CN101816743A - Composite intestine cleansing agent and preparation method and application thereof - Google Patents
Composite intestine cleansing agent and preparation method and application thereof Download PDFInfo
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- CN101816743A CN101816743A CN200910058436A CN200910058436A CN101816743A CN 101816743 A CN101816743 A CN 101816743A CN 200910058436 A CN200910058436 A CN 200910058436A CN 200910058436 A CN200910058436 A CN 200910058436A CN 101816743 A CN101816743 A CN 101816743A
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Abstract
The invention relates to a composite intestine cleansing agent and a preparation method and application thereof. The intestine cleansing agent is prepared from raw materials comprising the following components: active carbon, a cellulose derivant and a food component, wherein the weight ratio of the active carbon, the cellulose derivant and the food component is 10-99:10-80:1-80; and the food component is one or more of garlic, konjak, soybean, ginger, capsicum, onion and pepper. The composite intestine cleansing agent can cleanse harmful substances in intestinal tract omnidirectionally, has remarkable effect, and has effects of expelling toxin, beautifying, reducing fat, reducing weight and the like after long-term use.
Description
Technical field
The present invention relates to a kind of composite intestine cleansing agent and its production and application, particularly a kind of compound active charcoal intestine cleansing agent and its production and application.
Background technology
Active carbon has the abundant microporous structure, the about 1000m of specific surface area
2-3000m
2/ g, active carbon are the most frequently used clinically non-specific antidotes, and poisonous substance, medicine, antibacterial, the toxin (comprising ethanol, lead etc.) of thumping majority all had powerful adsorption, and the stable composite that the absorption back forms can not dissociated in 24 hours at least.Active carbon oral is not absorbed, parmacodynamics-less activity, without any side effects, fool proof.At present, activated carbon is but very limited in the use of human body: only be used for clinical detoxifcation, antidiarrheal.Most important reason has: active carbon is directly taken the mouthfeel extreme difference, the each using dosage of clinical detoxifcation greatly reaches the 50-100 gram; Present limited only two kinds of the tablet of active carbon and capsules merely of the active carbon dosage form of directly using for human body; Simple active carbon is taken for a long time and constipation and alteration of intestinal flora can be occurred.
Summary of the invention
In view of being not suitable for human body, existing simple CharcoAid is extensive use of, on the one hand, technical problem to be solved by this invention provides a kind of compound active charcoal intestinal lavage preparation, its suitable life-time service, the comprehensive cleaning harmful intestinal tract material of energy, effect is remarkable, can be used for eliminating toxin and beautifying the skin, lowering blood-fat and reducing weight, relieves the effect of alcohol.
On the other hand, the present invention also provides the preparation method of this compound active charcoal intestinal lavage preparation.
Also on the one hand, the present invention also provides the application of this compound active charcoal intestinal lavage preparation.
This compound preparation produces synergism by multiple composition and reduces active carbon dosage; The constipation and the dysbacteriosis that prevent and avoid to occur; Simultaneously range of application is extended to intestinal lavage and removes the harmful intestinal tract material, eliminating toxin and beautifying the skin, lowering blood-fat and reducing weight, detoxifcation are relieved the effect of alcohol.This compound preparation is selected the food composition prescription for use, and prescription is simple; Preparation technology adopts extremely sophisticated modern pharmaceutical industrial technology method.
According to a first aspect of the invention, the invention provides a kind of compound active charcoal intestine cleansing agent of suitable life-time service, it is to be formed by the feedstock production that comprises following composition: active carbon, cellulose derivative and food composition; Wherein, the weight ratio of described active carbon, cellulose derivative and food composition is followed successively by 10-99: 10-80: 1-80; Described food composition is to be selected from one or more of Bulbus Allii, Rhizoma amorphophalli, Semen sojae atricolor, Rhizoma Zingiberis Recens, Fructus Capsici, Bulbus Allii Cepae, Pericarpium Zanthoxyli.
Above-mentioned raw materials used other adjuvant that also can comprise surplus.
The weight ratio of described active carbon, cellulose derivative and food composition is preferably 40-90: 10-60: 10-60, more preferably 60-90: 10-40: 10-40.
In composite intestine cleansing agent of the present invention, described cellulose derivative can be low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, hydroxypropyl emthylcellulose, ethyl cellulose, carboxymethyl cellulose or its combination in any, but is not limited thereto.
