
12～18 parts of Auricularia submicron powder
Vitamin B
21～1.5 part
4～8 parts of vitamin Cs.
The present invention also provides the Sanguis sus domestica chewable tablet of being made by described Sanguis sus domestica compositions, described Sanguis sus domestica chewable tablet mainly is made up of the component of following proportion by weight: remove these and form, Sanguis sus domestica chewable tablet of the present invention can also contain a spot of other pharmaceutic adjuvant, as flavoring agent etc.;
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs
10～25 parts of microcrystalline Cellulose
18～36 parts in mannitol
10～20 parts of pregelatinized Starch
0.1～1 part of micropowder silica gel
0.5～3 part of magnesium stearate.
Sanguis sus domestica chewable tablet of the present invention can also contain cyclamate and chocolate essence, is made up of the component of following proportion by weight:
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs
10～25 parts of microcrystalline Cellulose
18～36 parts in mannitol
10～20 parts of pregelatinized Starch
0.1～1 part of micropowder silica gel
0.5～3 part of magnesium stearate
0.05～0.2 part of cyclamate
0.05～0.5 part of hydroxypropyl embedding chocolate essence;
Described hydroxypropyl embedding chocolate essence mixes spray-dried then making by the hydroxypropyl aqueous solution of quality percentage composition 5% with chocolate essence at 5: 1 with the mass ratio of chocolate essence by hydroxypropyl.
Described Sanguis sus domestica chewable tablet prescription more preferably is made up of the component of following proportion by weight:
25～35 parts of Sanguis sus domestica
12～18 parts of Auricularia submicron powder
Vitamin B
21～1.5 part
4～8 parts of vitamin Cs
16～20 parts of microcrystalline Cellulose
0.1～0.15 part of cyclamate
24～30 parts in mannitol
12～16 parts of pregelatinized Starch
0.1～0.2 part of hydroxypropyl embedding chocolate essence
0.1～0.5 part of micropowder silica gel
1～1.5 part of magnesium stearate.
Sanguis sus domestica chewable tablet described in the present invention can prepare by the step of each group component by following method (A) or method (B):
When (A) not containing cyclamate and chocolate essence in the component:
(1) get adding citric acid sodium anticoagulant pig blood boils 5～15min in boiling water bath, boil into the coagulated mass after-filtration, get coagulated mass and break into pastel, add the hydroxypropyl that quality is a coagulated mass quality 1/2 then, under 30～50 ℃ of conditions of temperature, make Sanguis sus domestica behind ultrasonic Treatment 10～20min with 20～40KHz and stick with paste, the addition of sodium citrate is for adding 1/9 3.8% sodium citrate aqueous solution of pig blood quality; (2) get the coarse pulverization of dry Auricularia machinery, cross 40 mesh sieves, pulverize with super micron mill then, the regulation and control rotation speed of fan is 10000～22000r/min, obtains Auricularia submicron powder; (3) take by weighing mannitol, pregelatinized Starch, microcrystalline Cellulose, vitamin B by the prescription mass parts
2The vitamin C pulverize separately, cross 100～120 mesh sieves, the Auricularia submicron powder that the Sanguis sus domestica that makes with the step (1) of prescription amount is stuck with paste and the step (2) of prescription amount makes mix mixed powder A, add adhesive system soft material, the consumption of described adhesive is 0.6～1.8ml/g mixed powder A, drop into pelletize in the oscillating granulator then, cross 16～20 mesh sieves and granulate (preferred 18 mesh sieves) 40～60 ℃ of dryings, granulate, weighing dried particles weight, in dried particles, press the prescription amount and add micropowder silica gel, magnesium stearate, mix homogeneously, tabletting, packing makes described Sanguis sus domestica chewable tablet; Described adhesive is the ethanol water of 10～40wt%, the ethanol water of preferred 30wt%.
