CN101711825A - Preparation method of rhizoma pinelliae preparata - Google Patents
Preparation method of rhizoma pinelliae preparata Download PDFInfo
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- CN101711825A CN101711825A CN200910185172A CN200910185172A CN101711825A CN 101711825 A CN101711825 A CN 101711825A CN 200910185172 A CN200910185172 A CN 200910185172A CN 200910185172 A CN200910185172 A CN 200910185172A CN 101711825 A CN101711825 A CN 101711825A
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Abstract
The invention relates to a preparation method of rhizoma pinelliae preparata, in particular to a preparing method of rhizoma pinelliae preparata, comprising the following steps of: preparing clean rhizoma pinelliae, separating according to the size, soaking in clear water till no dried cores are found, and taking out; preparing an appropriate amount of liquorice, adding water and decocting twice, merging the decocted liquor, adding calcined lime blocks in the obtained liquorice juice, adding an appropriate amount of clear water, fusing and removing lime mud, adding soaked rhizoma pinelliae, soaking and stirring once or twice everyday, keeping the pH value of the soaked liquor above 12, taking out till the section is yellow evenly and the mouthfeel is slightly numb, and drying to obtain the finished product, wherein 15kg of liquorice and 10g of calcined lime are used relative to every 100kg of clean rhizoma pinelliae. The method shortens the production time, improves the production efficiency, fully preserves the effective ingredients of the rhizoma pinelliae, greatly reduces the toxic ingredients, ensures the product quality, reduces the accessory consumption, saves the production cost, has easily controlled production process and guarantees the normalization of the rhizoma pinelliae preparation process.
Description
[technical field]
The present invention relates to the concocting method of Chinese crude drug, more particularly, relate to the concocting method of Rhizoma Pinelliae Preparatum.
[background technology]
Chinese crude drug must just can be used as medicine after concocting into decoction pieces; this is characteristics of tcm clinical practice medication; it also is the pharmaceutical technology a kind of uniqueness, proprietary of Chinese medicine; processing technique that it is of long standing and well established, of extensive knowledge and profound scholarship and process of preparing Chinese medicine culture have risen to the core technology and the independent intellectual property right of country; become a kind of significance sign that Chinese medicine is different from Western medicine; at present, the country also just be devoted to this national tradition technology protection, inherit, carry forward and develop.
" being three fens poison of medicine ", Chinese medicine is also inevitable.Although the toxic herb decoction pieces has untoward reaction or toxic and side effects, usually must utilize the unique effect treatment or the control some diseases of these decoction pieces clinically, the toxic component of these toxic herb decoction pieces often also is the effective ingredient of treatment disease.Must can be applicable to clinical through concocting the attenuation rear for minority toxic traditional Chinese medicine material.
The process of preparing Chinese medicine is by eliminating or reducing under the Drug therapy dosage injury to human body to the influence of Chinese materia medica tocixity.Traditional concocting method of Rhizoma Pinelliae Preparatum is: get the Rhizoma Pinelliae, and sieve dedust bits, size is separately put respectively in the bubble medicine pond, soaks with clear water.The water yield exceeds the powder chi to be permitted, and is sure not Exposure to Sunlight.Spring and autumn soaked 21 days, and suitably shorten summer, the proper extension time in winter.Steep after 10 days (summer in winter proper extension or shortening) spring and steep when the Rhizoma Pinelliae plays foam, must in time be sprinkled into the Alumen face and stir evenly.Steep after 3 days and to get rid of vitriol water, injected the clear water bubble 1-2 days, change water 2 times every day with detoxifcation, cutting opening is tasted no spicy sense and is advisable.The emptying clear water.The extracting liquorice sheet adds water and stews soup in right amount (endure 2 times, 2,1 hour time, medicine juice is about 5 times of amounts of Radix Glycyrrhizae).Add the fused back of proper amount of clear water delime slag with Sucus Glycyrrhizae bubble lime block, pour in the Rhizoma Pinelliae of no spicy sense, continue to soak 6-7 days.Stir every day gently, make its color even be yellow in no Bai Xinwei degree, pull out with flushing with clean water totally, behind the dryness in the sun, process cleaning.Warehouse-in promptly.Every 100kg Rhizoma Pinelliae is with Radix Glycyrrhizae 20kg, Calx 30kg and Alumen 2kg.
