CN101816549B - Nerve signal detection/excitation electrode, twin-electrode, electrode array and preparation methods thereof - Google Patents
Nerve signal detection/excitation electrode, twin-electrode, electrode array and preparation methods thereof Download PDFInfo
- Publication number
- CN101816549B CN101816549B CN2010101203861A CN201010120386A CN101816549B CN 101816549 B CN101816549 B CN 101816549B CN 2010101203861 A CN2010101203861 A CN 2010101203861A CN 201010120386 A CN201010120386 A CN 201010120386A CN 101816549 B CN101816549 B CN 101816549B
- Authority
- CN
- China
- Prior art keywords
- needle
- electrode
- acupuncture
- epoxy resin
- nerve signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Finger-Pressure Massage (AREA)
Abstract
The invention discloses a nerve signal detection/excitation electrode, a twin-electrode, an electrode array and preparation methods thereof. The electrode comprises an acupuncture needle body, an acupuncture needle of which the lower part is a needle tip and the upper part is a needle handle, and an insulating layer is coated on the part above the needle tip and below the needle handle; and epoxy resin and polyimide composite are adopted as the materials. The setting method thereof is as follows: polymerizing 4, 4'-diaminodiphenyl ether and pyromellitic dianhydride in ice bath with the temperature of 0 DEG C to obtain polyamide according to the molar ratio of 1:1; and adding epoxy resin in the polyamide according to the ration that each 20ml of polyamide is added with 1g of epoxy resin, stirring to enable the solution to be uniform and clear so as to obtain the composite solution of the epoxy resin and the polyamide, using a spin coater for spin coating to enable the needle body of the acupuncture to be coated with a layer of epoxy resin and polyamide composite, placing into an oven for baking for 1h at the temperature of 125 DEG C, then baking for 1h at the temperature of 250 DEG C, and forming the epoxy resin and polyamide composite on the needle body serving as the insulating layer.
Description
Technical field
The present invention relates to a kind of with acupuncture needle as nerve signal detection and exciting electrode and processing technology, relate in particular to electrode, bipolar electrode, electrod-array and the method for preparing of nerve signal detection/excitation.
Background technology
Neural engineering system is significant to the effective means that people disclose neural working mechanism and treatment of exploration sacred disease and rehabilitation, and microelectrode then is the parts that constitute the most critical of nerve-electrical interface in the neural engineering system.Its major function is: 1) nerve action and sensory potential signal record are got off to analyze and research 2) utilize signal of telecommunication excitation or suppress neural activity with the realization functional electric stimulation (functionalelectrical stimulation, FES).
Be applied to nerve-electrical interface microelectrode the design consideration application scenario and decide.Can work effectively in order to make microelectrode; Need the form (such as locating in number, spatial density, electrode material, the tissue etc.) of counter electrode to carry out appropriate design, make it satisfy particular demands at aspect of performances such as electricity, mechanics, chemistry, biology, calorifics, magnetics and optics.
The present invention proposes with the electrode of acupuncture needle as nerve signal detection and excitation.Acupuncture is an ancient and magical science, and the history in more than 2,000 year is arranged in China.Needle set develops into metal needles such as afterwards copper pin and ferrum pin from early stage spicule, bamboo pin.At present, the material as acupuncture needle has copper, silver, gold, rustless steel etc.The easy corrosion of copper pin, elasticity, toughness, fastness are poor; The heat transfer of acupuncture needle, acupuncture needle, excellent conductivity, but intensity, toughness are not as stainless pin.Stainless pin is as the most general needle set of clinical practice, and cost is low, and is easy to use, and than general copper pin, the resistant to rust of ferrum pin, but biocompatibility is than acupuncture needle difference.In addition, the stainless pin as electronic acupuncture and moxibustion therapeutic is exactly common acupuncture needle usually at present, and the metal of whole needle body all is exposed the conduction.Therefore, it is the band of a tissue that needle body thrusts what excite behind the health, rather than a specific site.That is to say its poor selectivity.Such pin is surveyed as bio signal, except the problem of poor selectivity, also exists the problem that interfering signal is strong thereby sensitivity is low.