When (B) containing cyclamate and chocolate essence in the component:
(1) get adding citric acid sodium anticoagulant pig blood boils 5～15min in boiling water bath, boil into the coagulated mass after-filtration, get coagulated mass and break into pastel, add the hydroxypropyl that quality is a coagulated mass quality 1/2 then, under 30～50 ℃ of conditions of temperature, make Sanguis sus domestica behind ultrasonic Treatment 10～20min with 20～40KHz and stick with paste, the addition of sodium citrate is for adding 1/9 3.8% sodium citrate aqueous solution of pig blood quality; (2) get the coarse pulverization of dry Auricularia machinery, cross 40 mesh sieves, pulverize with super micron mill then, the regulation and control rotation speed of fan is 10000～22000r/min, obtains Auricularia submicron powder; (3) take by weighing mannitol, pregelatinized Starch, microcrystalline Cellulose, vitamin B by the prescription mass parts
2Vitamin C, pulverize separately, cross 100～120 mesh sieves, the Auricularia submicron powder that the Sanguis sus domestica that makes with the step (1) of prescription amount is stuck with paste and the step (2) of prescription amount makes mix mixed powder B, add adhesive system soft material, the consumption of described adhesive is 0.6～1.8ml/g mixed powder B, drops into pelletize in the oscillating granulator then, crosses 18 mesh sieves and granulates, 40～60 ℃ of dryings, with 16 orders and 20 mesh sieve granulate, weighing dried particles weight, in dried particles, press the prescription mass parts and add micropowder silica gel, magnesium stearate, cyclamate, hydroxypropyl embedding chocolate essence, mix homogeneously, tabletting, packing makes described Sanguis sus domestica chewable tablet; Described adhesive is the ethanol water of 10～40wt%, the ethanol water of preferred 30wt%; Described hydroxypropyl embedding chocolate essence mixes spray-dried then making by the hydroxypropyl aqueous solution of quality percentage composition 5% with chocolate essence at 5: 1 with the mass ratio of chocolate essence by hydroxypropyl.
Described 40～60 ℃ of dryings are reduced to 3%～5% with pellet moisture content and are advisable.
The present invention is a raw material to contain the highest Sanguis sus domestica of heme iron in the food, adopt embedding techniques and ultrasonic technique to act on Sanguis sus domestica, effectively make the Sanguis sus domestica eliminating sargassum smell, cooperate nutritional labeling abundant, be rich in the Auricularia submicron powder of mineral such as vitamin and irony, and vitamin C and vitamin B
2Make auxotype iron supplement chewable tablet.The technical essential of invention is embedding process and ultrasonic process acts effectively to make the Sanguis sus domestica eliminating sargassum smell, and to cooperate nutritious Auricularia submicron powder, vitamin C and vitamin B in Sanguis sus domestica
2, the chewable tablet iron absorptivity height that makes, have no side effect, natural nutrition, mouthfeel be good.
Beneficial effect of the present invention is mainly reflected in:
1. the used main material of the present invention is natural animal blood and edible fungi material, and animal blood is rich in the high heme iron of human absorptivity, and the edible fungi Auricularia is rich in ferrum and vitamin and mineral, and the raw material cost that is easy to get is low, safety non-toxic.Simultaneously, Sanguis sus domestica belongs to low in calories, low fat, high-protein food, after contained albumen is decomposed by the intravital gastric acid of people, can produce a kind of detoxifcation, the bowel relieving analyte, can with invade the intravital dust of people, poisonous metal microgranule generation combination reaction, be easy to toxin and excrete, and contain abundant colloid in the Auricularia, can promote gastrointestinal peristalsis, prevent constipation, have and wash the gastrointestinal effect clearly, can be with the impurity that remains in the digestive tract, refuse absorption excretes, and is rich in active polysaccharide, both are used, in iron supplement, can improve body machine immunity, remove refuse in the body.
2. natural Sanguis sus domestica has big fishy smell, if do not handle final products sense organ taste-affect very big.Industrial useful hydrogen peroxide eliminating sargassum smell, but have safety issue.The present invention is wall material with the hydroxypropyl, and embedding process and ultrasonic technology are combined, and can cover the fishy smell of Sanguis sus domestica effectively, cooperates chocolate essence, and the chewable tablet mouthfeel that makes is good, and chocolate fragrance is arranged, and does not have bad abnormal flavour and fishy smell.
3. the abrading type super micron mill of preparation Auricularia submicron powder employing has the smashing fineness height, the pulverizing temperature is low, the pulverizing cost is low, pollution-free to material, can guarantee advantages such as material cleanliness factor, and help the stripping of nutritional labeling in the Auricularia sporophore.Simultaneously, Auricularia belongs to jelly fungus, and the toughness of its sporophore is bigger, and common pulverizer is difficult to it is ground into the impalpable powder rank, adopts the abrading type super micron mill can obtain ideal superfine powder body under lower pulverizing temperature.After the Auricularia superfine grinding, the Auricularia of pulverizing with standard machinery compares, and the stripping quantity of Auricularia polycose is increased to 269.40mg/g by 65.91mg/g, has increased by 4.09 times, and the dissolution of ferrum is increased to 71.8% by 52.6% in the chewable tablet, has improved 36.5%.
