CN101785751A - Sustained-release freshener for disposable hygienic product, preparation method and application thereof - Google Patents
Sustained-release freshener for disposable hygienic product, preparation method and application thereof Download PDFInfo
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- CN101785751A CN101785751A CN 200910070430 CN200910070430A CN101785751A CN 101785751 A CN101785751 A CN 101785751A CN 200910070430 CN200910070430 CN 200910070430 CN 200910070430 A CN200910070430 A CN 200910070430A CN 101785751 A CN101785751 A CN 101785751A
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- Prior art keywords
- sustained
- refrigerant
- additive
- freshener
- release
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- 238000013268 sustained release Methods 0.000 title claims abstract description 23
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 29
- 239000000654 additive Substances 0.000 claims abstract description 13
- 230000000996 additive effect Effects 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000003507 refrigerant Substances 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000003756 stirring Methods 0.000 claims description 19
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical group CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 18
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- 229940041616 menthol Drugs 0.000 claims description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 229920000858 Cyclodextrin Polymers 0.000 claims description 8
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 8
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 8
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 7
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 7
- 235000019438 castor oil Nutrition 0.000 claims description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
- 244000246386 Mentha pulegium Species 0.000 claims description 6
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- 229920001249 ethyl cellulose Polymers 0.000 claims description 6
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 6
- 235000001050 hortel pimenta Nutrition 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 239000011343 solid material Substances 0.000 claims description 5
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims description 4
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000419 plant extract Substances 0.000 claims description 4
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims description 4
- -1 polyhexamethylene guanidine Polymers 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000000341 volatile oil Substances 0.000 claims description 4
- 244000251953 Agaricus brunnescens Species 0.000 claims description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims description 3
- 229920002413 Polyhexanide Polymers 0.000 claims description 3
- 229910021529 ammonia Inorganic materials 0.000 claims description 3
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical group CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 claims description 3
- 230000003647 oxidation Effects 0.000 claims description 3
- 238000007254 oxidation reaction Methods 0.000 claims description 3
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 3
- CFQPVBJOKYSPKG-UHFFFAOYSA-N 1,3-dimethylimidazol-2-one Chemical compound CN1C=CN(C)C1=O CFQPVBJOKYSPKG-UHFFFAOYSA-N 0.000 claims description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 2
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 2
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 125000005456 glyceride group Chemical group 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 239000003049 inorganic solvent Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 229940057847 polyethylene glycol 600 Drugs 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims 2
- 241001479543 Mentha x piperita Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000000638 stimulation Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 26
- 239000000047 product Substances 0.000 description 15
- 239000010410 layer Substances 0.000 description 10
- 238000001514 detection method Methods 0.000 description 9
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 8
- 229940116229 borneol Drugs 0.000 description 8
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 8
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 8
- 239000007921 spray Substances 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 6
- 239000000022 bacteriostatic agent Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 241001478240 Coccus Species 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 239000003094 microcapsule Substances 0.000 description 3
- 238000011017 operating method Methods 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 238000005352 clarification Methods 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 210000004914 menses Anatomy 0.000 description 2
- 230000003821 menstrual periods Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- 230000028016 temperature homeostasis Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 235000008418 Hedeoma Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000010813 internal standard method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a combination of a sustained-release freshener, a preparation method and the application thereof. Raw materials of the combination are mainly are follows (proportion by weight of each component is shown in brackets): a freshening factor (10 to 30%), a sustained-release agent (30 to 50%), a preservative (0.1 to 1%), an inclusion agent (10 to 20%), an additive (1 to 25%) and a medical solvent (10 to 30%). With simple manufacturing process, cheap raw materials, good effect, strong adaptability and obvious economic as well as social benefits, the combination of the sustained-release freshener overcomes the stimulation to a human body due to high content of the freshening factor and improves the problem that the content utilizing rate of effective components of the common freshener is low.
Description
Technical field
The present invention relates to a kind of sustained-release freshener compositions and preparation method and application.Can be applicable to prepare disposable sanitary napkin, sanitary pad, diaper or wet tissue.The sustained-release freshener compositions continuously or be interrupted and be sprayed on sanitary towel or the protective pad surface layer and then is finished product through physics heat seal and gum.
Technical background
Freshener is widely used in medicine and cosmetic industry in the market.Skin surface is smeared or be sprayed to freshener, thus by the pennyroyal chemical compound constantly the calcium ion inlet of chafe cell make the people produce cool sense.
