CN101802208A - 通过提取式发酵减少原料中杂质的毒性作用 - Google Patents
通过提取式发酵减少原料中杂质的毒性作用 Download PDFInfo
- Publication number
- CN101802208A CN101802208A CN200880106604A CN200880106604A CN101802208A CN 101802208 A CN101802208 A CN 101802208A CN 200880106604 A CN200880106604 A CN 200880106604A CN 200880106604 A CN200880106604 A CN 200880106604A CN 101802208 A CN101802208 A CN 101802208A
- Authority
- CN
- China
- Prior art keywords
- ester
- hydrophobic solvent
- fermented liquid
- biological product
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 63
- 230000004151 fermentation Effects 0.000 title claims abstract description 63
- 231100000331 toxic Toxicity 0.000 title abstract description 4
- 230000002588 toxic effect Effects 0.000 title abstract description 4
- 239000002994 raw material Substances 0.000 title description 20
- 239000012535 impurity Substances 0.000 title description 5
- 230000009467 reduction Effects 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 207
- 239000002904 solvent Substances 0.000 claims abstract description 145
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 132
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 130
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 129
- 239000006227 byproduct Substances 0.000 claims abstract description 47
- 150000002148 esters Chemical class 0.000 claims description 204
- 239000000047 product Substances 0.000 claims description 168
- 239000007788 liquid Substances 0.000 claims description 148
- 239000002253 acid Substances 0.000 claims description 63
- 239000002551 biofuel Substances 0.000 claims description 58
- 244000005700 microbiome Species 0.000 claims description 57
- 239000002028 Biomass Substances 0.000 claims description 54
- 108090000623 proteins and genes Proteins 0.000 claims description 39
- 150000002632 lipids Chemical class 0.000 claims description 37
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 claims description 33
- 239000000463 material Substances 0.000 claims description 33
- 150000001336 alkenes Chemical class 0.000 claims description 29
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 28
- 238000012360 testing method Methods 0.000 claims description 28
- -1 C18:1 ester Chemical class 0.000 claims description 27
- 150000002191 fatty alcohols Chemical class 0.000 claims description 24
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 claims description 24
- 102000005488 Thioesterase Human genes 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 23
- 108020002982 thioesterase Proteins 0.000 claims description 23
- RGHHSNMVTDWUBI-UHFFFAOYSA-N 4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1 RGHHSNMVTDWUBI-UHFFFAOYSA-N 0.000 claims description 20
- 150000002576 ketones Chemical class 0.000 claims description 20
- YIBXWXOYFGZLRU-UHFFFAOYSA-N syringic aldehyde Natural products CC12CCC(C3(CCC(=O)C(C)(C)C3CC=3)C)C=3C1(C)CCC2C1COC(C)(C)C(O)C(O)C1 YIBXWXOYFGZLRU-UHFFFAOYSA-N 0.000 claims description 19
- 229920002488 Hemicellulose Polymers 0.000 claims description 18
- JMSVCTWVEWCHDZ-UHFFFAOYSA-N syringic acid Chemical compound COC1=CC(C(O)=O)=CC(OC)=C1O JMSVCTWVEWCHDZ-UHFFFAOYSA-N 0.000 claims description 18
- 102000004190 Enzymes Human genes 0.000 claims description 17
- 108090000790 Enzymes Proteins 0.000 claims description 17
- 150000001299 aldehydes Chemical class 0.000 claims description 16
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims description 16
- 239000001913 cellulose Substances 0.000 claims description 16
- 229920002678 cellulose Polymers 0.000 claims description 16
- 230000014509 gene expression Effects 0.000 claims description 15
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 15
- 230000007062 hydrolysis Effects 0.000 claims description 15
- 238000006460 hydrolysis reaction Methods 0.000 claims description 15
- 238000002203 pretreatment Methods 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- HJZPSCOKFMKQHS-UHFFFAOYSA-N icosa-1,3,5,7,9,11,13,15,17,19-decaene Chemical compound C=CC=CC=CC=CC=CC=CC=CC=CC=CC=C HJZPSCOKFMKQHS-UHFFFAOYSA-N 0.000 claims description 12
- 150000002989 phenols Chemical class 0.000 claims description 12
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 11
- NOEGNKMFWQHSLB-UHFFFAOYSA-N 5-hydroxymethylfurfural Chemical compound OCC1=CC=C(C=O)O1 NOEGNKMFWQHSLB-UHFFFAOYSA-N 0.000 claims description 11
- RJGBSYZFOCAGQY-UHFFFAOYSA-N hydroxymethylfurfural Natural products COC1=CC=C(C=O)O1 RJGBSYZFOCAGQY-UHFFFAOYSA-N 0.000 claims description 11
- 150000002240 furans Chemical class 0.000 claims description 10
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 10
- 238000011081 inoculation Methods 0.000 claims description 10
- KCDXJAYRVLXPFO-UHFFFAOYSA-N syringaldehyde Chemical compound COC1=CC(C=O)=CC(OC)=C1O KCDXJAYRVLXPFO-UHFFFAOYSA-N 0.000 claims description 10
- 239000006188 syrup Substances 0.000 claims description 10
- 235000020357 syrup Nutrition 0.000 claims description 10
- IAEGWXHKWJGQAZ-UHFFFAOYSA-N trimethylpyrazine Chemical compound CC1=CN=C(C)C(C)=N1 IAEGWXHKWJGQAZ-UHFFFAOYSA-N 0.000 claims description 10
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000002699 waste material Substances 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 9
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims description 9
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 9
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims description 9
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims description 9
- 239000002023 wood Substances 0.000 claims description 9
- ZBCATMYQYDCTIZ-UHFFFAOYSA-N 4-methylcatechol Chemical compound CC1=CC=C(O)C(O)=C1 ZBCATMYQYDCTIZ-UHFFFAOYSA-N 0.000 claims description 8
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 claims description 8
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 8
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 8
- 235000012141 vanillin Nutrition 0.000 claims description 8
- 244000025254 Cannabis sativa Species 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 125000001931 aliphatic group Chemical group 0.000 claims description 7
