CN101801367A - The expellent and the expelling method thereof of fish pathogens antibacterial class - Google Patents
The expellent and the expelling method thereof of fish pathogens antibacterial class Download PDFInfo
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- CN101801367A CN101801367A CN200780100210A CN200780100210A CN101801367A CN 101801367 A CN101801367 A CN 101801367A CN 200780100210 A CN200780100210 A CN 200780100210A CN 200780100210 A CN200780100210 A CN 200780100210A CN 101801367 A CN101801367 A CN 101801367A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
As cheap, safe and to the disease antibacterials of the Fish expellent of the disease antibacterial of the bacterial disease of slipping etc. of Yellowtail fish, snapper, flounder for example with high effect, in order to organic acid as the inorganic agent of main constituent to parasitism the Fish of disease antibacterial class handle, can securely and effectively prevent and drive away disease antibacterial class thus.
Description
Technical field
The present invention relates in the breed of Fish, to be used to drive away expellent and expelling method thereof in the fish pathogens antibacterial class of Fish surface or the inner pathogenic bacteria class of adhering to and even breeding.
Background technology
In the field of fish culture, it is indispensable for the output that improves the breed fish driving away in the surperficial or inner antibacterial class of adhering to and even breeding of Fish.
For the bacterial disease of Fish, known have a multiple bacterial disease, can list vibriosis, pseudotuberculosis, streptococcicosis, nocardiosis, the bacterial disease of slipping, the fish bud mycete disease of Yellowtail fish particularly; The vibriosis of snapper, Ai Dehuashi disease, the bacterial disease of slipping; The hemorrhagic septicemia of black porgy; The streptococcicosis of oplegnathus fasciatus, achromobacter disease; The streptococcicosis of flounder (being also referred to as Paralichthys olivaceus), Ai Dehuashi disease, nocardiosis, the bacterial disease of slipping, vibriosis, streptococcicosis; Vibriosis, streptococcicosis, the bacterial disease of slipping of black Cao fish (Kurosoi); The nocardiosis of tuna; The vibriosis of Anguillar japonica, red fin fish disease, head Peptic Ulcers, red spot disease, edwardsiella tarda disease, column disease, streptococcicosis, skin sporidiosis, continuous mould (わ か ぶ り) disease; Vibriosis, furunculosis, column disease, bacillary gill disease, the fish molds of big Ma Hake; Mobility's aeromonas hydrophila disease of Cyprinus carpio, Cyprinus carpio L.; Column disease, mycobacteriosis etc.
As the expellent of present known Fish, for example in the breed of flounder, use furan benzene olefin(e) acid etc., but because the carcinogenecity of medicament self, so environment for use is restricted.
In addition, although developed and used the antibiotic (fosfomycin) (for example with reference to patent documentation 1) of a part of bacterial disease (the bacillary pseudotuberculosis of pasteurella) being brought into play effect, but, therefore be under the out of use situation of antibiotic because of effect is also insufficient or antibiotic is bigger to the influence of environment.
And then the illness agent is controlled in the infection mitigation of known a kind of Fish, it is characterized in that, contain be selected from thick leaf separate in graceful genus algae, the Gelidium algae etc. more than a kind or 2 kinds and be selected from lactic acid coccus and the polyphenol more than a kind or 2 kinds (for example with reference to patent documentation 2); Also known a kind of parasite expellent of culturing fish, it is to utilize acid such as hydrochloric acid, sulphuric acid, methanesulfonic acid that pH is adjusted to 3.0～5.0 and (for example with reference to the patent documentation 3) that form.
But the infection mitigation of Fish of record is controlled the illness agent and is had problem aspect also inadequate driving away therapeutic effect in the above-mentioned patent documentation 2.
In addition, the parasite expellent of record is to be that 3.0～5.0 concentration is driven away protozoacide (sporozoa, flagellat, Infusoria), platyhelminthes parasites such as (trematode, tapeworms) with pH in the above-mentioned patent documentation 3.Relative therewith, surface or the inner pathogenic bacteria class of adhering to and even breeding Fish are compared with parasite, because its size is very little, and the structure of biological cell etc. is also different, therefore only pH being adjusted into the pathogenic bacteria apoplexy due to endogenous wind that 3.0～5.0 inorganic agent is used for Fish can not drive away sometimes effectively, oppose that mutually Fish produce harmful effect, thereby aspect above-mentioned, have problems.Further, for the expellent that obtains for adjusting pH, have the problems such as pathogenic bacteria class that to drive away Fish effectively with hydrochloric acid or sulphuric acid.