(4) Figure of description
Preparation technology's flow process of accompanying drawing 1 Sanguis sus domestica chewable tablet
(5) specific embodiment
The present invention is described further below in conjunction with specific embodiment, but protection scope of the present invention is not limited in this:
Embodiment 1
1 material and reagent
(addition of sodium citrate is: 1/9 3.8% the sodium citrate aqueous solution that adds the pig blood quality), Auricularia is produced in northeast to adding citric acid sodium anticoagulant Sanguis sus domestica; Vitamin B
2, vitamin C, microcrystalline Cellulose, cyclamate, mannitol, pregelatinized Starch, micropowder silica gel, magnesium stearate is pharmaceutical grade, and hydroxypropyl, chocolate essence are food grade.
2 experimental apparatus
The HMB-701 super micron mill; The HELDS/BF laser particle analyzer; The TEA-1 ultrasonic washing unit.
3 experimental techniques and result
3.1 Sanguis sus domestica fishy smell elimination process
Get the 500ml Sanguis sus domestica in the 1000ml beaker, in boiling water bath, boil 10min and become coagulated mass, filter and remove clear liquid, get the 200g coagulated mass and in cooking machine, break into pastel; The hydroxypropyl that adds 100g in the pastel under 50 ℃ of conditions of temperature, makes Sanguis sus domestica and sticks with paste standby in ultrasound wave behind the ultrasonic Treatment 10min with 30KHz.
3.2 Auricularia is pulverized technology
Get the Auricularia of 200g, after the standard machinery coarse pulverization, sieve with 40 mesh standard sieves earlier, adopt siftage super micron mill to pulverize then, regulation and control super micron mill rotation speed of fan is 16000r/min, obtains the Auricularia submicron powder body.Use the HELDS/BF laser particle analyzer, adopt the VIBRI injector, in dispersive pressure is 3.01bar, dispersion vacuum is 87.00mbar, sample rate is 65.00%, the funnel height is 2.00mm, and the dispersion pipe diameter is under the condition of 4mm the particle diameter of Auricularia submicron powder body to be measured, and black fungus powder body surface area mean diameter is 35.89 μ m.
3.3 the preparation technology of chewable tablet
Auricularia is carried out micronizing according to step 3.2, cross 120 mesh sieves behind other material pulverize separately, prepare chewable tablet by the technological process of accompanying drawing 1.
Wherein the consumption of raw material is:
Sanguis sus domestica stick with paste 300g (by 200g Sanguis sus domestica coagulated mass and 100g hydroxypropyl beta-
Cyclodextrin was made by 2: 1)
Auricularia submicron powder 150g
Vitamin B
210g
Vitamin C 60g
Microcrystalline Cellulose 150g
Cyclamate 0.8g
Mannitol 280g
Pregelatinized Starch 150g
Hydroxypropyl embedding chocolate essence 1g
Micropowder silica gel 3g
Magnesium stearate 12g
Hydroxypropyl embedding chocolate essence prepares by the following method: behind the hydroxypropyl aqueous solution of 100g quality percentage composition 5% and the 1g chocolate essence mix homogeneously, and spray-dried making.
Description of the process:
3.3.1 former powder degree screening
The granularity of screening black fungus powder is to the influence of mouthfeel and outward appearance, and when granularity was respectively 60,120,200 and 300 orders, mouthfeel and outward appearance be respectively-,+,+and +++, promptly after micronizing, make superfine powder mouthfeel delicate fragrance and do not have glue-like feeling when the Auricularia coarse powder.Choose black fungus powder and cross the superfine powder of 300 mesh sieves.Use the HELDS/BF laser particle analyzer, adopt the VIBRI injector, in dispersive pressure is 3.01bar, dispersion vacuum is 87.00mbar, sample rate is 65.00%, the funnel height is 2.00mm, and the dispersion pipe diameter is under the condition of 4mm the particle diameter of Auricularia superfine powder to be measured, and black fungus powder body surface area mean diameter is 35.89 μ m.
