CN101744862A - Radix Codonopsis Pilosulae oral liquid and preparation method as well as application thereof - Google Patents
Radix Codonopsis Pilosulae oral liquid and preparation method as well as application thereof Download PDFInfo
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- CN101744862A CN101744862A CN200810080046A CN200810080046A CN101744862A CN 101744862 A CN101744862 A CN 101744862A CN 200810080046 A CN200810080046 A CN 200810080046A CN 200810080046 A CN200810080046 A CN 200810080046A CN 101744862 A CN101744862 A CN 101744862A
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Abstract
The invention relates to a Radix Codonopsis Pilosulae oral liquid which is prepared by using Radix Codonopsis Pilosulae as a main raw material through water extraction, concentration, alcohol precipitation and filtration. The Radix Codonopsis Pilosulae oral liquid has the functions of invigorating spleen-stomach and replenishing qi, strengthening the spleen, tonifying the lung, nourishing and strengthening the body and enhancing the human immunity, is suitable for deficiency syndrome of the spleen and lung, short breath, palpitation, deficiency of food, loose stool, dyspnea due to deficiency and cough, and is mainly used for treating spleen deficiency type infantile diarrhea, gynecological anemia, chronic gastritis, chronic nephritis and spleen-lung qi deficiency and other symptoms after radiotherapy and chemotherapy.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, relate to a kind of Radix codonopsis pilosulae (Radix Codonopsis) oral liquid and preparation method thereof, the invention still further relates to the application of this Radix codonopsis pilosulae's oral liquid aspect the treatment disease.
Background technology
Deficiency of both the splenic and pulmonary QI disease behind chronic gastritis, chronic nephritis, infantile diarrhea, department of obstetrics and gynecology anemia and the chemicotherapy etc. belongs to common clinical, and the side effect of western medicine is big, the drug cost height, and effect is undesirable.Chinese medicine adopts prescription to treat above-mentioned disease more, lacks pointed patent medicine, faces the disease randomness by force, lacks relevant criterion, and it is slow to produce effects.
Summary of the invention
The object of the present invention is to provide a kind of Radix codonopsis pilosulae's oral liquid with invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, strengthening by means of tonics, enhancing human body immunity effect, and the preparation method of this Radix codonopsis pilosulae's oral liquid and application.
Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid is to be primary raw material with the Radix codonopsis pilosulae (Radix Codonopsis), carries, concentrates, makes oral liquid behind the precipitate with ethanol, filtration through water.
The concrete preparation method of Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid is:
Get Radix codonopsis pilosulae (Radix Codonopsis), decoct with water 2 times, add 8 times of water gagings the 1st time, soaked 0.5 hour earlier, decocted again 1 hour, and added 6 times of water gagings, decocted 1 hour for the 2nd time, merge 2 times decocting liquid, filter, it is 1.18～1.20 that filtrate is concentrated into relative density, add 90～95% ethanol of 1 times of amount, left standstill 24 hours, filter, reclaim ethanol, adding water move to relative density is 1.12～1.14, cold preservation 24～48 hours, filter, sterilization, oral liquid is made in embedding.
Radix codonopsis pilosulae's oral liquid invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, strengthening by means of tonics, the enhancing human body immunity of the present invention's preparation, be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, cure mainly all diseases of deficiency of both the splenic and pulmonary QI behind spleen-deficient infantile diarrhea, department of obstetrics and gynecology anemia, chronic gastritis, chronic nephritis and the chemicotherapy.
Instructions of taking: oral, a 10mL, twice on the one.
Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid can be used for the treatment of insufficiency of the spleen property infantile diarrhea;
Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid can be used for the treatment of department of obstetrics and gynecology anemia;
Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid can be used for the treatment of chronic gastritis;
Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid can be used for the treatment of chronic nephritis;
Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid can be used for putting, the treatment of syndrome of qi deficiency of spleen and lung after the chemotherapy.
One, is used for the treatment of insufficiency of the spleen property infantile diarrhea
Infantile spleen deficiency have loose bowels the card choice criteria be:
Main symptom: chronic diarrhea, big loose stool is thin, and the food back is done to rush down, abdominal distention, lethargy, indigestion and loss of appetite stagnating eaten in the complexion jaundice.
Inferior card: tastelessness and no thirst, long-term sialorrhea, the stool color is light, and stink is not outstanding, puffiness due to deficiency, edema, abundant expectoration is rare clearly, clear urine in large amounts.
The deficiency of spleen-QI main symptom: spiritlessness and weakness, pale white complexion, the chronic diarrhea proctoptosis, tongue fur turns white or is fat tender, and indentation is arranged, and thready and weak pulse or fingerprint are light.
