CN101716317A - Orally taken and externally applied traditional Chinese medicine composite for treating rheumatoid arthritis - Google Patents
Orally taken and externally applied traditional Chinese medicine composite for treating rheumatoid arthritis Download PDFInfo
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Abstract
The invention discloses an orally taken and externally applied traditional Chinese medicine composite for treating rheumatoid arthritis. The composite is prepared from the following first and second groups of medicines in parts by weight: the first group: 20 parts of radix-polygoni multiflori, 10 parts of medlar, 10 parts of eucommia bark, 10 parts of Curculigo orchioides, 10 parts of epimedium, 20 parts of Fructus Psoraleae, 10 parts of ginseng, 10 parts of ophiopogon root, 15 parts of angelica, 20 parts of radix sileris, 12 parts of prepared radix aconiti carmichaeli, 15 parts of radix aconiti preparata, 10 parts of tuckahoe, 15 parts of pawpaw, 10 parts of radix angelicae pubescentis, 10 parts of Salvia miltiorrhiza, 15 parts of Scutellaria baicalensis, 10 parts of radix curcumae, 20 parts of rehmannia and 6 parts of liquorice; the second group: 20 parts of radix angelicae, 10 parts of monkshood, 10 parts of radix aconiti agrestis, 15 parts of radix sileris, 20 parts of rhizoma atractylodis, 10 parts of rhizoma arisaematis, 10 parts of peach kernel, 10 parts of angelica, 5 parts of natural borneol, 10 parts of sinapis semina and 3 parts of asarum, wherein the first group of medicines is orally taken medicines, and the second group of medicines is externally applied medicines. The total effective rate is 95.0 percent, according to 60 cases of the composite used to treat patients with rheumatoid arthritis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of rheumatoid arthritis, belong to the field of Chinese medicines.
Background technology
Rheumatoid arthritis is based on the person disease of joint and joint surrounding tissue nonsuppurative inflammation, often accompanies disease symptoms outside the joint, so claim rheumatoid disease.Articular cavity synovial membrane inflammation, sepage, cell proliferation, granuloma form, cartilage and bone destruction, last ankylosis and dysfunction.The little joint of many infringements as hands, foot and carpal joint etc., often is a symmetry, is chronic process, and temporary alleviation can be arranged, because the multisystem infringement can be found autoantibody, so think that primary disease is self property disease in the serum.Age of onset is many at 20～40 years old.The women is more than the male.How rational use of drug, early stage disease controlling progress stops osteoarthrosis to destroy, and has become current domestic and international research focus.
At present, doctor trained in Western medicine is for the treatment of rheumatoid arthritis, and different opinions are respectively held one and said.What is called " classical pyramid " pattern is arranged; So-called " inverted pyramid pattern ", promptly begin treatment just uses strong medicine, as the antirheumatic of the change state of an illness such as cytotoxic immune inhibitor; So-called " leave from office stepwise " promptly begins with multiple medicine connection platform " encirclings and suppressing ", and be inactive respectively gradually composition of medicine then, selects a kind of effective and the little medicine of side effect is kept at last; So-called " wave pattern ", promptly on a kind of medicine treatment basis, in addition interim treatment is in the state of an illness and strengthens treating when fluctuation is risen.Recover Primary Care later on again, so repeat repeatedly.But with regard to above all methods at present obtained in the recent period, with regard to the late result, the result but is difficult to satisfactory.And the toxic and side effects of antirheumatic is serious.As nephrotoxicity, liver toxicity etc., often patient is difficult to accept, and is forced to drug withdrawal.Therefore, seeking high-efficiency low-toxicity, stop new drug, the new method of PD, is the tackling key problem difficult problem of pendulum in face of medical circle
Rheumatoid arthritis belongs to categories such as traditional Chinese medical science arthromyodynia, severe and migratory arthralgia, the arthroncus of knee.Simulataneous insufficiency and excessive is the main pathogenesis of this disease.With the Liver and kidney insufficiency of vital energy and blood is basis.Wind, cold, wet, pathogenic heat gas cut are attacked joint, muscle, muscles and bones, the retardance meridians, and QI-blood circulation is not smooth, and causes " blood stops being expectorant for the stasis of blood, wet coagulating ", phlegm and blood stasis, the impatency meridians go deep into the bone joint, and cause arthroncus, distortion.Have treatment by Chinese herbs rheumatoid arthritis good efficacy better at present, as triptolide or Glucosidorum Tripterygll Totorum etc., clinical report is all obtained good curative effect, but the toxic and side effects of this medicine has influenced its application prospect.
