CN101637449A - Nanometer vitamin self-microemulsion and preparation method thereof - Google Patents
Nanometer vitamin self-microemulsion and preparation method thereof Download PDFInfo
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- CN101637449A CN101637449A CN200910018210A CN200910018210A CN101637449A CN 101637449 A CN101637449 A CN 101637449A CN 200910018210 A CN200910018210 A CN 200910018210A CN 200910018210 A CN200910018210 A CN 200910018210A CN 101637449 A CN101637449 A CN 101637449A
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Abstract
The invention relates to a nanometer vitamin self-microemulsion system and a preparation method thereof. The self-microemulsion is a uniform and slightly viscous dispersion system formed by the following steps: adding vitamin, emulsifiers, co-emulsifiers and other components into a little purified water and simply stirring the mixture. Water is added to the system to dilute the system and the mixture is stirred, or the system is added by post-spraying process after feed and food forming. After animals take in the system, the system spontaneously forms the microemulsion in the digestive tract through mixing with digestive juice and peristalsis of the gastrointestinal tract. The preparation technology has the following main characteristics: simple mechanical stirring is only needed instead of high-pressure homogenization treatment in the production process, and the self-microemulsion system can be widely applied to feeds and additives of the feeds, pet health products, cosmetics, medicines, health products, drinks and other industries.
Description
Affiliated technical field
The present invention relates to vitamin, relate in particular to a kind of nanometer vitamin self-microemulsion, the invention still further relates to the preparation method of nanometer vitamin self-microemulsion.
Technical background
Vitamin is the low-molecular-weight organic compound of a class biologically active, is that humans and animals is kept the requisite nutrient substance of normal physiological function.Vitamin generally can not in body, synthesize or capacity synthetic, most vitamin must be by providing in the food or other external arbitrary way supply.
If vitamin is liquid, can produce lamination after long-time the placement when supplying with.Moment formed when vitamin microemulsion prepared, but long-time the placement will form the mixture of one deck fatsoluble vitamin on the surface, produces lamination.Therefore will form a homogeneous microemulsion, each is formed stable each other and does not disturb mutually, improves the stability of microemulsion.Nano material is familiar with by people just gradually as a kind of new state that material exists, and the scientific value of nanotechnology and nano material and application prospect are accepted by people gradually.The utilization nanotechnology improves or changes water solublity, dispersibility and the absorbance of vitamin, improves between vitamin and the food processing, the compatibility between the feedstuff processing, is the focus of present vitamin research.And vitamin microemulsion adds a large amount of water in preparation process, effective ingredient is few in the microemulsion, and power consumption increases in transportation by contrast.
At present existing prepare the report of aspect about vitamin nanoscale microemulsion, number be 200410006272.9 invention as application (patent), the preparation method of this patent disclosure need be fully emulsified with vitamin by high pressure homogenizer.High pressure homogenizer is the powerful shearing force that is subjected to when utilizing liquid at high speed to flow through narrow gap, produce impact force during to the metal parts high speed impact, a series of resultant force effects that produce by high pressure such as the hole explosive force that produces because of the static pressure bust, vitamin mixture is ground into nano level stable microemulsion liquid, but adopt high pressure homogenizer need be equipped with cooler, this has increased energy consumption undoubtedly, has improved cost.
Summary of the invention
Technical assignment of the present invention is to provide nanometer vitamin self-microemulsion at the deficiencies in the prior art.
Another object of the present invention is to provide the preparation method of nanometer vitamin self-microemulsion.
So-called nanometer vitamin self-microemulsion system is meant by certain fine machining method, and fatsoluble vitamin is crushed in 45 nanometers, forms the new skill type vitamin with nanoscale.Nanometer vitamin has the different physical characteristics that are different from micron granularity (10 μ m～25 μ m) vitamin, be its optics, calorifics, physiological and biochemical procedure and trophism aspect, all have different significantly with supporting one's family of micron granularity, at specific surface area, surface activity, dissolubility, absorbance, trophism with in the intravital physiological and biochemical procedure of machine and between the micron granularity vitamin, have huge difference, its unique dissolubility, absorbance, Physiology and biochemistry characteristics are arranged and to the high trophism and the quick-acting of body.
Previous purpose of the present invention realizes in the following manner:
Nanometer vitamin self-microemulsion is characterized in that adding in 10 parts of purified water:
100-500 part vitamin
500-800 part emulsifying agent
500-800 part co-emulsifier
1-2 part antioxidant
Above umber is parts by weight.