- 230000008034 disappearance Effects 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- LNWWQYYLZVZXKS-UHFFFAOYSA-N 1-pyrrolidin-1-ylethanone Chemical compound CC(=O)N1CCCC1 LNWWQYYLZVZXKS-UHFFFAOYSA-N 0.000 claims description 5
- GOUHYARYYWKXHS-UHFFFAOYSA-N 4-formylbenzoic acid Chemical compound OC(=O)C1=CC=C(C=O)C=C1 GOUHYARYYWKXHS-UHFFFAOYSA-N 0.000 claims description 5
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 5
- 235000021314 Palmitic acid Nutrition 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 5
- 150000002475 indoles Chemical class 0.000 claims description 5
- IIISLCMALFIFKE-UHFFFAOYSA-N propan-2-yl furan-2-carboxylate Chemical compound CC(C)OC(=O)C1=CC=CO1 IIISLCMALFIFKE-UHFFFAOYSA-N 0.000 claims description 5
- 229940005605 valeric acid Drugs 0.000 claims description 5
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 229940070765 laurate Drugs 0.000 claims description 3
- 230000009466 transformation Effects 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 2
- NUHFUSJMFGONIZ-UHFFFAOYSA-N 4-hydroxybenzoic acid;terephthalic acid Chemical compound OC(=O)C1=CC=C(O)C=C1.OC(=O)C1=CC=C(C(O)=O)C=C1 NUHFUSJMFGONIZ-UHFFFAOYSA-N 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000002242 deionisation method Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 30
- 230000000813 microbial effect Effects 0.000 abstract description 3
- 238000010565 inoculated fermentation Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 142
- 239000003921 oil Substances 0.000 description 41
- 239000000126 substance Substances 0.000 description 39
- 239000003053 toxin Substances 0.000 description 39
- 231100000765 toxin Toxicity 0.000 description 39
- 239000000446 fuel Substances 0.000 description 29
- 241000588724 Escherichia coli Species 0.000 description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
- 230000001580 bacterial effect Effects 0.000 description 20
- 230000036983 biotransformation Effects 0.000 description 20
- 239000003208 petroleum Substances 0.000 description 19
- 235000014113 dietary fatty acids Nutrition 0.000 description 18
- 229930195729 fatty acid Natural products 0.000 description 18
- 239000000194 fatty acid Substances 0.000 description 18
- 230000012010 growth Effects 0.000 description 18
- 229920000642 polymer Polymers 0.000 description 16
- 239000010779 crude oil Substances 0.000 description 14
- 150000004665 fatty acids Chemical class 0.000 description 14
- 229930195733 hydrocarbon Natural products 0.000 description 14
- 150000002430 hydrocarbons Chemical class 0.000 description 14
- 239000004215 Carbon black (E152) Substances 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 13
- 238000000605 extraction Methods 0.000 description 13
- 238000012545 processing Methods 0.000 description 13
- 150000001720 carbohydrates Chemical class 0.000 description 12
- 235000014633 carbohydrates Nutrition 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 11
- 238000011084 recovery Methods 0.000 description 11
- 238000007670 refining Methods 0.000 description 11
- 230000008859 change Effects 0.000 description 10
- 101150016526 fadE gene Proteins 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 235000000346 sugar Nutrition 0.000 description 10
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 9
- 239000012071 phase Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 8
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 8
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 8
- 150000002194 fatty esters Chemical class 0.000 description 8
- 241000193830 Bacillus <bacterium> Species 0.000 description 7
- 241000192700 Cyanobacteria Species 0.000 description 7
- 239000002283 diesel fuel Substances 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 239000000314 lubricant Substances 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 7
- 230000002018 overexpression Effects 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 241000588625 Acinetobacter sp. Species 0.000 description 6
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 241000588902 Zymomonas mobilis Species 0.000 description 6
- 230000010261 cell growth Effects 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 230000002045 lasting effect Effects 0.000 description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- 150000007523 nucleic acids Chemical group 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- 239000001993 wax Substances 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- 241000191938 Micrococcus luteus Species 0.000 description 5
- 244000044822 Simmondsia californica Species 0.000 description 5
- 235000004433 Simmondsia californica Nutrition 0.000 description 5
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 125000001924 fatty-acyl group Chemical group 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 150000002894 organic compounds Chemical class 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000195493 Cryptophyta Species 0.000 description 4
- 241000252867 Cupriavidus metallidurans Species 0.000 description 4
- 101710088194 Dehydrogenase Proteins 0.000 description 4
- 101150071111 FADD gene Proteins 0.000 description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 4
- 241000190932 Rhodopseudomonas Species 0.000 description 4
- 241000607142 Salmonella Species 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000000295 fuel oil Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000004817 gas chromatography Methods 0.000 description 4
- 239000003502 gasoline Substances 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 108090001018 hexadecanal dehydrogenase (acylating) Proteins 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 230000001473 noxious effect Effects 0.000 description 4
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 4
- 101150112552 plsB gene Proteins 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000010902 straw Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 3
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 3
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 description 3
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 3
- 101100388296 Arabidopsis thaliana DTX51 gene Proteins 0.000 description 3
- 241000186063 Arthrobacter Species 0.000 description 3