Have following problem in the intrinsic Clinics and Practices of state: (1) diagnosis is inaccurate: according to the criteria for classification diagnosis of rheumatoid arthritis, higher misdiagnosis rate and rate of missed diagnosis are not arranged.(2) therapeutic purposes are indeterminate: a lot of doctors and patient oneself are unique purpose with alleviating pain.(3) nonsteroidal antiinflammatory drug misapplication: subject matter is that consumption is less than normal and frequently change dressings.(4) glucocorticoid misapplication: subject matter is the bigger than normal and life-time service of consumption.(5) make the medication misapplication slowly: subject matter is that application is too late, too short with the course of treatment very little.
Summary of the invention
In order to overcome the shortcoming that above-mentioned prior art exists, the object of the present invention is to provide a kind of Orally taken and externally to treat the Chinese medicine composition of rheumatoid arthritis.
The Chinese medicine composition of a kind of Orally taken and externally treatment of the present invention rheumatoid arthritis is made by following raw medicaments in portion by weight: the 1st group: Radix Polygoni Multiflori 20, Fructus Lycii 10, the Cortex Eucommiae 10, Rhizoma Curculiginis 10, Herba Epimedii 10, Fructus Psoraleae 20, Radix Ginseng 10, Radix Ophiopogonis 10, Radix Angelicae Sinensis 15, Radix Saposhnikoviae 20, Radix Aconiti Lateralis Preparata 12, Radix Aconiti Preparata 15, Poria 10, Fructus Chaenomelis 15, Radix Angelicae Pubescentis 10, Radix Salviae Miltiorrhizae 10, Radix Scutellariae 15, Radix Curcumae 10, Radix Rehmanniae 20, Radix Glycyrrhizae 6; The 2nd group: the Radix Angelicae Dahuricae 20, Radix Aconiti 10, Radix Aconiti Kusnezoffii 10, Radix Saposhnikoviae 15, Rhizoma Atractylodis 20, Rhizoma Arisaematis 10, Semen Persicae 10, Radix Angelicae Sinensis 10, natural Broneolum Syntheticum 5, Semen Sinapis 10, Herba Asari 3.
Configuration and instructions of taking: the 1st group of medicine is decocted in water for oral dose, and every day, potion was taken at twice sooner or later.To make popular behind the 2nd group of medicine pulverization, and press every dose of medicine adding 100ml Chinese liquor (more than 50 degree, the number of degrees of Chinese liquor are as the criterion with commercially available Chinese liquor) and the ratio of 100ml Mel adds Chinese liquor and Mel is mixed well, spread on joint while hot, 1 dose of every day, divide 2 hot compresses, each 2-3 hour, during the 2nd application, be to mix well the back hot compress with the heating of the medicine after the 1st application and in the ratio adding Chinese liquor and the Mel of every dose of medicine adding 50ml Chinese liquor and 30ml Mel, one month is a course of treatment.
The present invention treats the Chinese medicine composition of rheumatoid arthritis, and its single dose is: the 1st group: Radix Polygoni Multiflori 20g, Fructus Lycii 10g, Cortex Eucommiae 10g, Rhizoma Curculiginis 10g, Herba Epimedii 10g, Fructus Psoraleae 20g, Radix Ginseng 10g, Radix Ophiopogonis 10g, Radix Angelicae Sinensis 15g, Radix Saposhnikoviae 20g, Radix Aconiti Lateralis Preparata 12g, Radix Aconiti Preparata 15g, Poria 10g, Fructus Chaenomelis 15g, Radix Angelicae Pubescentis 10g, Radix Salviae Miltiorrhizae 10g, Radix Scutellariae 15g, Radix Curcumae 10g, Radix Rehmanniae 20g, Radix Glycyrrhizae 6g; The 2nd group: Radix Angelicae Dahuricae 20g, Radix Aconiti 10g, Radix Aconiti Kusnezoffii 10g, Radix Saposhnikoviae 15g, Rhizoma Atractylodis 20g, Rhizoma Arisaematis 10g, Semen Persicae 10g, Radix Angelicae Sinensis 10g, natural Broneolum Syntheticum 5g, Semen Sinapis 10g, Herba Asari 3g.
