CN101744849A - Glabrous sarcandra herb dripping pill and preparation technology - Google Patents
Glabrous sarcandra herb dripping pill and preparation technology Download PDFInfo
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- CN101744849A CN101744849A CN200810188550A CN200810188550A CN101744849A CN 101744849 A CN101744849 A CN 101744849A CN 200810188550 A CN200810188550 A CN 200810188550A CN 200810188550 A CN200810188550 A CN 200810188550A CN 101744849 A CN101744849 A CN 101744849A
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- dripping pill
- glabrous sarcandra
- sarcandra herb
- polyethylene glycol
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Abstract
The invention discloses a glabrous sarcandra herb dripping pill and a preparation method thereof, the glabrous sarcandra herb dripping pill per 1000 parts of dosage contains 1562.5g of glabrous sarcandra herb crude drug and a fixed amount of dripping pill matrix. The matrix is one or more than two components selected from the group consisting of polyethylene glycol 6000, polyethylene glycol 4000 and polyethylene glycol 2000. The preparation method comprises the steps: cutting glabrous sarcandra herb into pieces and adding water into the pieces for decoction, combining and filtering decoction, concentrating filtrate to thick paste, depressurizing and drying the thick paste to dry extract, crushing the dry extract, adding the matrix, melting and uniformly mixing, drip-forming the dripping pill via a dripping pill machine with methyl silicone oil as condensing agent, removing the condensing agent, checking the amount of ingredients and packaging. Compared with other preparations, the dripping pill preparation according to the invention is fast in effecting and high in bioavailability, and the preparation technology is suitable for industrial production.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of oral administration dripping pill, relate in particular to a kind of treatment pneumonia, appendicitis, cellulitis belong to the hyperactivity of toxic heat patient, and can be used for the glabrous sarcandra herb dripping pill and the preparation method of assistant treating cancer.
Background technology
Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Has heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds.
Found in recent years that Herba Sarcandrae had pharmacological action comparatively widely, experimental results show that the main component coumarone of Herba Sarcandrae and lactone material etc. are the antimicrobial effective constituent that mainly contains, broad-spectrum antibacterial action is arranged, to staphylococcus aureus, dysentery bacterium, escherichia coli all have stronger inhibitory action, and the resisiting influenza virus effect is arranged simultaneously; Succinic acid and volatile oil have the effect of obvious anti-S180 and w 256 tumor strains; Materials such as while ingredient flavone, coumarone, lactone, tannic acid, antiinflammatory, convergence, protection ulcer surface are arranged, regulate central nervous system's function, gastric mucosa there are stronger protection and repair, rotten to the corn hemorrhage ulcer there is tangible astriction, gastric ulcer is healed in a short time; Succinic acid has antitussive, phlegm-dispelling functions, feels that chest is comfortable behind patient's clothes, and sputum dilutes easy expectoration.The patient who is used for various allergic asthmas, bronchial asthma and is unsuitable for taking ephedrine, aminophylline; Show by long-term experiment that in addition the continuing of glabrous sarcandra herb dripping pill taken, and do not have any toxic reaction, and be safe.
Glabrous sarcandra herb dripping pill mean with Chinese medicinal material of sarcandra glaber through extract, concentrate, dry back is with after relevant substrate melting mixing is even, splashes in the immiscible condensing agent contraction condensation and the preparation made.Its main feature is, the dissolution rate and the infiltration rate of Chinese medicinal material of sarcandra glaber composition are fast, and curative effect is rapid, the bioavailability height, and few side effects is convenient to take and carry, and production equipment is simple, and is easy to operate, and weight differential is little, and dosage is accurate, and production cost is low.
Summary of the invention
The object of the present invention is to provide a kind of glabrous sarcandra herb dripping pill and preparation method thereof.