The present invention is with the electrode of clinical stainless pin acupuncture needle commonly used as nerve signal detection and excitation; Through to the insulation processing of needle body and the gold-plated processing of needle point, solve the biocompatibility issues and the problem that contacts with biological tissue's line rather than single-point of stainless pin.
In addition, the present invention will solve the technical problem of parallel crosspointer and coaxial probe, and purpose is nerve signal detection and the exciting electrode that obtains best input signal-to-noise ratio.
The present invention carries out finishing to acupuncture needle on the basis of clinical stainless pin acupuncture needle commonly used, principal right requires to relate to the insulation of needle body, the modification and the jamproof crosspointer structure of needle point.
Summary of the invention
Technical problem to be solved by this invention is for nerve signal detection and excitation a kind of electrode, electrod-array, bipolar electrode and method for preparing that when improving capacity of resisting disturbance, reduces the nerve signal detection/excitation of threshold value to be provided.
For solving the problems of the technologies described above, the present invention adopts following technical scheme:
The electrode of a kind of nerve signal detection/excitation of the present invention comprises needle body, and said needle body is the acupuncture needle of needle handle on needle point and the top of bottom, on the needle body more than the needle point, below the needle handle, scribbles insulating barrier; And needle point is coated with one deck bio-compatible precious metal plating or conducting polymer coating.
The electrod-array of a kind of nerve signal detection/excitation of the present invention; Comprise: the compatibility is macromolecular material or semi-conducting material matrix preferably; Be provided with the electrode of at least 2 nerve signal detection/excitations side by side at matrix; The electrode of said nerve signal detection/excitation comprises needle body, and said needle body is the acupuncture needle of needle handle on needle point and the top of bottom, on the needle body more than the needle point, below the needle handle, scribbles insulating barrier; And needle point is coated with one deck bio-compatible precious metal plating or conducting polymer coating.
The bipolar electrode of a kind of nerve signal excitation of the present invention; Comprise: the electrode and the ground wire of nerve signal excitation; The electrode of said nerve signal excitation comprises needle body; Said needle body is the acupuncture needle of needle handle on needle point and the top of bottom, on the needle body more than the needle point, below the needle handle, scribbles insulating barrier; And needle point is coated with one deck bio-compatible precious metal plating or conducting polymer coating, said ground wire be located at needle handle and with needle body side by side.
The coaxial type bipolar electrode of a kind of nerve signal excitation of the present invention; Comprise: the electrode and the ground wire of nerve signal excitation; The electrode of said nerve signal excitation comprises needle body; Said needle body is the acupuncture needle of needle handle on needle point and the top of bottom, on the needle body more than the needle point, below the needle handle, scribbles insulating barrier; And needle point is coated with one deck bio-compatible precious metal plating or conducting polymer coating, and said ground wire is cylindrical electrode, and cylindrical electrode is set on the insulating barrier of needle body.