Motherland's medical science thinks that rheumatoid arthritis is to cause because of void, heresy, expectorant, the stasis of blood, poison, void is deficiency of the liver and kindey, deficiency of qi and blood is the intrinsic factor of rheumatoid arthritis morbidity, and positive so-called " healthy energy exists; can not do; the institute of heresy gathers, its gas must void " be so should benefiting QI and nourishing blood, invigorating the kidney and strengthening the bones to be to set upright, dispel the wind, cold expelling, dehumidifying, heat clearing away be with eliminating evil, hold concurrently with collateral dredging.We use Radix Polygoni Multiflori, Fructus Lycii, the Cortex Eucommiae, Rhizoma Curculiginis, Herba Epimedii, Fructus Psoraleae invigorating function of kidney and strengthening bone, liver and kidney tonifying, the enhancing human body immunity function, disease resistance enhancemen, and can improve osteoporosis, repair bone destruction, Radix Ginseng, Radix Ophiopogonis, Radix Angelicae Sinensis, Fructus Lycii nourishing YIN and benefiting blood, liver and kidney tonifying, heresy is that the damp and hot invasion and attack human body of wind and cold is the common risk factor of rheumatoid arthritis morbidity, wind and cold humidification or wet and heat seal are gone into face as oil, and difficult speed is gone.We use Radix Aconiti Preparata, Radix Saposhnikoviae, Radix Aconiti Lateralis Preparata, Poria expelling wind and cold, dampness removing collateral dredging, end exopathogen and continue invasion, eliminate the pathogenic factor of having invaded again, the recurrence of blocking-up rheumatoid arthritis, the risk factor that increases the weight of, Fructus Chaenomelis, Radix Angelicae Pubescentis expelling wind and dampness for relieving pain are equipped with Radix Salviae Miltiorrhizae, Radix Scutellariae promoting blood circulation to remove obstruction in the collateral, the pain relieving of Radix Curcumae promoting flow of QI and blood, the Radix Rehmanniae YIN nourishing and the production of body fluid promoting suppresses the dry strong of blood circulation promoting medicine, and stomach function regulating is a messenger drug in transferring with Radix Glycyrrhizae again.Liniment has played expelling cold and dampness, activating blood circulation to dissipate blood stasis, the effect of removing obstruction in the collateral to relieve pain, use with oral medicine clothes are collaborative, played from interior benefiting QI and nourishing blood, invigorating the kidney and strengthening the bones, dispel the wind, cold expelling, dehumidifying, heat clearing away, from outer expelling cold and dampness, activating blood circulation to dissipate blood stasis, removing obstruction in the collateral to relieve pain is worked along both lines thereby reached, the effect for the treatment of both the principal and secondary aspects of a disease.
The pharmacological action of each medicine is as follows:
Radix Polygoni Multiflori: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function with cure mainly: the detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Fructus Lycii: sweet, flat.Return liver, kidney channel.Function with cure mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
The Cortex Eucommiae: nature and flavor: sweet, temperature.Gui Jing: return liver, kidney channel.Effect: invigorating the liver and kidney, bone and muscle strengthening.Antiabortive.Curing mainly: be used for lumbago due to renal deficiency. muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Rhizoma Curculiginis: suffering, heat; Poisonous.Return the kidney,liver,spleen warp.Function with cure mainly: kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.Be used for the sexual impotence cold sperm, the muscles and bones flaccidity is soft, the cold numbness of waist knee joint, yang deficiency cold diarrhea.
Herba Epimedii: hot, sweet, temperature.Return liver, kidney channel.Function with cure mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Fructus Psoraleae: nature and flavor: hot, bitter, temperature.Gui Jing: return kidney, spleen channel.Effect: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.Cure mainly: be used for impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily, and has loose bowels just before dawn; The external curing vitiligo, alopecia areata.