Like this, the high medicament of dispel effect of the pathogenic bacteria classes of Fish not being developed basically as yet is existing situation.And recently, various bacterial diseases are just producing compoundly, and the situation of concurrent various diseases is also increasing.
Therefore, urgent hope can utilize safe material to prevent and drive away the exploitation of the medicament of pathogenic bacteria class efficiently.
Patent documentation 1: TOHKEMY 2004-307346 communique (claims, embodiment etc.)
Patent documentation 2: Japanese kokai publication hei 6-227986 communique (claims, embodiment etc.)
Patent documentation 3: Japanese kokai publication hei 10-72344 communique (claims, embodiment etc.)
Summary of the invention
The present invention is in view of problem in the above-mentioned conventional art and present situation etc., and will overcomes the invention of these problems and present situation, its purpose is to provide a kind of medicament that can drive away the pathogenic bacteria class of Fish effectively, this medicament cheapness, spendable temperature and range of concentrations are also wide, and safe.
Present inventors etc. are in order to solve above-mentioned problem in the past etc., through research with keen determination, found that by using organic acid is diluted to the aqueous solution that suitable concentration obtains, the disease antibacterials of Fish being demonstrated high bactericidal effect, thereby finished the present invention as the cheap and safe material of target.
That is, there are following (1)～(4) in the present invention.
(1) a kind of expellent of fish pathogens antibacterial class is characterized in that, with organic acid as main constituent.
(2) expellent of the fish pathogens antibacterial class of being put down in writing according to above-mentioned (1), it is characterized in that organic acid is to be selected from least a in formic acid, acetic acid, propanoic acid, lactic acid, fumaric acid, butanoic acid, citric acid, malic acid, gluconic acid, ketoglutaric acid, phytic acid, tartaric acid, succinic acid, ascorbic acid, itaconic acid and the adipic acid.
(3) expellent of the fish pathogens antibacterial class of being put down in writing according to above-mentioned (1) or (2) is characterized in that the concentration during processing is more than the 1ppm.
(4) expelling method of a kind of fish pathogens antibacterial is characterized in that, water or sea water with above-mentioned (1)～(3) in each expellent of putting down in writing dilution and in the treatment fluid that obtains, with parasitism the Fish of pathogenic bacteria carry out impregnation process.
In addition, in the present invention, " Fish " of parasitic pathogenic bacteria are except comprising Fish such as common fresh-water fishes, marine fish, also comprise marine animal such as shellfish (Concha Ostreae, Fu Keduo Margarita clam, Patinopecten (Mizuhopecten) yessoensis, Carnis Haliotidis, Conch Meretricis seu Cyclinae, clam son etc.), shell-fish (japonicus, portunus trytuberculatus, Japanese Lobster etc.), Trionyx sinensis Wiegmann, echinoid, Stichopus japonicus, true ascidean, and, in their fish roe, young shellfish, fry etc. all are included in.
In addition, in the present invention,, for example can list vibriosis, pseudotuberculosis, streptococcicosis, nocardiosis, the bacterial disease of slipping, the fish bud mycete disease of Yellowtail fish for bacterial disease as object; The vibriosis of snapper, Ai Dehuashi disease, the bacterial disease of slipping; The hemorrhagic septicemia of black porgy, the streptococcicosis of oplegnathus fasciatus, achromobacter disease; The streptococcicosis of flounder, Ai Dehuashi disease, nocardiosis, the bacterial disease of slipping, vibriosis, streptococcicosis; Vibriosis, streptococcicosis, the bacterial disease of slipping of black Cao fish; The nocardiosis of tuna; The vibriosis of Anguillar japonica, red fin fish disease, head Peptic Ulcers, red spot disease, edwardsiella tarda disease, column disease, streptococcicosis, skin sporidiosis, continuous mildew; Vibriosis, furunculosis, column disease, bacillary Carp disease, the fish molds of big Ma Hake; Mobility's aeromonas hydrophila disease of Cyprinus carpio and Cyprinus carpio L., column disease, mycobacteriosis; The bacillary gill disease of japonicus, the black disease of the gill; The mucormycosis of Trionyx sinensis Wiegmann etc.; And can list the various bacterial diseases of the fish roe in these Fish, young shellfish etc., can drive away the fish diseases that (comprising prevention, treatment), these diseases caused effectively.