3.3.2 system soft material
With mannitol, pregelatinized Starch, microcrystalline Cellulose, vitamin B
2, the vitamin C pulverize separately, cross 120 mesh sieves, stick with paste with Sanguis sus domestica and after Auricularia submicron powder mixes in mixer, slowly add 30% alcoholic solution 245mL, adjust humidity of materials, make soft material, the soft durometer of soft material is generally pinched with hands can be agglomerating, and light the pressure then loose for well.
3.3.3 pelletize is with dry
With carrying out pelletize in the soft material input oscillating granulator that makes, cross 18 mesh sieves and granulate.The granule of wet grain is answered neat, the few fine powder of size, no strip, and the grain that will wet places 55 ℃ of air dry ovens dryings, and 15min stirs once.To accelerate rate of drying, the pellet moisture of dry terminal point is 3.5%.
3.3.4 material all in one piece, tabletting and sterilization
The granule that drying is good is with 16 mesh sieves and 20 mesh sieve granulate, weighing dried particles weight, in dried particles, add cyclamate, hydroxypropyl embedding chocolate essence, micropowder silica gel, magnesium stearate, mix homogeneously, send into tabletting in the tablet machine, make the Sanguis sus domestica chewable tablet (every contains Sanguis sus domestica 106mg) of 600mg/ sheet.The tablet that presses is shone 20～30min sterilize under ultraviolet, in time packing is finished product.
Embodiment 2: the Sanguis sus domestica fishy smell elimination process
1. the hydroxypropyl addition is to the deodorization effect of Sanguis sus domestica
After coagulated mass after the anticoagulant Sanguis sus domestica boils is made pastel, the hydroxypropyl that adds coagulated mass weight 1/8,1/7,1/6,1/5,1/4,1/3,1/2,1/1 respectively, in ultrasound wave, under 50 ℃ of conditions of temperature, use the ultrasonic Treatment 10min of 30KHz.Selected 5 subjective appreciation persons that see service sort according to fishy smell intensity degree by specified characteristic to sample, with system scoring in 9 fens, disliking very much is 1 minute, and disliking is 2 minutes very much, and disliking is 3 minutes, do not like is 4 minutes, be generally 5 fens, liking slightly is 6 minutes, and liking is 7 minutes, being delithted with is 8 minutes, and enjoying a lot is 9 minutes.It is high more to mark, and shows that the fishy smell of sample and abnormal flavour are more little.The effect score value of covering of the fishy smell of 8 proportionings was respectively 5.2 fens, and 5.6 minutes, 6.0 minutes, 6.6 minutes, 7.8 minutes, 8.0 minutes, 8.4 minutes, 8.6 minutes.When the hydroxypropyl addition reached 1/4, fishy smell was less, increased to 1/2 and gradually at 1/1 o'clock, did not have fishy smell and abnormal flavour substantially.Consider that the hydroxypropyl addition is too much influential to follow-up film-making technology, preferred addition is 1/2 of a coagulated mass.
2. ultrasonic technology is to the deodorization effect of Sanguis sus domestica
After coagulated mass after the anticoagulant Sanguis sus domestica boils is made pastel, add the hydroxypropyl of coagulated mass weight 1/2 respectively, in ultrasound wave, handle, by experiment of single factor consequence devised L
9(3
3) orthogonal test table, as following table 1.
The ultrasonic test of table 1 L
9(3
3) three factors, three water-glasses
Press the operating condition of table 1, the deodorization effect score value of Sanguis sus domestica sees the following form 2.
The orthogonal test L of the ultrasonic technology of table 2
9(3
3) result
As shown in Table 2, when ultrasonic process conditions are under 40 ℃ of conditions of temperature, use the ultrasonic Treatment 15min of 30KHz, deodorization effect is best.
Embodiment 3～8: the Sanguis sus domestica paste is determined with the Auricularia submicron powder adding proportion
Change the composition of raw materials of step 3.3 among the embodiment 1, other raw material consumption and operating procedure are with the step among the embodiment 1, ((PBP) is big more with Auricularia submicron powder (AASP) proportion in prescription for the Sanguis sus domestica paste, nutritive value is high more, but also need consider the molding effect of chewable tablet and the needs that taste is adjusted simultaneously.Change the addition of Sanguis sus domestica paste and Auricularia submicron powder, the consumption of other raw materials is constant, carries out the tabletting experiment, the results are shown in Table 3.