Radix Ginseng: sweet, little hardship, flat.Return spleen, lung, heart channel.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Cure mainly: be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness is empty wins, the palpitation with fear insomnia, sun layer official is cold; Heart failure, cardiogenic shock.
Radix Ophiopogonis: sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.
Radix Angelicae Sinensis: sweet, hot, temperature.Return liver, the heart, spleen channel.Function with cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Saposhnikoviae: hot, sweet, temperature.Return bladder, liver, spleen channel.Function with cure mainly: inducing diaphoresis to dispel wind, win wet, relieving convulsion.Be used for headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Radix Aconiti Lateralis Preparata: nature and flavor with return through suffering, temperature; Poisonous.Return stomach, Liver Channel.Function with cure mainly: the expectorant that dispels the wind, arresting convulsion is jerked, the detoxicating and resolving stagnation of pathogens pain relieving.Be used for wind-phlegm and stop up, facial hemiparalysis, language is puckery stuttering, syncope due to accumulation of phlegm headache, migraine and general headache, sore throat pharyngalgia, tetanus; External treatment scrofula sucutaneous nodule, venom.
Radix Aconiti Preparata: hot, bitter, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.Function with cure mainly: expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Function with cure mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
Fructus Chaenomelis: acid, temperature.Return liver, spleen channel.Function with cure mainly: suppressing the hyperactive liver Shujin, stomach function regulating removing dampness.Be used for the arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, the convulsion of vomiting and diarrhoea, beriberi edema.
Radix Angelicae Pubescentis: hot, bitter, tepor.Gui Jing: return kidney, urinary bladder channel.Effect: expelling wind and removing dampness, numbness relieving and pain relieving.Cure mainly: be used for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.
Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel.Function with cure mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Scutellariae: hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication, the hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Curcumae: hot, bitter, cold.Return liver, the heart, lung meridian.Function with cure mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.
Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.Function with cure mainly: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function with cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The Radix Angelicae Dahuricae: suffering, temperature.Return stomach, large intestine, lung meridian.Function with cure mainly: the wind dehumidifying of loosing, understand things pain-stopping, detumescence and apocenosis.Be used for headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Aconiti: hot, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Function with cure mainly: expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Radix Aconiti Kusnezoffii: hot, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Function with cure mainly: expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Rhizoma Atractylodis: hot, bitter, temperature.Return spleen, stomach, Liver Channel.Function with cure mainly: drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Rhizoma Arisaematis: bitter, hot, temperature; Poisonous.Return lung, liver, spleen channel.Function with cure mainly: drying dampness to eliminate phlegm, expelling wind and relieving convulsion mass dissipating and swelling eliminating.Be used for the pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Give birth to and use external treatment carbuncle, snake bite and insect sting.
Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Function with cure mainly: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Semen Sinapis: suffering, temperature.Return lung meridian.Function with cure mainly: warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.Be used for cold-phlegm and breath with cough, distending pain in the chest and hypochondrium, the expectorant meridians that stagnate, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.
Natural Broneolum Syntheticum: hot, bitter, cool.Function with cure mainly: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be used for the calentura coma, convulsion is fainted, apoplexy syncope due to accumulation of phlegm, infantile convulsion expectorant fan, sore throat toothache, aphtha carbuncle and ulcer, conjunctival congestion.
Herba Asari: suffering, temperature.GUIXIN, lung, kidney channel.Function with cure mainly: expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.Be used for anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
The invention has the beneficial effects as follows: the present invention adopts the Chinese medicine preparation of pure natural, and toxic and side effects is little, and the cure rate height, Drug therapy rheumatoid arthritis 60 examples of the present invention, clinical cure 25 examples as a result, produce effects 22 examples, 10 examples that take a turn for the better, invalid 3 examples, total effective rate 95.0%.
Further specify its beneficial effect below in conjunction with clinical observation and typical proportions.
One, clinical observation
1. clinical data: be selected from outpatient's totally 120 examples that have complete case year July in July, 2008 to 2009.Be divided into treatment at random and organize 60 examples, matched group 60 examples.The treatment group age is 30-65 year, 41.5 years old mean age, course of disease 1-17, average 6.0 years; The matched group age is in 32-65 year, 41.3 years old mean age, and course of disease 1-15, average 5.7 years, the age and the course of disease be through X 2 test, no statistically-significant difference (p＞0.05).