Along with improving constantly of people's living standard, refrigerant product on the market can not satisfy the demands of consumers, for example refrigerant wet tissue in the market, the refrigerant sanitary pad of sanitary towel, chemicals is in the majority in the wherein refrigerant composition, act on and produce the strong impulse sense on the human body, What is more in use burning sensation.
Summary of the invention
The object of the invention is to provide a kind of sustained-release freshener compositions and preparation method and application, can overcome the defective of prior art.It is to adopt food grade materials, safety non-toxic, and select for use novel wall material that refrigerant composition is rolled into tiny microcapsule, make refrigerant composition have targeting and controlled capability, the skin surface that i.e. regulating action and concentration adjustment effect by body temperature selectively constantly is discharged into the refrigerant factor human body, solved because of the too high stimulation that human body is produced of refrigerant factor content, improved the low problem of common freshener working substance content utilization rate.Processing technology of the present invention is simple, and cost of material is cheap, and effect is remarkable, and the suitability is strong, economic benefit and obvious social benefit.
A kind of sustained-release freshener compositions provided by the invention, primary raw material comprise that the refrigerant factor, slow releasing agent, antiseptic, inclusion agents, additive and medical solvent make, and its component and weight proportion are:
Refrigerant factor 10-30%
Slow releasing agent 30-50%
Inclusion agents 10-20%
Antiseptic 0.1-1%
Solvent 10-30%
Additive 1-25%
Above-mentioned each component sum is 100%.
The refrigerant factor is selected from menthol, peppermint ester, Oleum menthae, Oleum menthae, Borneolum Syntheticum, menthol peppermint ester at least a in the molten thing altogether;
Slow releasing agent is selected from Polyethylene Glycol-200, Polyethylene Glycol-400, Polyethylene Glycol-600, propylene glycol, butanediol, pentanediol, glycerol, 1, at least a in 3-dimethyl-2-imidazolone;
Inclusion agents: at least a in cyclodextrin, soluble starch, polyvinyl alcohol 17-88, polyvinylpyrrolidone, hydroxypropyl methylcellulose, ethyl cellulose, cocoyl glyceride, castor oil hydrogenated, the ethyl cellulose;
Antiseptic: 2,4,4 ,-three chloro-2-dihydroxy diphenyl ethers, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene guanidine, poly hexamethylene biguanide, trichlorine kappa at least a;
Described medical solvent: water, ethanol and other inorganic and organic solvent;
The weight proportion of described additive is:
Flavouring agent 1-10%
Natural skin care agent 1-10%
Surfactant 1-25%
Described flavouring agent is compound essence, plant champignon.
Described natural skin care agent is natural plant extracts, natural plant essential oils, glycerol or lanoline.
Described surfactant is dimethyl dodecyl amine oxide, tertiary amine oxide or tween series.
The preferred composition and the weight proportion of a kind of sustained-release freshener compositions provided by the invention are:
Menthol 1-10%
Peppermint ester 1-5%
Borneolum Syntheticum 1-20%
Oleum menthae 1-10%
Oleum menthae 1-15%
Ethanol 1-30%
Propylene glycol 1-40%
Glycerol 1-5%
Polyethylene Glycol-200 10-30%
Cyclodextrin 1-20%
Ethyl cellulose 10-20%
Polyvinyl alcohol 17-88 1-10%
Castor oil hydrogenated 1-10%
Pentanediol 1-3%
1,3-dimethyl-2-imidazolone 1-10%
2,4,4 ,-three chloro-2-dihydroxy diphenyl ether 0.01-0.03%
Additive 1-25%
Water 10--30%
Additive is: compound essence, natural plant essential oils, natural plant extracts, natural-plant-essence, Tween 80, polysorbas20, oxidation ammonia, oxidation uncle ammonia, sodium lauryl sulphate at least a.
The step that a kind of sustained-release freshener preparation of compositions method provided by the invention comprises:
1) by the solid material single grinding respectively of measuring in will filling a prescription, sieve, it is stand-by to get 200-300 μ m;
2) inclusion agents is dissolved in the suitable quantity of water, adds and leave standstill after refrigerant composition stirs 30min, standby.
3) slow releasing agent, additive and solvent are mixed according to formulation ratio, stir, stand-by;
4) intermediate with the above-mentioned steps gained mixes, and stirs to clarify transparent.
