CN101721433B - Double-mushroom polysaccharide preparation containing flammulina velutipes polysaccharide and lentinan polysaccharide and preparation method and application thereof - Google Patents
Double-mushroom polysaccharide preparation containing flammulina velutipes polysaccharide and lentinan polysaccharide and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a double-mushroom polysaccharide preparation containing flammulina velutipes polysaccharide and lentinan polysaccharide and a preparation method and application thereof. The double-mushroom polysaccharide preparation is characterized by being prepared by using the flammulina velutipes polysaccharide and the lentinan polysaccharide as primary components and adding ethyl maltol and other auxiliary components. The obtained product of the invention has high content of the lentinan polysaccharide and the flammulina velutipes polysaccharide, ultra-low impurity content, good mouth feel, no color, clearness, good stability and safe eating, and no deposit appears after the product is placed for a long time; the preparation method adopted by the invention is simple and easy to operate, is safe and reliable and can realize large-scale production; and the product also has the functions of promoting intelligence development, improving memory and allaying brain cell tiredness, has the health care actions of strengthening the body resistance to consolidate the constitution of human bodies and increasing immunity, not only aims at tumor patients and postoperative crowds, but also is applicable for some patients with chronic diseases, has no toxic or side effect and is a functional health product beneficial to all ages.
Description
Technical field
The present invention relates to a kind of pharmaceutical product, relate in particular to a kind of two mushroom polysaccharide preparations and method for making and purposes that contains Flammukinan and lentinan.
Background technology
Lentinus Edodes (Lentinula edodes Pegler) is the traditional famous medicine-food two-purpose fungus of China, and the traditional Chinese medical science is thought Lentinus Edodes " QI invigorating, not hungry, control the wind removing blood stasis ".Lentinan often adopts Mechanical Method from mushroom fruiting body, to extract and obtains, and its method is earlier mushroom fruiting body to be pulverized, and is 1: 30 proportioning by solid-liquid ratio, with 85 ℃ water stirring and leaching 5 hours/inferior, and lixiviate 2 times.Be main with β-1-3D glucose in its polysaccharide component, contain a spot of xylose and mannose, contain the nutrient substance to the human body beneficial such as aminoacid, protein, trace element in addition.
The function that lentinan has antiviral, antitumor, adjusting immunologic function and stimulates interferon to form, be widely used at present can not operative treatment and chemotherapy after the rehabilitation of cancer patient.Compare with other antitumor drug; Lentinan has good antifatigue effect; Almost without any side effects, gastric cancer, nasopharyngeal carcinoma, rectal cancer, breast carcinoma and chronic myelocytic leukemia etc. there are the effect that suppresses and prevent the postoperative micrometastasis, be one of present the strongest known immunostimulant.Known lentinan is 97.5% to the tumor control rate of tumor-bearing mice, and other various tumors are all had inhibitory action.The human clinical uses and shows, only needs single administration 2mg weekly, and kinds of tumors is all had different inhibitory action.Lentinan also can be treated gastric cancer; Guo Cheng Ye in 1997 etc. use LNT (lentinan) the merging chemotherapeutic treatment patients with gastric cancer that Japanese Ajincomoto Co., Inc produces; Controlling back NK cell (natural killer cell) activity has raising in various degree, has confirmed LNT adjustment immunologic function, the effect that improves curative effect and prolong life cycle.The same year Liu Baiyu etc. again report used the adjuvant drug of LNT lyophilized injectable powder (commodity are called Lentinan) as chemotherapy; Observation is to the curative effect of 319 routine patients with gastric cancer; The same Lentinan of finding can obviously improve the objective effective percentage of chemotherapy of gastric cancer; Improve active state, improve the life quality of patients with terminal, and can alleviate bone marrow toxicity, the gastrointestinal toxicity of chemotherapeutics.Yao Yang in 1998 etc. also report with Lentinan and merge chemotherapy, and effective percentage of its treatment gastric cancer is 53%, and drenching immune indexes such as changeing percentage rate, NK cytoactive also all has obvious rising.Lentinan treatment pulmonary carcinoma, Li Zhen etc. also report LNT treatment late period or recurrent tumor and chemotherapy and usefulness, and are more obvious to the curative effect of III and IV phase pulmonary carcinoma, can make that tumor is dwindled, active state and symptom improve and reach 52%.Lentinan treatment hepatocarcinoma, Suto etc. also once used LNT associating 52Fu (52 fluorouracil) and had treated 58 routine liver cancer patients, and the result shows that combination group singly significantly strengthens with 52Fu group antitumor action.
