CN101797259B - Compound vitamin nanoemulsion - Google Patents
Compound vitamin nanoemulsion Download PDFInfo
- Publication number
- CN101797259B CN101797259B CN2010101241384A CN201010124138A CN101797259B CN 101797259 B CN101797259 B CN 101797259B CN 2010101241384 A CN2010101241384 A CN 2010101241384A CN 201010124138 A CN201010124138 A CN 201010124138A CN 101797259 B CN101797259 B CN 101797259B
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- CN
- China
- Prior art keywords
- vitamin
- fat
- aeo
- nanoemulsion
- product
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940088594 vitamin Drugs 0.000 title claims abstract description 32
- 229930003231 vitamin Natural products 0.000 title claims abstract description 32
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 32
- 239000011782 vitamin Substances 0.000 title claims abstract description 32
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 26
- -1 Compound vitamin Chemical class 0.000 title claims abstract description 19
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims abstract description 30
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 15
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 15
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 15
- 239000011710 vitamin D Substances 0.000 claims abstract description 15
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 15
- 229940046008 vitamin d Drugs 0.000 claims abstract description 15
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 12
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 12
- 239000011719 vitamin A Substances 0.000 claims abstract description 12
- 229940045997 vitamin a Drugs 0.000 claims abstract description 12
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 11
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 11
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 10
- 235000019445 benzyl alcohol Nutrition 0.000 claims abstract description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 10
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 10
- 229940046009 vitamin E Drugs 0.000 claims abstract description 10
- 239000011709 vitamin E Substances 0.000 claims abstract description 10
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 18
- 239000004615 ingredient Substances 0.000 claims description 12
- 229930003448 Vitamin K Natural products 0.000 claims description 5
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 5
- 235000019168 vitamin K Nutrition 0.000 claims description 5
- 239000011712 vitamin K Substances 0.000 claims description 5
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 5
- 229940046010 vitamin k Drugs 0.000 claims description 5
- 239000008215 water for injection Substances 0.000 claims description 2
- 244000144977 poultry Species 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 210000000941 bile Anatomy 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000019423 liver disease Diseases 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 244000144972 livestock Species 0.000 abstract 3
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- 235000012711 vitamin K3 Nutrition 0.000 abstract 1
- 239000011652 vitamin K3 Substances 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 11
- 239000000047 product Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 5
- 239000002131 composite material Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000005352 clarification Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 208000000412 Avitaminosis Diseases 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000002201 avitaminosis Nutrition 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000036397 gastrointestinal physiology Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Images
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101241384A CN101797259B (en) | 2010-03-15 | 2010-03-15 | Compound vitamin nanoemulsion |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101241384A CN101797259B (en) | 2010-03-15 | 2010-03-15 | Compound vitamin nanoemulsion |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101797259A CN101797259A (en) | 2010-08-11 |
CN101797259B true CN101797259B (en) | 2013-05-01 |
Family
ID=42593199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2010101241384A Active CN101797259B (en) | 2010-03-15 | 2010-03-15 | Compound vitamin nanoemulsion |
Country Status (1)
Country | Link |
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CN (1) | CN101797259B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103315957A (en) * | 2013-06-27 | 2013-09-25 | 海南卫康制药(潜山)有限公司 | Vitamin K1 lyophilized oral emulsion and preparation method thereof |
CN103520101B (en) * | 2013-10-14 | 2015-09-30 | 陕西科技大学 | A kind of vitamin A nano-emulsion and preparation method thereof |
CN103520102A (en) * | 2013-10-14 | 2014-01-22 | 陕西科技大学 | Vitamin D nano-emulsion and preparation method thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1236304A (en) * | 1996-10-07 | 1999-11-24 | 弗·哈夫曼-拉罗切有限公司 | Vitamin preparations for beverage applications |
CN1568938A (en) * | 2003-07-22 | 2005-01-26 | 范敏华 | Nanometer emulsion and preparation method thereof |
CN101637449A (en) * | 2009-08-25 | 2010-02-03 | 曹金党 | Nanometer vitamin self-microemulsion and preparation method thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050220866A1 (en) * | 2004-04-02 | 2005-10-06 | Dr. Reddy's Laboratories Limited | Novel capsule formulations of etoposide for oral use |
-
2010
- 2010-03-15 CN CN2010101241384A patent/CN101797259B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1236304A (en) * | 1996-10-07 | 1999-11-24 | 弗·哈夫曼-拉罗切有限公司 | Vitamin preparations for beverage applications |
CN1568938A (en) * | 2003-07-22 | 2005-01-26 | 范敏华 | Nanometer emulsion and preparation method thereof |
CN101637449A (en) * | 2009-08-25 | 2010-02-03 | 曹金党 | Nanometer vitamin self-microemulsion and preparation method thereof |
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Publication number | Publication date |
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CN101797259A (en) | 2010-08-11 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: CHEN PENGJU Free format text: FORMER OWNER: HE'NAN AGRICULTURAL UNIVERSITY Effective date: 20130122 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20130122 Address after: 450002, Henan Province, Zhengzhou cultural North Road, building 50, No. 9 Applicant after: Chen Pengju Address before: 450002 Zhengzhou Cultural Road, Henan, No. 95 Applicant before: HENAN AGRICULTURAL University |
|
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Chen Pengju Inventor after: Zhang Guanghui Inventor after: Wu Hua Inventor after: Zhao Qingfeng Inventor after: Wang Rudu Inventor after: Hu Mei Inventor after: Yuan Shuixia Inventor after: Chen Liming Inventor after: Zhang Guohui Inventor before: Chen Pengju Inventor before: Zhang Guanghui |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: CHEN PENGJU ZHANG GUANGHUI TO: CHEN PENGJU ZHANG GUANGHUI WU HUA ZHAO QINGFENG WANG RUDOU HU MEI YUAN SHUIXIA CHEN LIMING ZHANG GUOHUI |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20191210 Address after: Room 708, block B, No.7, Dongqing street, high tech Development Zone, Zhengzhou City, Henan Province Patentee after: Henan Institute of Modern Chinese Veterinary Medicine Address before: 450002 No. 50 building, No. 9 culture North Road, Zhengzhou, Henan Patentee before: Chen Pengju |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230427 Address after: 461500 No. 783 Senyuan East Road, Changge City, Xuchang City, Henan Province Patentee after: HENAN BRIGHT ANIMAL PHARMACEUTICAL CO.,LTD. Address before: Room 708, block B, No.7 Dongqing street, high tech Development Zone, Zhengzhou, Henan 450000 Patentee before: Henan Institute of Modern Chinese Veterinary Medicine |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20231208 Address after: 452570 16km away from G234 National Highway, Yuzhou City, Xuchang, Henan Province Patentee after: Henan Highlight Pharmaceutical Co.,Ltd. Address before: 461500 No. 783 Senyuan East Road, Changge City, Xuchang City, Henan Province Patentee before: HENAN BRIGHT ANIMAL PHARMACEUTICAL CO.,LTD. |