CN101791333A - Medicine combination for treating dry tinea and application of medicine combination in preparation of medicine for treating dry tinea - Google Patents
Medicine combination for treating dry tinea and application of medicine combination in preparation of medicine for treating dry tinea Download PDFInfo
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- CN101791333A CN101791333A CN201010042821A CN201010042821A CN101791333A CN 101791333 A CN101791333 A CN 101791333A CN 201010042821 A CN201010042821 A CN 201010042821A CN 201010042821 A CN201010042821 A CN 201010042821A CN 101791333 A CN101791333 A CN 101791333A
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Abstract
The invention discloses a medicine combination for treating dry tinea and application of the medicine combination in the preparation of the medicine combination for treating dry tinea. The medicine combination comprises the following raw medicine materials: artemisia capillaris thunb, Plumeria acutifolia and Melaleuca alternifolia. When the medicine combination is prepared, the crushed powder or the extract liquid of the raw medicine materials is used and pharmaceutically acceptable excipient can be selected.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of chronic eczema, and the purposes of a kind of pharmaceutical composition aspect preparation treatment chronic eczema medicine.
Background technology
Chronic eczema is called psoriasis, psoriasis again, is the chronic dermatosis that the imbalance of a kind of autoimmune causes, and does not have an infectiousness, can't infect to others via contact skin or other pipelines.Chronic eczema is to shorten unusually in the epidermis metabolism cycle of skin, and due to abnormal quick hypertrophy, the normal person took off once skin in about 50～60 days, and the chronic eczema epidermis just changed one deck in about 7 days, and horny layer often has Parakeratotic phenomenon, and argent squama is arranged.Clinically, as seen cutin increases caused epidermis and thickens, atopic dermatitis and normal skin have obviously marginal red circular speckle not of uniform size, there are the several layers of thick squama of silvery white the top, can scratch lightly with fingernail, following skin has piecemeal little hemorrhage, can't itch or little the itching of meeting.
The cause of disease of chronic eczema is not clear fully as yet, is merely able to control at present, is not easy radical cure.The general disease of thinking gene genetic more, relevant with the inflammatory response of T cell mediated, also may be that immune system goes wrong, add that some inherences, external inducement cause.If under the inherited genetic factors background, father and mother have a people to suffer from chronic eczema, and then children have 10% chance to get this disease; Parents all have chronic eczema, and then 30% children may suffer from primary disease.During outbreak, many and thick scurf and erythema both all may appear in each position of patient's whole body, and the position of normal infringement comprises: behind scalp, the ear, around the face, trunk, umbilicus, lower back portion, extremity (stretching side), elbow, palm, knee, sole, genitals and fingernail; Even also serious symptoms such as alopecia, arthritis can appear; Uric acid level regular meeting is higher in some blood.Treatment slight and the moderate chronic eczema comprises medicament and measures, as partial lubrication cream, local application, the goods that contain corticosteroid, coal tar or grace phenol and careful sun tan.If these medicaments can't produce enough benefits, ultraviolet and anti-chronic eczema medicine are used in available ultraviolet (ofuv00) or merging, and antimetabolic product or immunosuppressant can be used for nonreactive trouble of general treatment or chronic case.
Therefore, the medicine for treatment of chronic eczema exploitation is also carried out with aforesaid mechanism of action or metabolic characteristic.As United States Patent (USP) case No.4,210,633 (announcements on July 1st, 1980) are to adopt the film of a kind of Fu Annaide of containing (flurandrenolide) to form compositions to treat chronic eczema.It is polyvinyl alcohol and polyvinylpyrrolidone that film forms composition.And the relevant thin plastic with the infiltration corticoid of French Patent (FRP) case No.2539 system for example: ethene polymers, polyamide or polyester treatment chronic eczema.Australia patent case No.6218907 system is relevant again treats chronic eczema with a kind of medical composition that comprises coal tar and resilient support material.As for the medical composition of the relevant local chronic eczema of a kind of treatment of Germany bulletin case No.297329 system, the copolymer that wherein comprises acrylate and/or methacrylate is as activating agent.Said composition system is even hydrojet and uses, and forms one deck elastica.PCT application case No.92/04019 system is about the purposes with 6-methoxyl group-2-naphthyl acetic acid topical therapeutic chronic eczema in addition.(for example: compositions chronic eczema) wherein comprises a kind of film and forms protein, Reducing agent, reactive zinc salt and at least a film formation polymer that can compatibility PCT application case No.91/02538 system relevant treatment mammal keratinization tissue.Moreover United States Patent (USP) case No.4,826,677 (announcements on May 2nd, 1989) are the liquid formulation of relevant a kind of treatment chronic eczema, it contains the even film that is dispersed in of anthracene triol (dith-ranol) and forms in the polymer.And european patent application book No.223671 system is about a kind of anti-chronic eczema compositions that comprises corticosteroid and beta-2-agonists.Said composition can be used the formation film.