Selector closes and states condition person's 140 examples, is divided into two groups at random, and wherein 100 examples are organized in treatment, matched group 40 examples, two groups of sexes, age, clinical manifestation, diarrhoea degree etc. relatively there are no significant difference.
2 week of persistent period above person's 11 examples (11%) of suffering from diarrhoea outside the 100 routine infant institutes are organized in treatment; 2～4 all person's 15 examples (15%); Person's 16 examples in 1～March (16%); Person's 14 examples half a year (14%); 1 year person's 16 example (16%); Person's 28 examples (28%) more than 1 year.
Therapeutic Method
The treatment group: adopt Radix codonopsis pilosulae's oral liquid to treat, every day 2 times, below 3 years old 5mL/ time, 3～5 years old 7mL/ time, 5～10 years old 9mL/ time, more than 10 years old 10mL/ time, 10 days is a course of treatment.
Matched group: owing to contain the Radix Codonopsis composition in the infant spleen-tonifying Chinese patent medicine more, for avoid with the treatment group in the Radix codonopsis pilosulae (Radix Codonopsis) composition repeat employing decoction matched group.Treat diarrhea due to hypofunction of the spleen 40 examples altogether, writing out a prescription is Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Poria, Rhizoma Alismatis, Cortex Cinnamomi, Rhizoma Zingiberis, stir-fried kidney beans, stir-fry Semen Coicis, one day potion, and 7～10 days is a course of treatment.
Curative effect judging standard:
1, times of defecation and character comparatively normal (leading indicator).2, General Symptoms obviously improves, and increases as spirit, complexion improvement, appetite.3, tongue fur, pulse condition, fingerprint are normal.4, laboratory examination is normal.5, drug withdrawal 2 Zhou Houwu repeatedly.
Possess above 5 persons and be recovery from illness.Possess times of defecation minimizing and character and take a turn for the better, cardinal symptom is obviously improved, and tongue fur, pulse condition, fingerprint and sign take a turn for the better, and lab work improvement person is a produce effects.No changes such as symptom, Signs, tongue fur, pulse condition, fingerprint, laboratory examination index no change person is invalid.
Therapeutic outcome:
Treatment group: treat infantile spleen deficiency 100 examples of having loose bowels altogether, 78 examples of wherein fully recovering, produce effects 19 examples, invalid 3 examples, total effective rate 97%.
Matched group: treat infantile spleen deficiency 40 examples of having loose bowels altogether, 34 examples of wherein fully recovering, produce effects 5 examples, invalid 1 example, total effective rate 97.5%.
Two, be used for the treatment of the department of obstetrics and gynecology anemia
The outpatient service or the inpatient of all department of obstetrics and gynecology illness secondary, hysteromyoma, dysfunctional uterine hemorrhage, menorrhagia, climacteric irregular metrorrhagia, postoperative or anemia patient and pregnancy period such as post-abortion in puerperal, comprise early, middle and late phase anemia patient, but see accompanied symptoms person such as temper disease and insufficiency of the spleen folder silt are arranged, asthenia of both the spleen and kidney, insufficiency of the spleen blood deficiency, insufficiency of the spleen folder are wet, all can list among observation group and the matched group case.
Therapeutic Method
1, administrated method: 1) observation group: oral Radix codonopsis pilosulae (Radix Codonopsis) oral liquid, each 10mL, 10 days is 1 course of treatment, treats for 1～3 course of treatment.2) matched group: GUIPI TANG water decoction (Hemerocallis citrina Baroni, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygalae, the Radix Aucklandiae, Semen Ziziphi Spinosae, Radix Angelicae Sinensis, first meat, Radix Glycyrrhizae), 1 dose of every day, early, middle and lately respectively obey 1 time.
2, do not use in other during two groups of medications, medicine and blood transfusion are enriched blood in the west, available and the medicine of enriching blood treatment protopathy irrelevant.
3, monitor the situation of change of hemoglobin before and after the medication with hemogram.Hematochrome all needs check continuously 2 times.
Efficacy determination
Recovery from illness: hematochrome has been raised to normally; Produce effects: hematochrome improves more than the 1g; Take a turn for the better: color have raising, but is lower than 1g; Invalid: hematochrome no change before and after the treatment.
Anemia observation of curative effect due to the table 1 Radix codonopsis pilosulae (Radix Codonopsis) oral liquid treatment various diseases
Table 2 Radix codonopsis pilosulae (Radix Codonopsis) oral liquid treatment department of obstetrics and gynecology anemia clinical control table
Clinical conclusion
Radix codonopsis pilosulae's oral liquid has definite blood tonification effect, can improve hematochrome after the use, and to because of the insufficiency of the spleen loss of appetite that causes, spiritlessness and sparing of words, limbs asthenia, abdominal distention after meal, all cards of diarrhea with loose stool all have obvious curative effects.