Sustained-release freshener compositions provided by the invention can be applicable to prepare sanitary towel, sanitary pad, diaper or wet tissue.The sustained-release freshener compositions continuously or be interrupted and be sprayed on sanitary towel or the protective pad surface layer and then is finished product through physics heat seal and gum.
The characteristics of sustained-release freshener compositions provided by the invention:
1) product adopts microcapsule technology, is different from other fresheners, and refrigerant composition is wrapped up by wall materials such as cyclodextrin, avoids the refrigerant composition and the contact skin of excessive concentrations, has avoided the stimulation to human body; By thermoregulation effect and concentration adjustment effect refrigerant composition is discharged into skin surface slowly, has prolonged the refrigerant time, guaranteed the persistence of effect.
2) product adopts food grade materials, safe and harmless, affact women's privates and can not produce any negative effect, adopt slow releasing agent prescriptions such as Polyethylene Glycol, propylene glycol, polyvinyl alcohol, in use can long-acting release functional component, guarantee sanitary towel's (protective pad) stable effect in use.
3) administered area is concentrated, consumption is few, has reduced the production cost of sanitary towel, has improved the quality of product.
4) break through the pattern of traditional cold-type yellow (clear) sanitary towel, introduced the theory of slow release, tightly do not catered to the urgent needs with the trend women, and improved the effect of effective ingredient by the principle of microcapsule.
The specific embodiment
Example 1:
The manufacture method of a kind of sustained-release freshener compositions provided by the invention is an example, makes 1kg:
Accurately take by weighing food stage ethanol, menthol, Borneolum Syntheticum, cyclodextrin, Polyethylene Glycol-400, castor oil hydrogenated, propylene glycol, deionized water.Fill a prescription as table 1:
| Ethanol | Menthol | Borneolum Syntheticum | Cyclodextrin | PEG400 | Castor oil hydrogenated | Water | 2,4,4-three chloro-2-dihydroxy diphenyl ethers | Green tea essence | Tween 80 |
| ??12.7％ | ??15％ | ??10％ | ??5％ | ??10％ | ??12％ | ??5％ | 0.3％ | ??25％ | ??5％ |
| ??127g | ??150g | ??100g | ??50g | ??100g | ??120g | ??50g | 3g | ??250g | ??50g |
The manufacture method operating procedure:
Raw material is handled: with solid material menthol, Borneolum Syntheticum difference porphyrize, stand-by.
1, the first component:
150g menthol, 100g Borneolum Syntheticum mix with the 100g50% cyclodextrin aqueous solution, stir 30min, slowly add the 120g castor oil hydrogenated again and stir, and be stand-by.
2, the second components:
With 100g Polyethylene Glycol-400,3g2,4,4 ,-three chloro-2-dihydroxy diphenyl ethers slowly join in the 127g ethanol, stir, and add 250g green tea essence, the 50g Tween 80, and it is stand-by to stir.
Step 1,2 liang of groups are mixed fully and mixed, and add 50g water and stir to clarify, be product.
The product that example 1 is obtained carries out following a series of test:
Antiseptic effect checking: microorganism detection total number of bacterial colonies
Examination criteria: GB15979-2002 appendix B2, total number of bacterial colonies and initial contaminated bacteria detection method.
Sample treatment: evenly spray sample 0.15g on the sanitary towel top layer, the 1g of clip sanitary towel is dipped in the 100ml normal saline.Occurrence sees Table 2:
Table 2: microorganism detection total number of bacterial colonies testing result
This result shows that this product has very strong killing action to microbial bacterial, can suppress regrowing of antibacterial within a certain period of time, for the women provides safer physiological hygiene environment.And the sanitary towel that adds medicament by the stability tests in 2 years still possesses very strong killing rate to microbial bacterial.
The method of testing of refrigerant degree and checking:
Method 1
Accurately spray the 0.15g sample in the sanitary towel top layer, in all ages and classes section women, do refrigerant degree test respectively.Test result sees Table 3.
Table 3: refrigerant degree test result
| Ages | 15-22 year (100 people) | 23-30 year (100 people) | 30-40 year (100 people) | 40-50 year (100 people) |
| Test result | The cold degree is as snug as a bug in a rug moderate | The cold degree is as snug as a bug in a rug moderate | The cold degree is as snug as a bug in a rug moderate | The cold degree is as snug as a bug in a rug moderate |
The present invention can safeguard the comfortable dry and comfortable environment of women's privates through above-mentioned test proof, and is applicable to the healthy women of all age group.
