CN101711800A - Traditional Chinese medicine compound composition for treating arteriosclerotic cardiovascular diseases and processing method thereof - Google Patents
Traditional Chinese medicine compound composition for treating arteriosclerotic cardiovascular diseases and processing method thereof Download PDFInfo
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- CN101711800A CN101711800A CN200910200108A CN200910200108A CN101711800A CN 101711800 A CN101711800 A CN 101711800A CN 200910200108 A CN200910200108 A CN 200910200108A CN 200910200108 A CN200910200108 A CN 200910200108A CN 101711800 A CN101711800 A CN 101711800A
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Abstract
The invention relates to a traditional Chinese medicine compound composition, in particular to a traditional Chinese medicine compound composition for treating arteriosclerotic cardiovascular diseases and a processing method thereof. The traditional Chinese medicine compound composition for treating the arteriosclerotic cardiovascular diseases is characterized in that each 100g of traditional Chinese medicine compound composition comprises the following raw materials of traditional Chinese medicines in parts by weight: 10-25g of leech, 2-10g of piper longum, 8-30g of ground beetle, 10-30g of motherwort, 8-20g of Chinese pyrola herb and 10-35g of gynostemma pentaphylla. The processing method of the raw materials of various traditional Chinese medicines comprises the following steps: grinding the leech and the piper longum into fine powder directly in a form of original medicines, distilling and concentrating the motherwort, the ground beetle, the Chinese pyrola herb and the gynostemma pentaphylla by water cooking into granules, then grinding into fine powder, mixing various kinds of fine powder, stirring fully and pressing into tablets; coating a bowel solvent outside the tablets. The medicine combines long-term curative effect and short-term curative effect, treats both the incidental and fundamental aspects and is suitable for the treatment of each stage of the arteriosclerotic cardiovascular diseases.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound compositions, especially treat the Chinese medicine compound compositions and the processing method thereof of arteriosclerotic cardiovascular diseases.
Background technology
Arteriosclerotic cardiovascular diseases comprises atherosclerosis, hyperlipemia, coronary heart disease, angina pectoris, myocardial infarction etc., in the treatment atherosclerosis, hyperlipemia is during coronary heart disease at present, doctor trained in Western medicine lipid lowerers commonly used is statins and antiplatelet drug aspirin, these medicine expenses are expensive, and treatment time is long, are easy to bounce-back after the drug withdrawal; And angina pectoris, unstable angina particularly, there are the danger of generation myocardial infarction and the sequela of myocardial infarction, the thromboembolism treatment of doctor trained in Western medicine, place coronary artery bracket, coronary artery bypass grafting, operation risk is bigger, part patient's appearance far-end restenosis or blood flow are obstructed, and then present technology is unattainable.
Summary of the invention
The object of the present invention is to provide a kind of long-range curative effect and short term efficacy combines, treating both the principal and the secondary aspects of a disease at the same time, be applicable to the treatment in each stage of arteries and veins hardening cardiovascular diseases and the Chinese medicine compound compositions and the processing method thereof of treatment arteriosclerotic cardiovascular diseases easy to use.
The present invention is achieved in that a kind of Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases, it is characterized in that, the parts by weight of each raw material of Chinese medicine are in the described Chinese medicine compound compositions of every 100g (gram):
Hirudo 10g-25g, Piper longum 2g-10g, Eupolyphaga Seu Steleophaga 8g-30g, Herba Leonuri 10g-30g, Herba Pyrolae 8g-20g Herb Gynostemmae Pentaphylli 10g-35g.
The parts by weight of the every 100g of each raw material of Chinese medicine are: Hirudo 18g, Piper longum 6g, Eupolyphaga Seu Steleophaga 20g, Herba Pyrolae 16g, Herb Gynostemmae Pentaphylli 22g.