The method for preparing of the electrode of a kind of nerve signal detection/excitation of the present invention,
Earlier with 4 of mol ratio 1: 1, the polymerization in 0 ℃ of ice bath of 4 '-diaminodiphenyl ether and pyromellitic dianhydride obtains polyamic acid, again in polyamic acid according to the ratio adding epoxy resin that in every 20ml polyamic acid, adds 1g epoxy resin; And stir; Make solution be transparent and homogeneous, obtain the complex solution of epoxy resin and polyamic acid, make the needle body coating one deck epoxy resin of acupuncture needle and the complex of polyamic acid through getting rid of film with getting rid of the film machine; Place baking oven to put 125 ℃ of bakings 1 hour earlier; Put 250 ℃ of bakings 1 hour again, can on needle body, form as the epoxy resin of insulating barrier and the complex of polyimides
Compared with prior art, the present invention has the following advantages:
High sensitivity when 1) being used for acquisition of signal;
2) the present invention has reduced threshold value when improving capacity of resisting disturbance.Acupuncture electrode needle nose part conduction; Needle body has partly adopted insulant, makes electrode body and biological tissue realize electric isolation, and can accurately encourage and survey needs excitation and the position of surveying in the organism; Stop other unnecessary signal, improved the selectivity and the capacity of resisting disturbance of electrode.With unmodified (rustless steel) acupuncture needle, needle body insulating needle acupuncture needle, needle body insulation; Needle point gold-plated pin acupuncture needle, needle body insulation; Four kinds of dissimilar acupuncture needles of needle point polypyrrole modifying acupuncture needle carry out the Bufo siccus zoopery as electrode, insert animal (Bufo siccus) nerve or muscle to electrode, carry out
Signal excitation, it is as shown in table 1 to record threshold voltage.From table, can find out, through epoxy resin and polyimides
The insulating acupuncture needle of complex is owing to the rapid minimizing of the conductive area that contacts with organism, so threshold voltage
Improved, the present invention takes the gold-plated and modification polypyrrole processing of electrochemistry again on needle point, reduced threshold value
Voltage obtains selectivity and highly sensitive acupuncture electrode.
Table 1: the threshold voltage of dissimilar acupuncture needles relatively
| The acupuncture needle type | Threshold voltage |
| Unmodified (stainless pin acupuncture needle) | 200mV |
| Insulating needle acupuncture needle, needle point are rustless steel | 2200mV |
| The insulating needle acupuncture needle, the gold-plated modification of needle point | 170mV |
| The insulating needle acupuncture needle, the needle point polypyrrole modifying | 180mV |
3) height of each pin can be adjusted separately according to the position of nervous tissue in spinal cord or nerve fibre bundle, make them insert nervous tissue after, can contact with specific site, to realize the detection and the excitation of maximum sites nerve signal.Electrod-array forms has autonomy and motility.
4) design of driver bit electrode and cable type electrode can make exciting electrode and be implanted to simultaneously in the organism as the electrode of ground wire, to reduce disorganization and then to reduce and implant wound.
5) in the design of driver bit electrode and cable type electrode, exciting electrode and ground wire are separated by very near, can reduce stimulus artifact, the signal to noise ratio when improving electrode excitation.
Compare with acupuncture needle body stainless steel material, the acupuncture needle that precious metal material such as gold, platinumiridio and conducting polymer materials are modified is following as the advantage of electrode:
1) on the exposed electrode site of acupuncture needle needle point, covers noble metals such as one deck gold, platinumiridio, its electrical impedance is reduced, and phase delay is less, helps nerve microelectrode and works effectively.
2) with ultraviolet light absorption photometer method gold, polypyrrole, epoxy resin and polyimides complex and stainless steel material are carried out protein adsorption (albumin A lb, immunoglobulin IgG) experiment; Experimental result is as shown in table 1, and gold, polypyrrole, epoxy resin all lack than stainless steel surfaces with the protein layer of polyimides composite materials surface adsorption.The record site that the protein layer of absorption is thin to make electrode and neurocyte can be directly, stably contact, and the minimizing signal to noise ratio helps receiving the first signal of telecommunication of peripheral nerve.
Table 2: different materials surface protein adsorbance size relatively
| Material | Rustless steel | Gold-plated modification | Polypyrrole modifying | Epoxy resin+polyimide insulative |
| Alb adsorbance (μ g/cm 2) | 5.038±0.252 | 2.269±0.38 | 1.492±0.84 | 1.461±0.155 |
| IgG adsorbance (μ g/cm 2) | 4.656±0.582 | 2.522±0.336 | 1.939±0.336 | 2.14±0.535 |
3) electroconductive polymer coating (like polypyrrole, polythiophene etc.) can be beneficial to combining of cell and tissue through improving material surface area, promotes the contact of electrode tissue.And polymer is a kind of soft material, reduces tissue and electrode surface strain mismatch, reduces inflammatory reaction and then reduces non-conductive fiber thickness, helps the reception of nerve signal.