The method of testing of refrigerant time and checking:
Accurately spray the 0.15g sample in the sanitary towel top layer, in all ages and classes section women, do refrigerant time test respectively.Test result sees Table 4.
Table 4: refrigerant time test result
| Ages | 15-22 year (100 people) | 23-30 year (100 people) | 30-40 year (100 people) | 40-50 year (100 people) |
| Test result | ??2-3h | ??1-2h | ??1-2h | ??1-1.5h |
Prove that through above-mentioned test the women who the present invention is directed to all ages and classes section can both provide the refrigerant time of 1-2h.
Method 2
With reference to the plain p238 detection method of CP2005L Oleum menthae
Chromatographic column: Agilent DB-MS 30m*0.25mm
Detector: hydrogen flame
Accurately tear and get sanitary towel's top layer non-woven fabrics and be placed in the 50ml color comparison tube, add mark liquid in the 2.5ml, add normal hexane again and be diluted to 25ml, get filtrate 1ml sample introduction, calculate the content of refrigerant composition in every sanitary towel by internal standard method with pipet.The content that experimental results show that refrigerant composition in the every sanitary towel is greater than 4.6mg.Through repeatedly to difference sprinkling amount carry out human test and chromatography of gases detect sanitary towel's refrigerant component content in surface show when concentration during greater than 3.5mg human body tangible refrigerant sensation is arranged.
The slow release effect checking:
With reference to the plain p238 detection method of CP2005L Oleum menthae
Chromatographic column: Agilent DB-MS 30m*0.25mm
Detector: hydrogen flame
Accurately spray the 0.15g sample in the sanitary towel top layer, the sanitary towel that opens is fully put into airtight exsiccator fully, 37 ℃ of constant temperature, at the chromatography of gases testing result such as the table 5 of different time:
| Time (h) | 0 | ?1 | ?2 | ?3 |
| Content (mg) | 4.6 | ?4.6 | ?4.7 | ?4.4 |
Accurately spray the 0.15g sample in the sanitary towel top layer, the sanitary towel that opens is fully put into the exsiccator of uncapping, 37 ℃ of constant temperature, at the chromatography of gases testing result such as the table 6 of different time:
| Time (h) | 0 | ?1 | ?2 | ?3 |
| Content (mg) | 4.6 | ?4.7 | ?4.9 | ?4.4 |
Originally experimental results show that the present invention can keep constant concentration with refrigerant composition all the time by thermoregulation effect and concentration adjustment effect in the normal process of using, have tangible slow release effect.
The effect contrast of sustained-release freshener and common freshener:
Accurately spray the 0.15g sample in the sanitary towel top layer, contrast through the content of the refrigerant composition in chromatography of gases detection top layer and with common freshener.Testing result is seen Fig. 1
Description of drawings: be sprayed with the refrigerant component content contrast in sustained-release freshener and common freshener sanitary towel top layer.The top line is represented sustained-release freshener among the figure; The below line is represented common freshener.Find that after testing the refrigerant time of sustained-release freshener will be longer than the refrigerant time of common freshener, and delayed the maximum time of measuring arrival, reduced and used initial stimulation human body.
Example 2:
The preparation method of the refrigerant bacteriostat composition of a kind of slowly-releasing provided by the invention is example, makes 1kg:
Accurately take by weighing food-grade ethanol, menthol, borneol, PEG-4000, rilanit special, deionized water, 25% polyhexamethylene guanide (hereinafter to be referred as JG). Fill a prescription such as table 7:
Table 7: the refrigerant bacteriostatic agent prescription of slowly-releasing
| Ethanol | Menthol | Borneol | PEG-4000 | Rilanit special | Water | JG |
| 12％ | 15％ | 10％ | 16％ | 12％ | 15％ | 20％ |
| 120g | 150g | 100g | 160g | 120g | 150g | 200g |
The preparation method operating procedure:
Raw material is processed: with solid material menthol, borneol difference porphyrize, stand-by.
1, the first component:
The 150g menthol fully mixes with the 100g borneol, and is stand-by.
2, second component:
The 160g PEG-4000 slowly joined in the 120g ethanol stir, slowly adding the 120g rilanit special, stir, stand-by.
3, the three components:
200gJG is joined in the 150g water, and it is stand-by to stir.