The glabrous sarcandra herb dripping pill preparation that the present invention proposes is a kind of oral solid formulation, and it is a main component with the Herba Sarcandrae, is that the compatibility component is formulated with the Polyethylene Glycol, and the weight proportion of each component is: 1 part of Herba Sarcandrae, 1～3 part of Polyethylene Glycol.
The advantage of glabrous sarcandra herb dripping pill of the present invention is, the extraction ratio height of Chinese medicinal material of sarcandra glaber composition, and bioavailability increases, and drug effect is rapid, and side effect is little, and production technology is simple.
Drop pill substrate of the present invention is, polyethylene glycol 6000 100～2000g, Macrogol 4000 100～2000g, Macrogol 3000 100～2000g, Macrogol 2000 100～2000g, one of or two or more.
Contain the extract of Chinese medicinal material of sarcandra glaber 1562.5g and an amount of drop pill substrate in the per 1000 parts of doses of glabrous sarcandra herb dripping pill of the present invention.
Glabrous sarcandra herb dripping pill of the present invention can be used for treating pneumonia, and appendicitis, cellulitis belong to the hyperactivity of toxic heat patient, and can be used for assistant treating cancer.
The specific embodiment
Further specifically describe the present invention below by embodiment.
Embodiment one:
Get Herba Sarcandrae 1562.5g, chopping decocts with water three times, adds 8 times of water gagings at every turn and decocts 1 hour, and collecting decoction filters, and filtrate is condensed into the thick paste shape, and drying under reduced pressure becomes dry extract, pulverizes 85 mesh sieves.Make substrate with PEG 2000, by after (dry extract: PEG 2000) fusion in 1: 1.3 with the extractum mix homogeneously, last drop pill machine is a condensing agent with the methyl-silicone oil, droplet makes 1000, gets final product.The extract that contains Chinese medicinal material of sarcandra glaber 1562.5g in per 1000 parts of glabrous sarcandra herb dripping pill doses.
Embodiment two:
Get Herba Sarcandrae 1562.5g, chopping decocts with water three times, adds 8 times of water gagings at every turn and decocts 1 hour, and collecting decoction filters, and filtrate is condensed into the thick paste shape, and drying under reduced pressure becomes dry extract, pulverizes 85 mesh sieves.Make substrate with PEG 6000, by after (dry extract: PEG 6000) fusion in 1: 1.7 with the extractum mix homogeneously, last drop pill machine is a condensing agent with the methyl-silicone oil, droplet makes 1000, gets final product.The extract that contains Chinese medicinal material of sarcandra glaber 1562.5g in per 1000 parts of glabrous sarcandra herb dripping pill doses.
Embodiment three:
Get Herba Sarcandrae 1562.5g, chopping decocts with water three times, adds 8 times of water gagings at every turn and decocts 1 hour, and collecting decoction filters, and filtrate is condensed into the thick paste shape, and drying under reduced pressure becomes dry extract, pulverizes 85 mesh sieves.Make substrate with PEG4000, by 1: 2 (dry extract: PEG4000) after the fusion with the extractum mix homogeneously, last drop pill machine is a condensing agent with the methyl-silicone oil, droplet makes 1000, gets final product.The extract that contains Chinese medicinal material of sarcandra glaber 1562.5g in per 1000 parts of glabrous sarcandra herb dripping pill doses.
Claims (4)
1. one kind is used for pneumonia, appendicitis, cellulitis belongs to the hyperactivity of toxic heat patient, and can be used for the glabrous sarcandra herb dripping pill and the preparation technology thereof of assistant treating cancer, it is characterized in that with the Herba Sarcandrae being main component, with the Polyethylene Glycol is that the compatibility component is formulated, and the weight compatibility of each component is: 1 part of Herba Sarcandrae; 1～3 part of Polyethylene Glycol.
2. glabrous sarcandra herb dripping pill preparation according to claim 1 is characterized in that the weight compatibility ratio of each component is: 1 part of Herba Sarcandrae, 1～2.5 part of Polyethylene Glycol.