The therapeutic outcome of aforementioned medicament need be kept usually and can reach by several moons, but the patient becomes lose heart and carelessness on the contrary, therefore can't reach therapeutic effect.
Medical herbs contains many not principal components with potential pharmacological effect, is the source of drug development all the time therefore.It is reported that the traditional traditional Chinese medical science is used is different from the used dissection of doctor trained in Western medicine and diagnostic system is treated disease fully, and the medicine of being write out a prescription is generally multiple Chinese herbal medicine, and its traditional method with decoction (that is in water boil medical herbs) is prepared administration.Being used for this kind treatment part can needs combination ten kinds or the use of plurality of herbal and the prescription that all medical herbs of Chinese medicine teaching must reach a balance.Prescription is considered as a balance integral body that contains the medical herbs system, and its Chinese herbal medicine has the function of difference on the different phenomenons of treatment disease and symptom.Having has acceptable clinical activity to arbitrary special human diseases, and simultaneously the medical herbs of tool hypotoxicity is identified by for many years observation and try and error method.In some example, the prescription of Chinese medicine can effectively be treated west single therapy method and be failed the disease of effectively help.
The disease that the use of plurality of Chinese is manifested reaction has the not clear and complicated therefore disease that rises for these.Special example is a sensitivity eczema, wherein has the skin chronic inflammation, and it is caused by many different vehicles and keeps, and only wherein minority is known.Some is about antigen-antibody reaction.Many other persons are under a cloud but without defining.The anti-inflammatory medicine of single therapy agent such as on-steroidal, itself and specific inflammation vehicle such as prostaglandin interact, and be invalid to serious allergic eczema.On the other hand, corticosteroid has multiple efficacy of a drug effect and effective to eczema.Therefore, obviously the treatment of serious allergic eczema need be done synchronism's attack to multiple pathological lesion, may concern to cell and immunologic process in the body fluid.When high corticosteroid and some immunosuppressant had the extensive aspect of the required activity of attack like this, its purposes was restricted because of tool toxicity.As if it is active and do not have toxicity that the Chinese medicine that known treatment eczema is used is possessed necessity of corticosteroid and immunosuppressant.
And a kind ofly be selected from medical herbs and Pinyin equipollent thereof or be used to effectively treat allergic eczema and chronic eczema with the prescriptions of Chinese medicine of the medical herbs of its Materia Medica name nominating.The clinical efficacy that is used for allergic eczema child's prescription like this is described in BritishJournal ofDermatology (1992) 126P.179-184 by people such as Sheehan and is used for adult person and is described in The Lancet (1992) July 4th pp 13-17 by people such as Sheehan.The adhoc approach for preparing the extract of these 10 kinds of medical herbs that are used for the treatment of allergic eczema and other scytitiss is described in GB-A-2254783.In fact, the decoction liquor of known above-mentioned 10 kinds of medical herbs is effective, and the use that contains the compound prescription of most medical herbs is expensive, therefore can not jeopardize under the situation of effectiveness or safety, and hope can be simplified prescription.
Summary of the invention
The technical problem that the present invention mainly solves provides the purposes of a kind of pharmaceutical composition aspect preparation treatment chronic eczema medicine, and a kind of pharmaceutical composition for the treatment of chronic eczema.
For solving above-mentioned first technical problem, the technical solution used in the present invention is: the purposes of a kind of pharmaceutical composition aspect preparation treatment chronic eczema medicine, the crude drug of described pharmaceutical composition comprises following composition: Herba Artemisiae Scopariae Artemisia capillarisThumb, Flos Plumeriae Acutifoliae Plumeria acutifolia, Australia Camellia sinensis Melaleucaalternifolia, use the crude drug flour during pharmaceutical compositions, or use the crude drug extract.