2. diagnostic criteria:
Western medicine diagnose standard: with reference to the diagnostic criteria of U.S. rheumatism association rheumatoid arthritis in 1989: 1. morning deadlock: joint and the lasting at least 1h (course of disease＞=6 weeks) of stiff sense on every side thereof; 2. the arthritis of regional joint part more than 3 or 3: the doctor observes in 14 zones (proximal interphalangeal joint on left side or right side, metacarpal joint, wrist, elbow, knee joint, ankle and metatarsophalangeal joints) and involves 3, and soft tissue swelling or hydrops (not being simple bone protuberance) (course of disease＞=6 weeks) simultaneously; 3. cheirarthritis: wrist, the palm refer to or the proximal interphalangeal joint inflammation in, have an arthroncus (course of disease＞=6 weeks) at least; 4. symmetry arthritis: joint, both sides (when bilateral proximal interphalangeal joint, metacarpophalangeal joints and metatarsophalangeal joints are got involved, not necessarily absolute symmetry) (course of disease＞=6 weeks) of getting involved simultaneously; 5. rheumatoid nodules: the doctor observes at the apophysis position, and subcutaneous nodule is arranged around extensor surface or the joint; 6. the rheumatoid factor positive: any detection method proof serum rheumatoid factor (SRF) content is unusual, and the positive rate of this method in normal population is less than 5%; 7. radiology changes: have typical rheumatoid arthritis radiology to change in the postero-anterior position of hands and wrist on mutually: must comprise bone erosion or there is clear and definite sclerotin decalcification at get involved joint and contiguous position thereof.More than 7 satisfy more than 4 and get rid of other arthritis and can be diagnosed as rheumatoid arthritis.
The sick diagnostic criteria of traditional Chinese medical science numbness: 1. main clinical manifestation: position pain or swelling deadlocks in morning such as joint, skin, muscles and bones, numbness is weighing, joint stuffiness, even joint swelling deformation, tetanicly do not stretch, amyotrophy etc.: 2. characteristics of incidence: how relevant with climate change; 3. sex, age characteristics: good sending out in person between twenty and fifty, the woman is more than the man; 4. physico-chemical examination: the rheumatoid factor positive or erythrocyte sedimentation rate speed, the visible bone erosion of X line.Possess above-mentioned 1., 4. two, 2. or 3. in conjunction with making a definite diagnosis.
3. Therapeutic Method: the treatment group adds this Chinese medicine composition of external application according to the method for the invention is for oral administration, treats 3 courses of treatment; Matched group adopts penicillin 8,000,000 U to add 0.9% sodium chloride injection 250ml intravenous drip, once a day, cooperates Dicolfanac Sodium Sustained Release Tablets 75mg oral, and once a day, 8 weeks were 1 course of treatment, treated 3 courses of treatment.
4. efficacy assessment standard: 1. cure: arthralgia, swelling disappear (index reduces 〉=90%), and movable function is normal, and lab testing is normal; 2. produce effects: arthralgia, swelling alleviate (index reduces 60%～89%), and movable function takes a turn for the better, and lab testing take a favorable turn; 3. take a turn for the better: arthralgia, swelling alleviate (index reduces 31%～59%) to some extent, and movable function takes a turn for the better, and lab testing makes moderate progress; 4. invalid: arthralgia, swelling (index reduces≤30%) symptom and lab testing do not have improvement.
5. therapeutic outcome: two groups of therapeutic outcomes are as shown in table 1:
Table 1 liang group cure rate synopsis
| Group | Example is inferior | Recovery from illness/example | Produce effects number/example | Good revolution/example | Invalid number/example | Total effective rate (%) |
| The treatment group | ??60 | ??25 | ??22 | ??10 | ??3 | ??95 |
| Matched group | ??60 | ??5 | ??14 | ??16 | ??15 | ??75 |
Through X 2 test, two groups of effective percentage compare, and difference has highly significant (P＜0.001).