- 241000228212 Aspergillus Species 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 108010018763 Biotin carboxylase Proteins 0.000 description 3
- 241001164374 Calyx Species 0.000 description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 3
- 239000005977 Ethylene Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 241000223198 Humicola Species 0.000 description 3
- 241000235395 Mucor Species 0.000 description 3
- 241000186359 Mycobacterium Species 0.000 description 3
- 108090000854 Oxidoreductases Proteins 0.000 description 3
- 102000004316 Oxidoreductases Human genes 0.000 description 3
- 241000219843 Pisum Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000316848 Rhodococcus <scale insect> Species 0.000 description 3
- 101100215626 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADP1 gene Proteins 0.000 description 3
- 241000122973 Stenotrophomonas maltophilia Species 0.000 description 3
- 241000187747 Streptomyces Species 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 239000005864 Sulphur Substances 0.000 description 3
- 235000011941 Tilia x europaea Nutrition 0.000 description 3
- 241000223259 Trichoderma Species 0.000 description 3
- 101100119785 Vibrio anguillarum (strain ATCC 68554 / 775) fatB gene Proteins 0.000 description 3
- 240000008042 Zea mays Species 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 3
- 101150070497 accC gene Proteins 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 230000001588 bifunctional effect Effects 0.000 description 3
- 235000011089 carbon dioxide Nutrition 0.000 description 3
- 229910002091 carbon monoxide Inorganic materials 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 239000004568 cement Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 150000002016 disaccharides Chemical class 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 101150026389 fabF gene Proteins 0.000 description 3
- 235000019253 formic acid Nutrition 0.000 description 3
- 239000005431 greenhouse gas Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 239000004571 lime Substances 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 3
- 229920001542 oligosaccharide Polymers 0.000 description 3
- 239000012074 organic phase Substances 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 2
- 241000186361 Actinobacteria <class> Species 0.000 description 2
- 102000057234 Acyl transferases Human genes 0.000 description 2
- 108700016155 Acyl transferases Proteins 0.000 description 2
- 102100027841 Acyl-CoA wax alcohol acyltransferase 2 Human genes 0.000 description 2
- 241000908790 Alcanivorax jadensis Species 0.000 description 2
- 241000609240 Ambelania acida Species 0.000 description 2
- 241001513093 Aspergillus awamori Species 0.000 description 2
- 241001225321 Aspergillus fumigatus Species 0.000 description 2
- 241000351920 Aspergillus nidulans Species 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 2
- 240000006439 Aspergillus oryzae Species 0.000 description 2
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 2
- 241000193744 Bacillus amyloliquefaciens Species 0.000 description 2
- 101100012355 Bacillus anthracis fabH1 gene Proteins 0.000 description 2
- 241000193752 Bacillus circulans Species 0.000 description 2
- 241000193749 Bacillus coagulans Species 0.000 description 2
- 241000193422 Bacillus lentus Species 0.000 description 2
- 241000194108 Bacillus licheniformis Species 0.000 description 2
- 241000194107 Bacillus megaterium Species 0.000 description 2
- 241000194103 Bacillus pumilus Species 0.000 description 2
- 101100000756 Bacillus subtilis (strain 168) acpA gene Proteins 0.000 description 2
- 101100012357 Bacillus subtilis (strain 168) fabHA gene Proteins 0.000 description 2
- 241000193388 Bacillus thuringiensis Species 0.000 description 2
- 241000193764 Brevibacillus brevis Species 0.000 description 2
- 241000123346 Chrysosporium Species 0.000 description 2
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 241000186216 Corynebacterium Species 0.000 description 2
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 description 2
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 description 2
- 108050004099 Diacylglycerol O-acyltransferase 1 Proteins 0.000 description 2
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 description 2
- 239000004278 EU approved seasoning Substances 0.000 description 2
- 241000588722 Escherichia Species 0.000 description 2
- 108091029865 Exogenous DNA Proteins 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 241000186530 Gottschalkia acidurici Species 0.000 description 2
- 241000606768 Haemophilus influenzae Species 0.000 description 2
- 244000020551 Helianthus annuus Species 0.000 description 2
- 235000003222 Helianthus annuus Nutrition 0.000 description 2
- 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 2
- 241000235649 Kluyveromyces Species 0.000 description 2
- 241000191948 Kocuria rosea Species 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 101100393312 Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) gpsA1 gene Proteins 0.000 description 2
- 102100027329 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Human genes 0.000 description 2
- 231100000757 Microbial toxin Toxicity 0.000 description 2
- 241000294598 Moritella marina Species 0.000 description 2
- 241000907999 Mortierella alpina Species 0.000 description 2
- 102000002568 Multienzyme Complexes Human genes 0.000 description 2
- 108010093369 Multienzyme Complexes Proteins 0.000 description 2
- 101100412856 Mus musculus Rhod gene Proteins 0.000 description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
- 241000221960 Neurospora Species 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 241000228143 Penicillium Species 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 241000235648 Pichia Species 0.000 description 2
- 241000222350 Pleurotus Species 0.000 description 2
- 101710091608 Probable diacyglycerol O-acyltransferase tgs2 Proteins 0.000 description 2
- 241000589540 Pseudomonas fluorescens Species 0.000 description 2
- 241000235402 Rhizomucor Species 0.000 description 2
- 241000235403 Rhizomucor miehei Species 0.000 description 2
- 241000191033 Rhodomicrobium vannielii Species 0.000 description 2