Described food composition should have awake the intestines and stomach and strengthen gastrointestinal peristalsis or the effect of oligosaccharide is provided.This food composition can be independent a kind of, as Bulbus Allii powder, and the perhaps combination of several foods.This combination be with Bulbus Allii powder with the intestines and stomach and strengthen gastrointestinal peristalsis or provide the food Rhizoma amorphophalli, Semen sojae atricolor, Rhizoma Zingiberis Recens, Fructus Capsici, Bulbus Allii Cepae, Pericarpium Zanthoxyli etc. of oligosaccharide partly or completely to replace is provided, but be not limited thereto four kinds.The preferred drying of used food composition also is ground into powder type, as Bulbus Allii powder, Rhizoma Zingiberis Recens powder etc.Preferred Bulbus Allii powder of the present invention and the combination that comprises Bulbus Allii powder.
Composite intestine cleansing agent of the present invention can be made into various suitable common formulations, as pill, powder, granule, tablet, capsule, suspensoid etc.According to the difference of dosage form, can add other suitable adjuvant, as stomach dissolution type capsule shells, enteric coated capsule shell, flavoring agent, odor mask, pigment, binding agent, fluidizer, lubricant and/or stomach dissolution type coating materials, enteric solubility coating materials etc.
According to a second aspect of the invention, adopt existing pharmaceuticals industry technical method, composite intestine cleansing agent of the present invention is made pill, powder, granule, tablet, capsule, suspensoid etc.
Described preparation method can comprise the steps:
Active carbon, cellulose derivative and food composition are mixed in proportion;
Make stomach dissolution type preparation and/or enteric solubility preparation.
For example, this method can comprise the following steps:
1. get the abundant mixing of low-substituted hydroxypropyl cellulose, Bulbus Allii powder of proportional quantity, get No. 1 mixture;
2. get the active carbon of proportional quantity, add No. 1 mixture, mixing gets No. 2 mixture;
3. No. 2 mixture are dried to water content 2%-5%; Be filled directly in capsule or the enteric coated capsule, promptly get capsule, enteric coated capsule.
4. get flavoring agent, wetting agent, the lubricant of proportional quantity, fully mixing gets No. 3 mixture; Get mixture No. 4 with No. 2 abundant mixings of mixture;
5. get in No. 4 mixture of binding agent adding of proportional quantity, the limit edged stirs, and makes soft material; Further adopt modern pharmaceutical industrial technology method to make ball or granule, and be dried to dried granule or the dried ball of water content 2%-5%;
6. will do granule coating or enteric coated after be distributed into granule; Or directly will do grain packing and make capsule or enteric coated capsule in capsule or enteric coated capsule;
7. maybe with coating or enteric coated conventional tablet or the enteric coated tablet of making behind the fluidizer tabletting of dried granule adding proportional quantity; Maybe with direct coating of dried ball or enteric coated conventional tablet or the enteric coated tablet of making.
8. or with No. 2 mixture be added to suitable dispersion to wetting agent (as glycerol etc.) solvent in batches,, be prepared into suspensoid near being evenly dispersed in wetting agent (as the glycerol etc.) solvent.The concrete manufacture method of suspensoid is well known to a person skilled in the art.
According to a third aspect of the present invention, the invention provides the application of above-mentioned composite intestine cleansing agent, i.e. the cleaning medicine of toxin expelling or the application of health product in preparation is used for body, and the medicine of lowering blood-fat and reducing weight or the application of health product in preparation is used for body.It can supply life-time service, is used to remove the human body intestinal canal harmful substance, and eliminating toxin and beautifying the skin, lowering blood-fat and reducing weight, detoxifcation are relieved the effect of alcohol evident in efficacy, and be with the obvious advantage.Through testing:
1. the present invention adopts activated carbon and food ingredients prescription, effectively avoid taking the deficiency of simple activated carbon, cellulose, Bulbus Allii powder promote gastrointestinal motility can avoid taking the constipation that simple active carbon causes, Bulbus Allii powder contains oligosaccharide and promotes the intestinal beneficial bacterium growth to avoid taking the alteration of intestinal flora that simple active carbon causes.Have no side effect through verification experimental verification, fool proof.
2. each component of the present invention is worked in coordination with mutually and helped comprehensive removing harmful intestinal tract material: activated carbon drug abuse toxin expelling, cellulose promote gastrointestinal motility to hinder toxin absorption acceleration toxin expelling, Bulbus Allii powder promotion gastrointestinal motility Plumbum removing detoxifcation.Better through the composite intestine cleansing agent removing harmful substance effect that test confirmation the present invention makes.