3. glabrous sarcandra herb dripping pill according to claim 1 is characterized in that: described substrate is polyethylene glycol 6000 100～2000g, Macrogol 4000 100～2000g, Macrogol 3000 100～2000g, Macrogol 2000 100～2000g, one of or two or more.
4. the preparation method of a glabrous sarcandra herb dripping pill as claimed in claim 1 is characterized in that concrete steps are as follows:
(1) by the weight proportion of each component, it is an amount of to get Herba Sarcandrae, and chopping decocts with water, and collecting decoction filters, and filtrate is condensed into the thick paste shape, and drying under reduced pressure becomes dry extract, crushing screening.Make substrate with Polyethylene Glycol,, stand-by after the fusion with the extractum mix homogeneously;
(2) preheating drop pill machine, making fluid storage compartment constant temperature is fluid temperature, the coolant methyl-silicone oil is chilled to 10～35 degree in advance, when treating in dropping-pill machine head and the condensation column that the temperature of condensing agent reaches desired state of temperature, will prepare the ground mixture and drip system with 40～70 droplets/minute the speed of dripping;
(3) collect drop pill at valve, the filtering coolant, and absorb surperficial oil stain, and dry, promptly get the molding drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810188550A CN101744849A (en) | 2008-12-18 | 2008-12-18 | Glabrous sarcandra herb dripping pill and preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810188550A CN101744849A (en) | 2008-12-18 | 2008-12-18 | Glabrous sarcandra herb dripping pill and preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101744849A true CN101744849A (en) | 2010-06-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN200810188550A Pending CN101744849A (en) | 2008-12-18 | 2008-12-18 | Glabrous sarcandra herb dripping pill and preparation technology |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897740A (en) * | 2010-07-21 | 2010-12-01 | 江西省药物研究所 | Glabrous sarcandra herb formula particle and preparation method thereof |
| CN102633760A (en) * | 2012-03-20 | 2012-08-15 | 浙江维康药业有限公司 | Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound |
| CN102793731A (en) * | 2012-07-06 | 2012-11-28 | 广州白云山敬修堂药业股份有限公司 | Application of glabrous sarcandra glabrous herb extract in reducing susceptibility of influenza virus |
| CN102813685A (en) * | 2012-08-14 | 2012-12-12 | 海南中化联合制药工业股份有限公司 | Large specification glabrous scrcandra herb dripping pills and preparation method thereof |
| CN103127309A (en) * | 2013-02-28 | 2013-06-05 | 山东阿如拉药物研究开发有限公司 | Eight-medicine composition Chinese Eaglewood dropping pill for treating myocardial ischemia, and its preparation method |
-
2008
- 2008-12-18 CN CN200810188550A patent/CN101744849A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897740A (en) * | 2010-07-21 | 2010-12-01 | 江西省药物研究所 | Glabrous sarcandra herb formula particle and preparation method thereof |
| CN102633760A (en) * | 2012-03-20 | 2012-08-15 | 浙江维康药业有限公司 | Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound |
| CN102793731A (en) * | 2012-07-06 | 2012-11-28 | 广州白云山敬修堂药业股份有限公司 | Application of glabrous sarcandra glabrous herb extract in reducing susceptibility of influenza virus |
| CN102813685A (en) * | 2012-08-14 | 2012-12-12 | 海南中化联合制药工业股份有限公司 | Large specification glabrous scrcandra herb dripping pills and preparation method thereof |
| CN103127309A (en) * | 2013-02-28 | 2013-06-05 | 山东阿如拉药物研究开发有限公司 | Eight-medicine composition Chinese Eaglewood dropping pill for treating myocardial ischemia, and its preparation method |
| CN103127309B (en) * | 2013-02-28 | 2015-01-07 | 山东阿如拉药物研究开发有限公司 | Eight-medicine composition Chinese Eaglewood dropping pill for treating myocardial ischemia, and its preparation method |
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Open date: 20100623 |