CN1017434B - Synthesis and application of diphosphonate ester - Google Patents
Synthesis and application of diphosphonate esterInfo
- Publication number
- CN1017434B CN1017434B CN89108289A CN89108289A CN1017434B CN 1017434 B CN1017434 B CN 1017434B CN 89108289 A CN89108289 A CN 89108289A CN 89108289 A CN89108289 A CN 89108289A CN 1017434 B CN1017434 B CN 1017434B
- Authority
- CN
- China
- Prior art keywords
- phosphonic acid
- ethylhexyl phosphonic
- ester
- water
- diphosphonate ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Abstract
The present invention relates to a method for the synthesis of gem-diphosphonat ester. Esterification reaction is directly carried out by gem diphosphonat and alcohol. According to the values of molecular weight, oil solubility and water solubility, the gem-diphosphonat ester can be used as a universal chelating agent for the extraction and the purification of metal ions, the solidification of epoxy resin, the oxidation resistance of petroleum products, the catalytic oxidation of hydrocarbons, etc.
Description
The present invention relates to the synthetic method and the application of the new compound-diphosphonate ester of a class.
A compounds that connects two phosphonyl groups on the same carbon atom is commonly referred to as long-pending diphosphonic acids, and its general formula is
(wherein R is the alkyl of C1～C18, and X is OH or H yl).Long-pending di 2 ethylhexyl phosphonic acid belongs to organic polyphosphonic acid.
HEDP(1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid) chemical formula is
It is first representative that is synthesized in the long-pending diphosphonic acids, report is arranged its synthetic morning, but up to 1960's to its physicochemical property with after physiological function carried out more research, just draw attention, especially as water quality stabilizer, make industrial cycle water quality treatment technology that epoch-making progress take place.
Because the tight arrangement of long-pending two phosphonic acids chelation groups of di 2 ethylhexyl phosphonic acid intramolecularly, thereby have some special chelating abilities.For example HEDP and alkaline earth, transition and rare earth element can both form stable chelate in the pH value scope widely; Again because unusual stable to hydrolysis or the effect of body endoenzyme of the P-C-P key in the molecule, so no matter which kind of administration can both play a role in human body or in the aqueous solution for long periods; Domestic Tianjin City Dongfanghong Chemical Works, xiangtan, hunan province city Fine Chemical Works etc. has all been produced in enormous quantities, and synthetic convenient, with low cost; Therefore as a kind of novel chelating agents, in industry, agricultural or medically all used increasingly extensively.At the industrial the most frequently used water quality stabilizer of doing, pipeline rust-preventive agent; It replaces deleterious prussiate to be used for electroplating; In textile industry, be used to remove the calcium ions and magnesium ions that influences colour tone; The metal ion that in chemical industry, is used for the flush away raw material; As the additive of synthetic detergent, more superior than original tripoly phosphate sodium STPP commonly used, because the latter is easy to hydrolysis, generate undissolved orthophosphoric acid salt; As the annexing ingredient of soap, can make soap in hard water, still keep washing usefulness; In petroleum drilling, be used for the acidifying mineral acid solution and add the precipitation that HEDP can prevent iron, magnesium, calcium, avoid line clogging; Aspect daily-use chemical industry, it can be used as the toothpaste additive that prevents that the tooth dirt from forming, and is used for coupling development antifoggant etc.; Medically, be mainly used in prevention and treatment and calcium metabolism diseases associated, also be used for the decorporation of toxic metal and radioelement.HEDP(1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid) difference according to raw material has following several main synthetic route:
(1) phosphorus trichloride (PC13), Glacial acetic acid (CH3COOH) and water (H2O);
(2) ortho-phosphoric acid (H3PO4), aceticanhydride (Ac2O) and Acetyl Chloride 98Min. (CH3COCl);
(3) phosphorous acid (H3PO3) and aceticanhydride (Ac2O);
(4) ortho-phosphoric acid (H3PO4) and aceticanhydride (Ac2O).