In the described vitamin by at least a composition the among fat-soluble A, D, the E.Wherein, the effect of vitamin A comprises and keeps normal vision response; Keep the normal morphology and the function of epithelial tissue; Keep normal skeleton development; The effect of safeguarding the Skin Cell function is arranged, can make skin soft delicate, wrinkle resistant wrinkle removing effect is arranged.If be deficient in vitamin A, can make epithelial hypofunction, cause skin elasticity to descend, drying, coarse, tarnish.The effect of vitamin D comprises: improve the absorption of human body to calcium, phosphorus, make the level of plasma calcium and the blood plasma phosphorus degree that reaches capacity; Promote growth and skeleton calcification, promote tooth sound; Increase the absorption of phosphorus by intestinal wall, and increase the absorption again of phosphorus by renal tubules; Keep the normal level of citrate in the blood; Prevent that aminoacid from losing by kidney.Vitamin E has good non-oxidizability, promptly reduces cell senescence, keeps erythrocytic integrity, promotes cell synthetic, antipollution, the effect of antisterility.
Vitamin self-microemulsion can be used for feedstuff industry, can spray to during use on the feedstuff, and water mixing is stirred, and also can directly offer domestic animal as feedstuff, and domestic animal is drunk a large amount of water when edible, form microemulsion under the wriggling of stomach, is absorbed by domestic animal.
Vitamin has medicine and aesthetic health care function, and therefore the vitamin self-microemulsion by multiple fatsoluble vitamin preparation can be widely used in industries such as medicine, health product, pet care product, beverage, cosmetics.
Form stable self-microemulsion, must add emulsifying agent, described emulsifying agent is by at least a composition the in span, tween, polyoxyethylene castor oil, the hydrogenation polyoxyethylene castor oil.
Described co-emulsifier is a low-carbon alcohols, as ethanol, propylene glycol, glycerol etc.
Described antioxidant is wherein two kinds of mixture by a certain percentage of Butylated hydroxyanisole, dibenzylatiooluene, tert-butyl hydroquinone, sodium formaldehyde sulfoxylate, sodium pyrosulfite, Galla Turcica (Galla Helepensis) propionic ester.Wherein mixed proportion the best of two kinds of antioxidants is 1: 1.
A back purpose of the present invention is implemented in the following manner:
The preparation method of nanometer vitamin self-microemulsion is: add a small amount of purified water in reaction vessel, join 25～45 ℃, add emulsifying agent, co-emulsifier, antioxidant, vitamin then successively, maintain the temperature at 25～45 ℃, stir 10～30min and get final product.
The present invention has following beneficial effect:
1, Thermodynamically stable is put for a long time and is not produced layering, long shelf-life;
2, moisture less in the product, the active constituent content height, accumulating is convenient;
3, the product mean diameter is little, easily absorbs;
4, production cost is low.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further replenishing, but do not limit the present invention in any way.
Embodiment 1
In reaction vessel, add the 10mL purified water, be heated to 35 ℃, add 1g sodium pyrosulfite, 500g propylene glycol, 1g Galla Turcica (Galla Helepensis) propionic ester, 500g hydrogenation polyoxyethylene castor oil, vitamin A 75g, vitamin D1 5g, vitamin e1 00g then successively, keep temperature, stir 12min and get final product.
Embodiment 2
In reaction vessel, add the 10mL purified water, be heated to 30 ℃, add 1g sodium formaldehyde sulfoxylate, 500g hydrogenation polyoxyethylene castor oil, 500g glycerol, 1g Galla Turcica (Galla Helepensis) propionic ester, vitamin A 65g, vitamin D1 0g, vitamin E 40g then successively, keep temperature, stir 12min and get final product.
Embodiment 3
In reaction vessel, add the 10mL purified water, be heated to 30 ℃, add 1g sodium formaldehyde sulfoxylate, 500g hydrogenation polyoxyethylene castor oil, 500g glycerol, 1.1g Galla Turcica (Galla Helepensis) propionic ester, vitamin A 50g, vitamin D1 0g, vitamin E 60g then successively, keep temperature, stir 10min and get final product.
Embodiment 4
In reaction vessel, add the 10mL purified water, be heated to 30 ℃, add 500g hydrogenation polyoxyethylene castor oil, 500g propylene glycol, 0.5g Galla Turcica (Galla Helepensis) propionic ester, 0.5g dibenzylatiooluene, vitamin A 80g, vitamin D2 0g, vitamin e1 00g then successively, keep temperature, stir 15min and get final product.
Claims (6)
1, nanometer vitamin self-microemulsion is characterized in that adding in 10 parts of purified water:
100-500 part vitamin
500-800 part emulsifying agent
500-800 part co-emulsifier
1-2 part antioxidant
Above umber is weight fraction.
2, nanometer vitamin self-microemulsion according to claim 1 is characterized in that: in the described vitamin by at least a composition the among fat-soluble A, D, the E.
3, nanometer vitamin self-microemulsion according to claim 1 is characterized in that: described emulsifying agent is by at least a composition the in span, tween, polyoxyethylene castor oil, the hydrogenation polyoxyethylene castor oil.
4, nanometer vitamin self-microemulsion according to claim 1 is characterized in that: described antioxidant is wherein two kinds of mixture by a certain percentage of Butylated hydroxyanisole, dibenzylatiooluene, tert-butyl hydroquinone, sodium formaldehyde sulfoxylate, sodium pyrosulfite, Galla Turcica (Galla Helepensis) propionic ester.