- 240000000111 Saccharum officinarum Species 0.000 description 2
- 235000007201 Saccharum officinarum Nutrition 0.000 description 2
- 241000235346 Schizosaccharomyces Species 0.000 description 2
- 241001250070 Sporisorium reilianum Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 244000057717 Streptococcus lactis Species 0.000 description 2
- 235000014897 Streptococcus lactis Nutrition 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 241000192707 Synechococcus Species 0.000 description 2
- 241000775848 Syringa oblata Species 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 101100242191 Tetraodon nigroviridis rho gene Proteins 0.000 description 2
- 241000222354 Trametes Species 0.000 description 2
- 241000499912 Trichoderma reesei Species 0.000 description 2
- 244000301083 Ustilago maydis Species 0.000 description 2
- 235000015919 Ustilago maydis Nutrition 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 241001148070 Vibrio furnissii Species 0.000 description 2
- 206010047400 Vibrio infections Diseases 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 241000235015 Yarrowia lipolytica Species 0.000 description 2
- 101150008263 accD gene Proteins 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 101150023061 acpP gene Proteins 0.000 description 2
- 101150051130 acpP1 gene Proteins 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001345 alkine derivatives Chemical class 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 229940054340 bacillus coagulans Drugs 0.000 description 2
- 229940097012 bacillus thuringiensis Drugs 0.000 description 2
- 239000010905 bagasse Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 238000009412 basement excavation Methods 0.000 description 2
- KPGXRSRHYNQIFN-UHFFFAOYSA-N beta-keto-glutaric acid Natural products OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 2
- 239000003225 biodiesel Substances 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000002051 biphasic effect Effects 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 150000001721 carbon Chemical class 0.000 description 2
- 230000003915 cell function Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 2
- 239000005516 coenzyme A Substances 0.000 description 2
- 229940093530 coenzyme a Drugs 0.000 description 2
- 238000013016 damping Methods 0.000 description 2
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
- VLYUGYAKYZETRF-UHFFFAOYSA-N dihydrolipoamide Chemical compound NC(=O)CCCCC(S)CCS VLYUGYAKYZETRF-UHFFFAOYSA-N 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000005553 drilling Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 125000004494 ethyl ester group Chemical group 0.000 description 2
- 239000002360 explosive Substances 0.000 description 2
- 101150090981 fabG gene Proteins 0.000 description 2
- 101150035981 fabH gene Proteins 0.000 description 2
- 239000002921 fermentation waste Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 101150095733 gpsA gene Proteins 0.000 description 2
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 description 2
- 239000000413 hydrolysate Substances 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 235000011073 invertase Nutrition 0.000 description 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 101150041530 ldha gene Proteins 0.000 description 2
- 239000003915 liquefied petroleum gas Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 108010062385 long-chain-alcohol O-fatty-acyltransferase Proteins 0.000 description 2
- 239000010687 lubricating oil Substances 0.000 description 2
- 101150068528 mabA gene Proteins 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- 239000003345 natural gas Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 150000002972 pentoses Chemical class 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 239000003209 petroleum derivative Substances 0.000 description 2
- 229960003742 phenol Drugs 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 229940107700 pyruvic acid Drugs 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 239000004711 α-olefin Substances 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- NLJVXZFCYKWXLH-DXTIXLATSA-N 3-[(3r,6s,9s,12s,15s,17s,20s,22r,25s,28s)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-3,22,25-tribenzyl-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan Chemical compound C([C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(N[C@H](CC=2C=CC=CC=2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)N1)=O)CC(C)C)C(C)C)C1=CC=C(O)C=C1 NLJVXZFCYKWXLH-DXTIXLATSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 241000023308 Acca Species 0.000 description 1
- 101100230376 Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) celI gene Proteins 0.000 description 1
- 241000897241 Acinetobacter sp. ADP1 Species 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 101710104255 Acyl-CoA wax alcohol acyltransferase 2 Proteins 0.000 description 1
- 241000611270 Alcanivorax borkumensis Species 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- OSDWBNJEKMUWAV-UHFFFAOYSA-N Allyl chloride Chemical group ClCC=C OSDWBNJEKMUWAV-UHFFFAOYSA-N 0.000 description 1
- 241000221832 Amorphotheca resinae Species 0.000 description 1
- 241000192705 Aphanothece Species 0.000 description 1
- 241000219195 Arabidopsis thaliana Species 0.000 description 1
- 241000186073 Arthrobacter sp. Species 0.000 description 1
- 241000432824 Asparagus densiflorus Species 0.000 description 1
- 241000892910 Aspergillus foetidus Species 0.000 description 1
- 241000223678 Aureobasidium pullulans Species 0.000 description 1
- 241001328122 Bacillus clausii Species 0.000 description 1
- 241000006382 Bacillus halodurans Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 101100378010 Bacillus subtilis (strain 168) accC1 gene Proteins 0.000 description 1
- 101100322122 Bacillus subtilis (strain 168) accC2 gene Proteins 0.000 description 1
- 101100127701 Bacillus subtilis (strain 168) lcfB gene Proteins 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 241000588807 Bordetella Species 0.000 description 1
- 241001536303 Botryococcus braunii Species 0.000 description 1
- 241000616257 Calothrix scopulorum Species 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 244000281594 Cassia siamea Species 0.000 description 1