China according to the taking all factors into consideration of aspects such as raw material sources and price, mainly adopts (1) bar route at present, i.e. phosphorus trichloride, the synthetic route of Glacial acetic acid and water.This technological line raw material is easy to get low price.But be water miscible HEDP(1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid), oil soluble is poor, and this characteristic has hindered its purposes in oil product.So the above carboxylic acid of human C6 is arranged, for example: hexadecanoic acid or stearic acid replace acetic acid, with phosphorus trichloride and water reaction, generate oil-soluble long-pending di 2 ethylhexyl phosphonic acid, but product purity are low, purification difficult, and application is restricted.More than be the situation and the weak point of narration past technology.
The objective of the invention is with water miscible long-pending di 2 ethylhexyl phosphonic acid and alcohol is raw material, generation direct esterification reaction, the synthetic incomplete tart diphosphonate ester of oil-soluble gamma value, and make it continue the chelating function that keeps strong, develop its purposes on industrial technology simultaneously.
The present invention is the method for the new diphosphonate ester of a kind of general formula of preparation (1).
Chemical equation is:
R wherein, R ' is the alkyl of C1～C18; H is OH or H base.
m
1Be 0,1 or 2 integer, n
1=2-m
1; m
2Be 0,1 or 2 integer, n
2=2-m
2
m
1And m
2Be not 0 or 2 simultaneously, i.e. 1≤m
1+ m
2≤ 3
Can regulate the oil soluble and the water miscible size of product diphosphonate ester according to what of R in the raw material and the middle carbonatoms of R '.The long-pending di 2 ethylhexyl phosphonic acid of raw material can be that carbonatoms is 1～18 various long-pending di 2 ethylhexyl phosphonic acid among the R, preferably 1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid.Raw alcohol can be the various alcohol of C1～C18, preferably isooctyl alcohol.
The temperature of esterification is 150 ℃～200 ℃, and pressure can be normal pressure.
Above method synthetic diphosphonate ester can be used as the complexing extractant of metal ion, curing agent for epoxy resin, the antioxidant of oil product, the ligand of the ligand of hydrocarbon oxidation catalyzer and cyclohexyl hydroperoxide decomposition catalyst.
Synthetic method and application below in conjunction with example explanation diphosphonate ester.
Example 1 adds the 3500ml isooctyl alcohol in the there-necked flask of 5000ml, heat with electric furnace below, logical N2 stirs, and loads onto water trap and spherical condensating tube, and condensing tube tongs is applied mechanically water cooling, when temperature reaches 160 ℃, slowly add HEDP, isooctyl alcohol and water azeotropic, gas is through the prolong cooling, flow to water trap, lower floor emits moisture content at water trap, and the isooctyl alcohol Returning reactor on water trap upper strata, a still add about 1100 grams of solid HEDP altogether.Reinforced about 2 hours of the time, after stopping to feed in raw material, refluxed 30 minutes, tell the water that reaction generates.Obtain the thick product of about 4000ml in the reactor there-necked flask, wash with water after the cooling, add the 4000ml hexanaphthene simultaneously, after making it layering, lower floor's water contains nonesterified acid and catalyzer etc., the upper strata oil reservoir carries out vacuum distilling, and cat head separation water outlet, hexanaphthene, isooctyl alcohol, tower still obtain about 2000 grams of 1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid di-isooctyl.Chemical equation is:
Molten point-39 of product ℃, 215 ℃ of heat decomposition temperatures.The ultimate analysis of product process, the group titrimetry, analyses such as mass spectrum, infrared spectra and nucleus magnetic resonance prove that major ingredient is 1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid di-isooctyl.Contain a spot of 1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid-different monooctyl ester and octanol etc.