For solving above-mentioned second technical problem, the technical solution used in the present invention is: a kind of pharmaceutical composition for the treatment of chronic eczema, and the crude drug of described pharmaceutical composition comprises following composition: Herba Artemisiae Scopariae Artemisia capillaris Thumb, Flos Plumeriae Acutifoliae Plumeriaacutifolia, Australia Camellia sinensis Melaleuca alternifolia; Use above-mentioned described crude drug flour or extract when preparing this pharmaceutical composition, and selectively pharmaceutically acceptable excipient.
For making other people can further understand formation of the present invention, feature and other purposes, below be the preferred embodiment of lifting the present invention, and cooperate graphic detailed description as after, those skilled in the art can specifically implement the present invention simultaneously.
The specific embodiment
The present invention is a kind of Herba Artemisiae Scopariae (Artemisia capillaris Thumb), Flos Plumeriae Acutifoliae (Plumeriaacutifolia) and Australia Camellia sinensis (Melaleuca alternifolia) compound recipe or extract and that purposes on chronic eczema, the specific embodiment of the invention of enclosing only is used for conveniently being described, and unrestricted the present invention, when can be in the claim of not leaving the present invention, the design of specific embodiment and demand and change according to the present invention.
The present invention is a kind of Chinese herb compound in order to the treatment chronic eczema that utilizes natural herbal plant composition, should include Herba Artemisiae Scopariae (Artemisia capillarisThumb), Flos Plumeriae Acutifoliae (Plumeria acutifolia) and Australia Camellia sinensis Chinese herbal medicine such as Chinese herbal medicine composition such as (Melaleuca alternifolia) in order to the Chinese herb compound of treatment chronic eczema and form.
Wherein Herba Artemisiae Scopariae (Artemisia capillaris Thumb) accounts for 5%～21% of compound recipe gross weight, and Flos Plumeriae Acutifoliae (Plumeria acutifolia) accounts for 65%～90% of compound recipe gross weight, and (Melaleuca alternifolia) accounts for 4%～16% of compound recipe gross weight as for Australia Camellia sinensis;
The drug effect of each composition of compound recipe of the present invention again, effect are recited as according to the classic of TCM " Bencao Beiyao "; Wherein:
Herba Artemisiae Scopariae (Artemisia capillaris Thumb), bitter in the mouth, property are put down, are slightly cold.Go into spleen, stomach gallbladder meridian.Effect is exactly eliminating damp-heat, and the jaundice that disappears also can be used for the eczema pruritus, soaks diseases such as flowing yellow fluid.
And have another name called remote Fructus Gardeniae, India jasmine, Cornu Cervi tree, kind young flower, kind flower, Daji of Flos Plumeriae Acutifoliae (Plumeria acutifolia) spends, and belongs to one of Apocynaceae Burma Cape jasmine platymiscium.It has very strong antifungic action, and positive and negative bacteria and tuberculosis are all had obvious inhibition effect.Plumieride also has remarkable inhibitory action to negative and positive bacteria.It act as heat-clearing and toxic substances removing, dampness removing, cough-relieving.Be used to effect of preventing heatstroke, enteritis, bacillary dysentery, dyspepsia, lung moistening detoxifcation etc.
(Melaleuca alternifolia) has disinfectant character as for Australia Camellia sinensis, can suppress many ubiquitous malignant bacterias and mycete effectively.Be very helpful for numerous disease, wound.As incised wound, scratch, by insect bite, acne, burn, vaginal infection, tinea etc.Having very strong antibiotic property, active human body exempts from disease system, excitation leukocyte and prevents that antibacterial from invading human body.
Moreover be monarch with Flos Plumeriae Acutifoliae (Plumeria acutifolia) in the compound recipe of the present invention, be used for antifungal and suppress antibacterial.Be minister with Herba Artemisiae Scopariae (Artemisiacapillaris Thumb) in addition, can press down the eczema pruritus, active human body is exempted from the disease system with Australia Camellia sinensis (Melaleuca alternifolia).
The eliminating damp-heat of simultaneously all medicine energy, antibiotic bacterium, the co-therapy chronic eczema, and then group formation one Chinese herb compound of facing upward in order to the treatment chronic eczema.
Chinese herb compound of the present invention can typically extract, concentration technique is mixed into medicated powder at compound recipe crude drug [crude drug] or after distinctly composition crude drug [crude drug] extracts, concentrates and gets, this medicated powder also can directly be pulverized powdered and got by crude drug [crude drug], and comprise its amount for can effectively treating, slow down or suppress the Chinese herb compound of chronic eczema, and pharmaceutically selectively pharmaceutically acceptable excipient, and be modulated into the dosage forms such as ointment, cream, lotion or paster of percutaneous delivery.