3. each component of the present invention is worked in coordination with lowering blood-fat and reducing weight.Activated carbon fat absorption row fat, cellulose are ingested less in expansion 4-7 demultiplication and are promoted gastrointestinal motility row fat simultaneously.Better through the composite intestine cleansing agent lowering blood-fat and reducing weight effect that test confirmation the present invention makes.
Below just be used to illustrate order various aspects of the present invention and feature by preferred embodiment, and do not limit the scope of the invention.Protection scope of the present invention only is subjected to the restriction of claims.
The specific embodiment
Embodiment 1:
Adopt the known method of pharmaceuticals industry directly to mix, fill and make capsule or enteric coated capsule, component and content by weight percentage are as follows:
Active carbon 85%
Low-substituted hydroxypropyl cellulose 15%
Bulbus Allii powder 10%
Capsule shells is an amount of
1. get the abundant mixing of low-substituted hydroxypropyl cellulose, Bulbus Allii powder of proportional quantity, get No. 1 mixture;
2. get the active carbon of proportional quantity, add No. 1 mixture, mixing gets No. 2 mixture;
3. No. 2 mixture are dried to water content 2%-5%; Be filled directly in capsule or the enteric coated capsule, promptly get capsule, enteric coated capsule.
Embodiment 2:
Adopt the known method of pharmaceuticals industry to make tablet (or pill, granule, capsule, suspensoid) at last through mixing, granulation, coating, tabletting (fillings), component reaches that content is as follows by weight percentage:
Active carbon 30%
Low-substituted hydroxypropyl cellulose 50%
Rhizoma amorphophalli powder 10%
Bulbus Allii powder 6%
Rhizoma Zingiberis Recens powder 2%
Fructus Capsici powder 1.5%
Zanthoxyli Bungeani powder 0.5%
Wetting agent (glycerol), lubricant, coating material, capsule shells are all an amount of.
1. get the abundant mixing of Rhizoma amorphophalli powder, Bulbus Allii powder, Rhizoma Zingiberis Recens powder, Fructus Capsici powder, Zanthoxyli Bungeani powder of proportional quantity, get No. 1 mixture;
2. get proportional quantity active carbon, No. 1 abundant mixing of mixture of low-substituted hydroxypropyl cellulose adding, get No. 2 mixture;
3. get wetting agent, the lubricant of proportional quantity, fully mixing gets No. 3 mixture; Get mixture No. 4 with No. 2 abundant mixings of mixture
4. get in No. 4 mixture of binding agent adding of proportional quantity, the limit edged stirs, and makes soft material; Further adopt modern pharmaceutical industrial technology method to make ball or granule, and be dried to dried granule or the dried ball of water content 2%-5%;
5. will do granule coating or enteric coated after be distributed into granule; Or directly will do grain packing and make capsule or enteric coated capsule in capsule or enteric coated capsule;
6. maybe with coating or enteric coated conventional tablet or the enteric coated tablet of making behind the fluidizer tabletting of dried granule adding proportional quantity; Maybe with direct coating of dried ball or enteric coated conventional tablet or the enteric coated tablet of making.
7. or with No. 2 mixture be added to suitable dispersion to wetting agent (as glycerol etc.) solvent, the concrete manufacture method and the technical key point of the suspensoid of generally acknowledging by the technical staff are prepared into suspensoid in batches.
Embodiment 3:
Adopt the known method of pharmaceuticals industry to make tablet (or pill, granule, capsule, suspensoid) at last through mixing granulation, coating, tabletting (fillings), component reaches that content is as follows by weight percentage:
Active carbon 60%
Low-substituted hydroxypropyl cellulose 20%
Rhizoma amorphophalli powder 8%
Bulbus Allii powder 6%
Rhizoma Zingiberis Recens powder 4%
Fructus Capsici powder 1.5%
Zanthoxyli Bungeani powder 0.5%
Wetting agent, lubricant, coating material, capsule shells are all an amount of.