The process for preparing raw material of each Chinese medicine is:
Hirudo, Piper longum are with the direct pulverization of the form of former medicine, and granule pulverization is again distilled, is condensed into to Herba Leonuri, Eupolyphaga Seu Steleophaga, Herba Pyrolae, Herb Gynostemmae Pentaphylli then by decocting in water, and various smalls mix fully stirring, are pressed into tablet.The weight that tablet is every is approximately 1g.
Tablet coats enteric agents outward.
It is as follows that the present invention treats the instructions of taking of Chinese medicine compound compositions of arteriosclerotic cardiovascular diseases: coronary heart disease is early stage: every day 2 times, each 2; Angina pectoris: every day 2 times, each 4; Myocardial infarction and sequela: every day 3 times, each 4.
The Chinese medicine compound combination treatment that application the present invention treats arteriosclerotic cardiovascular diseases is simple oral drugs, easy to use, use its effect than long-range, determined curative effect, it contains the treatment in each stage of arteriosclerotic cardiovascular diseases, dosage with medicine is regulated and control, and is the new treatment field of treatment developing of angiopathy.
The Chinese medicine compound compositions that the present invention treats arteriosclerotic cardiovascular diseases is worked in coordination with jointly with various medicines and is reached therapeutic purposes, and pharmacological action mainly comprises following several respects: 1. prevention and thrombus.2. blood fat reducing and adjust metabolism disorder of blood lipid.3. remove blood vessel lipid speckle, protection tunica intima, antagonism ischemical reperfusion injury, the infringement that the protection heart ischemia causes.
In the prescription, Hirudo is a kind of potent inhibitor of natural thrombin, its effect rapidly, anticoagulant enzymatic activity, it can not only stop Fibrinogen to solidify, and also can stop the further blood clotting effect of catalyzed by thrombin, can reduce whole blood contrast viscosity and plasma viscosity simultaneously, shorten erythrocyte electrophoretic time, platelet is had significant inhibitory effect, and its antithrombotic thrombolytic effect mechanism of Eupolyphaga Seu Steleophaga mainly is that it can reduce erythrocytic hematocrit, the whole blood high specific viscosity simultaneously by suppressing hematoblastic gathering coagulation, whole blood hangs down specific viscosity, erythrocyte aggressiveness fat number, the erythrocyte rigidity index obviously reduces, and makes blood, the ESR equation number raises, adjust blood fat, to plasma viscosity, Fibrinogen does not have influence, and the two is by different approach antagonism thrombosis, the different links of thrombolytic have strengthened the effectiveness of Drug therapy process and have optimized curative effect.
The pharmacological action of Herb Gynostemmae Pentaphylli, it mainly is influence to lipid metabolism, it can reduce the content of apolipoprotein and lipoprotein, but eliminate myocardium fat matter, the triglyceride reducing low density lipoprotein, rising HDL/CDL (HDL-C/low-density lipoprotein cholesterol) ratio, promote hematoblastic depolymerization, can suppress simultaneously adipose cell oneself and produce free fatty and synthetic neutral fat, myocardial infarct size is dwindled, increase crown cell flow, improve the activity that ischemic myocardium pours into back oxygen dismutase again, suppress the release of lactic acid fat hydrogen enzyme, Piper longum has strong effect for reducing fat, and is main by promoting the excretion metabolism (cholesterol) of lipid, triglyceride reducing, the easypro coronary artery of living of rising HDL/CDL ratio selectivity improves the anti-ischemia ability of body myocardial ischemia, and arteriosclerotic formation and development is played inhibitory action, the two share and mainly is to strengthen its blood fat reducing, adjust metabolism disorder of blood lipid, collaborative antagonism reperfusion injury of cardiac muscle dwindles the ischemic necrosis area of myocardial infarction when myocardial infarction.