Three, be used for the treatment of chronic gastritis
Select patient's 45 examples, male 23 examples, women 22 examples, 22～40 years old 21 age example, 40～60 years old 18 example, 61～67 years old 6 example.The sick kind has chronic gastritis 42 examples, recurrent oral ulceration, behcets disease, each 1 example of anemia.
Diagnostic criteria: inappetence, spiritlessness and sparing of words, limbs asthenia, abdominal distention after meal, stool weighing apparatus or half congealed, and press spleen deficiency divide gently, in, weigh three grades.
Therapeutic Method: oral Radix codonopsis pilosulae (Radix Codonopsis) oral liquid is organized in treatment, each 10mL, and every day 2 times, 10 days is a course of treatment.Matched group is selected same patient's 15 examples, takes Pingwei San and adds the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae etc. and be decocted in water for oral dose.1 dose of every day, 10 days is a course of treatment.
Therapeutic outcome
Recovery from illness: syndrome of spleen-deficiency marquis complete obiteration person; Take a turn for the better: syndrome of spleen-deficiency is by in heavily transferring to or light level person; Invalid: as to treat 10 days no change persons.
Table 3 Radix codonopsis pilosulae (Radix Codonopsis) oral liquid treatment chronic gastritis clinical control table
Four, be used for the treatment of chronic nephritis
Use Radix codonopsis pilosulae's oral liquid that insufficiency of the spleen symptom 30 examples in the chronic nephritis (wherein renal anemia 20 examples) are carried out clinical observation, satisfied to the therapeutic effect of spleen doing well,improving and renal anemia, total effective rate 93.3%.
Case is chosen as in hospital or in the patient medical history obvious insufficiency of the spleen symptom, observes its insufficiency of the spleen symptom such as the variation of loss of appetite, spiritlessness and sparing of words, limbs asthenia, abdominal distention after meal, stool and edema and hematochrome variation of renal anemia before and after medication.
Oral Radix codonopsis pilosulae (Radix Codonopsis) oral liquid, each 10mL, every day 2 times.Carry out 1～6 month course of treatment simultaneously with the nephropathy whole body therapeutic.
Hematochrome situation of change before and after the medication of table 4 renal anemia
Table 5 Radix codonopsis pilosulae (Radix Codonopsis) oral liquid improves situation to the chronic nephritis syndrome of spleen-deficiency
Clinical conclusion
Chronic nephritis patient is common syndrome of spleen-deficiency and anemia in various degree in clinical, Radix codonopsis pilosulae's oral liquid has satisfied effect to the improvement of the insufficiency of the spleen symptom of chronic nephritis, can effectively reduce the retention of nitrogen matter, promote the synthetic of the interior erythropoietin of body, thereby stimulate the generation of bone marrow, raising discharges erythrocytic ability, makes renal anemia obtain in various degree improvement, treatment back hematochrome enhancer accounts for 60%, on average improves 1.57g.
Five, be used for the treatment of put, syndrome of qi deficiency of spleen and lung after the chemotherapy
The immunologic hypofunction of cancer patient own, chemicotherapy has further weakened patient's immunity, causes many secondary symptoms.Radix codonopsis pilosulae's oral liquid can reduce the damage of ray to the various kinds of cell immunologic function, make the syndrome of spleen-deficiency symptom be improved significantly, be beneficial to continue treatment.
The esophageal carcinoma, the lung cancer patient in radiotherapy just is divided into treatment group and matched group at random.The treatment group esophageal carcinoma 52 examples, pulmonary carcinoma 54 examples; The matched group esophageal carcinoma 70 examples, pulmonary carcinoma 36 examples, every group 106 example.Oral Radix codonopsis pilosulae (Radix Codonopsis) oral liquid is organized in treatment, and each 10mL, obeyed 60 days at every day 3 times; Matched group is not taken medicine, and chemicotherapy dosage is consistent with the treatment group.Measure cellular immunization and humoral immunization index before and after the treatment.
The result shows that the immunoglobulin 1gM index of treatment group has obvious rising behind chemicotherapy, and matched group descends, and confirms that Radix codonopsis pilosulae's oral liquid has the effect that promotes 1gM in chemicotherapy.