The effect of concocting: Rhizoma Pinelliae acrid in the mouth, warm in nature; Poisonous.Return spleen, stomach, lung meridian.Function with preventing phlegm from forming and stopping coughing, dispersing swelling and dissipating binds.Rhizoma Pinelliae Preparatum is partial to cold relieving expectorant, has the effect of the spleen and stomach regulating simultaneously, is used for the abundant expectoration cough, the phlegm retention vertigo and palpitation.Also Chinese traditional patent formulation preparations that are used for more.As XIANGSHA YANGWEI WAN (" Chinese medicine patent medicine preparation handbook).
But, mostly through the soaking, float of long period, and Rhizoma Pinelliae toxic component is insoluble or be insoluble in water in concocting process for the Rhizoma Pinelliae, and short-term is soaked can not reach toxicide purpose, long period of soaking then water soluble ingredient with a toll of 88.1%, alcohol soluble components loss 87.5%, chloroform, methanol stripping composition loss 76.6%, alkaloid loss 50%, its drug effect obviously reduces, therefore shorten water-soaking time, in order to avoid loss of effective components is a Chinese medicine industry technical barrier anxious to be solved.
[summary of the invention]
Technical problem to be solved by this invention is to provide a kind of new technology of concocting Rhizoma Pinelliae Preparatum, has shortened the production time, has reduced the proportion of goods damageds of finished product, has improved production efficiency.
Technical scheme of the present invention is: the concocting method of Rhizoma Pinelliae Preparatum: it is characterized in that taking following steps:
A. get Rhizoma Pinelliae and sieve, sieve dedust bits separate by size; With the described Rhizoma Pinelliae that cleaned, it is clean with the circulating water Rapid Cleaning to put into medicine-washing machine, and described medicine-washing machine drum speed is 8 rev/mins, and scavenging period is 15 minutes;
B. the Rhizoma Pinelliae of described cleaning is placed and carry out heat profit, pressure 1.6 * 10 in the medicine processing device
5Pa, 50 ℃ of temperature, amount of water is 4 times of Rhizoma Pinelliae weight, and infiltrating time 2 hours is dipped to the heart and is degree, and with the Rhizoma Pinelliae taking-up of described immersion, filter is done;
C. in addition the extracting liquorice sheet adds an amount of decocting liquid of water and obtains Sucus Glycyrrhizae, adds caustic lime block at described Sucus Glycyrrhizae and soaks, and add the fused back of proper amount of clear water delime slag, gets its mixed liquor;
D. the Rhizoma Pinelliae after described mixed liquor and the described immersion is put in the digester, 30 ℃ of temperature, pH value remains on more than 12, soaks 48 hours, taste little numb feeling in the tongue that has to Rhizoma Pinelliae mouth, the yellow evenly no Bai Xinwei degree of tangent plane takes out the soaked Rhizoma Pinelliae, cleaning, drying are the Rhizoma Pinelliae Preparatum finished product
Principle of the present invention is: the Rhizoma Pinelliae mouth is tasted very strong spicy sense, toxicity mainly shows as the strong twinge swelling to oral cavity, larynx and digestive tract mucosa, its main zest toxicity composition is the compound needle-like calcium oxalate crystal of toxalbumin that special pin sample crystal formation is arranged in the medical material, is called for short the toxalbumin needle.This poison needle is a complex, is made up of insoluble calcium oxalate and fibroin.The present invention soaks the Rhizoma Pinelliae jointly with quicklime and Radix Glycyrrhizae solution, wherein Calx process of preparing Chinese medicine detoxifcation principle is: pH value＞12 that keep quicklime solution when concocting, the toxicity needle that medical material contained is under this strong alkali solution effect, crystal formation and albumen are destroyed equally, thereby cause the effect of zest toxicity to reduce.Rhizoma Zingiberis Recens and Radix Glycyrrhizae mainly play potentiation in many adjuvants.The present invention adopts medicine processing device to be used for the fast softening and the infiltration of the Rhizoma Pinelliae, selecting soaking temperature, soak time, amount of water, four factors of pressure, adopt orthogonal design to carry out test of many times, the optimised process that obtains at last is 50 ℃ of temperature, soak time 48 hours, amount of water doubly, pressure 1.6 * 105Pa." concocting method of putting down in writing in the Chinese pharmacopoeia has shortened soak time to concocting method after the improvement greatly, has reduced the finished product proportion of goods damageds, and alkaloid also improves to some extent simultaneously, and antitussive action strengthens, and phlegm-dispelling functions and zest are suitable each other.