JINZHENGU (Flammulina velutiper), it contains multiple bioactive ingredients such as homopolysaccharide, heteropolysaccharide, glycoprotein, Dan Baijutang, Flammulin.Flammukinan adopts the ethanol step-by-step precipitation method to extract crude extracellular polysaccharide normally through JINZHENGU is carried out deep layer fermenting process, under 4 ℃, the condition of pH6 ~ 7, extracts the bag exo polysaccharides and obtains.
Flammukinan is considered to the important active substance of antitumor; Many researchs show that all Flammukinan has antiinflammatory, resisting fatigue, anoxia enduring and improves macrophage phagocytic function; And has an immunoloregulation function; And obviously antitumor, radioprotective, antihepatitic activity, often ediblely can prevent and treat diseases such as liver systemic disease and gastroenteritic ulcer, be again good health food.
Kinds such as lentinan film, lentinan capsule, shiitake fungus polyoses oral liquid, Flammukinan capsule, Flammukinan oral liquid are arranged in the market; Brain healthy is all arranged; Hypermnesis; Resisting fatigue improves immunity, suppresses effect such as tumor, but these kinds all are to be raw material with single lentinan or Flammukinan.And if only these two kinds of main polysaccharide components are simply mixed; The product that obtains like this has following problem; And make that this product is difficult to accepted by consumer: 1, mouthfeel is relatively poor: the product that allotment is good does not have peat-reek; The words that do not add explanation can not drunk the taste of Lentinus Edodes JINZHENGU, and aftertaste beastly is arranged, and the part crowd can produce the nauseating grade of giddy untoward reaction in various degree after the polydipsia.2, bad smell is difficult to shelter: raw material-shiitake mushroom hypha that product is used and golden mushroom mycelium extract; Strong disagreeable taste is arranged; This taste is not the fragrance of pure mushrooms material, but is made up of some tastes beastly, like the taste of the enzyme that brings in the processing technology; And offensive odours such as dry flavor and flavour of a drug, adopt existing screening agent such as essence, sweeting agent and tasty agents to be difficult to shelter this local flavor.3, deposition appears in product easily: sedimentary generation is owing in the extract fibrous matter or other water-fast materials are arranged.Lentinus Edodes and JINZHENGU contain a large amount of fibrous matters, and the lixiviate of raw material enzymolysis is insufficient or filtration is meticulous inadequately, finally all can cause containing in the extract powder insoluble matters such as a spot of fiber.The easy moisture absorption of Lentinus Edodes extract and gold needle mushroom extract and luming, the material dissolution speed behind the caking slows down, and can wrap insoluble substance, just is easy to generate insoluble granule at last, small amount of precipitate promptly occurs.
Summary of the invention
The purpose of this invention is to provide a kind of two mushroom polysaccharide preparations that contain Flammukinan and lentinan.Two mushroom polyoses contents are high in the product of the present invention, and impurity content is extremely low, and the products obtained therefrom mouthfeel is good, colourless, clarification, good stability.
Another object of the present invention provides a kind of method for making that contains two mushroom polysaccharide preparations of Flammukinan and lentinan.This method is simple, and is safe and reliable.
Further aim of the present invention provides a kind of purposes that contains two mushroom polysaccharide preparations of Flammukinan and lentinan.
The objective of the invention is to realize like this: a kind of two mushroom polysaccharide preparations that contain Flammukinan and lentinan is characterized in that: it is to be main component with Flammukinan and lentinan, and warp interpolation ethyl maltol and other auxiliary elements make.