Description of drawings
Fig. 1 is with structure half cut-away view of acupuncture needle as nerve signal detection and exciting electrode.
Fig. 2 is with the overlook enlarged drawing of acupuncture needle as nerve signal detection and exciting electrode, and wherein (A) is the enlarged drawing of overlooking of needle body part, (B) is the enlarged drawing of overlooking of tip portion.
Fig. 3 is as nerve signal detection and exciting electrode array flat-top 4 needle electrode sketch maps with acupuncture needle.
Fig. 4 tiltedly pushes up 4 needle electrode sketch maps with acupuncture needle as nerve signal detection and exciting electrode array.
Fig. 5 is as nerve signal detection and exciting electrode array flat-top 8 needle electrode sketch maps with acupuncture needle.
Fig. 6 is the driver bit electrode sketch map that is made into as nerve signal detection and excitation with acupuncture needle.
Fig. 7 is the driver bit electrode upward view that is made into as nerve signal detection and excitation with acupuncture needle.
Fig. 8 is the cable type electrode sketch map that is made into as nerve signal detection and excitation with acupuncture needle.
Fig. 9 is the cable type electrode upward view that is made into as nerve signal detection and excitation with acupuncture needle.
The specific embodiment
The electrode of a kind of nerve signal detection/excitation of the present invention comprises needle body 1, and the acupuncture needle of the needle handle 3 on needle point that said needle body 1 is the bottom 2 and top is at needle point more than 2, scribble insulating barrier on the needle body 1 of needle handle below 3; And needle point 2 is coated with one deck bio-compatible precious metal plating 6 or conducting polymer coating 7.
The electrod-array of a kind of nerve signal detection/excitation of the present invention; Comprise: the compatibility is macromolecular material or semi-conducting material matrix 8 preferably; Be provided with the electrode of at least 2 nerve signal detection/excitations side by side at matrix 8; The electrode of said nerve signal detection/excitation comprises needle body 1, and the acupuncture needle of the needle handle 3 on needle point that said needle body 1 is the bottom 2 and top is at needle point more than 2, scribble insulating barrier on the needle body 1 of needle handle below 3; And needle point 2 is coated with one deck bio-compatible precious metal plating 6 or conducting polymer coating 7.
The bipolar electrode of a kind of nerve signal excitation of the present invention; Comprise: the electrode 9 and ground wire 10 of nerve signal excitation; The electrode 9 of said nerve signal excitation comprises needle body 1; The acupuncture needle of the needle handle 3 on needle point that said needle body 1 is the bottom 2 and top is at needle point more than 2, scribble insulating barrier on the needle body 1 of needle handle below 3; And needle point 2 is coated with one deck bio-compatible precious metal plating 6 or conducting polymer coating 7, said ground wire 10 be located at needle handle 3 and with needle body 1 side by side.
The coaxial type bipolar electrode of a kind of nerve signal excitation of the present invention; Comprise: the electrode 9 and ground wire 10 of nerve signal excitation; The electrode 9 of said nerve signal excitation comprises needle body 1; The acupuncture needle of the needle handle 3 on needle point that said needle body 1 is the bottom 2 and top is realized the electricity isolation for making acupuncture electrode body and biological tissue, at needle point more than 2, scribble insulating barrier on the needle body 1 of needle handle below 3; And needle point 2 is coated with one deck bio-compatible precious metal plating 6 or conducting polymer coating 7, and said ground wire 10 is cylindrical electrode, and cylindrical electrode is set on the insulating barrier of needle body 1.