The invention has the advantages that: this technology is compared with traditional processing procedure, has following advantage:
(1) shortens the production time, reduced the proportion of goods damageds of finished product, improved production efficiency.Traditional handicraft was produced a collection of common needs 22 days, and new technology only needs 2 days, in addition, because traditional handicraft is soaked for a long time, caused the part Rhizoma Pinelliae to be difficult to cutting and was shaped, and caused the proportion of goods damageds too high.
(2) reduce supplementary product consumption, saved production cost.The every 100kg Rhizoma Pinelliae of new technology only needs Radix Glycyrrhizae 15kg, quicklime 10kg; The every 100kg Rhizoma Pinelliae of traditional handicraft then need be used Radix Glycyrrhizae 20kg, Calx 30kg and Alumen 2kg.
(3) simplified production procedure, production process is easy to control, has realized automatization, scale and the standardization of concocting; New technology adopts mechanized operation in a large number, as: adopt medicine processing device to be used for the fast softening and the infiltration of the Rhizoma Pinelliae, soak the Rhizoma Pinelliae with tilting-type steaming and decocting jacketed pan; Traditional handicraft then adopts fermentation vat, and it is big to take up room, and is not easy to control and operation.
(4) fully kept the effective ingredient of the Rhizoma Pinelliae, toxic component reduces greatly, has guaranteed product quality, improves the product curative effect, has guaranteed the safety of medication.The traditional handicraft long period of soaking cause the effective ingredient of the Rhizoma Pinelliae to run off in a large number, and new technology has shortened soak time greatly, has fully kept effective ingredient.
[specific embodiment]
Get the Rhizoma Pinelliae and sieve, sieve dedust bits, size is separately.With the Rhizoma Pinelliae that cleaned, clean with the circulating water Rapid Cleaning by its rule of operation at XY-720 type medicine-washing machine, drum speed is 8 rev/mins, and scavenging period is 15 minutes.The Rhizoma Pinelliae of cleaning put carry out heat in the RY1000 type medicine processing device and moisten pressure 1.6 * 10
5Pa, 50 ℃ of temperature, amount of water is 4 times of Rhizoma Pinelliae weight, infiltrating time 2 hours is dipped to the heart and is degree.The Rhizoma Pinelliae that soaked into is taken out, and filter is done; In addition the extracting liquorice sheet adds an amount of decocting liquid of water: fry in shallow oil 2 times, the time was respectively 2 hours and 1 hour, and with the decocting liquid merging that obtains for twice, the decocting liquid after the merging is about 5 times of Radix Glycyrrhizae tabellae weight.
The Sucus Glycyrrhizae that obtains in above-mentioned steps adds the caustic lime block immersion, adds the fused after-filtration delime slag of proper amount of clear water, gets its mixed liquor, the mixed liquor that obtains and the Rhizoma Pinelliae that soaked are placed in the tilting-type steaming and decocting jacketed pan, 30 ℃ of temperature keep PH＞12 (regulating if PH＜12 can add quicklime), soak 48 hours, taste little numb feeling in the tongue that has to Rhizoma Pinelliae mouth, the yellow evenly no Bai Xinwei degree of tangent plane takes out the Rhizoma Pinelliae, cleans, drying promptly obtains the Rhizoma Pinelliae Preparatum finished product.Every 100kg Rhizoma Pinelliae is with Radix Glycyrrhizae 15kg, quicklime 10kg.