Above-mentioned pair of mushroom polysaccharide preparation also is added with apple essence and Mel.Apple essence belongs to edible essence spice, can shelter abnormal flavour well through selecting apple essence for use, the local flavor of also can making better products, and do not influence the fine quality of product.Mel is sweeting agent, is again health-care components, and Mel have natural fragrance also can shelter lentinan extract and dry run in the abnormal flavour that produces, help the beverage flavouring.
The above-mentioned pair of mushroom polysaccharide preparation can be made into pop can like this with the dosage form finished product of beverage or oral liquid, is convenient to take, carries and preserves.
Above-mentioned pair of mushroom polysaccharide preparation is during with beverage or oral liquid finished product, and its prescription separately comprises each key component that is described below by mass ratio, and adds other conventional auxiliary elements and make:
Beverage:
Flammukinan 0.1%～0.5%,
Lentinan 0.1%～0.5%,
Mel 3%～10%,
Apple essence 0.01%～0.05%,
Ethyl maltol 0.1 * 10
-6%～1.0 * 10
-6%;
Oral liquid:
Flammukinan 1.0%～5.0%,
Lentinan 1.0%～5.0%,
Mel 3%～10%,
Apple essence 0.01%～0.05%,
Ethyl maltol 0.1 * 10
-6%～1.0 * 10
-6%.
More specifically, above-mentioned pair of mushroom polysaccharide preparation is during with beverage or oral liquid finished product, and its prescription separately comprises each component that is described below by mass ratio:
Beverage:
Flammukinan 0.1%～0.5%,
Lentinan 0.1%～0.5%,
Sucrose, A Siba is sweet or stevioside 5%～12%,
Mel 3%～10%,
Citric acid 0.05%～0.25%,
Apple essence 0.01%～0.05%,
Ethyl maltol 0.1 * 10
-6%～1.0 * 10
-6%,
Potassium sorbate or sodium benzoate 0.01%～0.05%,
Pure water adds to 100%;
Oral liquid:
Flammukinan 1.0%～5.0%,
Lentinan 1.0%～5.0%,
Sucrose, A Siba is sweet or stevioside 5%～12%,
Mel 3%～10%,
Citric acid 0.05%～0.15%,
Apple essence 0.01%～0.05%,
Ethyl maltol 0.1 * 10
-6%～1.0 * 10
-6%,
Potassium sorbate or sodium benzoate 0.01%～0.05%,
Pure water adds to 100%.
Sucrose in the prescription, A Siba are sweet, stevioside belongs to sweeting agent; Citric acid belongs to acidity regulator, and gentle frank tart flavour is arranged, and appetite strengthening is digested and assimilated with the interior calcium of promotion body, phosphorus substance; Potassium sorbate, sodium benzoate belong to the wide spectrum low toxicity organic acid antiseptic that state approval uses; Mould fungus inhibition effectively, the activity of yeast and aerobic bacteria can also prevent harmful microbes growth and breedings such as bacillus botulinus, staphylococcus, Salmonella; But to beneficial microbe nearly unavailables such as anaerobic sporeformer and bacillus acidophilus; It is stronger than bactericidal action that it restrains the effect of growing, thereby reach the holding time that prolongs food effectively, and keep original local flavor.
Another object of the present invention is achieved in that a kind of method for making that contains two mushroom polysaccharide preparations of Flammukinan and lentinan, it is characterized in that: it is the each component that adopts above-mentioned mass ratio, by the method for preparing that comprises the steps to carry out:
(1) raw material is prepared;
(2) batching, mixing
Take by weighing sucrose and citric acid, in the gross mass of sucrose and citric acid: the quality of pure water is that 1: 6 ratio adds pure water, heating for dissolving; Add Flammukinan, lentinan, Mel and potassium sorbate mixing again and stir, it is dissolved fully;
(3) filter
Adopt duplex strainer to filter, 200 order filter clothes, the impurity that the elimination raw material is brought into are installed in the filter;
(4) vacuum outgas;
(5) perfumery, standardize solution
In the mixture that after above-mentioned steps, obtains, add the pure water of surplus, mix standardize solution, add apple essence and ethyl maltol;
(6) conventional post processing.