Embodiment 5
The method for preparing of the electrode of a kind of nerve signal detection/excitation of the present invention,
Earlier with 4 of mol ratio 1: 1, the polymerization in 0 ℃ of ice bath of 4 '-diaminodiphenyl ether and pyromellitic dianhydride obtains polyamic acid, again in polyamic acid according to the ratio adding epoxy resin that in every 20ml polyamic acid, adds 1g epoxy resin; And stir; Make solution be transparent and homogeneous, obtain the complex solution of epoxy resin and polyamic acid, make the needle body coating one deck epoxy resin of acupuncture needle and the complex of polyamic acid through getting rid of film with getting rid of the film machine; Place baking oven to put 125 ℃ of bakings 1 hour earlier; Put 250 ℃ of bakings 1 hour again, can on needle body, form as the epoxy resin of insulating barrier and the complex of polyimides
To the foregoing description, the present invention can also further take following technical measures:
Said insulating barrier is the composite 4 of polyimides and epoxy resin; And the composite of said polyimides and epoxy resin is obtained by following method: earlier with 4 of mol ratio 1: 1, the polymerization in 0 ℃ of ice bath of 4 '-diaminodiphenyl ether and pyromellitic dianhydride obtains polyamic acid, again in polyamic acid according to the ratio adding epoxy resin that in every 20ml polyamic acid, adds 1g epoxy resin; And stir; Make solution be transparent and homogeneous, obtain the complex solution of epoxy resin and polyamic acid, place baking oven to put 125 ℃ of bakings 1 hour earlier; Put 250 ℃ of bakings 1 hour again, obtain the complex of epoxy resin and polyimides; Said insulating barrier also can natural hydroxyapatite 5.Above-mentioned nontoxic, do not produce simplified reaction.
As a tip electrode conductive sites are coated metal plating six for the gold, platinum-iridium alloy or iridium oxide, which can increase the electrode surface area and roughness of the electrode material to improve the organization and contacts to enhance biological signal detection and incentive effects .
Said conducting polymer coating 7 is polypyrrole layer.
As shown in Figure 1; The present invention, is made up of needle body 1 and coupled needle handle 3 as nerve signal detection and exciting electrode with acupuncture needle, and needle body 1 bottom is provided with needle point 2; Be provided with insulating barrier 4 at needle point more than 2, needle body 1 outer surface of needle handle below 3, needle point 2 is provided with conducting metal 5.Because nervous tissue realizes contact through the major part of insulating barrier and electrode, so necessary nontoxic, the good biocompatibility of material, so insulating barrier employing the insulating properties complex 4 or the natural hydroxyapatite 5 of epoxy resin and polyimides preferably.Needle point 2 belongs to the conduction site of electrode, requires to conduct electricity very well, lack adsorbed proteins, and good biocompatibility is selected precious metal materials such as gold or platinumiridio 6 or conducting polymer-polypyrrole 7.On this basis, the counter electrode number makes up, and length is adjusted, and is assembled into the electrod-array of the independent and flexible adjusting of electrode number and length.And the counter electrode structure is improved, and is made into the screwdriver head dummy symmetrical structure electrode that a kind of two acupuncture needles are placed side by side, can differential input signal be provided for differential amplifier, also can one as exciting electrode, another root is as ground wire.Another kind of the acupuncture needle insulating barrier outside again coating meet electrode with the metal level of electrology characteristic as ground wire, acupuncture needle is as the cable type electrode of exciting electrode.
Advantages such as that the natural hydroxyapatite that the present invention adopts has is nontoxic, nonirritant, no carcinogenesis, good biocompatibility.The present invention prepares natural hydroxyapatite through organic principle in the high-temperature heat treatment removal Os Sus domestica; Collect the healthy edible Os Sus domestica, clean back knock fritter, in the crucible of packing into; 850 ℃ of roastings are 2 hours in Muffle furnace, and it is hydroxyapatite that infared spectrum characterizes the prepared material of proof.Under vacuum condition, carry out vacuum coating on the acupuncture needle surface, make it cover the natural hydroxyapatite of one deck, play insulating effect.