- 229920000324 Cellulosome Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000191366 Chlorobium Species 0.000 description 1
- 241000191358 Chlorobium sp. Species 0.000 description 1
- 241000192702 Chlorogloeopsis fritschii Species 0.000 description 1
- 241000190831 Chromatium Species 0.000 description 1
- 208000031639 Chromosome Deletion Diseases 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000186542 Clostridium baratii Species 0.000 description 1
- 241000193171 Clostridium butyricum Species 0.000 description 1
- 241000193469 Clostridium pasteurianum Species 0.000 description 1
- 101100490145 Clostridium perfringens (strain 13 / Type A) ackA2 gene Proteins 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 241000589519 Comamonas Species 0.000 description 1
- 241000589518 Comamonas testosteroni Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
- 240000006262 Cuphea hookeriana Species 0.000 description 1
- 241000580885 Cutaneotrichosporon curvatus Species 0.000 description 1
- 101150042222 DGAT1 gene Proteins 0.000 description 1
- 241000192652 Desmonostoc muscorum Species 0.000 description 1
- 241000605716 Desulfovibrio Species 0.000 description 1
- 241000605739 Desulfovibrio desulfuricans Species 0.000 description 1
- 101710088335 Diacylglycerol acyltransferase/mycolyltransferase Ag85A Proteins 0.000 description 1
- 101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 description 1
- 101710088427 Diacylglycerol acyltransferase/mycolyltransferase Ag85C Proteins 0.000 description 1
- PXIKRTCSSLJURC-UHFFFAOYSA-N Dihydroeugenol Chemical compound CCCC1=CC=C(O)C(OC)=C1 PXIKRTCSSLJURC-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 101100502354 Escherichia coli (strain K12) fadK gene Proteins 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- 102000000476 Fatty Acid Transport Proteins Human genes 0.000 description 1
- 108010055870 Fatty Acid Transport Proteins Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 101710109177 Formate acetyltransferase 1 Proteins 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241000193385 Geobacillus stearothermophilus Species 0.000 description 1
- 108030000884 Glycerol-3-phosphate 1-O-acyltransferases Proteins 0.000 description 1
- 102100024017 Glycerol-3-phosphate acyltransferase 3 Human genes 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 101100135734 Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) pccB gene Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001480714 Humicola insolens Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 241000058981 Jeotgalicoccus sp. Species 0.000 description 1
- 241000902907 Kineococcus radiotolerans Species 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 101100433987 Latilactobacillus sakei subsp. sakei (strain 23K) ackA1 gene Proteins 0.000 description 1
- 244000182802 Mentha sylvestris Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
- 241000191936 Micrococcus sp. Species 0.000 description 1
- 241000179980 Microcoleus Species 0.000 description 1
- 241000264662 Microcoleus vaginatus Species 0.000 description 1
- 241001646725 Mycobacterium tuberculosis H37Rv Species 0.000 description 1
- 108700035964 Mycobacterium tuberculosis HsaD Proteins 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 241000605121 Nitrosomonas europaea Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical class CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000565771 Oscillatoria williamsii Species 0.000 description 1
- 241001668545 Pascopyrum Species 0.000 description 1
- 241000222385 Phanerochaete Species 0.000 description 1
- 101100462488 Phlebiopsis gigantea p2ox gene Proteins 0.000 description 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 description 1
- 241000424636 Plectonema terebrans Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical group CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241001240958 Pseudomonas aeruginosa PAO1 Species 0.000 description 1
- 108010042687 Pyruvate Oxidase Proteins 0.000 description 1
- 241000232299 Ralstonia Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241001148115 Rhizobium etli Species 0.000 description 1
- 241001524101 Rhodococcus opacus Species 0.000 description 1
- 241000190950 Rhodopseudomonas palustris Species 0.000 description 1
- 241000190967 Rhodospirillum Species 0.000 description 1
- 241000223252 Rhodotorula Species 0.000 description 1
- 241000223253 Rhodotorula glutinis Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241000235088 Saccharomyces sp. Species 0.000 description 1
- 241001489223 Saccharomycodes Species 0.000 description 1
- 241001489222 Saccharomycodes ludwigii Species 0.000 description 1
- 241000831652 Salinivibrio sharmensis Species 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 241000881771 Serratia rubidaea Species 0.000 description 1
- 241000221095 Simmondsia Species 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241001062472 Stokellia anisodon Species 0.000 description 1
- 101100398785 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) ldhD gene Proteins 0.000 description 1
- 241000187398 Streptomyces lividans Species 0.000 description 1
- 241001468239 Streptomyces murinus Species 0.000 description 1
- 241001655322 Streptomycetales Species 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 241001453313 Synechococcus sp. PCC 7002 Species 0.000 description 1
- 241000223258 Thermomyces lanuginosus Species 0.000 description 1
- 241001554087 Thiobacterium Species 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 241000378866 Trichoderma koningii Species 0.000 description 1
- 241000223262 Trichoderma longibrachiatum Species 0.000 description 1
- 241000223261 Trichoderma viride Species 0.000 description 1
- 241000192118 Trichodesmium Species 0.000 description 1
- DRQXUCVJDCRJDB-UHFFFAOYSA-N Turanose Natural products OC1C(CO)OC(O)(CO)C1OC1C(O)C(O)C(O)C(CO)O1 DRQXUCVJDCRJDB-UHFFFAOYSA-N 0.000 description 1
- 108010021006 Tyrothricin Proteins 0.000 description 1
- 101150014930 UFM1 gene Proteins 0.000 description 1
- 241000218199 Umbellularia Species 0.000 description 1
- 241000083901 Urocystis agropyri Species 0.000 description 1