Table 6 Radix codonopsis pilosulae (Radix Codonopsis) oral liquid is to the influence (treatment group) of immunoglobulin 1gM
It is high that cancer patient lymphocyte transformation and 1L-2 induction experiment all are not so good as normal person cmp position basically, is in low state.The treatment group is through behind the radiotherapy, and cmp potential drop low amplitude is little, and what have also slightly raises, and matched group obviously reduces through cmp behind the radiotherapy.
Table 8 Radix codonopsis pilosulae (Radix Codonopsis) oral liquid drenches the influence (treatment group) of changeing the 1L-2 induction experiment to radiotherapy cancer patient
Table 9 radiotherapy cancer patient matched group drenches to be changeed relatively
Radix codonopsis pilosulae (Radix Codonopsis) of the present invention oral liquid also finds to have following pharmacological action except that the curative effect with above clinical verification:
1, promotes cell metabolism, strengthen body immunity.
2, QI invigorating, enrich blood, stimulate the hematopoietic potential of medullary cell.
3, improve human endocrine and metabolism state, promote the utilization of tissue blood glucose.
4, regulate nervus centralis, strengthen gastrointestinal peristalsis and gastric secretion.
5, blood circulation promoting makes skin gloss, and is ruddy.
6, promote the generation of immunoglobulin, lymphocytic quantity obviously increased, reduce put, after the chemotherapy to the damage of human body various kinds of cell immunologic function.
The specific embodiment
Get the 10Kg of Radix codonopsis pilosulae (Radix Codonopsis) that cleans, cleans, dries, add 80Kg water logging bubble 0.5 hour, decocted again 1 hour, collect filtrate, filtering residue adds the 60Kg decocting and boiled 1 hour, merges 2 times decocting liquid, filter, be concentrated into relative density 1.20,95% ethanol that adds 100L left standstill 24 hours, filter, reclaim ethanol, add water move to relative density 1.12, cold preservation 24 hours, filter, sterilization, filling bottle, encapsulation, dress box, seal, case and make oral liquid.
Claims (7)
1. Radix codonopsis pilosulae's oral liquid is to be primary raw material with the Radix codonopsis pilosulae (Radix Codonopsis), carries, concentrates, makes oral liquid behind the precipitate with ethanol, filtration through water.
2. the preparation method of Radix codonopsis pilosulae's oral liquid of claim 1 is that Radix codonopsis pilosulae (Radix Codonopsis) is decocted with water 2 times, adds 8 times of water gagings the 1st time, soaks 0.5 hour earlier, decocted again 1 hour, and added 6 times of water gagings, decocted 1 hour for the 2nd time, merge 2 times decocting liquid, filter, it is 1.18～1.20 that filtrate is concentrated into relative density, add 90～95% ethanol of 1 times of amount, left standstill 24 hours, filter, reclaim ethanol, adding water move to relative density is 1.12～1.14, cold preservation 24～48 hours, filter, sterilization, oral liquid is made in embedding.
3. Radix codonopsis pilosulae's oral liquid of claim 1 is as the application of the insufficiency of the spleen property infantile diarrhea medicine of treatment.
4. Radix codonopsis pilosulae's oral liquid of claim 1 is as the application of treatment department of obstetrics and gynecology anemia medicine.
5. Radix codonopsis pilosulae's oral liquid of claim 1 is as the application of treatment chronic gastritis medicine.
6. Radix codonopsis pilosulae's oral liquid of claim 1 is as the application of treatment chronic nephritis medicine.
Radix codonopsis pilosulae's oral liquid of claim 1 as treatment put, the application of syndrome of qi deficiency of spleen and lung medicine after the chemotherapy.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525901A (en) * | 2012-01-19 | 2012-07-04 | 江西新世纪民星动物保健品有限公司 | Animal codonopsis pilosula polysaccharide oral solution and preparation method thereof |
| CN108606990A (en) * | 2018-06-01 | 2018-10-02 | 山西正来制药有限公司 | A kind of preparation method of RADIX CODONOPSIS PILOSULAE from Shanxi of China's oral solution |
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- 2008-12-02 CN CN200810080046A patent/CN101744862A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525901A (en) * | 2012-01-19 | 2012-07-04 | 江西新世纪民星动物保健品有限公司 | Animal codonopsis pilosula polysaccharide oral solution and preparation method thereof |
| CN102525901B (en) * | 2012-01-19 | 2013-10-30 | 江西新世纪民星动物保健品有限公司 | Animal codonopsis pilosula polysaccharide oral solution and preparation method thereof |
| CN108606990A (en) * | 2018-06-01 | 2018-10-02 | 山西正来制药有限公司 | A kind of preparation method of RADIX CODONOPSIS PILOSULAE from Shanxi of China's oral solution |
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Application publication date: 20100623 |