Two, model case is as follows:
Case 1: Lee, the woman, 40 years old, suffered from rheumatoid arthritis 5 years, both hands carpal joint redness, pain, stiff being difficult to of finger bend and stretch, carpal joint slightly is out of shape dislocation, morning, deadlock reached more than 2 hours, two ankle part pain unbearably, the patient can't take care of oneself.Fail to respond to any medical treatment in many places, after take Drug therapy of the present invention after, after the course of treatment morning stiff disappear, pain relief, after continuing to use 2 courses of treatment, swelling is eliminated, life can be taken care of oneself.Recurrence is not seen in the thoroughly rehabilitation after 4 courses of treatment of taking medicine so far.
Case 2: scape, the man, 48 years old, suffered from rheumatoid arthritis 7 years, symptom be daytime pain lighter, increase the weight of evening, the joint is symmetry and swells and ache.It is invalid to take multiple medicine, begins to use Drug therapy of the present invention before 2 years, and joint, the left and right sides on the 20th goes up painful obviously and alleviates, and daytime, appetite increased, and can go to sleep peacefully night.Recurrence is not seen in the thoroughly rehabilitation after 5 courses of treatment of taking medicine.
Case 3: willow, the man, 36, suffer from rheumatic arthritis for many years, the pain increased when overcast and rainy or winter in the both legs joint, two elbow arthroncuss, walking disorder.It is invalid to take multiple medicine, through friend introduce take one course of treatment of the present invention after, pain and swelling obviously alleviate, and adhere to taking two courses of treatment again, now fully recover.Through following up a case by regular visits to, not recurrence so far.
Case 4: Lee, the man, 45 years old, suffered from rheumatoid arthritis 12 years, once arrived hospital therapy, and hospitalization one month, though symptom alleviates, curative effect is not obvious, pain and swelling increase the weight of after the drug withdrawal.Accepted afterwards after doctor suggestion takes medicine of the present invention and take three courses of treatment, pain obviously alleviates, and buys two courses of treatment again and continues to take, and rehabilitation is not now seen recurrence through following up a case by regular visits to.
Case 5: Wang certain, the woman 52 years old, suffered from the rheumatoid rheumatism more than 9 year, each large and small joint migration pain, swelling sometimes, numbness, limitation of activity, difficulty in walking.Once used a lot of methods to treat, but poor effect.Adopt Drug therapy of the present invention after the ward mate introduces, only treat 2 the course of treatment General Symptoms all disappear, continue to strengthen treatment and reach curative effect 3 courses of treatment.
The specific embodiment
Embodiment 1:
Prescription: the 1st group: Radix Polygoni Multiflori 20, Fructus Lycii 10, the Cortex Eucommiae 10, Rhizoma Curculiginis 10, Herba Epimedii 10, Fructus Psoraleae 20, Radix Ginseng 10, Radix Ophiopogonis 10, Radix Angelicae Sinensis 15, Radix Saposhnikoviae 20, Radix Aconiti Lateralis Preparata 12, Radix Aconiti Preparata 15, Poria 10, Fructus Chaenomelis 15, Radix Angelicae Pubescentis 10, Radix Salviae Miltiorrhizae 10, Radix Scutellariae 15, Radix Curcumae 10, Radix Rehmanniae 20, Radix Glycyrrhizae 6; The 2nd group: the Radix Angelicae Dahuricae 20, Radix Aconiti 10, Radix Aconiti Kusnezoffii 10, Radix Saposhnikoviae 15, Rhizoma Atractylodis 20, Rhizoma Arisaematis 10, Semen Persicae 10, Radix Angelicae Sinensis 10, natural Broneolum Syntheticum 5, Semen Sinapis 10, Herba Asari 3.
Configuration and instructions of taking: the 1st group of medicine is decocted in water for oral dose, and every day, potion was taken at twice sooner or later.To make popular behind the 2nd group of medicine pulverization, and press every dose of medicine adding 100ml Chinese liquor (more than 50 degree, the number of degrees of Chinese liquor are as the criterion with commercially available Chinese liquor) and the ratio of 100ml Mel adds Chinese liquor and Mel is mixed well, spread on joint while hot, 1 dose of every day, divide 2 hot compresses, each 2-3 hour, during the 2nd application, be to mix well the back hot compress with the heating of the medicine after the 1st application and in the ratio adding Chinese liquor and the Mel of every dose of medicine adding 50ml Chinese liquor and 30ml Mel, one month is a course of treatment.