By this, be appreciated that the present invention is the splendid creation of an intention, except the problem that formula person faced is practised in effective solution, more significantly promote effect, and in identical technical field, do not see identical or proximate product creation or public use, the enhancement that has effect simultaneously so the present invention has met the condition of patent of invention about " novelty " and " creativeness ", is the patent of invention of in accordance with the law filing an application.
Claims (7)
1. the pharmaceutical composition purposes aspect preparation treatment chronic eczema medicine, it is characterized in that, the crude drug of described pharmaceutical composition comprises following composition: Herba Artemisiae Scopariae Artemisia capillaris Thumb, Flos Plumeriae Acutifoliae Plumeria acutifolia, Australia Camellia sinensis Melaleuca alternifolia, use the crude drug flour during pharmaceutical compositions.
2. the pharmaceutical composition purposes aspect preparation treatment chronic eczema medicine, it is characterized in that, the crude drug of described pharmaceutical composition comprises following composition: Herba Artemisiae Scopariae Artemisia capillaris Thumb, Flos Plumeriae Acutifoliae Plumeria acutifolia, Australia Camellia sinensis Melaleuca alternifolia, use the crude drug extract during pharmaceutical compositions.
3. purposes according to claim 1 and 2, it is characterized in that, wherein Herba Artemisiae Scopariae Artemisia capillaris Thumb accounts for 5%～21% of described pharmaceutical composition crude drug gross weight, Flos Plumeriae Acutifoliae Plumeria acutifolia accounts for 65%～90% of described pharmaceutical composition crude drug gross weight, and Australia Camellia sinensis Melaleuca alternifolia accounts for 4%～16% of described pharmaceutical composition crude drug gross weight.
4. purposes according to claim 1 and 2 is characterized in that, described treatment chronic eczema pharmaceutical composition is a skin-absorbent agents.
5. purposes according to claim 1 and 2 is characterized in that, described treatment chronic eczema pharmaceutical composition is any one in the following dosage form: powder, solution, suspension, emulsion, ointment, cream, lotion, paster.
6. pharmaceutical composition for the treatment of chronic eczema, it is characterized in that the crude drug of described pharmaceutical composition comprises following composition: Herba Artemisiae Scopariae Artemisia capillaris Thumb, Flos Plumeriae Acutifoliae Plumeria acutifolia, Australia Camellia sinensis Melaleuca alternifolia; Use above-mentioned described crude drug flour or extract when preparing this pharmaceutical composition.
7. according to the pharmaceutical composition of the described treatment chronic eczema of claim 6, it is characterized in that described treatment chronic eczema pharmaceutical composition is any one in the following dosage form: powder, solution, suspension, emulsion, ointment, cream, lotion, paster.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010042821A CN101791333A (en) | 2010-01-13 | 2010-01-13 | Medicine combination for treating dry tinea and application of medicine combination in preparation of medicine for treating dry tinea |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010042821A CN101791333A (en) | 2010-01-13 | 2010-01-13 | Medicine combination for treating dry tinea and application of medicine combination in preparation of medicine for treating dry tinea |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145032A (en) * | 2011-04-06 | 2011-08-10 | 江苏畜牧兽医职业技术学院 | Application of plumeria acutifolia for preparing medicine for treating poultry viral infection |
| CN103611155A (en) * | 2013-12-11 | 2014-03-05 | 西南林业大学 | Australia tea tree effervescent tablet and preparation method thereof |
| CN103610607A (en) * | 2013-11-21 | 2014-03-05 | 云南菩拉美生物科技开发有限公司 | Frangipani hand sanitizer |
-
2010
- 2010-01-13 CN CN201010042821A patent/CN101791333A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145032A (en) * | 2011-04-06 | 2011-08-10 | 江苏畜牧兽医职业技术学院 | Application of plumeria acutifolia for preparing medicine for treating poultry viral infection |
| CN102145032B (en) * | 2011-04-06 | 2012-10-03 | 江苏畜牧兽医职业技术学院 | Application of plumeria acutifolia for preparing medicine for treating poultry viral infection |
| CN103610607A (en) * | 2013-11-21 | 2014-03-05 | 云南菩拉美生物科技开发有限公司 | Frangipani hand sanitizer |
| CN103611155A (en) * | 2013-12-11 | 2014-03-05 | 西南林业大学 | Australia tea tree effervescent tablet and preparation method thereof |
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Open date: 20100804 |