The technology of the present invention advanced person, technological design is scientific and reasonable, meets the requirement that hi-tech industrialization is produced, and product quality is secure, and market prospect is wide, has high added value, meets the government investment policy, can satisfy the effective demand of people to health care; And automatization, through engineering approaches process that China's toxic traditional Chinese medicine decoction pieces is produced have been promoted, and, exemplary role is played in the industrial structure optimization and the technology upgrading of prepared slices of Chinese crude drugs production for fully, rationally utilizing resources such as existing production equipment that referential thinking is provided after the transformation of toxic traditional Chinese medicine decoction pieces tradition concocting method.
Claims (2)
1. the concocting method of Rhizoma Pinelliae Preparatum: it is characterized in that taking following steps:
A. get Rhizoma Pinelliae and sieve, sieve dedust bits separate by size; With the described Rhizoma Pinelliae that cleaned, it is clean with the circulating water Rapid Cleaning to put into medicine-washing machine, and described medicine-washing machine drum speed is 8 rev/mins, and scavenging period is 15 minutes;
B. the Rhizoma Pinelliae of described cleaning is placed and carry out heat profit, pressure 1.6 * 10 in the medicine processing device
5Pa, 50 ℃ of temperature, amount of water is 4 times of described Rhizoma Pinelliae weight, and infiltrating time 2 hours is dipped to the heart and is degree, and with the Rhizoma Pinelliae taking-up of described immersion, filter is done;
C. in addition the extracting liquorice sheet adds an amount of decocting liquid of water and obtains Sucus Glycyrrhizae, adds caustic lime block at described Sucus Glycyrrhizae and soaks, and add the fused back of proper amount of clear water delime slag, gets its mixed liquor;
D. the Rhizoma Pinelliae after described mixed liquor and the described immersion is put in the digester, 30 ℃ of temperature, pH value remains on more than 12, soaks 48 hours, taste little numb feeling in the tongue that has to Rhizoma Pinelliae mouth, the yellow evenly no Bai Xinwei degree of tangent plane takes out the soaked Rhizoma Pinelliae, cleaning, drying are the Rhizoma Pinelliae Preparatum finished product.
2. according to the concocting method of the described Rhizoma Pinelliae Preparatum of claim 1, it is characterized in that: in the C of described concocting method step, described Radix Glycyrrhizae tabellae need successively add decocting liquid 2 times, time was respectively 2 hours and 1 hour, then the decocting liquid that obtains for twice is merged and use, the decocting liquid that described merging obtains is 5 times of described Radix Glycyrrhizae tabellae weight.
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885947A (en) * | 2012-09-14 | 2013-01-23 | 康美药业股份有限公司 | Method for processing prepared pinellia tuber, product of prepared pinellia tuber and application of product |
| CN103006944A (en) * | 2012-12-10 | 2013-04-03 | 南京中医药大学 | Processing method for rhizoma typhonii flagelliformis |
| CN103961494A (en) * | 2014-05-14 | 2014-08-06 | 河南中医学院 | Method of processing pinellia ternate in producing area |
| CN104147280A (en) * | 2013-12-14 | 2014-11-19 | 郑州瑞龙制药股份有限公司 | Method for processing rhizoma pinellinae praeparata |
| CN104623151A (en) * | 2014-12-02 | 2015-05-20 | 江西江中中药饮片有限公司 | Preparation process of rhizoma pinelliae preparatum |
