CN101822747A - Sugar-free wind-eliminating and itching-relieving granule - Google Patents
Sugar-free wind-eliminating and itching-relieving granule Download PDFInfo
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- CN101822747A CN101822747A CN200910172873A CN200910172873A CN101822747A CN 101822747 A CN101822747 A CN 101822747A CN 200910172873 A CN200910172873 A CN 200910172873A CN 200910172873 A CN200910172873 A CN 200910172873A CN 101822747 A CN101822747 A CN 101822747A
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Abstract
The invention discloses a sugar-free wind-eliminating and itching-relieving granule, belongs to the field of medicaments, overcomes the defects that the traditional wind-eliminating and itching-relieving granule contains large amount of sugar and is not suitable for itching patients accompanying diabetes mellitus, hyperlipidemia, obesity, decayed tooth and the like to take. In the invention, a sugar-free accessory is screened to replace sugar powder in the traditional standard and a non-sugar sweetener is selected to correct the taste. In addition, the invention has the characteristics of good taste, no sugar and safe use and enlarges the application range of the wind-eliminating and itching-relieving granule.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Sugarless type Chinese medicine granules.
Background technology
Wind-repellent itching-relieving granules is the Chinese patent medicine of a kind of pathogenic wind expelling heat clearing away, removing damp to relieve itching, and the safety of its medication and definite curative effect have been approved to have good market prospect day by day by extensive patients since listing.
The preparation standard of former wind-repellent itching-relieving granules is recorded in " Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation " the 15.But former preparation technology adds a large amount of sucrose, is not suitable for taking with the pruritus patient of diseases such as diabetes, hypertension, obesity, dental caries.But in fact pruritus follows above-mentioned disease to take place more, so just greatly limited promoting the use of of this medicine according to primary standard production.And, because the adding of a large amount of sucrose, also make the gained granule in depositing process, be easy to the moisture absorption or corrupt and go bad.
200510200722.2 number patent disclosure a kind of be the preparation technology of the wind-repellent itching-relieving granules of adjuvant with the dextrin, but empirical tests, the dextrin addition is not most economical suitable value in this technology, and gained granule mouthfeel bitterness, can't adapt to the actual market needs.
Therefore, develop the urgent needs that economical and practical sugar-free wind-eliminating and itching-relieving granule becomes present consumption market.
Summary of the invention
Problem solved by the invention is fully to disclose economical and practical sugar-free wind-eliminating and itching-relieving granule and preparation method thereof.
Preferred implementation of the present invention has 3 kinds:
1, adopts the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing actual average paste-forming rate 22.2% calculates, add 2 parts of 440 parts in dextrin and steviosin, be prepared as follows into 600 parts of sugar type granules:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, 3 hours for the first time, 2 hours for the second time.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add dextrin, steviosin, make granule, drying, both.
Wind-repellent itching-relieving granules formability and dispersibility that this method makes are all better, and production cost has also obtained significantly reducing than raw sugar type wind-repellent itching-relieving granules and No. 200510200722.2 patent record granules.
2, adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing actual average paste-forming rate 22.2% calculates, add 2 parts of 440 parts of microcrystalline Cellulose and steviosin, be prepared as follows into 600 parts of sugar type granules:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, 3 hours for the first time, 2 hours for the second time.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add microcrystalline Cellulose, steviosin, make granule, drying, both.
This method makes the wind-repellent itching-relieving granules dispersion, moisture resistance is good, and does not have the glucose generation in metabolic process all the time, and just cost is higher relatively, is fit to the superior diabetics of serious type or economic condition and uses.
3, adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing actual average paste-forming rate 22.2% calculates, add 1.5 parts of 440 parts of starch and aspartames, be prepared as follows into 600 parts of sugar type granules:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, 3 hours for the first time, 2 hours for the second time.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add starch, aspartame, make granule, drying, both.
It is relatively poor relatively that this method makes the wind-repellent itching-relieving granules dispersibility, but it is good to use this method to make grain forming, and with low cost, is particularly suitable for present ordinary consumption market.
Experimental data:
1, adjuvant screening experiment
Prepare 7 groups of wind-repellent itching-relieving granules according to following method: get Gypsum Fibrosum and smash for 3 parts and added water boil 2 hours, add: Radix Saposhnikoviae 50 grams, Periostracum Cicadae 50 grams, Cortex Lycii 90 grams, Rhizoma Atractylodis (parched) 60 grams, Semen Lini 90 grams, Radix Angelicae Sinensis 90 grams, Radix Rehmanniae 150 grams, Caulis Akebiae 30 grams, Herba Schizonepetae 50 grams, Radix Glycyrrhizae 30 grams, continue to decoct twice, 3 hours for the first time, 2 hours for the second time.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.By adding adjuvant shown in the table 1, make granule.With raw sugar type granule is that matched group is observed detection respectively and respectively organized index, and the result gathers as table 1.