Example 2: in the there-necked flask of 5000ml, add the 3500ml lauryl alcohol, below electric furnace heating, logical N2 stirs, load onto water trap and prolong, condensing tube tongs is applied mechanically water cooling, when temperature reaches 160 ℃, adds 50ml dimethylbenzene earlier, slowly add HBDP(1-hydroxyl fourth fork-1.1-di 2 ethylhexyl phosphonic acid again), lauryl alcohol, dimethylbenzene and water azeotropic, gas is through condensing tube condensation, lower floor emits moisture content at water trap, the lauryl alcohol on upper strata and dimethylbenzene Returning reactor.Add HBDP 1500 grams altogether.Thick product is through washing, distill, obtain at last 2400 gram 1-hydroxyl fourth fork-1.1-di 2 ethylhexyl phosphonic acids, two lauryls.Chemistry
Example 3: in there-necked flask, add 3500ml ethylene glycol, with the electric furnace heating, logical N2 stirs, and adds 100ml dimethylbenzene below, load onto water trap and prolong, the chuck water cooling when temperature reaches 160 ℃～180 ℃, slowly adds HEDP(1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid again), water, ethylene glycol and dimethylbenzene azeotropic, gas is isolated moisture content, ethylene glycol and dimethylbenzene Returning reactor through condensing tube condensation.Add the HEDP1500 gram altogether.Thick product removes out dimethylbenzene and excessive ethylene glycol through vacuum distilling, obtains 3000 gram 1-hydroxy ethylidene-1.1-di 2 ethylhexyl phosphonic acid second two (alcohol) esters at last.
Example 4: in the 250ml separating funnel, add 100ml benzene, add a gram cobalt naphthenate again, cobalt naphthenate is evenly distributed in the benzene liquid, and when adding 100ml again when containing the aqueous solution of hexanodioic acid 2%, cobalt ion all is extracted into water.Add HEDP di-isooctyl one gram this moment, and the cobalt ion of lower floor's aqueous phase all is extracted to upper oil phase from water again.
Example 5: get 50g universal epoxy resin, add 5gHBDP two lauryls, stir, heated 40 minutes down at 160 ℃～200 ℃, the epoxy resin cure moulding is good, and the transparent various detection indexs of product are qualified.
Example 6: in hexanaphthene cobalt salt catalyzed oxidation full scale plant, keep original equipment and technological parameter constant, cobalt ion adds with the form of the cyclohexane solution of cobalt naphthenate, catalyst cobalt ionic concentration is 0.1～10PPm in the controlled oxidation system, and in Co: HEDP di-isooctyl=7: the ratio 1(mol ratio) adds the ligand that the HEDP di-isooctyl is done cobalt.Oxidizing reaction result shows that it is clear that oxidation liquid color becomes, and side reaction is few, and the selective paraffin oxidation characteristic is obvious, and yield improves, and has solved the slagging scorification problem of hexanaphthene cobalt salt catalyzed oxidation up hill and dale.The production cycle of hexanaphthene cobalt salt catalyzed oxidation was extended to more than 1 year.
Example 7: produce pimelinketone at cyclohexane oxidation, in the process of hexalin, the cyclohexyl hydroperoxide of generation is made catalyzer with the complex acid tert-butyl ester and is decomposed, and slagging scorification takes place during decomposition, blocks the equipment and the pipeline of splitter.Replace original precipitating inhibitor octyl phosphate with the HEDP di-isooctyl, then cyclohexyl hydroperoxide resolves into the yield raising of alcohol ketone, and the slagging scorification problem is resolved, and the continuous production cycle of device was extended to more than 1 year from six months.
Claims (3)
1, a kind of general formula is the preparation method of the diphosphonate ester compounds of (1)
R wherein, R
1Be C
1-C
18Alkyl; H=H, OH;
m
1Be 0,1 or 2 integer, n
1=2-m
1
m
2Be 0,1 or 2 integer, n
2=2-m
2
m
1And m
2Be not 0 or 2 simultaneously, i.e. 1≤m
1+ m
2≤ 3;
The preparation method of diphosphonate ester is characterized in that being 150 ℃～200 ℃ with long-pending di 2 ethylhexyl phosphonic acid and alcohol in temperature, carries out esterification under the normal pressure.