Claims (2)
1. the Chinese medicine composition of an Orally taken and externally treatment rheumatoid arthritis is characterized in that, is made by following raw medicaments in portion by weight:
The 1st group: Radix Polygoni Multiflori 20, Fructus Lycii 10, the Cortex Eucommiae 10, Rhizoma Curculiginis 10, Herba Epimedii 10, Fructus Psoraleae 20, Radix Ginseng 10, Radix Ophiopogonis 10, Radix Angelicae Sinensis 15, Radix Saposhnikoviae 20, Radix Aconiti Lateralis Preparata 12, Radix Aconiti Preparata 15, Poria 10, Fructus Chaenomelis 15, Radix Angelicae Pubescentis 10, Radix Salviae Miltiorrhizae 10, Radix Scutellariae 15, Radix Curcumae 10, Radix Rehmanniae 20, Radix Glycyrrhizae 6;
The 2nd group: the Radix Angelicae Dahuricae 20, Radix Aconiti 10, Radix Aconiti Kusnezoffii 10, Radix Saposhnikoviae 15, Rhizoma Atractylodis 20, Rhizoma Arisaematis 10, Semen Persicae 10, Radix Angelicae Sinensis 10, natural Broneolum Syntheticum 5, Semen Sinapis 10, Herba Asari 3;
Described the 1st group of medicine is endo-medicine, and the 2nd group of medicine is liniment.
2. the Chinese medicine composition of a kind of Orally taken and externally treatment rheumatoid arthritis as claimed in claim 1 is characterized in that, is made by the crude drug of following weight:
The 1st group: Radix Polygoni Multiflori 20g, Fructus Lycii 10g, Cortex Eucommiae 10g, Rhizoma Curculiginis 10g, Herba Epimedii 10g, Fructus Psoraleae 20g, Radix Ginseng 10g, Radix Ophiopogonis 10g, Radix Angelicae Sinensis 15g, Radix Saposhnikoviae 20g, Radix Aconiti Lateralis Preparata 12g, Radix Aconiti Preparata 15g, Poria 10g, Fructus Chaenomelis 15g, Radix Angelicae Pubescentis 10g, Radix Salviae Miltiorrhizae 10g, Radix Scutellariae 15g, Radix Curcumae 10g, Radix Rehmanniae 20g, Radix Glycyrrhizae 6g;
The 2nd group: Radix Angelicae Dahuricae 20g, Radix Aconiti 10g, Radix Aconiti Kusnezoffii 10g, Radix Saposhnikoviae 15g, Rhizoma Atractylodis 20g, Rhizoma Arisaematis 10g, Semen Persicae 10g, Radix Angelicae Sinensis 10g, natural Broneolum Syntheticum 5g, Semen Sinapis 10g, Herba Asari 3g.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902797A (en) * | 2016-06-30 | 2016-08-31 | 田引娣 | Medicine for treating rheumatic arthritis |
| CN105999069A (en) * | 2016-06-23 | 2016-10-12 | 广州暨南生物医药研究开发基地有限公司 | Argy wormwood leaf healthy wine for preventing and treating rheumatic arthritis and preparation method of argy wormwood leaf healthy wine |
| CN106362024A (en) * | 2016-11-03 | 2017-02-01 | 南通市第人民医院 | Chinese medicine formula for promoting recovery from rheumatism for middle aged and elderly people |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1099289A (en) * | 1994-02-08 | 1995-03-01 | 程志明 | Point moxibustion drug for treatment of arthralgia-syndrome and making method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999069A (en) * | 2016-06-23 | 2016-10-12 | 广州暨南生物医药研究开发基地有限公司 | Argy wormwood leaf healthy wine for preventing and treating rheumatic arthritis and preparation method of argy wormwood leaf healthy wine |
| CN105902797A (en) * | 2016-06-30 | 2016-08-31 | 田引娣 | Medicine for treating rheumatic arthritis |
| CN106362024A (en) * | 2016-11-03 | 2017-02-01 | 南通市第人民医院 | Chinese medicine formula for promoting recovery from rheumatism for middle aged and elderly people |
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