The conduction site that said acupuncture needle needle point is an electrode, the signal of telecommunication in the detectable nervous tissue or nervous tissue carried out the function electric excitation.The body stainless steel material also belongs to conducting metal, but it exists biocompatibility poor, causes stress shielding, the metal ion stripping, and problems such as electrochemical corrosion can take place under physiological environment.Therefore, the present invention provides acupuncture needle tip in the electrochemical polymerization layer of gold, platinum and iridium alloy or precious metals such as iridium oxide materials.These noble metal good biocompatibilities have good electric conductivity; And in metal electrode material, the protein layer of the last absorption of Au (be exposed in the blood plasma 7 to 28 days) is the most smooth and thin in all material, helps receiving the signal of telecommunication of peripheral nerve unit.Also can deposit one deck conducting polymer-polypyrrole, let tissue and electrode are in-plant to be contacted, reduce the decay of signal in the body fluid of extracellular.
The present invention is on the basis that above-mentioned single electrode is made, and the counter electrode structure is improved and obtained following three types electrode:
1) first kind is electrod-array, and the counter electrode number makes up, and length is adjusted, and is assembled into the electrod-array of the independent and flexible adjusting of electrode number and length.
2) second kind is the driver bit electrode, gets two and has carried out insulating acupuncture needle, and two acupuncture needles are placed side by side and are fixed together, and the electrode front end is made into " manifold " of screwdriver type.Like this can be for differential amplifier provide differential input signal, also can be with a pin as exciting electrode, another root is as ground wire.
3) the third is a coaxial cable type electrode, on the basis of insulating needle acupuncture needle, make one deck meet electrode with the metal level of electrology characteristic as ground wire.The stainless pin of innermost layer is as exciting electrode.
Claims (2)
1. the bipolar electrode of nerve signal excitation; It is characterized in that; Comprise: the electrode (9) and the ground wire (10) of nerve signal excitation; The electrode (9) of said nerve signal excitation comprises needle body (1), and said needle body (1) is the acupuncture needle of being made up of the needle handle (3) on the needle point (2) of bottom and top, on the needle body (1) more than the needle point (2), below the needle handle (3), scribbles insulating barrier; And needle point (2) is coated with one deck bio-compatible precious metal plating (6) or conducting polymer coating (7), said ground wire (10) be located at needle handle (3) and with needle body (1) side by side.
2. the coaxial type bipolar electrode of nerve signal excitation; It is characterized in that; Comprise: the electrode (9) and the ground wire (10) of nerve signal excitation; The electrode (9) of said nerve signal excitation comprises needle body (1), and said needle body (1) is the acupuncture needle of being made up of the needle handle (3) on the needle point (2) of bottom and top, on the needle body (1) more than the needle point (2), below the needle handle (3), scribbles insulating barrier; And needle point (2) is coated with one deck bio-compatible precious metal plating (6) or conducting polymer coating (7), and said ground wire (10) is cylindrical electrode, and cylindrical electrode is set on the insulating barrier of needle body (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101203861A CN101816549B (en) | 2010-03-09 | 2010-03-09 | Nerve signal detection/excitation electrode, twin-electrode, electrode array and preparation methods thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101203861A CN101816549B (en) | 2010-03-09 | 2010-03-09 | Nerve signal detection/excitation electrode, twin-electrode, electrode array and preparation methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101816549A CN101816549A (en) | 2010-09-01 |
| CN101816549B true CN101816549B (en) | 2012-06-27 |
Family
ID=42651945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101203861A Expired - Fee Related CN101816549B (en) | 2010-03-09 | 2010-03-09 | Nerve signal detection/excitation electrode, twin-electrode, electrode array and preparation methods thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101816549B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204865B (en) * | 2011-03-18 | 2013-01-30 | 东南大学 | Concentric-circle electrode for in-vivo meridian signal transfer characteristic test |