2, according to the preparation method of claim 1, diphosphonate ester wherein is a 1-hydroxy ethylidene-1,1-di 2 ethylhexyl phosphonic acid di-isooctyl.
It is characterized in that using
HEDP (1-hydroxy ethylidene-1,1-di 2 ethylhexyl phosphonic acid) and isooctyl alcohol react.
3, according to the application of the diphosphonate ester of claim 1 or the preparation of 2 described methods, it is characterized in that complexing extractant, the ligand of the ligand of hydrocarbon oxidation catalyzer and cyclohexyl hydroperoxide decomposition catalyst as metal.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN89108289A CN1017434B (en) | 1989-11-06 | 1989-11-06 | Synthesis and application of diphosphonate ester |
| JP2268261A JPH07103136B2 (en) | 1989-11-06 | 1990-10-04 | Diphosphonate compound, method for producing the same, and catalyst composition containing the compound |
| US07/822,385 US5233092A (en) | 1989-11-06 | 1992-01-17 | Diphosphonate compounds, their preparation and application |
| US08/062,974 US5449804A (en) | 1989-11-06 | 1993-06-23 | Diphosphonate compounds, their preparation and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN89108289A CN1017434B (en) | 1989-11-06 | 1989-11-06 | Synthesis and application of diphosphonate ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1044281A CN1044281A (en) | 1990-08-01 |
| CN1017434B true CN1017434B (en) | 1992-07-15 |
Family
ID=4857519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN89108289A Expired CN1017434B (en) | 1989-11-06 | 1989-11-06 | Synthesis and application of diphosphonate ester |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPH07103136B2 (en) |
| CN (1) | CN1017434B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061680C (en) * | 1996-11-22 | 2001-02-07 | 肖藻生 | Fuel oil and lubricating oil additive |
| CN105906477B (en) * | 2016-05-24 | 2018-11-23 | 济南大学 | A kind of method of continuous azeotropy distillation separation of methylbenzene-ethylene glycol mixture |
| CN105906471B (en) * | 2016-05-24 | 2018-11-09 | 济南大学 | A kind of method of continuous azeotropic distillation separation meta-xylene-ethylene glycol mixture |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251492A (en) * | 1978-06-07 | 1981-02-17 | Ciba-Geigy Corporation | Purification process |
| JPS5818631A (en) * | 1981-07-28 | 1983-02-03 | Fuji Photo Film Co Ltd | Method for processing color photographic material |
| EP0356866A3 (en) * | 1988-08-29 | 1991-03-27 | E.R. SQUIBB & SONS, INC. | Phosphorus-containing squalene synthetase inhibitors and method |
-
1989
- 1989-11-06 CN CN89108289A patent/CN1017434B/en not_active Expired
-
1990
- 1990-10-04 JP JP2268261A patent/JPH07103136B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1044281A (en) | 1990-08-01 |
| JPH03169887A (en) | 1991-07-23 |
| JPH07103136B2 (en) | 1995-11-08 |
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| C13 | Decision | ||
| GR02 | Examined patent application | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C53 | Correction of patent for invention or patent application | ||
| CB02 | Change of applicant information |
Address after: Hunan Yueyang Yingshan caprolactam plant Applicant after: Xiao Zaosheng Address before: Hunan Yueyang North District Yueyang Petrochemical General Factory Technology Development Office Applicant before: Xiao Zaosheng Co-applicant before: Xiao Zaofang |
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| COR | Change of bibliographic data |
Free format text: CORRECT: CO-APPLICANT; FROM: XIAO ZAOFANG TO: NONE |
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| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
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| CX01 | Expiry of patent term |
Granted publication date: 19930303 |