More specifically, the method for making of the two mushroom polysaccharide preparations that contain Flammukinan and lentinan that the present invention relates to is characterized in that: it is the each component that adopts above-mentioned mass ratio, by the method for preparing that comprises the steps to carry out:
(1) raw material is prepared;
(2) batching, mixing
Take by weighing sucrose and citric acid, in the gross mass of sucrose and citric acid: the quality of pure water is that 1: 6 ratio adds pure water, heating for dissolving; Add Flammukinan, lentinan, Mel and potassium sorbate mixing again and stir, it is dissolved fully;
(3) filter
Adopt duplex strainer to filter, 200 order filter clothes, the impurity that the elimination raw material is brought into are installed in the filter;
(4) vacuum outgas
Adopt vacuum degassing machine that air and bad smell are removed, degassing condition is: 45 ℃ of feeding temperatures, vacuum 93.3kPa;
(5) perfumery, standardize solution
In the mixture that after above-mentioned steps, obtains, add the pure water of surplus, mix standardize solution, add apple essence and ethyl maltol;
(6) preheating, canned
Beverage is heated to 85 ℃, canning sealing;
(7) antibacterial, cooling
In pressure sterilizer,, cool off with water for cooling in 121 ℃ of high pressure-temperature antibacterial 10min.
Because in operations such as allotment, stirring, filtration, feed liquid contacts with air, has caused sneaking into of air, and wherein oxygen not only destroys the effective ingredient in the product, also can react in this method, make fragrance, color and luster generation deterioration with some composition in the product.In addition, oxygen also can cause the corrosion of jar inwall, and making films peels off.Simultaneously; Flammukinan and lentinan have strong disagreeable taste, are not the fragrance of pure mushrooms material, but are made up of some tastes beastly; Like the taste of enzyme, dry flavor etc., adopt vacuum degassing machine that oxygen and bad smell are removed in the method for making of the present invention; In addition, essence needs after filtering completion, to add, otherwise can be absorbed by filter paper or filter cloth, influence the final local flavor of product.
The 3rd purpose of the present invention is achieved in that a kind of purposes that contains two mushroom polysaccharide preparations of Flammukinan and lentinan; It is characterized in that: said pair of mushroom polysaccharide preparation has promotion intelligence development in preparation; Improving memory; The elimination brain cell is tired, and human body is had strengthening the body resistance, the application in the health promoting product of increase immunity.
The present invention has following beneficial effect:
1. the ethyl maltol of selecting for use in this product belongs to fragrant and sweet and fruity synergist and abnormal flavour screening agent, can improve preparation abnormal smells from the patient and mouthfeel.Apple essence belongs to edible essence spice, can shelter abnormal flavour well through selecting apple essence for use, the local flavor of also can making better products, and do not influence the fine quality of product.Mel is sweeting agent, is again health-care components, and Mel have natural fragrance also can shelter lentinan extract and dry run in the abnormal flavour that produces, help the beverage flavouring.Lentinan and Flammukinan content are high in the product of final gained, and impurity content is extremely low, and mouthfeel is good, colourless, the clarification of products obtained therefrom, and good stability, deposition can not appear in long-time the placement yet, and is edible fool proof.
2. the present invention adopts that preparation is simple, and is safe and reliable, and can realize large-scale production.Adopt duplex strainer to filter in this method for making, elimination the impurity brought into of raw material, prevented sedimentary generation, and then guaranteed the fine quality of product; In addition, adopt vacuum degassing machine that oxygen and bad smell are removed in this method for making, avoided the effective ingredient in the product to be destroyed, also avoided making fragrance, color and luster generation deterioration, removed some tastes beastly simultaneously.
3. the function that lentinan has antiviral, antitumor, adjusting immunologic function and stimulates interferon to form in this product; The Flammukinan that adds; Strengthen anticancer, the effect that improves aspects such as immunity of shiitake fungus polyoses oral liquid, can also regulate the gastrointestinal tract of cancer patient; In addition, these article also have promotion intelligence development, improving memory; The elimination brain cell is tired, and human body is had strengthening the body resistance, increases the health-care effect of immunity; Not only, still very suitable to some chronics to tumor patient, postoperative crowd, and have no side effect; Be a kind of all-ages functional health care product, thereby the social benefit of this product is very big, has sizable market potential.