The tabletting experimental result of table 3 different proportion Auricularia submicron powder and Thallus Porphyrae powder addition
| Addition (g) | System granule effect | Tablet appearance | |
| Embodiment 3 | ??PBP200，AASP?200 | Evenly, can granulating | Tablet is complete bright and clean |
| Embodiment 4 | ??PBP240，AASP?180 | Evenly, can granulating | Tablet is complete bright and clean |
| Embodiment 5 | ??PBP280，AASP?160 | Evenly, can granulating | Tablet is complete bright and clean |
| Embodiment 6 | ??PBP350，AASP?120 | Evenly, can granulating | Tablet is complete brighter and cleaner |
| Embodiment 7 | ??PBP400，AASP?100 | Evenly, can granulating | Tablet is complete but not bright and clean |
| Embodiment 8 | ??PBP450，AASP?80 | Fine powder is more, is difficult to granulate | Imperfect, the easy loose sheet of tablet |
Embodiment 9～12: adhesive and consumption thereof are selected
Change the technology of step 3.3.2 among the embodiment 1, other changes adhesive with the step among the embodiment 1, and different material is used the moistening of Different concentrations of alcohol aqueous solution in mixer, the system soft material, and the result is as shown in table 4.
Table 4 adhesive and consumption effect
| Embodiment 9 | Embodiment 10 | Embodiment 1 | Embodiment 11 | Embodiment 12 | |
| 10% ethanol | 20% ethanol | 30% ethanol | 40% ethanol | 50% ethanol | |
| Bind effect | ??++ | ??+++ | ??++++ | ??++++ | ??+++ |
The Yin Ben prescription is designed to chewable tablet, considers the influence to principal agent of its mouthfeel factor and adjuvant, again because of the adding of Sanguis sus domestica paste and Auricularia submicron powder is arranged, so the consumption of adhesive is had certain requirement.The selected respectively Different concentrations of alcohol solution of this prescription is as adhesive, and the bonding effect of 5 kinds of different adhesive reaches the difference that influences to granulating efficiency, and wherein 30% and 40% alcoholic acid better effects if considers that saving cost selects 30% ethanol for use.
Embodiment 13: granulating working procedure is to the influence of chewable tablet sense organ and tabletting
Change the technology of 3.3.3, direct mistake 18 mesh sieves of the soft material that makes are granulated, the grain that will wet then places 55 ℃ of air dry ovens dry, and 15min stirs once.To accelerate rate of drying, the pellet moisture of dry terminal point is 3.5.%.
Other is with the step among the embodiment 1, through pelletize and as shown in table 5 without the result of pelletize.
Table 5 granulating working procedure is to the influence of chewable tablet sense organ and tabletting.
| Embodiment 1 | Embodiment 13 | |
| The evaluation project | Chewable tablet through pelletize | Chewable tablet without pelletize |
| Mouthfeel | There is not the powdery sense | Be prone to the powdery sense |
| Embodiment 1 | Embodiment 13 | |
| Local flavor | Sour-sweet degree is coordinated evenly | Sour-sweet degree skewness |
| Color and luster | The flower point on chewable tablet surface is more even | The flower point on surface is inhomogeneous |
| Structural state | Quality is harder, is difficult for sliver, and size evenly | Quality is softer, cracky |
| The tabletting performance | Good | Bad |
Pelletize can prevent that powdered food from adding the dust from flying in man-hour, improves pack effectiveness, prevents the water absorption of tablet.As shown in Table 5, through mouthfeel, local flavor, color and luster, structural state and the tabletting performance of the chewable tablet of pelletize in various degree raising is arranged all.This can improve the flowability and the compressibility of tabletting material to a certain extent mainly due to making behind the granule tabletting again.
Embodiment 14～16: lubricant is selected
Change the technology of 3.3.4 among the embodiment 1, micropowder silica gel, the magnesium stearate that adds in the dried particles changed into add magnesium stearate, micropowder silica gel, Pulvis Talci respectively, other is with the step among the embodiment 1, and different properties of lubricants evaluation results is as shown in table 6.