Herba Leonuri; Herba Pyrolae; main effect all has the selectivity coronary artery dilator increases the myocardial nutrition blood flow; protecting myocardial cell is to the damage of Hypoxia and ischemia; the effect of Herba Leonuri antiplatelet aggregation cohesion is obvious; Herba Pyrolae mainly the cAmp by promoting blood plasma (adenosine-3 ', 5 '-cyclisation one phosphoric acid) content, to reach its pharmacological action.The two share and is intended in different approaches, and coronary artery dilating on the link is strengthened coronary blood flow and avoided ischemic injuries to protect cardiac muscle, and both also have blood fat reducing simultaneously, prevent thrombotic effect.
In sum: working in coordination with between the herbal pharmacology effect that this formula agent adopts, center on the pathology evolution of arteriosclerosis, hyperlipemia, coronary heart disease, angina pectoris, myocardial infarction by different approaches, different link, dissolve from all many-side interventions, treating both the principal and the secondary aspects of a disease at the same time, be that the thromboembolism preventing thrombolytic is administered its mark, and blood fat reducing, removing blood vessel lipid, improve blood viscosity protection tunica intima Zhi Qiben, looking for another way the property of medicine Wen Tongfang that trembles with fear aspect the middle medical drugs property of medicine; Piper longum is warm in nature, and Herb Gynostemmae Pentaphylli usefulness cold in nature is lipid lowerers, the Herba Leonuri cold nature, and Herba Pyrolae is warm in nature, is all that to improve the circulation property of medicine then far different, and par is flat in whole prescription the property of medicine of patent medicine being adjusted at, and satisfies various body constitution patients' demand to try one's best.
The specific embodiment
Embodiment (one)
A kind of Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases, the parts by weight of each raw material of Chinese medicine are in the described Chinese medicine compound compositions of every 100g:
Hirudo 22g, Piper longum 4g, Eupolyphaga Seu Steleophaga 30g, Herba Leonuri 26g, Herba Pyrolae 8g Herb Gynostemmae Pentaphylli 10g.
The process for preparing raw material of each Chinese medicine is:
Hirudo, Piper longum are with the direct pulverization of the form of former medicine, and granule pulverization is again distilled, is condensed into to Herba Leonuri, Eupolyphaga Seu Steleophaga, Herba Pyrolae, Herb Gynostemmae Pentaphylli then by decocting in water, and various smalls mix fully stirring, are pressed into tablet.The weight that tablet is every is approximately 1g.
Embodiment (two)
A kind of Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases, the parts by weight of each raw material of Chinese medicine are in the described Chinese medicine compound compositions of every 100g:
Hirudo 25g, Piper longum 10g, Eupolyphaga Seu Steleophaga 10g, Herba Leonuri 10g, Herba Pyrolae 17g Herb Gynostemmae Pentaphylli 28g.
Processing method is identical with embodiment ().
Embodiment (three)
A kind of Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases, the parts by weight of each raw material of Chinese medicine are in the described Chinese medicine compound compositions of every 100g:
Hirudo 10g, Piper longum 8g, Eupolyphaga Seu Steleophaga 24g, Herba Leonuri 30g, Herba Pyrolae 10g, Herb Gynostemmae Pentaphylli 18g.
Processing method is identical with embodiment ().
Embodiment (four)
A kind of Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases, the parts by weight of each raw material of Chinese medicine are in the described Chinese medicine compound compositions of every 100g:
Hirudo 14g, Piper longum 2g, Eupolyphaga Seu Steleophaga 14g, Herba Leonuri 15g, Herba Pyrolae 20g Herb Gynostemmae Pentaphylli 35g.
Processing method is identical with embodiment ().
Embodiment (five)
A kind of Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases, the parts by weight of each raw material of Chinese medicine are in the described Chinese medicine compound compositions of every 100g:
Hirudo 18g, Piper longum 6g, Eupolyphaga Seu Steleophaga 20g, Herba Leonuri 20g, Herba Pyrolae 16g, Herb Gynostemmae Pentaphylli 22g.
Processing method is identical with embodiment ().