1. get the abundant mixing of Rhizoma amorphophalli powder, Bulbus Allii powder, Rhizoma Zingiberis Recens powder, Fructus Capsici powder, Zanthoxyli Bungeani powder of proportional quantity, get No. 1 mixture;
2. get the proportional quantity low-substituted hydroxypropyl cellulose and add No. 1 abundant mixing of mixture, get No. 2 mixture;
3. get wetting agent, the lubricant of proportional quantity, fully mixing gets No. 3 mixture; Get mixture No. 4 with No. 2 abundant mixings of mixture;
4. get in No. 4 mixture of binding agent adding of proportional quantity, the limit edged stirs, and makes soft material; Further adopt modern pharmaceutical industrial technology method to make granule, and be dried to the dried granule of water content 2%-5%; To do granule coating or enteric coated.
5. the activated carbon mixed filling with coated granule and proportional quantity makes capsule or enteric coated capsule in capsule or enteric coated capsule;
8. or with filling behind the activated carbon mixing coating of coated granule and proportional quantity make capsule or enteric coated capsule in capsule or enteric coated capsule;
9. or with coated granule mix coating or enteric coated conventional tablet or the enteric coated tablet of making behind the fluidizer tabletting that the back adds proportional quantity with the activated carbon of proportional quantity;
Embodiment 4:
Experiment in vitro: 4: the 1 by volume mixed preparing of Xiaojiaolou and 50% DDT EC of will often drinking go out the research mixing material.Adopt visible uv analyzer analysis of BECKMENDU600 type and record impurity, ethanol, dichlorvos peak-data, add 6 gram composite intestine cleansing capsules (make by embodiment 1, add behind the softgel shell that removes photoresist) in the per kilogram mixing material; Impurity, ethanol, dichlorvos peak-data are analyzed and write down to static 30 minutes of mix homogeneously once more, analyzes contrast as can be known, and the ethanol peak reduces 75% (205nm place), and the dichlorvos peak reduces 83%.This experimental results show that composite intestine cleansing agent can adsorb materials such as ethanol, harmful substance dichlorvos really simultaneously.In conjunction with being added with the edible composition that promotes bowel movement and increase function of intestinal canal in this prescription especially.More helping adsorption complex at human body gets rid of external.The effect of toxin expelling intestinal tract cleaning is better than external in the body.Therefore, composite intestine cleansing agent of the present invention is ideal intestinal abluent, to preventing drunk and alleviating the symptom of being still drank after a night after drinking good result is arranged all.
Embodiment 5:
This experiment selects for use medical experiment to use 12 of healthy dogs (body weight 12-15kg) always, and the conventional study method that experiment is declared efficacy of new drug research in the new drug research by the modern times is carried out.Animal adapts to 1 week back branch A, B two groups (6 every group) and experimentizes: A organizes matched group, feed to lead acetate, and 6mg/kg/ days, bid; Stop to change hello distilled water after continuing for 1 week; B organizes experimental group, feeds to lead acetate, and 6mg/kg/ days, bid; Stop to change hello composite intestine cleansing agent (making) after continuing for 1 week by embodiment 2; 3 weeks of Therapy lasted (21 days), collect Canis familiaris L. the 7th, 14 respectively, urine and feces in 21 days Canis familiaris L.s 24 hours, and get the 7th, 14,21 days venous blood of Canis familiaris L. respectively and detect.Sample all adopts the content of Atomic Absorption Spectrometry lead, and feces detects with nitration mixture digestion back.Each is organized data and carries out statistical analysis.Blood lead, excrement lead, lead in urine all have significance (p＜0.01) between A, B group, and promptly the B group compares with the A group, and wherein blood lead all obviously reduces (p＜0.01); Excrement plumbous output, significantly increase (p＜0.01); The lead in urine discharge capacity then significantly reduces (p＜0.05), and composite intestine cleansing agent tool lead-eliminating effect preferably is described.
Embodiment 6:
It is slight hyperlipemic patients experiment (can not give the medicine therapist in the clinical treatment) 24 people that this experiment is selected for use through clinical diagnosis, copies the conventional method of clinical medicine observation of curative effect experiment to carry out double blind experiment.Divide two groups of A, B, measure and write down every bit test person's blood fat before the experiment respectively, body weight.A organizes matched group: early, respectively obey 4 placebo evening, continued for 8 weeks; B organizes experimental group, early, respectively obey No. 2 capsules that make among 4 embodiment 3 evening.Continued for 8 weeks; Respectively at the 7th, 14, measured body weight and blood fat and record in 21,35,56 days in the experiment.Related data carries out statistical analysis.Body weight and blood fat all had significance (p＜0.01) between (56 days) A, B organized during the experiment end, and promptly the B group compares with the A group, and body weight and blood fat be obviously reduction (p＜0.01) all; 21, B group blood fat all obviously reduces (p＜0.01) than the A group 35,56 days the time; 35, B group body weight all obviously reduces (p＜0.01) than the A group 56 days the time; Blood fat reducing is rapid-action, and the fat-reducing onset is slower; This composite intestine cleansing agent has functions of lowering blood-fat and reducing weight preferably.