Step 1,2 liang of groups are stirred well to clarification after mixing, add again 3, stir to clarify and be product. The refrigerant bacteriostatic agent of slowly-releasing of getting embodiment 2 preparations carries out following effect checking and related check index:
The detection of 1＞bacteriostasis rate:
Sample treatment: on blank sanitary napkin print, evenly spray the refrigerant bacteriostatic agent of 0.15g slowly-releasing, dry 1h in 37 ± 2 ℃ of baking ovens. Active component is done bacteriostasis rate and is detected three groups of (according to the operation of GB15979-2002 method) parallel testings in the middle of the clip, sees Table 8:
Table 8: the refrigerant bacteriostatic agent bacteriostasis rate of slowly-releasing testing result
| The test item numbering | White is read coccus | Staphylococcus aureus | Escherichia coli |
| 1# | 98.23％ | 99.01％ | 99.12％ |
| 2# | 97.79％ | 99.25％ | 99.24％ |
| 3# | 98.34％ | 99.30％ | 99.19％ |
| On average | 98.12％ | 99.18％ | 99.18％ |
2 years stability experiments:
With reference to GB15979-2002 sanitary napkin stability test method of operating, the even sprinkling with sanitary napkin top layer (every is sprayed 0.15g) of example two samples after placing three months, 37 ℃ of baking ovens done detection again, and detection method is the same, sees Table 9
Table 9: bacteriostasis rate testing result after the stability test in 2 years
| The test item numbering | White is read coccus | Staphylococcus aureus | Escherichia coli |
| 1# | 98.02％ | 98.54％ | 99.24％ |
| 2# | 96.89％ | 99.12％ | 99.07％ |
| 3# | 98.14％ | 98.88％ | 99.15％ |
| On average | 97.68％ | 98.84％ | 99.15％ |
This testing result meets in the People's Republic of China's disposable use amenities sanitary standard fully reads coccus, staphylococcus aureus and colibacillary killing rate more than or equal to 50% regulation to white, and proof medicine itself has good stability. Thereby the fungistatic effect of the refrigerant bacteriostatic agent excellence of proof slowly-releasing.
Example 3
The preparation method of the refrigerant weak acid agent of a kind of slowly-releasing provided by the invention composition is example, makes 1kg:
Accurately take by weighing food-grade ethanol, menthol, borneol, PEG-4000, rilanit special, propane diols, deionized water, natural tartaric acid. Fill a prescription such as table 10:
Table 10: the refrigerant weak acid agent prescription of slowly-releasing
| Ethanol | Menthol | Borneol | PEG-4000 | Rilanit special | Water | Natural tartaric acid |
| 12％ | 15％ | 10％ | 34％ | 12％ | 15％ | 2％ |
| 120g | 150g | 100g | 340g | 120g | 150g | 20g |
The preparation method operating procedure:
Raw material is processed: with solid material menthol, borneol difference porphyrize, stand-by.
1, the first component:
The 150g menthol fully mixes with the 100g borneol, and is stand-by.
2, second component:
The 340g PEG-4000 slowly joined in the 120g ethanol stir, slowly adding the 120g rilanit special, stir, stand-by.
3, the three components:
The 20g natural tartaric acid is joined in the 150g water, and it is stand-by to stir.
Step 1,2 liang of groups are stirred well to clarification after mixing, add again 3, stir to clarify and be product.
The refrigerant bacteriostatic agent of slowly-releasing of getting embodiment 2 preparations carries out following effect checking and related check index:
1＞detect the pH value of simulating in the use procedure to change
Sample treatment: on blank sanitary napkin print, evenly spray the refrigerant weak acid agent of 0.15g slowly-releasing, dry 1h in 37 ± 2 ℃ of baking ovens.
Be 7.2 artificial menses (pH values of imitation menses) 15ml at the disposable pH value of pouring into of the middle active component of print, use special pH test paper to detect the variation of pH value, see Table 9:
Table 9:PH value testing result
| Time | 1min | 30min | 1h | 1.5h | 2h |
| PH value | 4.4-4.6 | 4.4-4.6 | 4.6-4.8 | 4.6-5.1 | 4.8-5.1 |
The pH value of simulating after testing in the use changes, the present invention can keep weakly acidic condition more than the 2h for women's privates, show that through consulting relevant authoritative documents and materials healthy women pH value in menstrual period is between the 4-6, the weakly acidic condition that the present invention built meets healthy women pH value in menstrual period fully, can help to be in subhealth state or unsound women recovers normal pH value, improve women's autoimmunity, the drug side effect of having avoided the treatment of medicine class to be brought.