Table 6 properties of lubricants evaluation effect
Lubricant has fluidizer, anti-glutinous and lubrication, but does not still have the lubricant that has above-mentioned 3 kinds of functions simultaneously concurrently at present.Compare by analysis, select the lubricant of magnesium stearate+micropowder silica gel for use as this prescription to different lubricant characteristics.The two share and fluidizer, lubricated and anti-glutinous three specific characters can be closed and be best.
Embodiment 17～20: diluent is selected
Change to become among the embodiment 1 addition of pregelatinized Starch and microcrystalline Cellulose in the 3.3.2 technology, other is with the step among the embodiment 1, wherein pregelatinized Starch has good flowability, compressibility, self-lubricity and dry adhesive, microcrystalline Cellulose has good compressibility, stronger adhesion is arranged, and the tablet that is pressed into has hardness more greatly.The evaluating characteristics result of different diluent is as shown in table 7.
The evaluating characteristics effect of table 7 diluent
| Addition (g) | Compressibility | Mobile | |
| Embodiment 17 | Pregelatinized Starch 100, microcrystalline Cellulose 250 | Excellent | In |
| Embodiment 18 | Pregelatinized Starch 120, microcrystalline Cellulose 200 | Excellent | Excellent |
| Embodiment 19 | Pregelatinized Starch 160, microcrystalline Cellulose 160 | Excellent | Excellent |
| Embodiment 20 | Pregelatinized Starch 200, microcrystalline Cellulose 100 | Very | Excellent |
Embodiment 21～25: correctives is selected
The addition of vitamin C, cyclamate and mannitol in the 3.3.2 technology among the change change embodiment 1, other is with the step among the embodiment 1, wherein mannitol absorbs heat when orally-dissolvable, cooling feeling is arranged, have certain sweet taste simultaneously concurrently, vitamin C also has certain tart flavour except that nutrition is provided, cyclamate is the artificial synthesis edulcorant.The evaluating characteristics result of different correctivess is as shown in table 8.
The evaluating characteristics effect of table 8 correctives
| Addition (g) | Mouthfeel | |
| Embodiment 21 | Vitamin C 30, cyclamate 0.5, mannitol 180 | Sour-sweet moderate, tasty and refreshing sense is not strong |
| Embodiment 22 | Vitamin C 50, cyclamate 1, mannitol 240 | Sour-sweet moderate, tasty and refreshing sense is better |
| Embodiment 23 | Vitamin C 80, cyclamate 1.5, mannitol 300 | Sour-sweet moderate, tasty and refreshing sense well |
| Embodiment 24 | Vitamin C 100, cyclamate 2, mannitol 320 | Sour-sweet more moderate, but certain metal aftertaste is arranged |
| Embodiment 25 | Vitamin C 120, cyclamate 1, mannitol 360 | Tart flavour is heavy, but tasty and refreshing sense well |
Claims (9)
1. Sanguis sus domestica compositions is characterized in that described compositions mainly is made up of following component: Sanguis sus domestica, Auricularia submicron powder, vitamin B
2, vitamin C; The proportion by weight of described each component is as follows:
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs.
Described Sanguis sus domestica is by adding the Sanguis sus domestica paste that sodium citrate anticoagulant pig blood is made with the hydroxypropyl embedding: will add sodium citrate anticoagulant pig blood and boil into the coagulated mass after-filtration in boiling water bath, get coagulated mass and break into pastel, add the hydroxypropyl that quality is a coagulated mass quality 1/2 then, under 30～50 ℃ of conditions of temperature, make Sanguis sus domestica with ultrasonic Treatment 10～20min of 20～40KHz and stick with paste, wherein the addition of sodium citrate is for adding 1/9 3.8% sodium citrate aqueous solution of pig blood quality; Described Auricularia submicron powder was the Auricularia powder of 300 mesh sieves.
2. Sanguis sus domestica compositions as claimed in claim 1, it is characterized in that, described Auricularia submicron powder is with the coarse pulverization of dry Auricularia machinery, cross 40 mesh sieves, pulverize with super micron mill then, the regulation and control rotation speed of fan is 10000～22000r/min, crosses 300 mesh sieves then and obtains Auricularia submicron powder.
3. Sanguis sus domestica compositions as claimed in claim 1 is characterized in that, the proportion by weight of described each component is as follows:
25～35 parts of Sanguis sus domestica
12～18 parts of Auricularia submicron powder
Vitamin B
21～1.5 part
4～8 parts of vitamin Cs.