- 241000221566 Ustilago Species 0.000 description 1
- 241000007070 Ustilago nuda Species 0.000 description 1
- 241000092104 Vibrio ponticus Species 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 241000235013 Yarrowia Species 0.000 description 1
- 241000235017 Zygosaccharomyces Species 0.000 description 1
- 101100386830 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) ddh gene Proteins 0.000 description 1
- 101150046124 accA gene Proteins 0.000 description 1
- 101150013885 accB gene Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 108020002494 acetyltransferase Proteins 0.000 description 1
- 102000005421 acetyltransferase Human genes 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 101150006213 ackA gene Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 101150014383 adhE gene Proteins 0.000 description 1
- WQZGKKKJIJFFOK-PQMKYFCFSA-N alpha-D-mannose Chemical compound OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-PQMKYFCFSA-N 0.000 description 1
- SRBFZHDQGSBBOR-LECHCGJUSA-N alpha-D-xylose Chemical compound O[C@@H]1CO[C@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-LECHCGJUSA-N 0.000 description 1
- SRBFZHDQGSBBOR-QMKXCQHVSA-N alpha-L-arabinopyranose Chemical compound O[C@H]1CO[C@@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-QMKXCQHVSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940091771 aspergillus fumigatus Drugs 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- TWFZGCMQGLPBSX-UHFFFAOYSA-N carbendazim Chemical compound C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000004177 carbon cycle Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 238000004523 catalytic cracking Methods 0.000 description 1
- 238000001833 catalytic reforming Methods 0.000 description 1
- 230000010307 cell transformation Effects 0.000 description 1
- 210000000166 cellulosome Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 150000001924 cycloalkanes Chemical class 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 108010003123 dihydrolipoamide acyltransferase Proteins 0.000 description 1
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 150000002081 enamines Chemical class 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 108010083294 ethanol acyltransferase Proteins 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 101150061398 fabR gene Proteins 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000003063 flame retardant Substances 0.000 description 1
- 108010008221 formate C-acetyltransferase Proteins 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 125000003745 glyceroyl group Chemical group C(C(O)CO)(=O)* 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- NYMPGSQKHIOWIO-UHFFFAOYSA-N hydroxy(diphenyl)silicon Chemical compound C=1C=CC=CC=1[Si](O)C1=CC=CC=C1 NYMPGSQKHIOWIO-UHFFFAOYSA-N 0.000 description 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 239000004434 industrial solvent Substances 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 101150026107 ldh1 gene Proteins 0.000 description 1
- 235000021190 leftovers Nutrition 0.000 description 1
- 229940040102 levulinic acid Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- LTYOQGRJFJAKNA-IJCONWDESA-N malonyl-coenzyme a Chemical compound O[C@@H]1[C@@H](OP(O)(O)=O)[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-IJCONWDESA-N 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012269 metabolic engineering Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003990 molecular pathway Effects 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 101150111581 pflB gene Proteins 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 101150060030 poxB gene Proteins 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002719 pyrimidine nucleotide Substances 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229920003987 resole Polymers 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 101150025220 sacB gene Proteins 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 238000004230 steam cracking Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 101150087812 tesA gene Proteins 0.000 description 1
- 101150026728 tesB gene Proteins 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- RULSWEULPANCDV-PIXUTMIVSA-N turanose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](C(=O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RULSWEULPANCDV-PIXUTMIVSA-N 0.000 description 1
- 229960003281 tyrothricin Drugs 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000009614 wildtype growth Effects 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- 239000008096 xylene Chemical class 0.000 description 1
- 229960003487 xylose Drugs 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 101150077217 yhfL gene Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/649—Biodiesel, i.e. fatty acid alkyl esters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
登录号 | 生物来源 | 基因 |
AAC73596 | E.coli | 不带前导序列的 tesA |
AAC73555 | E.coli | tesB |
登录号 | 生物来源 | 基因 |
Q41635,AAA34215 | 加利福尼亚桂树(Umbellularia California) | fatB |
AAC49269 | 萼距花(Cuphea hookeriana) | fatB2 |
Q39513;AAC72881 | 萼距花 | fatB3 |
Q39473,AAC49151 | 樟树(Cinnamonum camphorum) | fatB |
CAA85388 | 拟南芥(Arabidopsis thaliana) | fatB[M141T]* |
NP 189147:NP 193041 | 拟南 | fatA |
CAC39106 | 大豆慢生根瘤菌 (Bradvrhiizobium japonicum) | fatA |
AAC72883 | 萼距花 | fatA |
AAL79361 | 向日葵(Helianthus annus) | fatA1 |
基因名称/基因座 | 来源 | NCBI ID | 与E.coliFadD的同一性% | 与E.coliFadD的相似性% |
fadD | E.coli | NP_416319 | - | - |
fadK | E.coli | YP_416216 | 45 | 27 |
fadD | 不动杆菌(Acinetobacter sp.)ADP1 | YP_045024 | 51 | 70 |
fadD | 流感嗜血菌(Haemophilusinfluenza)RdKW20 | NP_438551 | 64 | 78 |
BH3103 | 嗜碱芽孢杆菌(Bacillushalodurans)C-125 | NP_243969 | 40 | 58 |
yhfL | 枯草芽孢杆菌 | NP_388908 | 39 | 57 |
Pfl-4354 | 荧光假单胞菌(Pseudomonasfluorescens)Pfo-1 | YP_350082 | 52 | 71 |
EAV15023 | 睾丸酮丛毛单胞菌(Comamonas testosterone)KF-1 | ZP_01520072 | 55 | 72 |
fadD1 | 铜绿假单胞菌(Pseudomonasaeruginosa) | NP_251989 | 54 | 72 |
fadD2 | 铜绿假单胞菌PAO1 | NP_251990 | 55 | 72 |
fadD | 根瘤菌(Rhizobium etli)CFN42 | YP_533919 | 55 | 72 |
RPC_4074 | 血色红假单胞菌(Rhodopseudomo naspalustris)Bis B18 | YP_533919 | 56 | 72 |
fadD1 | 茄科雷尔氏菌(RasltoniaSolanacearum)GMI 1000 | NP_520978 | 56 | 72 |