5, nanometer vitamin self-microemulsion according to claim 4 is characterized in that: wherein mixed proportion the best of two kinds of antioxidants is 1: 1.
6, the preparation method of nanometer vitamin self-microemulsion, it is characterized in that: in reaction vessel, add a small amount of purified water, be heated to 25～45 ℃, add emulsifying agent, co-emulsifier, antioxidant, vitamin then successively, keep temperature, stir 10～30min and get final product.
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| CN200910018210A CN101637449A (en) | 2009-08-25 | 2009-08-25 | Nanometer vitamin self-microemulsion and preparation method thereof |
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| CN200910018210A CN101637449A (en) | 2009-08-25 | 2009-08-25 | Nanometer vitamin self-microemulsion and preparation method thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797259A (en) * | 2010-03-15 | 2010-08-11 | 河南农业大学 | Compound vitamin nanoemulsion |
| CN101828645A (en) * | 2010-05-19 | 2010-09-15 | 格特生物制药（天津）有限公司 | Nano-scale multifunctional liquid premixed feed and preparation method thereof |
| CN102100304A (en) * | 2011-01-12 | 2011-06-22 | 崔增学 | Fat-soluble vitamin nano microemulsion oral liquid and preparation method thereof |
| CN102754738A (en) * | 2012-07-27 | 2012-10-31 | 陕西金冠牧业有限公司 | Nano vitamin D3 for producing feed and preparation method thereof |
| CN103520102A (en) * | 2013-10-14 | 2014-01-22 | 陕西科技大学 | Vitamin D nano-emulsion and preparation method thereof |
| CN104207145A (en) * | 2014-09-18 | 2014-12-17 | 苏州经贸职业技术学院 | Vitamin E nano-microemulsion and preparation method thereof |
| CN104706644A (en) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | Fat-soluble vitamin injection concentrated solution (II), preparation method and application thereof |
| CN104706643A (en) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | Fat-soluble vitamin injection concentrated solution (I), preparation method and application thereof |
| CN106306435A (en) * | 2016-08-24 | 2017-01-11 | 青岛农业大学 | Complex liquid premix feed for total mixed ration of cattle and sheep and preparing method thereof |
| CN108013319A (en) * | 2017-11-22 | 2018-05-11 | 恒枫食品科技有限公司 | Antioxidation activity lotion and preparation method thereof |
| CN108088925A (en) * | 2017-12-14 | 2018-05-29 | 金华傲农生物科技有限公司 | A kind of detection method of concentrated feed liposoluble vitamin content |
-
2009
- 2009-08-25 CN CN200910018210A patent/CN101637449A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797259A (en) * | 2010-03-15 | 2010-08-11 | 河南农业大学 | Compound vitamin nanoemulsion |
| CN101797259B (en) * | 2010-03-15 | 2013-05-01 | 陈鹏举 | Compound vitamin nanoemulsion |
| CN101828645A (en) * | 2010-05-19 | 2010-09-15 | 格特生物制药（天津）有限公司 | Nano-scale multifunctional liquid premixed feed and preparation method thereof |
| CN102100304A (en) * | 2011-01-12 | 2011-06-22 | 崔增学 | Fat-soluble vitamin nano microemulsion oral liquid and preparation method thereof |
| CN102100304B (en) * | 2011-01-12 | 2013-01-30 | 山东信得科技股份有限公司 | Fat-soluble vitamin nano microemulsion oral liquid and preparation method thereof |
| CN102754738A (en) * | 2012-07-27 | 2012-10-31 | 陕西金冠牧业有限公司 | Nano vitamin D3 for producing feed and preparation method thereof |
| CN103520102A (en) * | 2013-10-14 | 2014-01-22 | 陕西科技大学 | Vitamin D nano-emulsion and preparation method thereof |
| CN104706644A (en) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | Fat-soluble vitamin injection concentrated solution (II), preparation method and application thereof |
| CN104706643A (en) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | Fat-soluble vitamin injection concentrated solution (I), preparation method and application thereof |
| CN104207145A (en) * | 2014-09-18 | 2014-12-17 | 苏州经贸职业技术学院 | Vitamin E nano-microemulsion and preparation method thereof |
| CN106306435A (en) * | 2016-08-24 | 2017-01-11 | 青岛农业大学 | Complex liquid premix feed for total mixed ration of cattle and sheep and preparing method thereof |
| CN108013319A (en) * | 2017-11-22 | 2018-05-11 | 恒枫食品科技有限公司 | Antioxidation activity lotion and preparation method thereof |
| CN108088925A (en) * | 2017-12-14 | 2018-05-29 | 金华傲农生物科技有限公司 | A kind of detection method of concentrated feed liposoluble vitamin content |
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Application publication date: 20100203 |