More than the description of better embodiment of the present invention is not limited the present invention, those skilled in the art can make various changes or distortion according to the present invention, only otherwise break away from spirit of the present invention, all should belong to the scope of claims of the present invention.
Claims (10)
1. composite intestine cleansing agent, it is to be formed by the feedstock production that comprises following composition: active carbon, cellulose derivative and food composition; Wherein, the weight ratio of described active carbon, cellulose derivative and food composition is followed successively by 10-99: 10-80: 1-80; Described food composition is to be selected from one or more of Bulbus Allii, Rhizoma amorphophalli, Semen sojae atricolor, Rhizoma Zingiberis Recens, Fructus Capsici, Bulbus Allii Cepae, Pericarpium Zanthoxyli.
2. the described composite intestine cleansing agent of claim 1, wherein, described cellulose derivative is to be selected from one or more of low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, hydroxypropyl emthylcellulose, ethyl cellulose and carboxymethyl cellulose.
3. the described composite intestine cleansing agent of claim 1, wherein, described food composition comprises Bulbus Allii.
4. the described composite intestine cleansing agent of claim 1, wherein, raw materials used one or more the adjuvant that is selected from stomach dissolution type capsule shells, enteric coated capsule shell, flavoring agent, odor mask, pigment, binding agent, fluidizer, lubricant and/or stomach dissolution type coating materials and enteric solubility coating materials that further comprises.
5. the described composite intestine cleansing agent of claim 1, wherein, the dosage form of described composite intestine cleansing agent is pill, powder, granule, tablet, capsule or suspensoid.
6. the described composite intestine cleansing agent of claim 1, wherein, the weight ratio of described active carbon, cellulose derivative and food composition is followed successively by 40-90: 10-60: 10-60.
7. the described composite intestine cleansing agent of claim 1, wherein, the weight ratio of described active carbon, cellulose derivative and food composition is followed successively by 60-90: 10-40: 10-40.
8. the preparation method of the described composite intestine cleansing agent of one of claim 1～7, it comprises the steps:
Active carbon, cellulose derivative and food composition are mixed in proportion;
Make stomach dissolution type preparation and/or enteric solubility preparation.
9. the described composite intestine cleansing agent of one of claim 1～7 cleans the application of medicine, health product or the functional food of toxin expelling in preparation is used for body.
10. the application of medicine, health product or the functional food of the described composite intestine cleansing agent of one of claim 1～7 lowering blood-fat and reducing weight in preparation is used for body.
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| CN200910058436A CN101816743A (en) | 2009-02-26 | 2009-02-26 | Composite intestine cleansing agent and preparation method and application thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380020A (en) * | 2011-11-10 | 2012-03-21 | 新疆维吾尔自治区中药民族药研究所 | Garlic enteric-coated tablets and production method thereof |
| CN109125637A (en) * | 2017-06-19 | 2019-01-04 | 王丽敏 | A kind of lipolysin Chinese medicine preparation and preparation method |
| CN112261880A (en) * | 2018-06-07 | 2021-01-22 | 协同组合拉特斯特 | Functional food |
| CN112826872A (en) * | 2021-01-15 | 2021-05-25 | 尼腾(广州)生物科技有限公司 | Composition for expelling toxin and losing weight in stomach and intestine and application thereof |
-
2009
- 2009-02-26 CN CN200910058436A patent/CN101816743A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380020A (en) * | 2011-11-10 | 2012-03-21 | 新疆维吾尔自治区中药民族药研究所 | Garlic enteric-coated tablets and production method thereof |
| CN109125637A (en) * | 2017-06-19 | 2019-01-04 | 王丽敏 | A kind of lipolysin Chinese medicine preparation and preparation method |
| CN112261880A (en) * | 2018-06-07 | 2021-01-22 | 协同组合拉特斯特 | Functional food |
| CN112826872A (en) * | 2021-01-15 | 2021-05-25 | 尼腾(广州)生物科技有限公司 | Composition for expelling toxin and losing weight in stomach and intestine and application thereof |
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Open date: 20100901 |