fadDD35 | 结核分支杆菌(Mycobacterium tuberculosis)H37Rv | NP_217021 | 28 | 46 |
基因名称/基因座 | 来源 | NCBI ID | 与E.coliFadD的同一性% | 与E.coliFadD的相似性% |
fadDD22 | 结核分支杆菌H37Rv | NP_217464 | 23 | 42 |
PRK0059 | 嗜麦芽糖寡养单胞菌(StenotrophomonasMaltophilia)R551-3 | ZP_01644857 | 59 | 75 |
毒素 | 报道的MIC(g/L) | LS9-ID1的%抑制 |
对照 | 0 | 0 |
糠醛 | 3.5 | 100 |
丁香醛 | 2.5 | 100 |
4-羟基苯甲醛 | 1.25 | 100 |
5-羟甲基糠醛 | 4.0 | 100 |
4-甲基儿茶酚 | 1.5 | 25 |
邻甲氧基苯酚 | 3.0 | 100 |
Claims (102)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97579807P | 2007-09-27 | 2007-09-27 | |
US60/975,798 | 2007-09-27 | ||
PCT/US2008/077996 WO2009042950A1 (en) | 2007-09-27 | 2008-09-26 | Reduction of the toxic effect of impurities from raw materials by extractive fermentation |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101802208A true CN101802208A (zh) | 2010-08-11 |
CN101802208B CN101802208B (zh) | 2016-05-18 |
Family
ID=40319594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880106604.7A Expired - Fee Related CN101802208B (zh) | 2007-09-27 | 2008-09-26 | 通过提取式发酵减少原料中杂质的毒性作用 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8313934B2 (zh) |
CN (1) | CN101802208B (zh) |
AU (1) | AU2008304180B2 (zh) |
CA (1) | CA2692266C (zh) |
WO (1) | WO2009042950A1 (zh) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
US20100199548A1 (en) * | 2007-07-06 | 2010-08-12 | Ls9, Inc. | Systems and methods for the production of fatty esters |
US8183028B2 (en) * | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
CN102027109B (zh) * | 2008-05-16 | 2016-01-06 | Reg生命科学有限责任公司 | 产生碳氢化合物的方法和组合物 |
WO2010021711A1 (en) * | 2008-08-18 | 2010-02-25 | Ls9, Inc. | Systems and methods for the production of mixed fatty esters |
BRPI0920650A2 (pt) * | 2008-10-07 | 2019-08-27 | Ls9 Inc | métodos para produzir um aldeído graxo, microrganismo geneticamente modificado, aldeído graxo |
CN102264910B (zh) | 2008-10-28 | 2015-08-26 | Reg生命科学有限责任公司 | 用于产生脂肪醇的方法和组合物 |
US8835137B2 (en) | 2008-12-23 | 2014-09-16 | Matrix Genetics, Llc | Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products |
AU2009329970B2 (en) | 2008-12-23 | 2016-07-28 | Genomatica, Inc. | Methods and compositions related to thioesterase enzymes |
US8512774B2 (en) * | 2009-03-03 | 2013-08-20 | Eyal Research Consultants Ltd | Fermentation processes |
US8138371B2 (en) | 2009-03-11 | 2012-03-20 | Biofine Technologies Llc | Production of formic acid |
BR122018010309B1 (pt) | 2009-04-02 | 2020-11-10 | Amyris, Inc. | métodos de estabilização e de hidrogenação para olefinas micróbio-derivadas |
CN102459569B (zh) * | 2009-04-10 | 2018-02-23 | Reg生命科学有限责任公司 | 脂肪酸衍生物的产生 |
WO2010118410A1 (en) * | 2009-04-10 | 2010-10-14 | Ls9, Inc. | Production of fatty acid derivatives |
CN111808892A (zh) | 2009-04-27 | 2020-10-23 | 基因组股份公司 | 脂肪酸酯的产生 |
BR112012006801A2 (pt) | 2009-09-27 | 2018-04-10 | Opx Biotechnologies Inc | método para produção de ácido 3-hidroxipropiônico e outros produtos |
US20110124071A1 (en) * | 2009-11-17 | 2011-05-26 | LS9, Inc | Methods and compositions for producing hydrocarbons |
WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
WO2011127069A1 (en) | 2010-04-06 | 2011-10-13 | Targeted Growth, Inc. | Modified photosynthetic microorganisms for producing lipids |
WO2011155799A2 (ko) * | 2010-06-10 | 2011-12-15 | 한국과학기술원 | 탄화수소 생성능을 가지는 변이 미생물 및 이를 이용한 탄화수소의 제조방법 |
US9040263B2 (en) | 2010-07-28 | 2015-05-26 | Butamax Advanced Biofuels Llc | Production of alcohol esters and in situ product removal during alcohol fermentation |
BR112012032172A2 (pt) | 2010-06-18 | 2015-11-24 | Butamax Tm Advanced Biofuels | método para produzir um álcool e composição |
EP2585606A4 (en) | 2010-06-26 | 2016-02-17 | Virdia Ltd | SUGAR MIXTURES, METHODS OF PRODUCTION AND USE THEREOF |
EP2678410B1 (en) | 2011-02-17 | 2017-09-13 | The Procter and Gamble Company | Composiitons comprising mixtures of c10-c13 alkylphenyl sulfonates |
RU2013136501A (ru) | 2011-02-17 | 2015-03-27 | Дзе Проктер Энд Гэмбл Компани | Линейные алкилфенилсульфонаты на основе биологического сырья |
US20120290221A1 (en) * | 2011-05-09 | 2012-11-15 | Abengoa Bioenergia Nuevas Tecnologias, S.A. | System and method for measuring ghg emissions associated to bioproduct industry |
US20120290205A1 (en) * | 2011-05-09 | 2012-11-15 | Abengoa Bioenergia Nuevas Technologias, S.A. | System and method for measuring ghg emissions in bioproduct production processes |
US20120290220A1 (en) * | 2011-05-09 | 2012-11-15 | Abengoa Bioenergia Nuevas Tecnologias, S.A. | System and method for calculating greenhouse gas emissions in the production of raw material for obtaining bioproducts |
BRPI1105142B1 (pt) * | 2011-12-07 | 2019-12-24 | Univ Estadual Campinas Unicamp | processo de fermentação extrativa e uso do mesmo |
SG11201501013PA (en) | 2012-08-10 | 2015-04-29 | Opx Biotechnologies Inc | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
US9546361B2 (en) | 2012-10-12 | 2017-01-17 | Lehigh University | Thermally stable enzymes, compositions thereof and methods of using same |
CA2891353A1 (en) | 2012-12-12 | 2014-06-19 | REG Life Sciences, LLC | Acp-mediated production of fatty acid derivatives |
US20150119601A1 (en) | 2013-03-15 | 2015-04-30 | Opx Biotechnologies, Inc. | Monofunctional mcr + 3-hp dehydrogenase |
CN105378486B (zh) | 2013-06-14 | 2024-05-14 | 基因组股份公司 | 生产omega-羟基化的脂肪酸衍生物的方法 |
US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
BR112016001026A2 (pt) | 2013-07-19 | 2017-10-24 | Cargill Inc | organismo geneticamente modificado |
US9469586B2 (en) | 2013-08-19 | 2016-10-18 | REG Life Sciences, LLC | Production of partially refined waste glycerol |
CA2921625C (en) | 2013-08-19 | 2020-05-26 | REG Life Sciences, LLC | Production of partially refined waste glycerol |
CN105705513B (zh) | 2013-09-13 | 2021-06-01 | 基因组股份公司 | 改进的乙酰-coa羧化酶变体 |
WO2015157719A1 (en) | 2014-04-10 | 2015-10-15 | REG Life Sciences, LLC | Semisynthetic routes to organic compounds |
BR112016029235B1 (pt) | 2014-06-16 | 2023-11-28 | Genomatica, Inc | Variante de polipeptídeo de fusão híbrida cyp153a-redutase, célula hospedeira recombinante, cultura de células, método de produção de um ácido graxo ômega-hidroxilado que possui um aumento na titulação e microorganismo recombinante |
CA2955370A1 (en) | 2014-07-18 | 2016-01-21 | REG Life Sciences, LLC | Microbial production of fatty diols |
EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
WO2017101987A1 (en) | 2015-12-15 | 2017-06-22 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
MX2019002913A (es) | 2016-09-14 | 2019-10-15 | Reg Life Sciences Llc | Compuestos de 1,3-dioles grasos y sus derivados. |
EP3354742A1 (en) | 2017-01-26 | 2018-08-01 | Metabolic Explorer | Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid |
CN110494566A (zh) | 2017-02-02 | 2019-11-22 | 嘉吉公司 | 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞 |
CN111094558A (zh) | 2017-04-03 | 2020-05-01 | 基因组股份公司 | 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5158887A (en) * | 1990-09-09 | 1992-10-27 | Hsu Edward J | Process for massive conversion of clostridia in synchronized cells of elongated length or refractile endospores |
EP2295595B1 (en) * | 2000-01-19 | 2019-05-01 | DSM IP Assets B.V. | Solventless extraction process |
JP3740062B2 (ja) * | 2000-02-24 | 2006-01-25 | テバ ジョジセルジャール レースベニュタールシャシャーグ | 培養液の精製方法 |
US20070192900A1 (en) * | 2006-02-14 | 2007-08-16 | Board Of Trustees Of Michigan State University | Production of beta-glucosidase, hemicellulase and ligninase in E1 and FLC-cellulase-transgenic plants |
US7566813B2 (en) * | 2002-03-21 | 2009-07-28 | Monsanto Technology, L.L.C. | Nucleic acid constructs and methods for producing altered seed oil compositions |
US7056714B2 (en) * | 2003-03-11 | 2006-06-06 | University Of Iowa Research Foundation, Inc. | Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use |
US7652167B2 (en) * | 2004-07-19 | 2010-01-26 | Board Of Trustees Of Michigan State University | Process for production of organic acid esters |
WO2008100251A1 (en) | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
US8535916B2 (en) * | 2006-02-13 | 2013-09-17 | Ls9, Inc. | Modified microorganisms and uses therefor |
DE102006022718B4 (de) * | 2006-05-16 | 2008-10-02 | Clariant International Limited | Zusammensetzung von Brennstoffölen |
US8110670B2 (en) * | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
US20100242345A1 (en) * | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
ES2529176T3 (es) * | 2006-05-19 | 2015-02-17 | Ls9, Inc. | Producción de ácidos grasos y derivados de los mismos |
EP2129785B2 (en) | 2007-03-28 | 2021-11-17 | Genomatica, Inc. | Enhanced production of fatty acid derivatives |
US20100199548A1 (en) * | 2007-07-06 | 2010-08-12 | Ls9, Inc. | Systems and methods for the production of fatty esters |
-
2008
- 2008-09-26 US US12/239,562 patent/US8313934B2/en not_active Expired - Fee Related
- 2008-09-26 AU AU2008304180A patent/AU2008304180B2/en not_active Ceased
- 2008-09-26 WO PCT/US2008/077996 patent/WO2009042950A1/en active Application Filing
- 2008-09-26 CA CA2692266A patent/CA2692266C/en not_active Expired - Fee Related
- 2008-09-26 CN CN200880106604.7A patent/CN101802208B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2008304180B2 (en) | 2014-02-27 |
CA2692266A1 (en) | 2009-04-02 |
WO2009042950A1 (en) | 2009-04-02 |
US8313934B2 (en) | 2012-11-20 |
CA2692266C (en) | 2019-04-16 |
AU2008304180A1 (en) | 2009-04-02 |
US20090084025A1 (en) | 2009-04-02 |
CN101802208B (zh) | 2016-05-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101802208B (zh) | 通过提取式发酵减少原料中杂质的毒性作用 | |
Vyas et al. | Isolation, identification and characterization of Cystobasidium oligophagum JRC1: A cellulase and lipase producing oleaginous yeast | |
Elbahloul et al. | Pilot-scale production of fatty acid ethyl esters by an engineered Escherichia coli strain harboring the p (Microdiesel) plasmid | |
Arora et al. | Co-culturing of oleaginous microalgae and yeast: paradigm shift towards enhanced lipid productivity | |
CN102712858B (zh) | 在重组异养型微生物中制备特制油 | |
CA2822322C (en) | An integrated process for producing biofuels | |
JP2019013258A (ja) | バイオリファイナリーシステム、その方法および組成物 | |
US20140038248A1 (en) | Product of fatty acid esters from biomass polymers | |
WO2010022090A1 (en) | Systems and methods for the production of mixed fatty esters | |
Rodrigues Reis et al. | Critical applications of Mucor circinelloides within a biorefinery context | |
US8870980B2 (en) | Process for producing enzymes | |
Caporusso et al. | Conversion of cardoon crop residues into single cell oils by Lipomyces tetrasporus and Cutaneotrichosporon curvatus: Process optimizations to overcome the microbial inhibition of lignocellulosic hydrolysates | |
Bardhan et al. | Microbes as bio-resource for sustainable production of biofuels and other bioenergy products | |
EP2465868B1 (en) | Improvement of lipid production | |
Hashemizadeh et al. | A comparative study of immobilized-whole cell and commercial lipase as a biocatalyst for biodiesel production from soybean oil | |
Mahmoud et al. | Recent advancements in biofuels production with a special attention to fungi | |
Shaheen et al. | Oleaginous microbes for biodiesel production using lignocellulosic biomass as feedstock | |
Uma et al. | Microbial Biofuels–A Comprehensive view | |
Mangla et al. | Biofuels: an overview with special emphasis on biodiesel and the role of lipase enzyme in its synthesis | |
Klein | Use of fungi to aid the implementation of biofuels amid the current energy crisis | |
Madavi et al. | Biofuels: Fueling the Future with Whole-Cell-Derived Fuels | |
Rezahasani et al. | Sugar fermentation: C4 platforms | |
Yehia et al. | Recent advancements in biofuels production with a special attention to fungi | |
Showkat et al. | Biotechnological Intercession in Biofuel Production | |
Choudhury et al. | Microbes and biofuel production. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: REG LIFE SCIENCES, LLC Free format text: FORMER OWNER: LS9 INC. Effective date: 20141124 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20141124 Address after: American California Applicant after: REG Life Sciences Co.,Ltd. Address before: California, South San Francisco, USA Applicant before: Ls9 Inc. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20191213 Address after: California, USA Patentee after: Genomatica, Inc. Address before: California, USA Patentee before: REG Life Sciences Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160518 Termination date: 20200926 |