According to the present invention, the expellent and the expelling method thereof that can have the fish pathogens antibacterial class of high dispel effect to the pathogenic bacteria class of Fish are provided, and this expellent and expelling method thereof can satisfy also wide, the safe condition of amplitude of cheap and spendable temperature conditions.
The specific embodiment
Below, describe embodiments of the present invention in detail.
The expellent of fish pathogens antibacterial class of the present invention is characterised in that, as main constituent, and its expelling method is characterised in that with organic acid, in the treatment fluid that water or sea water obtain expellent dilution of the present invention, with parasitism the Fish of pathogenic bacteria carry out impregnation process.
For expellent of the present invention, organic acid all can be used as the employed organic acid of main constituent.Particularly preferably be the safe formic acid that in food additive, is allowed to, acetic acid, propanoic acid, lactic acid, fumaric acid, butanoic acid, citric acid, malic acid, gluconic acid, ketoglutaric acid, phytic acid, tartaric acid, succinic acid, ascorbic acid, itaconic acid, adipic acid etc.
Employed organic acid can be distinguished use separately, also can use organic acid mixture (organic acid more than 2 kinds).
In addition, employed organic acid is so long as become the amount of main constituent and get final product, and wish to be: preferably be more than the 0.1 weight % in the expellent total amount, more preferably 1～100 weight % is preferably 4～100 weight % especially.
Expellent of the present invention (preparation) dosage form is that Powdered, pasty state, graininess, Any shape such as liquid all can, be when belonging to the material of danger, forming common danger such as 30% aqueous solution, 50% aqueous solution and get final product without the goods of blast, dangerous concentration such as on fire in handling.
In use, this expellent water or sea water are diluted dissolving in good time, the impregnation process stipulated time uses.
Concentration when handling, hope be: contain 1ppm (1 * 10
-4Weight %) above, be preferably 10ppm (1 * 10
-3Weight %) above, be preferably 40ppm (4 * 10 especially
-3Weight %) Yi Shang organic acid.For the upper limit, it changes according to the fingerling of driving away object, the kind of antibacterial class, is below the 10000ppm (1 weight %), is preferably 1000ppm (1 * 10
-1Weight %) following, 500ppm (5 * 10
-2Weight %) below.
In addition, the water temperature during for processing, hope is 0 ℃～50 ℃, is preferably 5 ℃～45 ℃, characteristic is preferably 10 ℃～40 ℃.
And then, for the processing time, get final product according to operation adjustment, be preferably 10～90 minutes dip time usually.
Expellent of the present invention as mentioned above, be with organic acid as main constituent, but under the organic acid situation that is slightly solubility, in the scope of not damaging effect of the present invention, can suitably contain dissolution aids such as alcohol, emulsifying agent.
For expellent of the present invention, under the situation of not damaging effect of the present invention, the viewpoint of the survival rate of the breed fish from further raising is handled, can further contain water soluble polymer, for example gelatin, chitosan, methylcellulose, sodium alginate, agar, sodium polyacrylate or natural polysaecharides etc. in the above-mentioned organic acid.For the concentration of these compositions when handling, change according to the fingerling of driving away object, the kind of antibacterial class, hope be: promptly [1ppm (1 * 10 for the concentration identical with organic acid
-4Weight %)～10000ppm (1 weight %)], be preferably 10～1000ppm, be preferably 40～500ppm especially.
By the present invention who constitutes like this, can obtain the pathogenic bacteria class of Fish is had the expellent and the expelling method thereof of the fish pathogens antibacterial class of high dispel effect, this expellent and expelling method thereof can satisfy also wide, the safe condition of scope of cheap and spendable temperature conditions.
Embodiment
Below, the present invention will be described in more detail according to test example, but the present invention is not subjected to the qualification of following test example etc.