Product of the present invention adopts food grade materials fully, and the addition strictness guarantees the being perfectly safe property of product according to national Specification, affacts the unsafe hidden danger of human body thereby eliminated common freshener.In addition, add different auxiliary functional components in the product, as antibacterial, weak acid agent etc., when assurance has no side effect to human body, by the regulating action of body temperature, make antibacterial, weak acid agent send to women's privates continuously, reach purpose antibacterial for a long time, that regulate pH value.Because the existence of slow releasing agent, greatly reducing stimulates the human body thoughts and feelings, has effectively improved the utilization ratio of medicine, and its product stability can be followed sanitary towel all the time.In addition, this production technology is simple, and cost of material is cheap, and general; Be convenient to buy.And effect is remarkable, has certain economic, practicality, social perspective in market in the future.
Claims (4)
1. sustained-release freshener compositions, the primary raw material that it is characterized in that it comprise that the refrigerant factor, slow releasing agent, antiseptic, inclusion agents, additive and medical solvent make component and weight proportion:
Refrigerant factor 10-30%
Slow releasing agent 30-50%
Inclusion agents 10-20%
Antiseptic 0.1-1%
Solvent 10-30%
Additive 1-25%
Above-mentioned each component sum is 100%;
The refrigerant factor is selected from menthol, peppermint ester, Oleum menthae, Oleum menthae, Borneolum Syntheticum, menthol peppermint ester at least a in the molten thing altogether;
Slow releasing agent is selected from Polyethylene Glycol-200, Polyethylene Glycol-400, Polyethylene Glycol-600, propylene glycol, butanediol, pentanediol, glycerol, 1, at least a in 3-dimethyl-2-imidazolone;
Inclusion agents: at least a in cyclodextrin, soluble starch, polyvinyl alcohol 17-88, polyvinylpyrrolidone, hydroxypropyl methylcellulose, ethyl cellulose, cocoyl glyceride, castor oil hydrogenated, the ethyl cellulose;
Antiseptic: 2,4,4 ,-three chloro-2-dihydroxy diphenyl ethers, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene guanidine, poly hexamethylene biguanide, trichlorine kappa at least a;
The weight proportion of described additive is:
Flavouring agent 1-10%
Natural skin care agent 1-10%
Surfactant 1-25%
Described flavouring agent is natural perfume material, champignon or compound essence.
Described natural skin care agent is natural plant extracts, natural plant essential oils, glycerol or lanoline;
Described surfactant is dimethyl dodecyl amine oxide, tertiary amine oxide or tween series;
Described medical solvent: water, ethanol and other inorganic and organic solvent.
2. sustained-release freshener compositions according to claim 1 is characterized in that its composition and weight proportion are:
Menthol 1-10%
Peppermint ester 1-5%
Borneolum Syntheticum 1-20%
Oleum menthae 1-10%
Oleum menthae 1-15%
Ethanol 1-30%
Propylene glycol 1-40%
Glycerol 1-5%
Polyethylene Glycol-200 10-30%
Cyclodextrin 1-20%
Ethyl cellulose 10-20%
PVA?17-88?????????????????????1-10％
Castor oil hydrogenated 1-10%
Pentanediol 1-3%
1,3-dimethyl-2-imidazolone 1-10%
2,4,4 ,-three chloro-2-dihydroxy diphenyl ether 0.01-0.03%
Additive 1-25%
Water 10--30%
Above-mentioned each component sum is 100%.
Additive is: natural perfume material, champignon, compound essence, natural plant essential oils, natural plant extracts, Tween 80, polysorbas20, dimethyl dodecyl amine oxide, oxidation uncle ammonia, sodium lauryl sulphate at least a.
3. sustained-release freshener preparation of compositions method is characterized in that the step that comprises:
1) by the solid material single grinding respectively of measuring in will filling a prescription, sieve, it is stand-by to get 200-300 μ m;
2) inclusion agents is dissolved in the suitable quantity of water, adds and leave standstill after refrigerant composition stirs 30min, standby.
3) slow releasing agent, additive and solvent are mixed according to formulation ratio, stir, stand-by;
4) intermediate of above-mentioned steps gained is mixed, stir to clarify transparently, be product.
4. the application of the described sustained-release freshener compositions of claim 1 is characterized in that can be applicable to prepare sanitary towel, sanitary pad, diaper or wet tissue.
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