4. Sanguis sus domestica compositions as claimed in claim 1 is characterized in that, described Sanguis sus domestica compositions is made up of the component of following proportion by weight:
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs.
5. Sanguis sus domestica chewable tablet that Sanguis sus domestica compositions as claimed in claim 1 is made is characterized in that described Sanguis sus domestica chewable tablet mainly is made up of the component of following proportion by weight:
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs
10～25 parts of microcrystalline Cellulose
18～36 parts in mannitol
10～20 parts of pregelatinized Starch
0.1～1 part of micropowder silica gel
0.5～3 part of magnesium stearate.
6. Sanguis sus domestica chewable tablet as claimed in claim 5 is characterized in that described Sanguis sus domestica chewable tablet prescription is made up of the component of following proportion by weight:
20～40 parts of Sanguis sus domestica
10～20 parts of Auricularia submicron powder
Vitamin B
20.5～2 parts
3～12 parts of vitamin Cs
10～25 parts of microcrystalline Cellulose
18～36 parts in mannitol
10～20 parts of pregelatinized Starch
0.1～1 part of micropowder silica gel
0.5～3 part of magnesium stearate
0.05～0.2 part of cyclamate
0.05～0.5 part of hydroxypropyl embedding chocolate essence;
Described hydroxypropyl embedding chocolate essence mixes spray-dried then making by the hydroxypropyl aqueous solution of quality percentage composition 5% with chocolate essence at 5: 1 with the mass ratio of chocolate essence by hydroxypropyl.
7. Auricularia chewable tablet as claimed in claim 5 is characterized in that described Auricularia chewable tablet prescription is made up of the component of following proportion by weight:
25～35 parts of Sanguis sus domestica
12～18 parts of Auricularia submicron powder
Vitamin B
21～1.5 part
4～8 parts of vitamin Cs
16～20 parts of microcrystalline Cellulose
0.1～0.15 part of cyclamate
24～30 parts in mannitol
12～16 parts of pregelatinized Starch
0.1～0.2 part of hydroxypropyl embedding chocolate essence
0.1～0.5 part of micropowder silica gel
1～1.5 part of magnesium stearate.
8. Sanguis sus domestica chewable tablet as claimed in claim 5, it is characterized in that described Sanguis sus domestica chewable tablet is made by following method by each group component: (1) gets that adding citric acid sodium anticoagulant pig blood boils 5～15min in boiling water bath, boil into the coagulated mass after-filtration, get coagulated mass and break into pastel, add the beta-schardinger dextrin-that quality is a coagulated mass quality 1/2 then, under 30～50 ℃ of conditions of temperature, make Sanguis sus domestica behind ultrasonic Treatment 10～20min with 20～40KHz and stick with paste, the addition of sodium citrate is for adding 1/9 3.8% sodium citrate aqueous solution of pig blood quality; (2) get the coarse pulverization of dry Auricularia machinery, cross 40 mesh sieves, pulverize with super micron mill then, the regulation and control rotation speed of fan is 10000～22000r/min, obtains Auricularia submicron powder; (3) take by weighing mannitol, pregelatinized Starch, microcrystalline Cellulose, vitamin B by the prescription mass parts
2, the vitamin C pulverize separately, cross 100～120 mesh sieves, the Auricularia submicron powder that the Sanguis sus domestica that makes with the step (1) of prescription amount is stuck with paste and the step (2) of prescription amount makes mix mixed powder A, add adhesive system soft material, the consumption of described adhesive is 0.6～1.8ml/g mixed powder A, drop into pelletize in the oscillating granulator then, cross 16～20 mesh sieves and granulate 40～60 ℃ of dryings, granulate, weighing dried particles weight, in dried particles, press the prescription amount and add micropowder silica gel, magnesium stearate, mix homogeneously, tabletting, packing makes described Sanguis sus domestica chewable tablet; Described adhesive is the ethanol water of 10～40wt%.