Embodiment (six)
A kind of Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases, the optimum weight umber of each raw material of Chinese medicine is in the described Chinese medicine compound compositions of every 100g:
Hirudo 18g, Piper longum 6g, Eupolyphaga Seu Steleophaga 20g, Herba Leonuri 18g, Herba Pyrolae 16g, Herb Gynostemmae Pentaphylli 22g.
Processing method is identical with embodiment ().
Model case
1. river * *, the man 46 years old, finds blood pressure 146/92mmHg during health check-up, the electrocardiogram prompting: left ventricular hypertrophy, the S-T section is forced down, and serum detects: T-CHOL 5.25mmol/l, triglyceride 3.56mmol/l, HDL1 .01mmol/l is diagnosed as coronary heart disease, hypertension.Adopt we's treatment, detailed directions: each 2 of this medicine, every day secondary, take 30 days after, the check electrocardiogram, the S-T section is forced down disappearance, blood pressure 136/84mmHg.Serum detects: T-CHOL 4.22mmol/l, triglyceride 1.68mmol/l, HDL1 .22mmol/l.
2. model * *, the women 64 years old, was diagnosed as coronary heart disease 3 years.Closely over the past half year, it is uncomfortable in chest to occur several, pareordia squeezing property pain, shoulder radiation left the companion perspire, blood pressure 156/90mmHg, electrocardiogram prompting, accidental ventricular premature contraction, the S-T section is forced down obviously, serum is checked: T-CHOL 5.82mmol/l, triglyceride 2.16mmol/l, high density lipoprotein 0.98mmol/l, creatine kinase 262u/l, sugared 6.84mmol/l.Be diagnosed as coronary heart disease, angina pectoris.Adopt we's treatment, detailed directions: each 4 of this medicine, every day secondary, shared 8 weeks.Do not find the pareordia discomfort during the medication, the check electrocardiogram: do not see ventricular premature contraction, the ST section forces down＜and 0.5, blood pressure 146/82mmHg.Serum is checked: T-CHOL 4.74mmol/l, triglyceride 1.88mmol/l, HDL1 .30mmol/l, creatine kinase 86.2u/l, sugared 6.28mmol/l.
Claims (4)
1. a Chinese medicine compound compositions for the treatment of arteriosclerotic cardiovascular diseases is characterized in that, the parts by weight of each raw material of Chinese medicine are in the described Chinese medicine compound compositions of every 100g:
Hirudo 10g-25g, Piper longum 2g-10g, Eupolyphaga Seu Steleophaga 8g-30g, Herba Leonuri 10g-30g, Herba Pyrolae 8g-20g Herb Gynostemmae Pentaphylli 10g-35g.
2. the Chinese medicine compound compositions of treatment arteriosclerotic cardiovascular diseases according to claim 1 is characterized in that, the parts by weight of the every 100g of each raw material of Chinese medicine are: Hirudo 18g, Piper longum 6g, Eupolyphaga Seu Steleophaga 20g, Herba Pyrolae 16g, Herb Gynostemmae Pentaphylli 22g.
3. the Chinese medicine compound compositions of treatment arteriosclerotic cardiovascular diseases according to claim 1 and 2 is characterized in that, the process for preparing raw material of each Chinese medicine is:
Hirudo, Piper longum are with the direct pulverization of the form of former medicine, and granule pulverization is again distilled, is condensed into to Herba Leonuri, Eupolyphaga Seu Steleophaga, Herba Pyrolae, Herb Gynostemmae Pentaphylli then by decocting in water, and various smalls mix fully stirring, are pressed into tablet.
4. the Chinese medicine compound compositions of treatment arteriosclerotic cardiovascular diseases according to claim 3 is characterized in that tablet coats enteric agents outward.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327003A (en) * | 2015-12-02 | 2016-02-17 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine for treating cardiovascular diseases and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327003A (en) * | 2015-12-02 | 2016-02-17 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine for treating cardiovascular diseases and preparation method thereof |
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Open date: 20100526 |