| CN105663527A (en) * | 2016-02-26 | 2016-06-15 | 江西青春康源中药饮片有限公司 | Processing method suitable for rhizoma pinellinae praeparata and rhizoma typhonii flagelliformis |
| CN106361928A (en) * | 2016-10-12 | 2017-02-01 | 康美（北京）药物研究院有限公司 | Processing method of Rhizoma Pinellinae Praeparata and Rhizoma Pinellinae Praeparata |
| CN107496631A (en) * | 2017-10-13 | 2017-12-22 | 河南省三禾药业有限公司 | A kind of rhizoma pinellinae praeparata and its concocting method |
| CN107898892A (en) * | 2017-12-11 | 2018-04-13 | 亳州市同科药业有限公司 | A kind of preparation method of rhizoma pinellinae praeparata |
| CN109381579A (en) * | 2018-12-25 | 2019-02-26 | 广州市药材公司中药饮片厂 | A kind of Preparation process method of rhizoma pinellinae praeparata |
| CN109999118A (en) * | 2019-04-19 | 2019-07-12 | 河南省青山药业股份有限公司 | A kind of preparation method of rhizoma pinellinae praeparata |
| CN112957414A (en) * | 2021-02-09 | 2021-06-15 | 贵州中医药大学 | Rhizoma pinellinae praeparata and production place processing and concocting integrated preparation process thereof |
| CN115702918A (en) * | 2021-08-10 | 2023-02-17 | 四川新荷花中药饮片股份有限公司 | Integrated pinellia ternata processing method suitable for industrial mass production |
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2009
- 2009-10-10 CN CN200910185172A patent/CN101711825A/en active Pending
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885947A (en) * | 2012-09-14 | 2013-01-23 | 康美药业股份有限公司 | Method for processing prepared pinellia tuber, product of prepared pinellia tuber and application of product |
| CN103006944A (en) * | 2012-12-10 | 2013-04-03 | 南京中医药大学 | Processing method for rhizoma typhonii flagelliformis |
| CN104147280B (en) * | 2013-12-14 | 2018-01-02 | 郑州瑞龙制药股份有限公司 | A kind of concocting method of rhizoma pinellinae praeparata |
| CN104147280A (en) * | 2013-12-14 | 2014-11-19 | 郑州瑞龙制药股份有限公司 | Method for processing rhizoma pinellinae praeparata |
| CN103961494A (en) * | 2014-05-14 | 2014-08-06 | 河南中医学院 | Method of processing pinellia ternate in producing area |
| CN104623151A (en) * | 2014-12-02 | 2015-05-20 | 江西江中中药饮片有限公司 | Preparation process of rhizoma pinelliae preparatum |
| CN105663527A (en) * | 2016-02-26 | 2016-06-15 | 江西青春康源中药饮片有限公司 | Processing method suitable for rhizoma pinellinae praeparata and rhizoma typhonii flagelliformis |
| CN106361928A (en) * | 2016-10-12 | 2017-02-01 | 康美（北京）药物研究院有限公司 | Processing method of Rhizoma Pinellinae Praeparata and Rhizoma Pinellinae Praeparata |
| CN107496631A (en) * | 2017-10-13 | 2017-12-22 | 河南省三禾药业有限公司 | A kind of rhizoma pinellinae praeparata and its concocting method |
| CN107898892A (en) * | 2017-12-11 | 2018-04-13 | 亳州市同科药业有限公司 | A kind of preparation method of rhizoma pinellinae praeparata |
| CN109381579A (en) * | 2018-12-25 | 2019-02-26 | 广州市药材公司中药饮片厂 | A kind of Preparation process method of rhizoma pinellinae praeparata |
| CN109999118A (en) * | 2019-04-19 | 2019-07-12 | 河南省青山药业股份有限公司 | A kind of preparation method of rhizoma pinellinae praeparata |
| CN112957414A (en) * | 2021-02-09 | 2021-06-15 | 贵州中医药大学 | Rhizoma pinellinae praeparata and production place processing and concocting integrated preparation process thereof |
| CN115702918A (en) * | 2021-08-10 | 2023-02-17 | 四川新荷花中药饮片股份有限公司 | Integrated pinellia ternata processing method suitable for industrial mass production |
| CN115702918B (en) * | 2021-08-10 | 2024-03-22 | 四川新荷花中药饮片股份有限公司 | Method for integrally processing pinellia ternate suitable for industrial mass production |
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Application publication date: 20100526 |