(test example 1, fish diseases therapeutic test 1～3)
Used the flounder that obtains according to following method, that is, and will be by cultivating the antibacterial liquid that slips that obtains (bacterial disease of slipping pathogen, テ Na シ バ Network リ ユ one system マ リ チ system ス, bacterial strain: 46501 strains, in 24 hours from the Flounder fish; 050603 strain, from flounder) 20 times of dilutions and dipping (the bacterium liquid measure during infection is 3L) flounder 30 minutes in the liquid that obtains, thereby make the antibacterial of slipping force to infect.
Adding tank (the 30L circular channels of the bacterial infection flounder of slipping, the processing water yield is 10L) in, drop into the organic acid of each concentration shown in the following table 1, carry out the impregnation process of stipulated time, investigation survival rate thereafter according to the test method 1～3 shown in following.
In addition, in test, raise too and do not carry out organic acid-treated bacterial infection fish of slipping, by with this non-processor district (matched group) relatively estimate therapeutic effect.
These be the results are shown in the following table 1.
Test method 1 (fish diseases therapeutic test 1)
Infectious bacteria: 050603 strain (1.0 * 10
7CFU/ml)
For trying fish: average weight is that the flounder of 14.9g is 15 in per 1 zone
Handle: 26 ℃ of temperature, 20 minutes
Raising temperature: 26 ℃
Test method 2 (fish diseases therapeutic test 2)
Infectious bacteria: 46501 strains (6.3 * 10
5CFU/ml)
For trying fish: average weight is that the flounder of 26.1g is 15 in per 1 zone
Handle: 16 ℃ of temperature, 20 minutes
Raising temperature: 16 ℃
Test method 3 (fish diseases therapeutic test 3)
Infectious bacteria: 46501 strains (2.9 * 10
6CFU/ml)
For trying fish: average weight is that the flounder of 37.1g is 15 in per 1 zone
Handle: 16 ℃ of temperature, 30 minutes
Raising temperature: 16 ℃
Table 1
[antibacterial of slipping forces to infect the therapeutic test 1 of fish]
[antibacterial of slipping forces to infect the therapeutic test 2 of fish]
[antibacterial of slipping forces to infect the therapeutic test 3 of fish]
From the result of above-mentioned table 1 as can be known, if make healthy normal flounder infect the antibacterial of slipping, then for survival rate, in the non-processor district, in the test 1, survival rate was 0% in the 2nd day, and in the test example 2, survival rate was 0% in the 7th day, and in test example 3, survival rate is reduced to 20%.
Relative therewith, can distinguish: the survival rate of the flounder that crosses with organic acid (formic acid, propanoic acid, the citric acid) impregnation process of each concentration is increased to 35%～100%.
(test example 2, various organic acid are to the influence of the propagation of the antibacterial of slipping)
Use bacterial strain by cultivating the antibacterial liquid that slips, the bacterial disease of slipping pathogen, テ Na シ バ Network リ ユ one system マ リ チ system ス (T.maritimus), the bacterial strain that obtains in 24 hours: 46501 strains, from the Flounder fish; 46502 strains, from the Flounder fish; 040355 strain, from the Flounder fish; 46416 strains, from the Flounder fish; 050603 strain, from flounder
Use organic acid: citric acid, malic acid, adipic acid, fumaric acid, itaconic acid, tartaric acid, succinic acid, ascorbic acid, gluconic acid, phytic acid, lactic acid, butanoic acid, formic acid, acetic acid, propanoic acid
Use culture medium: improvement Zobell culture medium (among the 80% sea water 1L, peptone 5g, yeast extract 1g)
Test method: after organic acid concentration diluted interimly, add various bacterium liquid, vibration is cultivated under 25 ℃, the condition of 100ppm.The propagation of investigation bacterium was obtained minimum inhibitory concentration (MIC) with 630nm mensuration light absorption value in per 6 hours.
To be shown in the following table 2 with respect to the slip minimum inhibitory concentration (ppm) of bacterial disease pathogen, テ Na シ バ Network リ ユ one system マ リ チ system ス of various organic acids.
[table 2]
Investigate from the result of above-mentioned table 2, can distinguish, for minimum inhibitory concentration, lactic acid-46501 strain becomes Cmin, is 20.3ppm; Tartaric acid-050603 strain becomes maximum concentration, is 390.6ppm.