As shown in Table 1, than raw sugar type wind-repellent itching-relieving granules, above sugar type granules all can make diabetics take danger to reduce greatly.Wherein: also can save production cost significantly as adjuvant with dextrin, starch; Make adjuvant with microcrystalline Cellulose (MCC) and can reduce the granule moisture absorption greatly, and microcrystalline Cellulose itself can not absorb by body, not influence the body carbohydrate metabolism fully, be particularly suitable for accompanying the pruritus patient of severe diabetes mellitus to use.
Table 1 adjuvant screening experiment
2, flavoring experiment
(1) correctives kind screening
The every index of non-sugar sweetener is screened, the results are shown in Table 2
Table 2 sweeting agent screening investigation
As shown in Table 2, aspartame, steviosin all have the characteristics that safety is excellent, moderate, the mouthfeel satisfaction is high.Wherein the aspartame price is cheaper; And steviosin is a natural sweetener, and has the effect of auxiliary hyperglycemic.Both can satisfy the different market demands respectively.
The toxicological experiment data:
1, chmice acute toxicity test
40 of healthy male KM mices, male and female half and half, body weight 18～22 grams are divided into 4 groups at random.Blank group is irritated stomach equivalent distilled water, all the other the 3 groups dosage difference gastric infusions that use the preferred 3 kinds of sugar-free wind-eliminating and itching-relieving granules of the present invention to press 75720mg/kg.Observed for 2 weeks continuously after the administration, write down death, poisoning and the active situation of mice simultaneously.Result such as table 4.
Table 4 acute toxicity testing
The result shows, several preferred sugar-free wind-eliminating and itching-relieving granules of the present invention are still safe without toxic side effect under the situation of clinical 100 times of consumptions.
2, rat long term toxicity test
40 of healthy SD rats, male and female half and half, body weight 180～220 grams are divided into 4 groups at random.Matched group is irritated stomach equivalent distilled water, presses 750mg/kg for all the other 3 groups and irritates 3 kinds of preferred wind-repellent itching-relieving granules of stomach the present invention, every day 3 times, successive administration 3 months.Carrying out the general situation observation of rat (comprising: indexs such as outward appearance sign, behavioral activity, glandular secretion, breathing, feces character, appetite, body weight, local response), carry out inspections such as hematological indices, biochemical indexes, body temperature, ophthalmology, urine, electrocardiogram simultaneously.When finishing, experiment carries out that system becomes celestial and histopathological examination.
As a result, with matched group relatively: each experimental group rat generally in order; Every inspection such as hematological indices is no abnormal; System becomes celestial all no abnormal with histopathological examination.
Above toxicological experiment shows that sugar-free wind-eliminating and itching-relieving granule drug safety of the present invention is good.
The specific embodiment
Embodiment 1:
Adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing paste-forming rate 22.2% calculates, add 440 parts of dextrin and 2 parts of steviosin, be prepared as follows into 600 parts sugar-free wind-eliminating and itching-relieving granule:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, add 8 times of amounts of water for the first time, decocted 3 hours, add 8 times of amounts of water the second time, decocted 2 hours.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add dextrin, steviosin, make granule, drying, both.
Embodiment 2:
Adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing paste-forming rate 5% calculates, add 560 parts of microcrystalline Cellulose and 1 part of sucralose, be prepared as follows into 600 parts sugar-free wind-eliminating and itching-relieving granule:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, add 4 times of amounts of water for the first time, decocted 3 hours, add 4 times of amounts of water the second time, decocted 2 hours.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add microcrystalline Cellulose, sucralose, make granule, drying, both.
Embodiment 3:
Adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing paste-forming rate 28% calculates, add 400 parts of starch and 1 part of aspartame, be prepared as follows into 600 parts sugar-free wind-eliminating and itching-relieving granule:
Getting Gypsum Fibrosum smashes and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae continuation decoction twice, add 12 times of amounts of water for the first time, decocted 3 hours, for the second time add 10 times of amounts of water, decocted 2 hours.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add starch, aspartame, make granule, drying, both.