The specific embodiment
Through embodiment the present invention is specifically described below; Be necessary to be pointed out that at this; Following examples only are used for the present invention is further explained; Can not be interpreted as the restriction to protection domain of the present invention, the person skilled in the art in this field can make some nonessential improvement and adjustment to the present invention according to the foregoing invention content.
Embodiment 1
The preparation dosage form is the finished product of beverage, and its concrete steps are:
(1) raw material is prepared
The proportioning raw materials that employing is described below is prepared raw material, and wherein each proportioning ratio is mass ratio, and various raw materials are all selected food stage for use:
Flammukinan 0.1%
Lentinan 0.1%
Sucrose 5%
Mel 3%
Citric acid 0.05%
Apple essence 0.01%
Ethyl maltol 0.1 * 10
-6%
Potassium sorbate 0.01%
Pure water adds to 100%
(2) batching, mixing
Take by weighing sucrose and citric acid, in the gross mass of sucrose and citric acid: the quality of pure water is that 1: 6 ratio adds pure water, heating for dissolving; Add Flammukinan, lentinan, Mel and potassium sorbate mixing again and stir, it is dissolved fully;
(3) filter
Adopt duplex strainer to filter, 200 order filter clothes, the impurity that the elimination raw material is brought into are installed in the filter;
(4) vacuum outgas
Adopt vacuum degassing machine that air and bad smell are removed, degassing condition is: 45 ℃ of feeding temperatures, and vacuum 93.3kPa:
(5) perfumery, standardize solution
In the mixture that after above-mentioned steps, obtains, add the pure water of surplus, mix standardize solution, and add apple essence and ethyl maltol;
(6) preheating, canned
Beverage is heated to 85 ℃, canning sealing;
(7) antibacterial, cooling
In pressure sterilizer,, cool off with water for cooling in 121 ℃ of high pressure-temperature antibacterial 10min.
Embodiment 2-6
Embodiment 2-6 adopts the proportioning raw materials that is described below to prepare raw material respectively, and the preparation dosage form is the finished product of beverage, and wherein each proportioning ratio is mass ratio, and various raw materials are all selected food stage for use, and other step is said with embodiment 1:
Embodiment 7-12
Embodiment 7-12 adopts the proportioning raw materials that is described below to prepare raw material respectively, and the preparation dosage form is the finished product of oral liquid, and wherein each proportioning ratio is mass ratio, and various raw materials are all selected food stage for use, and other step is said with embodiment 1:
Study on the stability:
A kind of resulting product of arbitrary extracting from embodiment 1～12; Carry out study on the stability: product is put into 37 ℃ of constant temperature placed 10 days; Observation has or not phenomenons such as deposition, variable color, corruption; Carry out uncork then and taste check, the result finds that this product does not have deposition, variable color, phenomenon such as putrid and deteriorated, explains quality homogeneous, the steady quality of this product.
Claims (4)
1. two mushroom polysaccharide preparations that contain Flammukinan and lentinan is characterized in that: it is to be main component with Flammukinan and lentinan, makes through adding ethyl maltol and other auxiliary elements; Said pair of mushroom polysaccharide preparation also is added with apple essence and Mel; The said pair of mushroom polysaccharide preparation is with the dosage form finished product of beverage or oral liquid;
The said pair of mushroom polysaccharide preparation is during with the dosage form finished product of beverage, and its prescription comprises each component that is described below by mass ratio:
Flammukinan 0.1%～0.5 %,
Lentinan 0.1%～0.5%,
Sucrose, A Siba is sweet or stevioside 5%～12%,
Mel 3%～10%,
Citric acid 0.05%～0.25%,
Apple essence 0.01%～0.05%,
Ethyl maltol 0.1 * 10
-6%～1.0 * 10
-6%,
Potassium sorbate or sodium benzoate 0.01%～0.05%,
Pure water adds to 100%;
The said pair of mushroom polysaccharide preparation is during with the dosage form finished product of oral liquid, and its prescription comprises each component that is described below by mass ratio:
Flammukinan 1.0%～5.0%,
Lentinan 1.0%～5.0%,
Sucrose, A Siba is sweet or stevioside 5%～12%,
Mel 3%～10%,
Citric acid 0.05%～0.15%,
Apple essence 0.01%～0.05%,
Ethyl maltol 0.1 * 10
-6%～1.0 * 10
-6%,
Potassium sorbate or sodium benzoate 0.01%～0.05%,
Pure water adds to 100%.