As the result from above-mentioned table 2 can show, employed 15 kinds of organic acid stop, drive away the breeding of the bacterial disease pathogen of slipping was extremely effective.
(test example 3, fish diseases therapeutic test 4)
Used the flounder that obtains according to following method, promptly, dipping (the bacterium liquid measure 3L during infection) flounder is 30 minutes in will cultivating the antibacterial liquid that slips obtain (bacterial disease of slipping pathogen, 46501 strains, from flounder) 20 times of resulting liquid of dilution by 24 hours, thereby makes the antibacterial of slipping force to infect.
In the tank that has added the bacterial infection flounder of slipping (30L circular channels, processing water yield 10L), drop into the citric acid and the gelatin of the concentration shown in the following table 3, carry out the impregnation process of stipulated time, investigation in per 12 hours survival rate thereafter according to the test method shown in following.
In addition, in test, raise too and do not carry out organic acid-treated bacterial infection fish of slipping, by with this non-processor district (matched group) relatively estimate therapeutic effect.
These be the results are shown in the table 3.
Test method (fish diseases therapeutic test 4)
Infectious bacteria: 46501 strains (2.8 * 10
6CFU/ml)
For trying fish: average weight is that the flounder of 26.1g is 15 in each zone
Handle: 21.5 ℃ of temperature, 20 minutes
[table 3]
As indicated in the result of above-mentioned table 3, can distinguish: the survival rate of the flounder that crosses with citric acid 100ppm impregnation process is than non-processor district's (survival rate is 0% after the 2nd day) height, and by and can further improve survival rate with natural polymer (gelatin).
In addition, can distinguish that for the also usefulness of natural polymer (gelatin), the survival rate in the interpolation district of 100ppm is the highest.
(the organic acid long duration test of test example 4, snapper)
In dipping groove jar (30L circular channels, processing water yield 10L), modulate the treatment fluid of citric acid concentration 500ppm, treatment fluid, the non-processor district of citric acid concentration 500ppm+ gelatin 100ppm respectively.
Manage throughout and drop into 10 snappeies (average weight is 9.5g) in the liquid (treatment temperature is 17.5 ℃), carry out 20 minutes impregnation process.Then, transfer in the continuous-flow type tank, measure the state of the snapper after 1 hour, after 24 hours.
These be the results are shown in the following table 4.
[table 4]
As indicated in from the result of above-mentioned table 4, can distinguish: even 500ppm-20 minute the dipping that snapper is carried out driving away the antibacterial of slipping is handled, the poisoning to snapper can not take place, the antibacterial of slipping that also can be used as snapper is driven away and uses.
As indicated in from above result of the test, can distinguish, the scope of the spendable temperature conditions of the expellent of fish pathogens antibacterial class of the present invention is also wide, owing to used the organic acid of being confirmed as safeties such as food acids, additives, therefore can satisfy safe condition, and the pathogenic bacteria class of Fish is had high dispel effect.
According to the present invention, can provide expellent cheap, safe and that the disease antibacterial of Fish is had high effect.
Claims (4)
1. the expellent of a fish pathogens antibacterial class is characterized in that, with organic acid as main constituent.
2. the expellent of the fish pathogens antibacterial class of putting down in writing according to claim 1, it is characterized in that organic acid is to be selected from least a in formic acid, acetic acid, propanoic acid, lactic acid, fumaric acid, butanoic acid, citric acid, malic acid, gluconic acid, ketoglutaric acid, phytic acid, tartaric acid, succinic acid, ascorbic acid, itaconic acid and the adipic acid.
3. the expellent of the fish pathogens antibacterial class of being put down in writing according to claim 1 or 2 is characterized in that the concentration during processing is more than the 1ppm.