Embodiment 4:
Adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing paste-forming rate 22.2% calculates, add 330 parts of lactose and 110 portions of mannitol, be prepared as follows into 600 parts sugar-free wind-eliminating and itching-relieving granule:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, add 8 times of amounts of water for the first time, decocted 3 hours, add 8 times of amounts of water the second time, decocted 2 hours.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add lactose, mannitol, make granule, drying, both.
Embodiment 5:
Adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing paste-forming rate 22.2% calculates, add 440 parts of xylitol, be prepared as follows into 600 parts sugar-free wind-eliminating and itching-relieving granule:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, add 8 times of amounts of water for the first time, decocted 3 hours, add 8 times of amounts of water the second time, decocted 2 hours.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add xylitol, make granule, drying, both.
Embodiment 6:
Adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing paste-forming rate 22.2% calculates, add 440 parts of starch and 1.5 parts of aspartames, be prepared as follows into 600 parts sugar-free wind-eliminating and itching-relieving granule:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, add 8 times of amounts of water for the first time, decocted 3 hours, add 8 times of amounts of water the second time, decocted 2 hours.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add starch, aspartame, make granule, drying, both.
Embodiment 7:
Adopt the medical material of following weight ratio: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, pressing paste-forming rate 22.2% calculates, add 440 parts of microcrystalline Cellulose and 2 parts of steviosin, be prepared as follows into 600 parts sugar-free wind-eliminating and itching-relieving granule:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, add 8 times of amounts of water for the first time, decocted 3 hours, add 8 times of amounts of water the second time, decocted 2 hours.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add microcrystalline Cellulose, steviosin, make granule, drying, both.
Claims (4)
1. wind-repellent itching-relieving granules, it is characterized in that, it is the medical material that adopts the following weight proportioning: 50 parts of Radix Saposhnikoviaes, 50 parts of Periostracum Cicadaes, 90 parts of Cortex Lycii, 60 parts of Rhizoma Atractylodis (parched), 90 parts of Semen Linis, 90 parts of Radix Angelicae Sinensis, 150 parts of Radix Rehmanniae, 30 parts of Caulis Akebiaes, 50 parts of Herba Schizonepetae, 30 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, add 400-560 part Sugarless type adjuvant and an amount of non-sugared flavoring agent, be prepared as follows into 600 parts sugar type granules:
Get Gypsum Fibrosum and smash and added water boil 2 hours, add Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae, Radix Glycyrrhizae and continue to decoct twice, 3 hours for the first time, 2 hours for the second time.Collecting decoction filters, and filtrate is concentrated into every 1ml and contains medical material 0.5 gram.Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, relative density was 1.36 when filtrate was concentrated into 20 ℃.Add adjuvant, sweeting agent, make granule, drying, both.
2. the described wind-repellent itching-relieving granules of claim 1 is characterized in that its described Sugarless type adjuvant is one or more the combination in dextrin, starch, xylitol, microcrystalline Cellulose, lactose, the mannitol.
3. claim 1 or 2 described wind-repellent itching-relieving granules is characterized in that described non-sugar sweetener is one or more the combination in steviosin, glycyrrhizin, cyclamate, acesulfame potassium, saccharin sodium, sucralose, the aspartame.
4. the described wind-repellent itching-relieving granules of claim 1 is characterized in that its described Sugarless type adjuvant is a kind of in dextrin, starch, the microcrystalline Cellulose; Described non-sugar sweetener is a kind of in steviosin, the aspartame.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038646A (en) * | 2010-12-27 | 2011-05-04 | 山东鲁抗医药股份有限公司 | Sugar-free cefprozil dry suspension and preparation method thereof |
| CN102499971A (en) * | 2012-01-06 | 2012-06-20 | 黑龙江新医圣制药有限责任公司 | Sugar-free brain-nourishing tablet for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
-
2009
- 2009-09-02 CN CN200910172873A patent/CN101822747A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038646A (en) * | 2010-12-27 | 2011-05-04 | 山东鲁抗医药股份有限公司 | Sugar-free cefprozil dry suspension and preparation method thereof |
| CN102038646B (en) * | 2010-12-27 | 2013-02-13 | 山东鲁抗医药股份有限公司 | Sugar-free cefprozil dry suspension and preparation method thereof |
| CN102499971A (en) * | 2012-01-06 | 2012-06-20 | 黑龙江新医圣制药有限责任公司 | Sugar-free brain-nourishing tablet for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
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Open date: 20100908 |