| CN103949009B (en) * | 2014-04-30 | 2016-06-15 | 广东机电职业技术学院 | A kind of electric acupuncture therapeutic instrument for rehabilitation based on image copying and execute needle method |
| CN108720966A (en) * | 2017-04-18 | 2018-11-02 | 林伯刚 | neural connection device |
| CN108201507B (en) * | 2018-03-12 | 2024-04-09 | 朱彦铭 | Acupuncture needle with electric heating sharing shielding heat reflection insulation heat insulation function |
| CN110974690B (en) * | 2019-11-22 | 2021-05-11 | 中国科学院电子学研究所 | Bidirectional electric needle, accurate acupuncture point stimulation device and system suitable for animals |
| CN112370347A (en) * | 2020-10-28 | 2021-02-19 | 无锡佳健医疗器械股份有限公司 | Prevent needle body corrosion fracture's special acupunture needle of electricity needle |
| CN113171553A (en) * | 2021-03-18 | 2021-07-27 | 上海骊霄医疗技术有限公司 | Neuromuscular electrical stimulation calibration system |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1012257B (en) * | 1986-09-09 | 1991-04-03 | 顾涵森 | Bioelectric signal measuring apparatus |
| CN2221426Y (en) * | 1995-02-16 | 1996-03-06 | 李双斌 | Double-electrode pacing needle |
| JP2009508558A (en) * | 2005-09-15 | 2009-03-05 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Apparatus and method for electrical stimulation / sensing in vivo |
| CN101361696B (en) * | 2008-09-25 | 2010-12-08 | 东南大学 | Electronic informatics measuring method and device for human channels and collaterals |
| CN201759547U (en) * | 2010-03-09 | 2011-03-16 | 东南大学 | Neural signal Electrode, bipolar electrode and electrode array for detecting/stimulating neural signals |
-
2010
- 2010-03-09 CN CN2010101203861A patent/CN101816549B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101816549A (en) | 2010-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101816549B (en) | Nerve signal detection/excitation electrode, twin-electrode, electrode array and preparation methods thereof | |
| Lai et al. | Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording | |
| US20240090814A1 (en) | Rapid manufacturing of absorbent substrates for soft, conformable sensors and conductors | |
| Ferguson et al. | Creating low-impedance tetrodes by electroplating with additives | |
| US9700221B2 (en) | Non-invasive segmentable three-dimensional microelectrode array patch for neurophysiological diagnostics and therapeutic stimulation | |
| WO2019055784A1 (en) | Implantable devices using 2d metal carbides and nitrides (mxenes) | |
| CN108904972A (en) | A kind of embedded nerve electrode based on carbon nano tube line | |
| Sperry et al. | Flexible microelectrode array for interfacing with the surface of neural ganglia | |
| Fejtl et al. | On micro-electrode array revival: its development, sophistication of recording, and stimulation | |
| CN201333036Y (en) | Detection electrode for meridian signals on human body surface | |
| CN101474071B (en) | Electrode array for detecting channels and collaterals signals on human body surface | |
| CN201759547U (en) | Neural signal Electrode, bipolar electrode and electrode array for detecting/stimulating neural signals | |
| CN209508276U (en) | It is a kind of for cultivating the electrical stimulation device of cell | |
| Datta-Chaudhuri | Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine | |
| CN114692459A (en) | Method for simulating peripheral nerve injury accurate array electrical stimulation | |
| JP5069003B2 (en) | Multi electrode | |
| CN112587156A (en) | Bioelectric signal acquisition and electrical stimulation device | |
| CN107928671B (en) | Method for measuring channel impedance | |
| CN110946563A (en) | Method and device for detecting biological information of human body channels, collaterals and viscera | |
| Ross et al. | Multielectrode impedance tuning: reducing noise and improving stimulation efficacy | |
| CN214485297U (en) | Electrical stimulation current double-needle measuring probe with depth reading function | |
| EP0833585B1 (en) | Method and apparatus for use in imaging a body | |
| CN104757970B (en) | Utilize the detection means of mandibular surface checking with EMG method genioglossus muscular function | |
| Han et al. | A new chronic neural probe with electroplated iridium oxide microelectrodes | |
| Wu et al. | Effects of bath resistance on action potentials in the squid giant axon: myocardial implications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120627 Termination date: 20140309 |