2. the method for making that contains two mushroom polysaccharide preparations of Flammukinan and lentinan as claimed in claim 1 is characterized in that: it is the each component that adopts said mass ratio, by the method for preparing that comprises the steps to carry out:
(1) raw material is prepared;
(2) batching, mixing
Take by weighing sucrose and citric acid, in the gross mass of sucrose and citric acid: the quality of pure water is that the ratio of 1:6 adds pure water, heating for dissolving; Add Flammukinan, lentinan, Mel and potassium sorbate mixing again and stir, it is dissolved fully;
(3) filter
Adopt duplex strainer to filter, 200 order filter clothes, the impurity that the elimination raw material is brought into are installed in the filter;
(4) vacuum outgas;
(5) perfumery, standardize solution
In the mixture that after above-mentioned steps, obtains, add the pure water of surplus, mix standardize solution, add apple essence and ethyl maltol;
(6) conventional post processing.
3. the method for making that contains two mushroom polysaccharide preparations of Flammukinan and lentinan as claimed in claim 1 is characterized in that: it is the each component that adopts above-mentioned mass ratio, by the method for preparing that comprises the steps to carry out:
(1) raw material is prepared;
(2) batching, mixing
Take by weighing sucrose and citric acid, in the gross mass of sucrose and citric acid: the quality of pure water is that the ratio of 1:6 adds pure water, heating for dissolving; Add Flammukinan, lentinan, Mel and potassium sorbate mixing again and stir, it is dissolved fully;
(3) filter
Adopt duplex strainer to filter, 200 order filter clothes, the impurity that the elimination raw material is brought into are installed in the filter;
(4) vacuum outgas
Adopt vacuum degassing machine that air and bad smell are removed, degassing condition is: 45 ℃ of feeding temperatures, vacuum 93.3kPa;
(5) perfumery, standardize solution
In the mixture that after above-mentioned steps, obtains, add the pure water of surplus, mix standardize solution, add apple essence and ethyl maltol;
(6) preheating, canned
Beverage is heated to 85 ℃, canning sealing;
(7) antibacterial, cooling
In pressure sterilizer,, cool off with water for cooling in 121 ℃ of high pressure-temperature antibacterial 10min.
4. like any described purposes that contains two mushroom polysaccharide preparations of Flammukinan and lentinan of claim 1-3; It is characterized in that: said pair of mushroom polysaccharide preparation has promotion intelligence development in preparation; Improving memory; The elimination brain cell is tired, and human body is had strengthening the body resistance, the application in the health promoting product of increase immunity.
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| CN102178319A (en) * | 2011-04-21 | 2011-09-14 | 天津商业大学 | Pholiota nameko drink and preparation method thereof |
| CN103239470B (en) * | 2013-05-16 | 2015-01-07 | 陕西众兴菌业科技有限公司 | Dual-mushroom polysaccharide composition containing coprinus comatus polysaccharide and lentinan as well as preparation method and application thereof |
| CN103750450A (en) * | 2013-12-27 | 2014-04-30 | 秦燕 | Sargassum fusiforme polysaccharide beverage and preparation method thereof |
| CN105011123A (en) * | 2015-08-05 | 2015-11-04 | 南京贝杉国际贸易有限公司 | Functional food for preventing tumor and assisting in anti-tumor treatment and preparing method thereof |
| CN106798220A (en) * | 2016-10-13 | 2017-06-06 | 成都中医药大学 | A kind of mushroom health drink containing green apple essence and preparation method thereof |
| CN114053302A (en) * | 2021-11-09 | 2022-02-18 | 福建农林大学 | Preparation of compound edible fungus polysaccharide compound with anti-fatigue effect |
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