4. the expelling method of a fish pathogens antibacterial is characterized in that, water or sea water with claim 1～3 in each expellent of putting down in writing dilution and in the treatment fluid that obtains, with parasitism the Fish of pathogenic bacteria carry out impregnation process.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2007/065960 WO2009022424A1 (en) | 2007-08-16 | 2007-08-16 | Agent for exterminating pathogenic bacteria in fishes and method of exterminating the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101801367A true CN101801367A (en) | 2010-08-11 |
Family
ID=40350488
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780100210A Pending CN101801367A (en) | 2007-08-16 | 2007-08-16 | The expellent and the expelling method thereof of fish pathogens antibacterial class |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR20100061685A (en) |
| CN (1) | CN101801367A (en) |
| WO (1) | WO2009022424A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186621A (en) * | 2018-01-19 | 2018-06-22 | 海南大学 | Purposes of the succinic acid in aquatic livestock streptococcosis protective agents are prepared |
| CN109464457A (en) * | 2018-11-30 | 2019-03-15 | 中国水产科学研究院黑龙江水产研究所 | Prevent fish skin disease and promotes the medical fluid of skin repair |
| CN110200993A (en) * | 2019-07-09 | 2019-09-06 | 长沙拜特生物科技研究所有限公司 | A kind of preparation and preparation method thereof for preventing and treating saprolegniasis of aquatic animals |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5283007B1 (en) * | 2012-08-30 | 2013-09-04 | 株式会社片山化学工業研究所 | How to kill gliding bacteria in aquaculture |
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|---|---|---|---|---|
| JP2535557B2 (en) * | 1987-09-17 | 1996-09-18 | 日清製粉株式会社 | Agent for preventing and treating Vibrio alderi infection of fish |
| JP2535556B2 (en) * | 1987-09-17 | 1996-09-18 | 日清製粉株式会社 | Agent for prevention and treatment of vibrio disease in fish |
| JP2535558B2 (en) * | 1987-09-17 | 1996-09-18 | 日清製粉株式会社 | Agent for prevention and treatment of fin fin disease of fish |
| JP3187412B2 (en) * | 1990-08-23 | 2001-07-11 | 太陽化学株式会社 | Agent for prevention and treatment of bacterial fish disease |
| JP4024886B2 (en) * | 1996-08-29 | 2007-12-19 | 第一製網株式会社 | Parasiticides for cultured fish and methods for controlling them |
| JP3814415B2 (en) * | 1998-06-04 | 2006-08-30 | 築野ライスファインケミカルズ株式会社 | Disease prevention effects of ferulic acid, phytic acid, inositol and oryzanol contained in plants and their seeds on pale, marine fish and crustaceans |
| IL141614A0 (en) * | 1998-08-25 | 2002-03-10 | Nippon Suisan Kaisha Ltd | Natural physiologically active material effective on fish diseases and fish food containing the material |
| KR100365151B1 (en) * | 2000-05-08 | 2003-02-11 | 김형락 | Novel use of delta-aminolevulinic acid for the prevention and treatment of infection by pathogenic microorganism |
| EP1483975A1 (en) * | 2003-06-05 | 2004-12-08 | PURAC Biochem BV | Antimicrobial composition comprising a mixture of lactic acid or a derivative thereof and an inorganic acid |
| JP2006077000A (en) * | 2004-08-10 | 2006-03-23 | Fuji Seifun Kk | Method for exterminating fish parasite and method for preventing infection |
| JP4225385B2 (en) * | 2006-02-23 | 2009-02-18 | 国立大学法人高知大学 | Disinfectant for fish pathogenic bacteria and method for the disinfection |
-
2007
- 2007-08-16 CN CN200780100210A patent/CN101801367A/en active Pending
- 2007-08-16 KR KR1020107005826A patent/KR20100061685A/en not_active Application Discontinuation
- 2007-08-16 WO PCT/JP2007/065960 patent/WO2009022424A1/en active Search and Examination
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186621A (en) * | 2018-01-19 | 2018-06-22 | 海南大学 | Purposes of the succinic acid in aquatic livestock streptococcosis protective agents are prepared |
| CN109464457A (en) * | 2018-11-30 | 2019-03-15 | 中国水产科学研究院黑龙江水产研究所 | Prevent fish skin disease and promotes the medical fluid of skin repair |
| CN110200993A (en) * | 2019-07-09 | 2019-09-06 | 长沙拜特生物科技研究所有限公司 | A kind of preparation and preparation method thereof for preventing and treating saprolegniasis of aquatic animals |
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| Publication number | Publication date |
|---|---|
| WO2009022424A1 (en) | 2009-02-19 |
| KR20100061685A (en) | 2010-06-08 |
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