9. as claim 6 or 7 described Sanguis sus domestica chewable tablet, it is characterized in that described Sanguis sus domestica chewable tablet is made by following method by each group component: (1) gets that adding citric acid sodium anticoagulant pig blood boils 5～15min in boiling water bath, boil into the coagulated mass after-filtration, get coagulated mass and break into pastel, add the beta-schardinger dextrin-that quality is a coagulated mass quality 1/2 then, under 30～50 ℃ of conditions of temperature, make Sanguis sus domestica behind ultrasonic Treatment 10～20min with 20～40KHz and stick with paste, the addition of sodium citrate is for adding 1/9 3.8% sodium citrate aqueous solution of pig blood quality; (2) get the coarse pulverization of dry Auricularia machinery, cross 40 mesh sieves, pulverize with super micron mill then, the regulation and control rotation speed of fan is 10000～22000r/min, obtains Auricularia submicron powder; (3) take by weighing mannitol, pregelatinized Starch, microcrystalline Cellulose, vitamin B by the prescription mass parts
2Vitamin C, pulverize separately, cross 100～120 mesh sieves, the Auricularia submicron powder that the Sanguis sus domestica that makes with the step (1) of prescription amount is stuck with paste and the step (2) of prescription amount makes mix mixed powder B, add adhesive system soft material, the consumption of described adhesive is 0.6～1.8ml/g mixed powder B, drops into pelletize in the oscillating granulator then, crosses 18 mesh sieves and granulates, 40～60 ℃ of dryings, with 16 orders and 20 mesh sieve granulate, weighing dried particles weight, in dried particles, press the prescription mass parts and add micropowder silica gel, magnesium stearate, cyclamate, hydroxypropyl embedding chocolate essence, mix homogeneously, tabletting, packing makes described Sanguis sus domestica chewable tablet; Described adhesive is the ethanol water of 10～40wt%, described hydroxypropyl embedding chocolate essence mixes spray-dried then making by the hydroxypropyl aqueous solution of quality percentage composition 5% with chocolate essence at 5: 1 with the mass ratio of chocolate essence by hydroxypropyl.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102763817A (en) * | 2012-08-15 | 2012-11-07 | 中华全国供销合作总社济南果品研究院 | Method for preparing black fungus puffed ultramicro powder |
| CN103876141A (en) * | 2014-03-20 | 2014-06-25 | 中国药材公司 | Composition with effects of clearing away lung-heat and detoxifying and preparation method and application thereof |
| CN105767920A (en) * | 2016-04-07 | 2016-07-20 | 芭夯餐饮管理有限公司 | Method for making rabbit heads ready to eat |
| CN109078175A (en) * | 2018-08-31 | 2018-12-25 | 南京钦润生物科技有限公司 | A kind of heme iron multiple emulsion and preparation method thereof for mending iron |
| CN111528395A (en) * | 2020-05-06 | 2020-08-14 | 安徽省争华羊业集团有限公司 | Mutton smell removing process |
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| US20040142001A1 (en) * | 2003-01-16 | 2004-07-22 | Kuok Koon Yong | Herbal compositions for prostate conditions |
| CN101574151A (en) * | 2009-03-18 | 2009-11-11 | 北京惠中铭捷生物科技有限公司 | Nutritional food with function of strengthening immunity and preparation method thereof |
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| CN1152415A (en) * | 1995-12-19 | 1997-06-25 | 张应德 | Antihypertensive and weight-losing health care black food and making method |
| US20040142001A1 (en) * | 2003-01-16 | 2004-07-22 | Kuok Koon Yong | Herbal compositions for prostate conditions |
| CN101574151A (en) * | 2009-03-18 | 2009-11-11 | 北京惠中铭捷生物科技有限公司 | Nutritional food with function of strengthening immunity and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102763817A (en) * | 2012-08-15 | 2012-11-07 | 中华全国供销合作总社济南果品研究院 | Method for preparing black fungus puffed ultramicro powder |
| CN103876141A (en) * | 2014-03-20 | 2014-06-25 | 中国药材公司 | Composition with effects of clearing away lung-heat and detoxifying and preparation method and application thereof |
| CN103876141B (en) * | 2014-03-20 | 2016-03-30 | 中国药材公司 | A kind of composition of clearing lung-heat toxin expelling, its preparation method and application thereof |
| CN105767920A (en) * | 2016-04-07 | 2016-07-20 | 芭夯餐饮管理有限公司 | Method for making rabbit heads ready to eat |
| CN109078175A (en) * | 2018-08-31 | 2018-12-25 | 南京钦润生物科技有限公司 | A kind of heme iron multiple emulsion and preparation method thereof for mending iron |
| CN111528395A (en) * | 2020-05-06 | 2020-08-14 | 安徽省争华羊业集团有限公司 | Mutton smell removing process |
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